JPH11500733A - 微小粒子のための表面改質剤としてのポリアルキレンブロックコポリマー - Google Patents
微小粒子のための表面改質剤としてのポリアルキレンブロックコポリマーInfo
- Publication number
- JPH11500733A JPH11500733A JP8525803A JP52580396A JPH11500733A JP H11500733 A JPH11500733 A JP H11500733A JP 8525803 A JP8525803 A JP 8525803A JP 52580396 A JP52580396 A JP 52580396A JP H11500733 A JPH11500733 A JP H11500733A
- Authority
- JP
- Japan
- Prior art keywords
- therapeutic
- diagnostic
- agents
- agent
- particle size
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/70—Nanostructure
- Y10S977/734—Fullerenes, i.e. graphene-based structures, such as nanohorns, nanococoons, nanoscrolls or fullerene-like structures, e.g. WS2 or MoS2 chalcogenide nanotubes, planar C3N4, etc.
- Y10S977/742—Carbon nanotubes, CNTs
- Y10S977/745—Carbon nanotubes, CNTs having a modified surface
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/70—Nanostructure
- Y10S977/773—Nanoparticle, i.e. structure having three dimensions of 100 nm or less
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/70—Nanostructure
- Y10S977/773—Nanoparticle, i.e. structure having three dimensions of 100 nm or less
- Y10S977/775—Nanosized powder or flake, e.g. nanosized catalyst
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/70—Nanostructure
- Y10S977/788—Of specified organic or carbon-based composition
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
- Y10S977/927—Diagnostic contrast agent
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Pigments, Carbon Blacks, Or Wood Stains (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Processes Of Treating Macromolecular Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.その表面上に吸着された表面改質剤を有する治療又は診断剤を含む微小粒 子を含む組成物であって、前記表面改質剤が、1又は複数のポリオキシエチレン ブロックと、1又は複数のポリオキシ(高級アルキレン)ブロックと、を含むブ ロックコポリマーであり、ここで前記ブロックの少くともいくつかがオキシメチ レン基であることを特徴とする架橋基により一緒に連結される改良を特徴とする 組成物。 2.前記ブロックコポリマーが、次の繰り返し単位: −〔(ErPsEr)CH2O〕z− (式中、Pはオキシプロピレンであり; Eはオキシエチレンであり; rは2〜160、好ましくは75〜150の整数であり; sは15〜65、好ましくは30〜50の整数であり;そして zは2〜50、好ましくは2〜10の整数である) を任意の順序で有することを特徴とする請求項1に記載の組成物。 3.前記ブロックコポリマーが、式: (式中、rは141であり;sは44であり;そしてzは3〜4である)を有するこ とを特徴とする請求項2に記載の組成物。 4.前記治療剤が緑内障を治療するための薬剤であることを特徴とする請求項 1に記載の組成物。 5.前記治療剤が、(S)−1−〔(1,1−ジメチル−エチル)アミノ〕− 3−〔(4−4−モルホリニル)−1,2,5−チアジアゾール−3−イル−オ キシ〕−2−プロパノール(Z)ブテン ジオエート(1:1)塩であることを特徴とする請求項4に記載の組成物。 6.前記診断剤がラジオグラフィーの造影剤であることを特徴とする請求項1 に記載の組成物。 7.前記造影剤がエチル3,5−ジアセタミド−2,4,6−トリイオドベン ゾエートであることを特徴とする請求項6に記載の組成物。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/393,972 US5565188A (en) | 1995-02-24 | 1995-02-24 | Polyalkylene block copolymers as surface modifiers for nanoparticles |
US08/393,972 | 1995-02-24 | ||
PCT/US1996/002356 WO1996025921A1 (en) | 1995-02-24 | 1996-02-22 | Polyalkylene block copolymers as surface modifiers for nanoparticles |
Publications (1)
Publication Number | Publication Date |
---|---|
JPH11500733A true JPH11500733A (ja) | 1999-01-19 |
Family
ID=23557014
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP8525803A Pending JPH11500733A (ja) | 1995-02-24 | 1996-02-22 | 微小粒子のための表面改質剤としてのポリアルキレンブロックコポリマー |
Country Status (8)
Country | Link |
---|---|
US (2) | US5565188A (ja) |
EP (1) | EP0810855B1 (ja) |
JP (1) | JPH11500733A (ja) |
AT (1) | ATE242628T1 (ja) |
AU (1) | AU5025596A (ja) |
CA (1) | CA2213663C (ja) |
DE (1) | DE69628640T2 (ja) |
WO (1) | WO1996025921A1 (ja) |
Families Citing this family (173)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6284503B1 (en) | 1993-08-20 | 2001-09-04 | University Of Utah Research Foundation | Composition and method for regulating the adhesion of cells and biomolecules to hydrophobic surfaces |
WO1996025918A1 (en) | 1995-02-24 | 1996-08-29 | Nanosystems L.L.C. | Aerosols containing nanoparticle dispersions |
WO1996029998A1 (en) * | 1995-03-28 | 1996-10-03 | Fidia Advanced Biopolymers S.R.L. | Nanospheres comprising a biocompatible polysaccharide |
US5766629A (en) | 1995-08-25 | 1998-06-16 | Sangstat Medical Corporation | Oral cyclosporin formulations |
US5834025A (en) | 1995-09-29 | 1998-11-10 | Nanosystems L.L.C. | Reduction of intravenously administered nanoparticulate-formulation-induced adverse physiological reactions |
US20050267302A1 (en) * | 1995-12-11 | 2005-12-01 | G.D. Searle & Co. | Eplerenone crystalline form exhibiting enhanced dissolution rate |
US5863560A (en) * | 1996-09-11 | 1999-01-26 | Virotex Corporation | Compositions and methods for topical application of therapeutic agents |
US20050004049A1 (en) * | 1997-03-11 | 2005-01-06 | Elan Pharma International Limited | Novel griseofulvin compositions |
HU230338B1 (hu) * | 1997-06-27 | 2016-02-29 | Abraxis Bioscience Llc | Gyógyászati hatóanyagokat tartalmazó új készítmények, eljárás ilyen készítmények előállítására és alkalmazására |
UA72189C2 (uk) | 1997-11-17 | 2005-02-15 | Янссен Фармацевтика Н.В. | Фармацевтична композиція, що містить водну суспензію субмікронних ефірів 9-гідроксирисперидон жирних кислот |
EP1048301A4 (en) * | 1998-01-16 | 2005-03-09 | Takeda Chemical Industries Ltd | COMPOSITIONS WITH DELAYED ACTIVE INGREDIENTS, PROCESS FOR THEIR PREPARATION AND THEIR USE |
GB9802088D0 (en) * | 1998-01-30 | 1998-03-25 | Scherer Ltd R P | Pharmaceutical products |
JP2002512945A (ja) | 1998-04-29 | 2002-05-08 | ノバルティス アクチエンゲゼルシャフト | アセチルコリン組成物を安定化させる方法及び組成物 |
GB9815271D0 (en) | 1998-07-14 | 1998-09-09 | Cambridge Display Tech Ltd | Particles and devices comprising particles |
WO2000003753A2 (en) * | 1998-07-14 | 2000-01-27 | Em Industries, Inc. | Microdisperse drug delivery systems |
US6143830A (en) * | 1998-08-17 | 2000-11-07 | Basf Corporation | Emulsifier composition comprising ethylene oxide/propylene oxide block copolymers and amine-containing ethylene oxide/propylene oxide block copolymers |
US6165506A (en) * | 1998-09-04 | 2000-12-26 | Elan Pharma International Ltd. | Solid dose form of nanoparticulate naproxen |
US8236352B2 (en) | 1998-10-01 | 2012-08-07 | Alkermes Pharma Ireland Limited | Glipizide compositions |
US20080213378A1 (en) * | 1998-10-01 | 2008-09-04 | Elan Pharma International, Ltd. | Nanoparticulate statin formulations and novel statin combinations |
US20070160675A1 (en) * | 1998-11-02 | 2007-07-12 | Elan Corporation, Plc | Nanoparticulate and controlled release compositions comprising a cephalosporin |
ID29852A (id) | 1998-11-02 | 2001-10-18 | Elan Corp Plc Cs | Komposisi pelepasan modifikasi multi partikulasi |
US6969529B2 (en) * | 2000-09-21 | 2005-11-29 | Elan Pharma International Ltd. | Nanoparticulate compositions comprising copolymers of vinyl pyrrolidone and vinyl acetate as surface stabilizers |
US6375986B1 (en) | 2000-09-21 | 2002-04-23 | Elan Pharma International Ltd. | Solid dose nanoparticulate compositions comprising a synergistic combination of a polymeric surface stabilizer and dioctyl sodium sulfosuccinate |
US6428814B1 (en) * | 1999-10-08 | 2002-08-06 | Elan Pharma International Ltd. | Bioadhesive nanoparticulate compositions having cationic surface stabilizers |
US7459283B2 (en) | 2002-02-04 | 2008-12-02 | Elan Pharma International Limited | Nanoparticulate compositions having lysozyme as a surface stabilizer |
US6395300B1 (en) | 1999-05-27 | 2002-05-28 | Acusphere, Inc. | Porous drug matrices and methods of manufacture thereof |
US7919119B2 (en) * | 1999-05-27 | 2011-04-05 | Acusphere, Inc. | Porous drug matrices and methods of manufacture thereof |
US6610317B2 (en) | 1999-05-27 | 2003-08-26 | Acusphere, Inc. | Porous paclitaxel matrices and methods of manufacture thereof |
US6656504B1 (en) | 1999-09-09 | 2003-12-02 | Elan Pharma International Ltd. | Nanoparticulate compositions comprising amorphous cyclosporine and methods of making and using such compositions |
CO5261556A1 (es) * | 1999-12-08 | 2003-03-31 | Pharmacia Corp | Composiciones inhibidoras de ciclooxigenasa-2 que tiene rapido acceso de efecto terapeutico |
EP1175434A2 (en) * | 1999-12-08 | 2002-01-30 | Pharmacia Corporation | Eplerenone crystalline form |
US20030083493A1 (en) * | 1999-12-08 | 2003-05-01 | Barton Kathleen P. | Eplerenone drug substance having high phase purity |
UA74539C2 (en) | 1999-12-08 | 2006-01-16 | Pharmacia Corp | Crystalline polymorphous forms of celecoxib (variants), a method for the preparation thereof (variants), a pharmaceutical composition (variants) |
MY120279A (en) | 2000-05-26 | 2005-09-30 | Pharmacia Corp | Use of a celecoxib composition for fast pain relief |
PE20020146A1 (es) * | 2000-07-13 | 2002-03-31 | Upjohn Co | Formulacion oftalmica que comprende un inhibidor de ciclooxigenasa-2 (cox-2) |
US20020128267A1 (en) * | 2000-07-13 | 2002-09-12 | Rebanta Bandyopadhyay | Method of using COX-2 inhibitors in the treatment and prevention of ocular COX-2 mediated disorders |
US6634576B2 (en) | 2000-08-31 | 2003-10-21 | Rtp Pharma Inc. | Milled particles |
US20030224058A1 (en) * | 2002-05-24 | 2003-12-04 | Elan Pharma International, Ltd. | Nanoparticulate fibrate formulations |
US7198795B2 (en) * | 2000-09-21 | 2007-04-03 | Elan Pharma International Ltd. | In vitro methods for evaluating the in vivo effectiveness of dosage forms of microparticulate of nanoparticulate active agent compositions |
US20080241070A1 (en) * | 2000-09-21 | 2008-10-02 | Elan Pharma International Ltd. | Fenofibrate dosage forms |
US7276249B2 (en) * | 2002-05-24 | 2007-10-02 | Elan Pharma International, Ltd. | Nanoparticulate fibrate formulations |
US7998507B2 (en) * | 2000-09-21 | 2011-08-16 | Elan Pharma International Ltd. | Nanoparticulate compositions of mitogen-activated protein (MAP) kinase inhibitors |
US6887493B2 (en) * | 2000-10-25 | 2005-05-03 | Adi Shefer | Multi component controlled release system for oral care, food products, nutraceutical, and beverages |
US6589562B1 (en) * | 2000-10-25 | 2003-07-08 | Salvona L.L.C. | Multicomponent biodegradable bioadhesive controlled release system for oral care products |
US6565873B1 (en) | 2000-10-25 | 2003-05-20 | Salvona Llc | Biodegradable bioadhesive controlled release system of nano-particles for oral care products |
US7749539B2 (en) * | 2000-11-30 | 2010-07-06 | Efrat Biopolymers Ltd. | Polymeric formulations for drug delivery |
US6509027B2 (en) | 2001-02-12 | 2003-01-21 | Supergen, Inc. | Injectable pharmaceutical composition comprising coated particles of camptothecin |
US6497896B2 (en) | 2001-02-12 | 2002-12-24 | Supergen, Inc. | Method for administering camptothecins via injection of a pharmaceutical composition comprising microdroplets containing a camptothecin |
US20020150615A1 (en) * | 2001-02-12 | 2002-10-17 | Howard Sands | Injectable pharmaceutical composition comprising microdroplets of a camptothecin |
US6976647B2 (en) * | 2001-06-05 | 2005-12-20 | Elan Pharma International, Limited | System and method for milling materials |
US7758890B2 (en) | 2001-06-23 | 2010-07-20 | Lyotropic Therapeutics, Inc. | Treatment using dantrolene |
JP4464129B2 (ja) * | 2001-09-19 | 2010-05-19 | エラン ファーマ インターナショナル,リミティド | ナノ粒子インスリン製剤 |
CA2461080A1 (en) * | 2001-09-25 | 2003-04-03 | Pharmacia Corporation | Solid-state forms of n-(2-hydroxyacetyl)-5-(4-piperidyl)-4-(4-pyrimidinyl)-3-(4-chlorophenyl)pyrazole |
ATE371442T1 (de) * | 2001-10-12 | 2007-09-15 | Elan Pharma Int Ltd | Zusammensetzungen mit einer kombination aus eigenschaften sofortiger freisetzung und kontrollierter freisetzung |
US20040015519A1 (en) * | 2001-10-15 | 2004-01-22 | Yukitoshi Maeda | Content delivery server and content delivery system having the same |
US20030152519A1 (en) * | 2001-11-07 | 2003-08-14 | Reinhard Koenig | Methods for vascular imaging using nanoparticulate contrast agents |
US20030129242A1 (en) * | 2002-01-04 | 2003-07-10 | Bosch H. William | Sterile filtered nanoparticulate formulations of budesonide and beclomethasone having tyloxapol as a surface stabilizer |
US20030215502A1 (en) * | 2002-03-20 | 2003-11-20 | Elan Pharma International Limited | Fast dissolving dosage forms having reduced friability |
WO2003082213A2 (en) * | 2002-03-28 | 2003-10-09 | Imcor Pharmaceutical Company | Compositions and methods for delivering pharmaceutically active agents using nanoparticulates |
US7101576B2 (en) | 2002-04-12 | 2006-09-05 | Elan Pharma International Limited | Nanoparticulate megestrol formulations |
US20100226989A1 (en) * | 2002-04-12 | 2010-09-09 | Elan Pharma International, Limited | Nanoparticulate megestrol formulations |
US9101540B2 (en) | 2002-04-12 | 2015-08-11 | Alkermes Pharma Ireland Limited | Nanoparticulate megestrol formulations |
DK1494649T3 (da) | 2002-04-12 | 2012-04-10 | Alkermes Pharma Ireland Ltd | Nanopartikel-megestrolformuleringer |
US20040105889A1 (en) * | 2002-12-03 | 2004-06-03 | Elan Pharma International Limited | Low viscosity liquid dosage forms |
EP1503737B1 (en) * | 2002-05-06 | 2009-01-07 | Elan Pharma International Limited | Nanoparticulate nystatin formulations |
US20070264348A1 (en) * | 2002-05-24 | 2007-11-15 | Elan Pharma International, Ltd. | Nanoparticulate fibrate formulations |
JP4533134B2 (ja) * | 2002-06-10 | 2010-09-01 | エラン ファーマ インターナショナル,リミティド | ナノ粒子ポリコサノール製剤および新規なポリコサノールの組合せ |
AU2003261167A1 (en) | 2002-07-16 | 2004-02-02 | Elan Pharma International, Ltd | Liquid dosage compositions of stable nanoparticulate active agents |
EP1530457B1 (en) | 2002-08-12 | 2009-09-09 | Bend Research, Inc. | Pharmaceutical compositions of drugs in semi-ordered form and polymers |
UY27939A1 (es) | 2002-08-21 | 2004-03-31 | Glaxo Group Ltd | Compuestos |
JP4878839B2 (ja) * | 2002-09-11 | 2012-02-15 | エラン ファーマ インターナショナル,リミティド | ゲル安定化ナノパーティクル活性物質組成物 |
JP2006501936A (ja) * | 2002-10-04 | 2006-01-19 | エラン ファーマ インターナショナル,リミティド | 固体ナノ粒子活性薬剤のガンマ線照射 |
US20060188471A1 (en) * | 2002-10-31 | 2006-08-24 | Podolsky Daniel K | Methods of treating epithelial lesions |
US20040156895A1 (en) * | 2002-11-12 | 2004-08-12 | Elan Pharma International Ltd. | Solid dosage forms comprising pullulan |
WO2004058216A2 (en) * | 2002-12-17 | 2004-07-15 | Elan Pharma International Ltd. | Milling microgram quantities of nanoparticulate candidate compounds |
JP4469846B2 (ja) * | 2003-01-31 | 2010-06-02 | エラン ファーマ インターナショナル,リミティド | ナノ粒子状トピラメート製剤 |
US20040208833A1 (en) * | 2003-02-04 | 2004-10-21 | Elan Pharma International Ltd. | Novel fluticasone formulations |
US8512727B2 (en) * | 2003-03-03 | 2013-08-20 | Alkermes Pharma Ireland Limited | Nanoparticulate meloxicam formulations |
US20100297252A1 (en) | 2003-03-03 | 2010-11-25 | Elan Pharma International Ltd. | Nanoparticulate meloxicam formulations |
US7842232B2 (en) * | 2003-05-22 | 2010-11-30 | Elan Pharma International, Ltd. | Sterilization of dispersions of nanoparticulate active agents with gamma radiation |
DE602004018150D1 (de) * | 2003-08-08 | 2009-01-15 | Elan Pharma Int Ltd | Neue metaxalon-zusammensetzungen |
US7879360B2 (en) * | 2003-11-05 | 2011-02-01 | Elan Pharma International, Ltd. | Nanoparticulate compositions having a peptide as a surface stabilizer |
US20050101582A1 (en) | 2003-11-12 | 2005-05-12 | Allergan, Inc. | Compositions and methods for treating a posterior segment of an eye |
US20070224278A1 (en) | 2003-11-12 | 2007-09-27 | Lyons Robert T | Low immunogenicity corticosteroid compositions |
AU2005209201B2 (en) | 2004-01-20 | 2010-06-03 | Allergan, Inc. | Compositions for localized therapy of the eye, comprising preferably triamcinolone acetonide and hyaluronic acid |
ATE446581T1 (de) * | 2004-03-12 | 2009-11-15 | Trinity College Dublin | Magnetoresistives medium |
US8147865B2 (en) | 2004-04-30 | 2012-04-03 | Allergan, Inc. | Steroid-containing sustained release intraocular implants and related methods |
US8119154B2 (en) | 2004-04-30 | 2012-02-21 | Allergan, Inc. | Sustained release intraocular implants and related methods |
US20090004277A1 (en) * | 2004-05-18 | 2009-01-01 | Franchini Miriam K | Nanoparticle dispersion containing lactam compound |
EP2623095A1 (en) * | 2004-11-16 | 2013-08-07 | Elan Pharma International Limited | Injectable nanoparticulate olanzapine formulations |
US20090155331A1 (en) * | 2005-11-16 | 2009-06-18 | Elan Pharma International Limited | Injectable nanoparticulate olanzapine formulations |
UA89513C2 (uk) * | 2004-12-03 | 2010-02-10 | Элан Фарма Интернешнл Лтд. | Стабільна композиція з наночастинок ралоксифену гідрохлориду |
WO2006062875A1 (en) * | 2004-12-08 | 2006-06-15 | Merck & Co., Inc. | Ophthalmic nanoparticulate formulation of a cyclooxygenase-2 selective inhibitor |
WO2006066063A1 (en) * | 2004-12-15 | 2006-06-22 | Elan Pharma International Ltd. | Nanoparticulate tacrolimus formulations |
AU2005326168A1 (en) * | 2004-12-21 | 2006-08-03 | Baxter Healthcare S.A. | (polyalkoxy)sulfonate surface modifiers |
US20060159767A1 (en) * | 2004-12-22 | 2006-07-20 | Elan Pharma International Limited | Nanoparticulate bicalutamide formulations |
MX2007008212A (es) * | 2005-01-06 | 2007-08-16 | Elan Pharma Int Ltd | Formulaciones de candesartan en nanoparticulas. |
EP1853234A2 (en) * | 2005-02-15 | 2007-11-14 | Elan Pharma International Limited | Aerosol and injectable formulations of nanoparticulate benzodiazepine |
US20060204588A1 (en) * | 2005-03-10 | 2006-09-14 | Elan Pharma International Limited | Formulations of a nanoparticulate finasteride, dutasteride or tamsulosin hydrochloride, and mixtures thereof |
CA2601179A1 (en) * | 2005-03-16 | 2006-09-21 | Elan Pharma International Limited | Nanoparticulate leukotriene receptor antagonist/corticosteroid formulations |
KR20070121759A (ko) * | 2005-03-17 | 2007-12-27 | 엘란 파마 인터내셔널 리미티드 | 나노입자형 비스포스포네이트 조성물 |
BRPI0609700A2 (pt) * | 2005-03-23 | 2010-04-20 | Elan Pharma Int Ltd | formulações de corticosteróide nanoparticulado e antihistamina |
WO2006110809A2 (en) * | 2005-04-12 | 2006-10-19 | Elan Pharma International, Limited | Nanoparticulate lipase inhibitor formulations |
CA2603084A1 (en) * | 2005-04-12 | 2006-10-19 | Elan Pharma International Limited | Nanoparticulate and controlled release compositions comprising cyclosporine |
AU2006235487B2 (en) * | 2005-04-12 | 2011-12-22 | Elan Pharma International Limited | Nanoparticulate quinazoline derivative formulations |
CA2606861C (en) * | 2005-05-05 | 2012-08-07 | Sanofi-Aventis U.S. Llc | Stable nanoparticle formulations |
WO2006132752A1 (en) * | 2005-05-10 | 2006-12-14 | Elan Pharma International Limited | Nanoparticulate and controlled release compositions comprising vitamin k2 |
WO2007086914A2 (en) * | 2005-05-10 | 2007-08-02 | Elan Pharma International, Limited | Nanoparticulate clopidogrel formulations |
US20060292214A1 (en) * | 2005-06-03 | 2006-12-28 | Elan Pharma International Limited | Nanoparticulate acetaminophen formulations |
WO2006133045A1 (en) * | 2005-06-03 | 2006-12-14 | Elan Pharma International, Limited | Nanoparticulate benidipine compositions |
JP2008542397A (ja) * | 2005-06-03 | 2008-11-27 | エラン ファーマ インターナショナル リミテッド | ナノ粒子メシル酸イマチニブ製剤 |
JP2009517485A (ja) | 2005-06-08 | 2009-04-30 | エラン・ファルマ・インターナショナル・リミテッド | セフジトレンを含むナノ粒子状および制御放出組成物 |
US20070059371A1 (en) * | 2005-06-09 | 2007-03-15 | Elan Pharma International, Limited | Nanoparticulate ebastine formulations |
US20070003615A1 (en) * | 2005-06-13 | 2007-01-04 | Elan Pharma International Limited | Nanoparticulate clopidogrel and aspirin combination formulations |
CA2612384A1 (en) * | 2005-06-15 | 2006-12-28 | Elan Pharma International, Limited | Nanoparticulate azelnidipine formulations |
CA2614412A1 (en) * | 2005-07-07 | 2007-01-18 | Elan Pharma International, Limited | Nanoparticulate clarithromycin formulations |
CN103462943A (zh) * | 2005-07-15 | 2013-12-25 | Map药物公司 | 在离散的吸入粒子中结合的多种活性药物成分及其制剂 |
DE102005035374A1 (de) * | 2005-07-22 | 2007-01-25 | Universität Potsdam | Nanohohlkapseln |
JP2009507925A (ja) * | 2005-09-13 | 2009-02-26 | エラン ファーマ インターナショナル リミテッド | ナノ粒子タダラフィル製剤 |
EP1954252B1 (en) * | 2005-12-02 | 2016-02-03 | GlaxoSmithKline Biologicals SA | Nanoparticles for use in immunogenic compositions |
US20070197486A1 (en) * | 2005-12-20 | 2007-08-23 | Verus Pharmaceuticals, Inc. | Methods and systems for the delivery of corticosteroids |
US20070160542A1 (en) * | 2005-12-20 | 2007-07-12 | Verus Pharmaceuticals, Inc. | Methods and systems for the delivery of corticosteroids having an enhanced pharmacokinetic profile |
US20070249572A1 (en) * | 2005-12-20 | 2007-10-25 | Verus Pharmaceuticals, Inc. | Systems and methods for the delivery of corticosteroids |
US20070185066A1 (en) * | 2005-12-20 | 2007-08-09 | Verus Pharmaceuticals, Inc. | Systems and methods for the delivery of corticosteroids |
GB2434152A (en) * | 2006-01-16 | 2007-07-18 | Whitford Plastics Ltd | Fluoropolymer powdered materials |
US20070178051A1 (en) * | 2006-01-27 | 2007-08-02 | Elan Pharma International, Ltd. | Sterilized nanoparticulate glucocorticosteroid formulations |
WO2007095341A2 (en) * | 2006-02-15 | 2007-08-23 | Tika Läkemedel Ab | Sterilization of corticosteroids with reduced mass loss |
US8367112B2 (en) * | 2006-02-28 | 2013-02-05 | Alkermes Pharma Ireland Limited | Nanoparticulate carverdilol formulations |
CL2007002689A1 (es) | 2006-09-18 | 2008-04-18 | Vitae Pharmaceuticals Inc | Compuestos derivados de piperidin-1-carboxamida, inhibidores de la renina; compuestos intermediarios; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como hipertension, insuficiencia cardiaca, fibrosis cardiaca, entre otras. |
CN1946120B (zh) * | 2006-10-20 | 2010-05-12 | 华为技术有限公司 | 实现话单关联的方法及系统 |
WO2008135855A2 (en) | 2007-05-03 | 2008-11-13 | Pfizer Products Inc. | Nanoparticles comprising a cholesteryl ester transfer protein inhibitor and a nonionizable polymer |
WO2008135828A2 (en) | 2007-05-03 | 2008-11-13 | Pfizer Products Inc. | Nanoparticles comprising a drug, ethylcellulose, and a bile salt |
US9545384B2 (en) | 2007-06-04 | 2017-01-17 | Bend Research, Inc. | Nanoparticles comprising drug, a non-ionizable cellulosic polymer and tocopheryl polyethylene glocol succinate |
EP2162120B1 (en) | 2007-06-04 | 2016-05-04 | Bend Research, Inc | Nanoparticles comprising a non-ionizable cellulosic polymer and an amphiphilic non-ionizable block copolymer |
US9125807B2 (en) | 2007-07-09 | 2015-09-08 | Incept Llc | Adhesive hydrogels for ophthalmic drug delivery |
US8642062B2 (en) | 2007-10-31 | 2014-02-04 | Abbott Cardiovascular Systems Inc. | Implantable device having a slow dissolving polymer |
EP2231169B1 (en) | 2007-12-06 | 2016-05-04 | Bend Research, Inc. | Pharmaceutical compositions comprising nanoparticles and a resuspending material |
US9233078B2 (en) | 2007-12-06 | 2016-01-12 | Bend Research, Inc. | Nanoparticles comprising a non-ionizable polymer and an Amine-functionalized methacrylate copolymer |
US20090238867A1 (en) * | 2007-12-13 | 2009-09-24 | Scott Jenkins | Nanoparticulate Anidulafungin Compositions and Methods for Making the Same |
JP2011520779A (ja) * | 2008-03-21 | 2011-07-21 | エラン・ファルマ・インターナショナル・リミテッド | イマチニブの部位特異的送達のための組成物および使用の方法 |
US20090311335A1 (en) * | 2008-06-12 | 2009-12-17 | Scott Jenkins | Combination of a triptan and an nsaid |
US8409606B2 (en) | 2009-02-12 | 2013-04-02 | Incept, Llc | Drug delivery through hydrogel plugs |
US20120065221A1 (en) | 2009-02-26 | 2012-03-15 | Theraquest Biosciences, Inc. | Extended Release Oral Pharmaceutical Compositions of 3-Hydroxy-N-Methylmorphinan and Method of Use |
US7828996B1 (en) * | 2009-03-27 | 2010-11-09 | Abbott Cardiovascular Systems Inc. | Method for the manufacture of stable, nano-sized particles |
US20100291221A1 (en) * | 2009-05-15 | 2010-11-18 | Robert Owen Cook | Method of administering dose-sparing amounts of formoterol fumarate-budesonide combination particles by inhalation |
AU2010254180B2 (en) | 2009-05-27 | 2015-08-27 | Alkermes Pharma Ireland Limited | Reduction of flake-like aggregation in nanoparticulate active agent compositions |
FR2945950A1 (fr) | 2009-05-27 | 2010-12-03 | Elan Pharma Int Ltd | Compositions de nanoparticules anticancereuses et procedes pour les preparer |
US8309489B2 (en) * | 2009-06-18 | 2012-11-13 | University Of Central Florida Research Foundation, Inc. | Thermally stable nanoparticles on supports |
US20110117182A1 (en) * | 2009-07-30 | 2011-05-19 | Allergan, Inc. | Combination of dapsone with other anti-acne agents |
AR077692A1 (es) | 2009-08-06 | 2011-09-14 | Vitae Pharmaceuticals Inc | Sales de 2-((r)-(3-clorofenil) ((r)-1-((s) -2-(metilamino)-3-((r)-tetrahidro-2h-piran-3-il) propilcarbamoil) piperidin -3-il) metoxi) etilcarbamato de metilo |
KR20120093892A (ko) * | 2009-09-21 | 2012-08-23 | 나노그램 코포레이션 | 박막 태양전지 제조용 실리콘 잉크, 이의 제조방법, 및 태양 전지 구조 |
JP2013524275A (ja) | 2010-04-03 | 2013-06-17 | ドシ,プラフル | 薬剤を含む医療機器、その製造方法とその使用方法 |
US10413506B2 (en) | 2010-04-03 | 2019-09-17 | Praful Doshi | Medical devices including medicaments and methods of making and using same including enhancing comfort, enhancing drug penetration, and treatment of myopia |
WO2011146583A2 (en) | 2010-05-19 | 2011-11-24 | Elan Pharma International Limited | Nanoparticulate cinacalcet formulations |
US8895962B2 (en) * | 2010-06-29 | 2014-11-25 | Nanogram Corporation | Silicon/germanium nanoparticle inks, laser pyrolysis reactors for the synthesis of nanoparticles and associated methods |
US8961501B2 (en) | 2010-09-17 | 2015-02-24 | Incept, Llc | Method for applying flowable hydrogels to a cornea |
CN103813793A (zh) | 2011-07-22 | 2014-05-21 | 葛兰素史克知识产权开发有限公司 | 4-叔丁基-n-[4-氯-2-(1-氧基-吡啶-4-羰基)-苯基]-苯磺酰胺钠盐的多晶型 |
RS56023B1 (sr) | 2011-07-22 | 2017-09-29 | Chemocentryx Inc | Kristalni oblik natrijumove soli 4-terc-butil-n-[4-hlor-2-(1-okso-piridin-4-karbonil)-fenil]-benzensulfonamida |
KR20190075172A (ko) | 2011-09-01 | 2019-06-28 | 글락소 그룹 리미티드 | 신규한 결정 형태 |
US10226417B2 (en) | 2011-09-16 | 2019-03-12 | Peter Jarrett | Drug delivery systems and applications |
WO2013086015A1 (en) | 2011-12-05 | 2013-06-13 | Incept, Llc | Medical organogel processes and compositions |
GB201222455D0 (en) * | 2012-12-13 | 2013-01-30 | Perioc Ltd | Novel pharmaceutical formulations and their use in the treatment of periodontaldisease |
WO2014189886A1 (en) | 2013-05-24 | 2014-11-27 | Nanogram Corporation | Printable inks with silicon/germanium based nanoparticles with high viscosity alcohol solvents |
PT3160958T (pt) | 2014-06-25 | 2021-04-07 | Glaxosmithkline Ip Dev Ltd | Sais cristalinos de (s)-6-((1-acetilpiperidin-4-il)amino)- n-(3-(3,4-di-hidroisoquinolin-2(1h)-il)-2- hidroxipropil)pirimidina-4-carboxamida |
KR102470460B1 (ko) * | 2014-07-18 | 2022-11-23 | 쓰리엠 이노베이티브 프로퍼티즈 컴파니 | 공기 필터를 위한 방향제 분배기 |
US20170283404A1 (en) | 2014-09-08 | 2017-10-05 | Glaxosmithkline Intellectual Property Development Limited | Crystalline forms of 2-(4-(4-ethoxy-6-oxo-1,6-dihydropyridin-3-yl)-2-fluorophenyl)-n-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)acetamide |
EP3233964B1 (en) | 2014-12-18 | 2020-06-17 | Dexcel Pharma Technologies Ltd. | Alternating and semi-alternating poly(ester-anhydride) copolymers |
US10166197B2 (en) | 2015-02-13 | 2019-01-01 | St. John's University | Sugar ester nanoparticle stabilizers |
WO2016178876A2 (en) | 2015-05-01 | 2016-11-10 | Cocrystal Pharma, Inc. | Nucleoside analogs for treatment of the flaviviridae family of viruses and cancer |
WO2018178963A1 (en) | 2017-03-29 | 2018-10-04 | Dexcel Pharma Technologies Ltd. | Compositions comprising biodegradable copolymers |
IL292487A (en) | 2019-11-01 | 2022-06-01 | Aquestive Therapeutics Inc | Compositions of medicinal meters and methods of treatment |
JP2023502069A (ja) | 2019-11-14 | 2023-01-20 | アクエスティブ セラピューティクス インコーポレイテッド | マルチモーダルな組成物及び治療方法 |
EP4277611A1 (en) | 2021-01-15 | 2023-11-22 | Aquestive Therapeutics, Inc. | Prodrug compositions and methods of treatment |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3740421A (en) * | 1966-09-19 | 1973-06-19 | Basf Wyandotte Corp | Polyoxyethylene-polyoxypropylene aqueous gels |
US3867533A (en) * | 1968-12-20 | 1975-02-18 | Basf Wyandotte Corp | Preparation of aqueous gel compositions containing a water-insoluble organic ingredient |
DE2536121A1 (de) * | 1974-08-19 | 1976-03-04 | Basf Wyandotte Corp | Oberflaechenaktive block-polyoxyalkylencopolymere |
US4465663A (en) * | 1981-07-27 | 1984-08-14 | Basf Wyandotte Corporation | Polyoxybutylene-polyoxyethylene aqueous gels |
US4587365A (en) * | 1984-10-29 | 1986-05-06 | Basf Corporation | Preparing capped polyoxyalkylene polyols |
GB8716559D0 (en) * | 1987-07-14 | 1987-08-19 | Secr Defence | Ion conductors |
US5145684A (en) * | 1991-01-25 | 1992-09-08 | Sterling Drug Inc. | Surface modified drug nanoparticles |
US5326552A (en) * | 1992-12-17 | 1994-07-05 | Sterling Winthrop Inc. | Formulations for nanoparticulate x-ray blood pool contrast agents using high molecular weight nonionic surfactants |
GB2283977B (en) * | 1993-10-30 | 1998-01-28 | Kodak Ltd | Polymers and a process for preparing them |
CA2207589C (en) * | 1994-12-21 | 2005-10-18 | Nanosystems L.L.C. | Polyether copolymers and a process for preparing them |
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1995
- 1995-02-24 US US08/393,972 patent/US5565188A/en not_active Expired - Lifetime
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1996
- 1996-02-22 AU AU50255/96A patent/AU5025596A/en not_active Abandoned
- 1996-02-22 CA CA002213663A patent/CA2213663C/en not_active Expired - Fee Related
- 1996-02-22 JP JP8525803A patent/JPH11500733A/ja active Pending
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- 1996-02-22 EP EP96907083A patent/EP0810855B1/en not_active Expired - Lifetime
- 1996-10-08 US US08/727,863 patent/US5705194A/en not_active Expired - Lifetime
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CA2213663A1 (en) | 1996-08-29 |
WO1996025921A1 (en) | 1996-08-29 |
ATE242628T1 (de) | 2003-06-15 |
EP0810855B1 (en) | 2003-06-11 |
EP0810855A4 (en) | 1999-04-07 |
US5565188A (en) | 1996-10-15 |
DE69628640T2 (de) | 2004-05-19 |
DE69628640D1 (de) | 2003-07-17 |
EP0810855A1 (en) | 1997-12-10 |
US5705194A (en) | 1998-01-06 |
CA2213663C (en) | 2009-11-03 |
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