JPH10147529A - 乳癌を予防する方法 - Google Patents

乳癌を予防する方法

Info

Publication number
JPH10147529A
JPH10147529A JP9298654A JP29865497A JPH10147529A JP H10147529 A JPH10147529 A JP H10147529A JP 9298654 A JP9298654 A JP 9298654A JP 29865497 A JP29865497 A JP 29865497A JP H10147529 A JPH10147529 A JP H10147529A
Authority
JP
Japan
Prior art keywords
product
compound
breast cancer
effective amount
pharmaceutical formulation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP9298654A
Other languages
English (en)
Japanese (ja)
Other versions
JPH10147529A5 (enExample
Inventor
Fredric Jay Cohen
フレドリック・ジェイ・コーエン
Joan Ellen Glusman
ジョーン・エレン・グラスマン
Ronald Keith Knickerbocker
ロナルド・キース・ニッカボッカー
Nikolaus Thomas Nickelsen
ニコラウス・トーマス・ニッケルセン
Teri Janine Scott
テリー・ジェイニー・スコット
Steven Eckert Robert
ロバート・スティーブン・エッカート
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27268608&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JPH10147529(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GBGB9624800.0A external-priority patent/GB9624800D0/en
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of JPH10147529A publication Critical patent/JPH10147529A/ja
Publication of JPH10147529A5 publication Critical patent/JPH10147529A5/ja
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP9298654A 1996-10-30 1997-10-30 乳癌を予防する方法 Pending JPH10147529A (ja)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US2985096P 1996-10-30 1996-10-30
US60/029850 1996-10-30
GBGB9624800.0A GB9624800D0 (en) 1996-11-29 1996-11-29 Methods of preventing breast cancer
US4026097P 1997-03-10 1997-03-10
US60/040260 1997-03-10
US9624800 1997-03-10

Publications (2)

Publication Number Publication Date
JPH10147529A true JPH10147529A (ja) 1998-06-02
JPH10147529A5 JPH10147529A5 (enExample) 2005-07-07

Family

ID=27268608

Family Applications (2)

Application Number Title Priority Date Filing Date
JP9298654A Pending JPH10147529A (ja) 1996-10-30 1997-10-30 乳癌を予防する方法
JP9298682A Withdrawn JPH10147530A (ja) 1996-10-30 1997-10-30 乳癌の予防に関する改善

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP9298682A Withdrawn JPH10147530A (ja) 1996-10-30 1997-10-30 乳癌の予防に関する改善

Country Status (43)

Country Link
US (2) US6303634B1 (enExample)
EP (3) EP0839532B1 (enExample)
JP (2) JPH10147529A (enExample)
CN (2) CN1182590A (enExample)
AP (1) AP971A (enExample)
AR (2) AR010538A1 (enExample)
AT (2) ATE338551T1 (enExample)
AU (3) AU5005697A (enExample)
BE (2) BE1011382A5 (enExample)
BG (1) BG63841B1 (enExample)
BR (1) BR9712703A (enExample)
CA (2) CA2219070C (enExample)
CH (2) CH693820A5 (enExample)
CZ (2) CZ300261B6 (enExample)
DE (2) DE69721692T2 (enExample)
DK (2) DK1369115T3 (enExample)
EA (2) EA006083B1 (enExample)
EE (1) EE03663B1 (enExample)
ES (4) ES2135343A1 (enExample)
FR (2) FR2755014B1 (enExample)
GB (3) GB2318734B (enExample)
GE (1) GEP20032910B (enExample)
GR (2) GR1003189B (enExample)
HU (2) HUP9701777A3 (enExample)
IE (2) IE970772A1 (enExample)
IL (2) IL122026A0 (enExample)
IS (1) IS5035A (enExample)
IT (2) ITMI972434A1 (enExample)
LU (2) LU90157B1 (enExample)
LV (1) LV12353B (enExample)
MY (1) MY121623A (enExample)
NL (2) NL1007386C2 (enExample)
NO (2) NO322468B1 (enExample)
NZ (1) NZ329042A (enExample)
PT (2) PT1369115E (enExample)
RO (1) RO120813B1 (enExample)
SG (2) SG83672A1 (enExample)
SI (3) SI1369115T1 (enExample)
SK (1) SK287047B6 (enExample)
TR (1) TR199900951T2 (enExample)
UA (1) UA46762C2 (enExample)
WO (2) WO1998018325A1 (enExample)
YU (1) YU42397A (enExample)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6458811B1 (en) * 1996-03-26 2002-10-01 Eli Lilly And Company Benzothiophenes formulations containing same and methods
GB9624800D0 (en) * 1996-11-29 1997-01-15 Lilly Co Eli Methods of preventing breast cancer
FI982733L (fi) * 1998-12-17 2000-06-18 Orion Yhtymae Oyj Trifenyylietyleeniantiestrogeenien liukoisia koostumuksia
FI109332B (fi) 1998-12-17 2002-07-15 Orion Yhtymae Oyj Toremifeenin liukoisia koostumuksia
EP1401446B1 (en) 2001-05-22 2005-02-09 Eli Lilly And Company Tetrahydroquinolin derivatives for the inhibition of diseases associated with estrogen deprivation or with an aberrant physiological response to endogenous estrogen
EP1395563B1 (en) 2001-05-22 2006-03-29 Eli Lilly And Company 2-substituted 1,2,3,4-tetrahydroquinolines and derivatives thereof, compositions and methods
US20040225200A1 (en) * 2003-05-09 2004-11-11 Edmundson Catherine M. System and method of analyzing the health of a population
GR1005694B (el) * 2005-06-08 2007-10-22 Αλεξης Μιχαηλ Ιστοειδικα αντιοιστρογονα ειδικα για τον αλφα υποδοχεα των οιστρογονων
UA97813C2 (uk) * 2006-12-05 2012-03-26 Янссен Фармацевтика Н.В. Фумаратна сіль (альфа s, бета r)-6-бром-альфа-[2-(диметиламіно)етил]-2-метоксі-альфа-1-нафталеніл-бета-феніл-3-хінолінетанолу
MD24Z (ro) * 2008-12-02 2010-01-31 Василе ЖОВМИР Metodă de tratament diferenţiat al carcinomului neinvaziv al glandei mamare
MD35Z (ro) * 2008-12-02 2010-01-31 Василе ЖОВМИР Metodă de apreciere a riscului dezvoltării carcinomului neinvaziv in situ al glandei mamare
MD36Z (ro) * 2008-12-02 2010-01-31 Василе ЖОВМИР Metodă de tratament diferenţiat al carcinomului ductal in situ neinvaziv al glandei mamare
MD23Z (ro) * 2008-12-02 2010-01-31 Василе ЖОВМИР Metodă de tratament diferenţiat al carcinomului lobular in situ neinvaziv al glandei mamare
WO2011099942A1 (en) 2010-02-09 2011-08-18 Silverstone Pharma New addition salts of raloxifene, process for the preparation thereof and use thereof in therapy
CN102973573B (zh) * 2012-11-28 2015-04-08 玉林师范学院 一种人乳腺癌细胞抑制剂及制备方法
CN103830197A (zh) * 2014-03-14 2014-06-04 崔书豪 一种盐酸雷洛昔芬分散片及其制备方法
CN116650484A (zh) * 2023-05-11 2023-08-29 南通大学 一种乳腺癌相关蛋白的抑制剂及其应用
MX2023013107A (es) * 2023-11-06 2025-06-02 Centro De Investig Y De Estudios Avanzados Del I P N Composiciones sinergicas de loratadina-raloxifeno-sorafenib para el tratamiento de cancer hepatico.

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4418068A (en) * 1981-04-03 1983-11-29 Eli Lilly And Company Antiestrogenic and antiandrugenic benzothiophenes
US4656187A (en) * 1981-08-03 1987-04-07 Eli Lilly And Company Treatment of mammary cancer
JP3157882B2 (ja) * 1991-11-15 2001-04-16 帝国臓器製薬株式会社 新規なベンゾチオフエン誘導体
CZ253694A3 (en) * 1993-10-15 1995-05-17 Lilly Co Eli Pharmaceutical preparation for treating resistant neoplasms
US5478847A (en) * 1994-03-02 1995-12-26 Eli Lilly And Company Methods of use for inhibiting bone loss and lowering serum cholesterol
IL112746A (en) * 1994-03-02 1999-12-31 Lilly Co Eli Orally administrable pharmaceutical formulation comprising raloxifene hydrochoride
US5604248A (en) * 1994-05-05 1997-02-18 Eli Lilly And Company Method for minimizing the uterotrophic effect of tamoxifen and tamoxifen analogs
US5521214A (en) * 1995-01-25 1996-05-28 Eli Lilly And Company Methods of inhibiting environmental estrogens
US5821254A (en) 1995-02-17 1998-10-13 The United States Of America As Represented By The Department Of Health And Human Services Uses of 9-cis-retinoic acids and derivatives thereof alone or in combination with antineoplastic agents in the prevention or treatment of cancer
JP2000507268A (ja) * 1996-03-26 2000-06-13 イーライ・リリー・アンド・カンパニー ベンゾチオフェン類、それを含む製剤、および方法

Also Published As

Publication number Publication date
CZ341297A3 (cs) 1998-05-13
LU90157B1 (fr) 1998-06-02
GEP20032910B (en) 2003-03-25
MX9708341A (es) 1998-08-30
AU4364897A (en) 1998-05-07
DK1369115T3 (da) 2007-01-02
AU5005197A (en) 1998-05-22
YU42397A (sh) 2000-10-30
EA002054B1 (ru) 2001-12-24
NO322468B1 (no) 2006-10-09
EP0839532A1 (en) 1998-05-06
EE9900162A (et) 1999-12-15
HUP9701777A2 (hu) 1999-06-28
DE69721692D1 (de) 2003-06-12
ES2271476T3 (es) 2007-04-16
SI20107A (sl) 2000-06-30
LV12353A (lv) 1999-10-20
AU5005697A (en) 1998-05-22
SG72765A1 (en) 2000-05-23
US6303634B1 (en) 2001-10-16
CH691847A5 (fr) 2001-11-15
DK0839532T3 (da) 2003-08-25
PT1369115E (pt) 2006-12-29
ES2135342B1 (es) 2000-05-16
AU731388B2 (en) 2001-03-29
NO974972D0 (no) 1997-10-28
AR013864A1 (es) 2001-01-31
CA2219070C (en) 2007-12-18
JPH10147530A (ja) 1998-06-02
CZ300261B6 (cs) 2009-04-01
ES2197312T3 (es) 2004-01-01
IL122025A0 (en) 1998-03-10
ES2135343A1 (es) 1999-10-16
NO974972L (no) 1998-05-04
BR9712703A (pt) 1999-10-26
GB2318734B (en) 1999-12-01
WO1998018449A1 (en) 1998-05-07
IS5035A (is) 1999-04-27
FR2756490B1 (fr) 2003-06-20
NL1007387C2 (nl) 1998-05-14
EP1369115B1 (en) 2006-09-06
GR970100408A (el) 1998-06-30
FR2756490A1 (fr) 1998-06-05
BE1011381A5 (fr) 1999-08-03
ATE338551T1 (de) 2006-09-15
UA46762C2 (uk) 2002-06-17
ATE239475T1 (de) 2003-05-15
BE1011382A5 (fr) 1999-08-03
EA199900431A1 (ru) 1999-10-28
NZ329042A (en) 1999-08-30
CN1182590A (zh) 1998-05-27
TR199900951T2 (xx) 1999-07-21
GB2318733A (en) 1998-05-06
HUP9701778A2 (hu) 1999-01-28
AU4364797A (en) 1998-05-07
EA200100716A1 (ru) 2002-06-27
PT839532E (pt) 2003-09-30
DE69736644D1 (de) 2006-10-19
HU9701777D0 (en) 1997-12-29
HU9701778D0 (en) 1997-12-29
NO974973D0 (no) 1997-10-28
AP9901494A0 (en) 1999-03-31
EP1369115A1 (en) 2003-12-10
CH693820A5 (fr) 2004-02-27
IL122026A0 (en) 1998-03-10
ES2135342A1 (es) 1999-10-16
GR1003189B (el) 1999-09-01
GB9722801D0 (en) 1997-12-24
IE970773A1 (en) 2000-02-09
EE03663B1 (et) 2002-04-15
EP0839533A1 (en) 1998-05-06
DE69721692T2 (de) 2004-03-25
HUP9701777A3 (en) 1999-07-28
SK55999A3 (en) 2000-06-12
LV12353B (en) 2000-02-20
IE970772A1 (en) 2000-02-09
DE69736644T2 (de) 2007-10-25
NL1007386C2 (nl) 1998-05-14
AP971A (en) 2001-05-30
WO1998018325A1 (en) 1998-05-07
SI1369115T1 (sl) 2006-12-31
GB2318734A (en) 1998-05-06
SK287047B6 (sk) 2009-10-07
BG103369A (en) 2000-05-31
HK1010495A1 (en) 1999-06-25
FR2755014A1 (fr) 1998-04-30
US20020019418A1 (en) 2002-02-14
EA006083B1 (ru) 2005-08-25
IL122025A (en) 2003-01-12
EP0839532B1 (en) 2003-05-07
MY121623A (en) 2006-02-28
CZ341197A3 (cs) 1998-05-13
GR970100409A (el) 1998-06-30
FR2755014B1 (fr) 1999-02-05
CA2219070A1 (en) 1998-04-30
LU90158B1 (fr) 1998-06-02
MX9708340A (es) 1998-08-30
ITMI972433A1 (it) 1999-04-29
GB9911557D0 (en) 1999-07-21
AR010538A1 (es) 2000-06-28
HUP9701778A3 (en) 1999-06-28
SG83672A1 (en) 2001-10-16
BG63841B1 (bg) 2003-03-31
GB9722796D0 (en) 1997-12-24
SI0839532T1 (en) 2003-10-31
ITMI972434A1 (it) 1999-04-29
IT1298470B1 (it) 2000-01-10
CN1182591A (zh) 1998-05-27
RO120813B1 (ro) 2006-08-30
CA2219377A1 (en) 1998-04-30

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