JPH09511256A - 固形の薬用調剤形態の製法 - Google Patents
固形の薬用調剤形態の製法Info
- Publication number
- JPH09511256A JPH09511256A JP8514379A JP51437996A JPH09511256A JP H09511256 A JPH09511256 A JP H09511256A JP 8514379 A JP8514379 A JP 8514379A JP 51437996 A JP51437996 A JP 51437996A JP H09511256 A JPH09511256 A JP H09511256A
- Authority
- JP
- Japan
- Prior art keywords
- solvent
- pharmaceutically active
- active substance
- unit
- water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D25/00—Filters formed by clamping together several filtering elements or parts of such elements
- B01D25/12—Filter presses, i.e. of the plate or plate and frame type
- B01D25/176—Filter presses, i.e. of the plate or plate and frame type attaching the filter element to the filter press plates, e.g. around the central feed hole in the plates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1. 許容しがたい味をもつ製薬的に活性な物質の、経口による迅速に分解する 固形の調剤形態の製法において、溶媒中に、許容しがたい味をもつ形態よりも水 に対して溶解性がより低く、より口に合うような形態の製薬的に活性な物質の形 態と、水溶性もしくは水中分散性の担体物質との溶液もしくは懸澗液を形成し、 この溶液もしくは懸濁液の不連続な単位を形成し、溶解性がより低くより口に合 う製薬的に活性な物質を担持する担体物質のネットワークが形成される条件の下 で不連続な単位から溶媒を除去することからなる製法。 2. 許容しがたい味をもつ製薬的に活性な物質が、前記溶液もしくは懸濁液の 形成に先立って、より溶解性の低い形態で与えられる請求項1に記載の製法。 3. 許容しがたい味をもつ製薬的に活性な物質が、溶液もしくは懸濁液の調製 の間に溶解性がより低いものに変換される請求項1に記載の製法。 4. 許容しがたい味をもつ製薬的に活性な物質が、塩から遊離の酸もしくは遊 離の塩基への変換、塩の形態を変えること、水和物の形成、もしくはその多形の 形態を変えることによって溶解性がより低いものとされる請求項1から3のいず れか一項に記載の製法。 5. 溶媒が水を含む請求項1から4のいずれか一項に記載の製法。 6. 水が共溶媒を含む請求項5の製法。 7. 担体物質がゼラチンである請求項1から6のいずれか一項に記載の製法。 8. 不連続な単位が、液状の、凍結したもしくはゲル化した単位である請求項 1から7のいずれか一項に記載の製法。 9. 不連続な単位が、複数のポケットを備えた型において成型される請求項8 に記載の製法。 10. 不連続な単位が、溶媒の除去に先立って凍結される液状の単位である請 求項8または9に記載の製法。 11. 前記単位が凍結した単位であって、溶媒が凍結乾燥によって除去される 請求項8または9に記載の製法。 12. 前記単位が凍結した単位であって、第一の溶媒、製薬的に活性な物質及 び担体物質を含む凍結した基質と、第一の溶媒の凝固点よりも低い温度において 第一の溶媒と本質的に混和することによって第一の溶媒を基質から除去すること のできる第二の溶媒とを、接触させることによって溶媒を除去する請求項8また は9に記載の製法。 13. 前記単位が凍結した単位であって、溶媒が液相を経て気体へと蒸発する ような条件の下での凍結乾燥により、溶媒が除去される請求項8または9に記載 の製法。 14. 不連続な単位がゲル化した単位であって、これより減圧もしくは強制空 気乾燥によって溶媒が除去される請求項8または9に記載の製法。 15. 型が、フィルム物質のシートに形成された一以上の窪みからなる請求項 9に記載の製法。 16. 溶液もしくは懸濁液から溶媒を除去した後、窪みの周囲の領域で被覆物 質のシートがフィルム物質に粘着される請求項15に記載の製法。 17. 許容しがたい味をもつ製薬的に活性な物質が、溶液もしくは懸濁液の調 製の間にロペラミド遊離塩基の形態に変換されるロペラミド塩酸塩である請求項 1から16のいずれか一項に記載の製法。 18. 溶解性がより低い、製薬的に活性な物質が、遊離のドンペリドン塩基で ある請求項1から16のいずれか一項に記載の製法。 19. 常に請求項1から18のいずれか一項に記載の方法により調製される、 製薬的に活性な物質の、経口により迅速に分解する固形の調剤形態。 20. 製薬的に活性な物質が、ロペラミド遊離塩基の形態で組成物中に存在す るロペラミドである請求項19に記載の経口により迅速に分解する固形の調剤形 態。 21. 製薬的に活性な物質が、ドンペリドン遊離塩基の形態で組成物中に存在 するドンペリドンである請求項19に記載の経口により迅速に分解する固形の調 剤形態。 22. 水性もしくは水中分散性の担体物質中に、製薬的に活性な成分としてロ ペラミド遊離塩基を含む経口により迅速に分解する固形の調剤形態。 23. 水性もしくは水中分散性の担体物質中に、製薬的に許容される界面活性 剤と共に製薬的に活性な成分としてドンペリドン遊離塩基を含む経口により迅速 に分解する固形の調剤形態。
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/330,936 US5738875A (en) | 1994-10-28 | 1994-10-28 | Process for preparing solid pharmaceutical dosage forms |
CA002134611A CA2134611C (en) | 1994-10-28 | 1994-10-28 | Process for preparing solid pharmaceutical dosage forms |
GB9421837A GB9421837D0 (en) | 1994-10-28 | 1994-10-28 | Process for preparing solid pharmaceutical dosage forms |
GB9421837.7 | 1994-10-28 | ||
PCT/GB1995/002486 WO1996013252A1 (en) | 1994-10-28 | 1995-10-20 | Process for preparing solid pharmaceutical dosage forms |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2005370451A Division JP2006111635A (ja) | 1994-10-28 | 2005-12-22 | 固形の薬用調剤形態の製法 |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH09511256A true JPH09511256A (ja) | 1997-11-11 |
JP3839845B2 JP3839845B2 (ja) | 2006-11-01 |
Family
ID=27169885
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP51437996A Expired - Lifetime JP3839845B2 (ja) | 1994-10-28 | 1995-10-20 | 固形の薬用調剤形態の製法 |
JP2005370451A Pending JP2006111635A (ja) | 1994-10-28 | 2005-12-22 | 固形の薬用調剤形態の製法 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2005370451A Pending JP2006111635A (ja) | 1994-10-28 | 2005-12-22 | 固形の薬用調剤形態の製法 |
Country Status (16)
Country | Link |
---|---|
US (1) | US5738875A (ja) |
EP (1) | EP0737065B1 (ja) |
JP (2) | JP3839845B2 (ja) |
CN (1) | CN1204877C (ja) |
AT (1) | ATE198150T1 (ja) |
AU (1) | AU3702895A (ja) |
CA (1) | CA2134611C (ja) |
DE (1) | DE69519664T2 (ja) |
DK (1) | DK0737065T3 (ja) |
ES (1) | ES2153498T3 (ja) |
GB (1) | GB9421837D0 (ja) |
GR (1) | GR3035194T3 (ja) |
MX (1) | MX9602514A (ja) |
PT (1) | PT737065E (ja) |
WO (1) | WO1996013252A1 (ja) |
ZA (1) | ZA959073B (ja) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2006504620A (ja) * | 2002-03-12 | 2006-02-09 | ブリストル−マイヤーズ スクイブ カンパニー | 快い味の経口懸濁液および方法 |
JP2013522308A (ja) * | 2010-03-16 | 2013-06-13 | アール.ピー. シェーラー テクノロジーズ エルエルシー | 凍結乾燥速溶多相剤形の製造方法 |
JP2022521319A (ja) * | 2019-02-22 | 2022-04-06 | キャタレント・ユーケー・スウィンドン・ザイディス・リミテッド | インライン混合中の懸濁液の通気の最小化 |
US11931464B2 (en) | 2019-02-22 | 2024-03-19 | Catalent U.K. Swindon Zydis Limited | Minimizing agglomeration, aeration, and preserving the coating of pharmaceutical compositions comprising ibuprofen |
Families Citing this family (56)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5738875A (en) * | 1994-10-28 | 1998-04-14 | R.P. Scherer Corporation | Process for preparing solid pharmaceutical dosage forms |
US8071128B2 (en) * | 1996-06-14 | 2011-12-06 | Kyowa Hakko Kirin Co., Ltd. | Intrabuccally rapidly disintegrating tablet and a production method of the tablets |
GB9702799D0 (en) * | 1997-02-12 | 1997-04-02 | Scherer Corp R P | Process for preparing solid pharmaceutical dosage forms |
US20040023948A1 (en) * | 1997-03-24 | 2004-02-05 | Green Richard David | Fast-dispersing dosage form containing 5-HT1 agonists |
US5976577A (en) * | 1997-07-11 | 1999-11-02 | Rp Scherer Corporation | Process for preparing fast dispersing solid oral dosage form |
DE19821625C1 (de) * | 1998-05-15 | 2000-01-05 | Merck Patent Gmbh | Pharmazeutische Zubereitung |
BR0007360A (pt) * | 1999-12-23 | 2001-08-14 | Johnson & Johnson | Composição de liberação controlada |
WO2001064202A2 (en) * | 2000-03-01 | 2001-09-07 | Euro-Celtique S.A. | Tramadol for the treatment of functional gastrointestinal disorders |
US6814978B2 (en) | 2000-12-29 | 2004-11-09 | Mcneil-Ppc, Inc. | Process for preparing a soft tablet |
CA2449731A1 (en) * | 2001-06-07 | 2002-12-19 | Tanabe Seiyaku Co., Ltd. | Functional grain-containing preparations quickly disintegrated in the oral cavity |
US20030153590A1 (en) * | 2001-08-14 | 2003-08-14 | Oy Contral Pharma Ltd | Method of treating alcoholism or alcohol abuse |
US20040258748A1 (en) * | 2001-09-25 | 2004-12-23 | Ashish Madan | Process for the preparation of fast dissolving dosage form |
CN1596100A (zh) * | 2001-09-28 | 2005-03-16 | 麦克内尔-Ppc股份有限公司 | 可食用组合物及含可食用外壳的制剂 |
US9358214B2 (en) * | 2001-10-04 | 2016-06-07 | Adare Pharmaceuticals, Inc. | Timed, sustained release systems for propranolol |
ATE516799T1 (de) * | 2002-02-13 | 2011-08-15 | Michael K Weibel | Arzneimitteldosenform und -herstellungsverfahren |
US20040001885A1 (en) * | 2002-06-27 | 2004-01-01 | Unchalee Kositprapa | Rapidly disintegrating antihistamine formulation |
US7985422B2 (en) * | 2002-08-05 | 2011-07-26 | Torrent Pharmaceuticals Limited | Dosage form |
US8367111B2 (en) * | 2002-12-31 | 2013-02-05 | Aptalis Pharmatech, Inc. | Extended release dosage forms of propranolol hydrochloride |
US20040234579A1 (en) * | 2003-05-22 | 2004-11-25 | Mark D. Finke, Inc. | Dietary supplements and methods of preparing and administering dietary supplements |
US20050036977A1 (en) * | 2003-08-11 | 2005-02-17 | Dilip Gole | Taste-masked resinate and preparation thereof |
US20050112196A1 (en) * | 2003-10-07 | 2005-05-26 | Jianbo Xie | Rapidly disintegrating formulation |
DE20321887U1 (de) | 2003-11-10 | 2012-01-20 | Allergan, Inc. | Arzneimittel umfassend niedrige Dosierungen von Desmopressin |
EP2322197A2 (en) | 2003-11-10 | 2011-05-18 | Reprise Biopharmaceutics, LLC | Pharmaceutical compositions including low dosages of desmopressin |
EP1582221A1 (en) | 2004-03-31 | 2005-10-05 | Chiesi S.A. | Pharmaceutical oral compositions with a taste masking effect |
US8545881B2 (en) | 2004-04-19 | 2013-10-01 | Eurand Pharmaceuticals, Ltd. | Orally disintegrating tablets and methods of manufacture |
US8747895B2 (en) * | 2004-09-13 | 2014-06-10 | Aptalis Pharmatech, Inc. | Orally disintegrating tablets of atomoxetine |
US9884014B2 (en) | 2004-10-12 | 2018-02-06 | Adare Pharmaceuticals, Inc. | Taste-masked pharmaceutical compositions |
EP1802285B1 (en) * | 2004-10-21 | 2013-02-27 | Aptalis Pharmatech, Inc. | Taste-masked pharmaceutical compositions with gastrosoluble pore-formers |
US20060105038A1 (en) * | 2004-11-12 | 2006-05-18 | Eurand Pharmaceuticals Limited | Taste-masked pharmaceutical compositions prepared by coacervation |
ITMI20042356A1 (it) * | 2004-12-10 | 2005-03-10 | Acraf | Composizione farmaceutica orodisperdibile e procedimento per prepararla |
US8697674B2 (en) * | 2004-12-29 | 2014-04-15 | Naturon, Inc. | Xanthurenic acid derivative pharmaceutical compositions and methods related thereto |
US9161918B2 (en) | 2005-05-02 | 2015-10-20 | Adare Pharmaceuticals, Inc. | Timed, pulsatile release systems |
GB0516604D0 (en) * | 2005-08-12 | 2005-09-21 | Sandoz Ag | Rapidly dispersing/disintegrating compositions |
US7811604B1 (en) | 2005-11-14 | 2010-10-12 | Barr Laboratories, Inc. | Non-effervescent, orally disintegrating solid pharmaceutical dosage forms comprising clozapine and methods of making and using the same |
US20070293580A1 (en) * | 2006-06-05 | 2007-12-20 | Malcolm Hill | Methods for Buccal, Lingual or Sublingual Dosing Regimens of Epinephrine for the Treatment of Allergic Emergencies |
US20070293582A1 (en) * | 2006-06-05 | 2007-12-20 | Malcolm Hill | Epinephrine dosing regimens comprising buccal, lingual or sublingual and injectable dosage forms |
US8545879B2 (en) | 2009-08-31 | 2013-10-01 | Wilmington Pharmaceuticals, Llc | Fast disintegrating compositions of meloxicam |
TWI471146B (zh) | 2009-12-02 | 2015-02-01 | Aptalis Pharma Ltd | 菲索特芬那定(fexofenadine)微膠囊及包含其之組合物 |
US20110212171A1 (en) * | 2010-01-08 | 2011-09-01 | Eurand, Inc. | Taste masked topiramate composition and an orally disintegrating tablet comprising the same |
CA2819663C (en) | 2010-12-02 | 2019-12-24 | Aptalis Pharmatech, Inc. | Rapidly dispersing granules, orally disintegrating tablets and methods |
US9511028B2 (en) | 2012-05-01 | 2016-12-06 | Johnson & Johnson Consumer Inc. | Orally disintegrating tablet |
EP2968181B1 (en) | 2013-03-15 | 2019-10-16 | Aprecia Pharmaceuticals LLC | Rapidly dispersible dosage form of topiramate |
US9339489B2 (en) | 2013-03-15 | 2016-05-17 | Aprecia Pharmaceuticals Company | Rapid disperse dosage form containing levetiracetam |
AU2014228990B2 (en) | 2013-03-15 | 2017-02-02 | Aprecia Pharmaceuticals LLC | Rapid disperse dosage form containing levetiracetam |
JP6463333B2 (ja) | 2013-03-15 | 2019-01-30 | アプレシア・ファーマスーティカルズ・カンパニー | オキシカルバゼピンの急速分散性の剤形 |
WO2015105992A1 (en) | 2014-01-10 | 2015-07-16 | Mcneil-Ppc, Inc. | Process for making tablet using radiofrequency and lossy coated particles |
KR102193599B1 (ko) | 2014-09-17 | 2020-12-21 | 스티어라이프 인디아 프라이빗 리미티드 | 발포성 조성물 및 이의 제조방법 |
WO2017098481A1 (en) | 2015-12-12 | 2017-06-15 | Steerlife India Private Limited | Effervescent compositions of metformin and processes for preparation thereof |
WO2017168174A1 (en) | 2016-04-02 | 2017-10-05 | N4 Pharma Uk Limited | New pharmaceutical forms of sildenafil |
WO2018002673A1 (en) | 2016-07-01 | 2018-01-04 | N4 Pharma Uk Limited | Novel formulations of angiotensin ii receptor antagonists |
IT201600078683A1 (it) * | 2016-07-27 | 2018-01-27 | Mattia Saporiti | Matrice edibile per uso veterinario e zootecnico e relativo metodo di produzione |
WO2018115888A1 (en) | 2016-12-21 | 2018-06-28 | N4 Pharma Uk Limited | Novel formulations of aprepitant |
US10493026B2 (en) | 2017-03-20 | 2019-12-03 | Johnson & Johnson Consumer Inc. | Process for making tablet using radiofrequency and lossy coated particles |
EP3883546A1 (en) | 2018-11-21 | 2021-09-29 | Rosemont Pharmaceuticals Ltd | Oral topiramate suspension formulations with extended shelf stability and enhanced bioavailability |
CN116018131A (zh) | 2020-06-26 | 2023-04-25 | 阿普雷奇亚制药有限责任公司 | 具有内腔的快速口腔分散片剂 |
WO2022179635A1 (zh) * | 2021-02-27 | 2022-09-01 | 北京兴源联合医药科技有限公司 | 一种β-烟酰胺单核苷酸冻干口服制剂 |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IE45770B1 (en) * | 1976-10-06 | 1982-11-17 | Wyeth John & Brother Ltd | Pharmaceutical dosage forms |
GB1548022A (en) * | 1976-10-06 | 1979-07-04 | Wyeth John & Brother Ltd | Pharmaceutial dosage forms |
CA1097233A (en) * | 1977-07-20 | 1981-03-10 | George K. E. Gregory | Packages |
GB2111423B (en) * | 1981-12-02 | 1985-06-26 | Wyeth John & Brother Ltd | Making quick-dissolving pills |
IE53696B1 (en) * | 1981-12-02 | 1989-01-18 | Wyeth John & Brother Ltd | Solid shaped articles |
GB8528195D0 (en) * | 1985-11-15 | 1985-12-18 | Boots Co Plc | Therapeutic compositions |
US5206025A (en) * | 1989-05-24 | 1993-04-27 | Rhone-Poulenc Sante | Porous pharmaceutical form and its preparation |
US5039540A (en) * | 1989-08-14 | 1991-08-13 | Neophore Technologies, Inc. | Freeze dry composition and method for oral administration of drugs, biologicals, nutrients and foodstuffs |
US5079018A (en) * | 1989-08-14 | 1992-01-07 | Neophore Technologies, Inc. | Freeze dry composition and method for oral administration of drugs, biologicals, nutrients and foodstuffs |
US5215756A (en) * | 1989-12-22 | 1993-06-01 | Gole Dilip J | Preparation of pharmaceutical and other matrix systems by solid-state dissolution |
US5188825A (en) * | 1989-12-28 | 1993-02-23 | Iles Martin C | Freeze-dried dosage forms and methods for preparing the same |
WO1992017209A1 (en) * | 1991-04-08 | 1992-10-15 | Sumitomo Pharmaceuticals Company, Limited | Porous solid preparation containing physiologically active protein substance |
JP2807346B2 (ja) * | 1991-12-24 | 1998-10-08 | 山之内製薬株式会社 | 口腔内崩壊製剤及びその製造法 |
US5298261A (en) * | 1992-04-20 | 1994-03-29 | Oregon Freeze Dry, Inc. | Rapidly distintegrating tablet |
JPH06298668A (ja) * | 1993-02-18 | 1994-10-25 | Takeda Chem Ind Ltd | 経口用医薬組成物 |
US5382437A (en) * | 1993-10-25 | 1995-01-17 | Hunter Research Corporation | Frozen liquified gas composition and method for oral administration of drugs, biologicals, nutrients and foodstuffs |
US5738875A (en) * | 1994-10-28 | 1998-04-14 | R.P. Scherer Corporation | Process for preparing solid pharmaceutical dosage forms |
-
1994
- 1994-10-28 US US08/330,936 patent/US5738875A/en not_active Expired - Lifetime
- 1994-10-28 GB GB9421837A patent/GB9421837D0/en active Pending
- 1994-10-28 CA CA002134611A patent/CA2134611C/en not_active Expired - Lifetime
-
1995
- 1995-10-20 DK DK95934712T patent/DK0737065T3/da active
- 1995-10-20 MX MX9602514A patent/MX9602514A/es unknown
- 1995-10-20 JP JP51437996A patent/JP3839845B2/ja not_active Expired - Lifetime
- 1995-10-20 AT AT95934712T patent/ATE198150T1/de active
- 1995-10-20 AU AU37028/95A patent/AU3702895A/en not_active Abandoned
- 1995-10-20 DE DE69519664T patent/DE69519664T2/de not_active Expired - Lifetime
- 1995-10-20 CN CNB95191538XA patent/CN1204877C/zh not_active Expired - Lifetime
- 1995-10-20 PT PT95934712T patent/PT737065E/pt unknown
- 1995-10-20 WO PCT/GB1995/002486 patent/WO1996013252A1/en active IP Right Grant
- 1995-10-20 EP EP95934712A patent/EP0737065B1/en not_active Expired - Lifetime
- 1995-10-20 ES ES95934712T patent/ES2153498T3/es not_active Expired - Lifetime
- 1995-10-26 ZA ZA959073A patent/ZA959073B/xx unknown
-
2001
- 2001-01-10 GR GR20010400012T patent/GR3035194T3/el unknown
-
2005
- 2005-12-22 JP JP2005370451A patent/JP2006111635A/ja active Pending
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2006504620A (ja) * | 2002-03-12 | 2006-02-09 | ブリストル−マイヤーズ スクイブ カンパニー | 快い味の経口懸濁液および方法 |
JP2013522308A (ja) * | 2010-03-16 | 2013-06-13 | アール.ピー. シェーラー テクノロジーズ エルエルシー | 凍結乾燥速溶多相剤形の製造方法 |
US10548839B2 (en) | 2010-03-16 | 2020-02-04 | Wei Tian | Process of manufacturing a lyophilized fast dissolving, multi-phasic dosage form |
JP2022521319A (ja) * | 2019-02-22 | 2022-04-06 | キャタレント・ユーケー・スウィンドン・ザイディス・リミテッド | インライン混合中の懸濁液の通気の最小化 |
US11931464B2 (en) | 2019-02-22 | 2024-03-19 | Catalent U.K. Swindon Zydis Limited | Minimizing agglomeration, aeration, and preserving the coating of pharmaceutical compositions comprising ibuprofen |
Also Published As
Publication number | Publication date |
---|---|
CN1140407A (zh) | 1997-01-15 |
US5738875A (en) | 1998-04-14 |
EP0737065B1 (en) | 2000-12-20 |
MX9602514A (es) | 1997-05-31 |
DE69519664D1 (de) | 2001-01-25 |
ES2153498T3 (es) | 2001-03-01 |
ATE198150T1 (de) | 2001-01-15 |
AU3702895A (en) | 1996-05-23 |
WO1996013252A1 (en) | 1996-05-09 |
GR3035194T3 (en) | 2001-04-30 |
JP3839845B2 (ja) | 2006-11-01 |
GB9421837D0 (en) | 1994-12-14 |
EP0737065A1 (en) | 1996-10-16 |
CA2134611A1 (en) | 1996-04-29 |
JP2006111635A (ja) | 2006-04-27 |
ZA959073B (en) | 1996-05-22 |
DE69519664T2 (de) | 2001-05-17 |
PT737065E (pt) | 2001-04-30 |
DK0737065T3 (da) | 2001-01-15 |
CN1204877C (zh) | 2005-06-08 |
CA2134611C (en) | 2002-12-24 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JPH09511256A (ja) | 固形の薬用調剤形態の製法 | |
KR100352881B1 (ko) | 소수성물질의제약학적인고체제형을제조하는방법 | |
JP2550362B2 (ja) | スプレードライしたアセトアミノフェン | |
JP4371435B2 (ja) | 両凸の迅速に崩壊する投薬形態 | |
JP4943581B2 (ja) | 迅速分散性固形経口投与用剤形の製造方法 | |
US5837287A (en) | Process for preparing solid pharmaceutical dosage forms | |
JP2542400B2 (ja) | スプレ―ドライしたアセトアミノフェン | |
JP4870386B2 (ja) | 口腔または体腔内で有効成分を放出するための迅速分解性投与可能剤形 | |
US6090401A (en) | Stable foam composition | |
JP5053865B2 (ja) | 口腔内崩壊性固形製剤の製造法 | |
US11517533B2 (en) | Compositions of different densities for fast disintegrating multi-layer tablet | |
CA2363592A1 (en) | Oral drug delivery system | |
WO2001089485A1 (en) | Rapidly disintegrating tablet and process for the manufacture thereof | |
JPS6250445B2 (ja) | ||
JP2550363B2 (ja) | スプレードライしたアセトアミノフェン | |
US6726928B2 (en) | Process for preparing solid dosage forms for unpalatable pharmaceuticals | |
TWI343262B (en) | Rapidly disintegrating lyophilized oral formulations of a thrombin receptor antagonist | |
JPH11310539A (ja) | 口腔内崩壊型組成物及びその製造方法 | |
KR100355060B1 (ko) | 고체약제투여형을제조하는방법 | |
TW202220638A (zh) | 包含經塗覆之活性醫藥成份之醫藥組合物 | |
AU2005202270B2 (en) | Rapidly Disintegrating Dosage form For Releasing Nicotine in the Oral Cavity or in Body Cavities |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20050920 |
|
A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20050926 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20051222 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20060804 |
|
R150 | Certificate of patent or registration of utility model |
Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20090811 Year of fee payment: 3 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20100811 Year of fee payment: 4 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20110811 Year of fee payment: 5 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20120811 Year of fee payment: 6 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20130811 Year of fee payment: 7 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
EXPY | Cancellation because of completion of term |