JPH09507057A - インドリン誘導体、その製造法、および医薬としてのその用途 - Google Patents

インドリン誘導体、その製造法、および医薬としてのその用途

Info

Publication number
JPH09507057A
JPH09507057A JP7517174A JP51717495A JPH09507057A JP H09507057 A JPH09507057 A JP H09507057A JP 7517174 A JP7517174 A JP 7517174A JP 51717495 A JP51717495 A JP 51717495A JP H09507057 A JPH09507057 A JP H09507057A
Authority
JP
Japan
Prior art keywords
formula
compound
alkyl
pharmaceutically acceptable
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP7517174A
Other languages
English (en)
Japanese (ja)
Inventor
チャールズ ノース，ピーター
クライブ カーター，マルコム
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of JPH09507057A publication Critical patent/JPH09507057A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Furan Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP7517174A 1993-12-22 1994-12-20 インドリン誘導体、その製造法、および医薬としてのその用途 Pending JPH09507057A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9326192.3 1993-12-22
GB939326192A GB9326192D0 (en) 1993-12-22 1993-12-22 Chemical compounds
PCT/EP1994/004220 WO1995017405A1 (en) 1993-12-22 1994-12-20 Indoline derivatives, method of preparation and their use as pharmaceuticals

Publications (1)

Publication Number Publication Date
JPH09507057A true JPH09507057A (ja) 1997-07-15

Family

ID=10747030

Family Applications (1)

Application Number Title Priority Date Filing Date
JP7517174A Pending JPH09507057A (ja) 1993-12-22 1994-12-20 インドリン誘導体、その製造法、および医薬としてのその用途

Country Status (15)

Country Link
US (1) US5633276A (enExample)
EP (1) EP0736028A1 (enExample)
JP (1) JPH09507057A (enExample)
AP (1) AP535A (enExample)
AU (1) AU684877B2 (enExample)
CA (1) CA2179402A1 (enExample)
CO (1) CO4340623A1 (enExample)
GB (1) GB9326192D0 (enExample)
IL (1) IL112097A (enExample)
IS (1) IS4244A (enExample)
MY (1) MY131641A (enExample)
SV (1) SV1994000083A (enExample)
TW (1) TW291479B (enExample)
WO (1) WO1995017405A1 (enExample)
ZA (1) ZA9410056B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007108442A1 (ja) * 2006-03-20 2007-09-27 Takeda Pharmaceutical Company Limited 過敏性腸症候群予防・治療薬

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2741799B1 (fr) * 1995-12-04 1998-01-02 Oreal Utilisation de melatonine dans une composition pour traiter les signes cutanes des etats de fatigue
CZ291626B6 (cs) * 1996-03-08 2003-04-16 Takeda Chemical Industries, Ltd. Tricyklické sloučeniny, způsob výroby a použití
US6034239A (en) * 1996-03-08 2000-03-07 Takeda Chemical Industries, Ltd. Tricyclic compounds, their production and use
EP1199304A1 (en) * 1997-03-05 2002-04-24 Takeda Chemical Industries, Ltd. Bicyclic compounds and pharmaceutical composition containing tricyclic compound for treating or preventing sleep disorders
TW476758B (en) * 1996-12-10 2002-02-21 Bristol Myers Squibb Co Benzodioxole, benzofuran, dihydrobenzofuran and benzodioxane melatonergic agents
AU6540598A (en) * 1997-03-05 1998-09-22 Bristol-Myers Squibb Company Polycyclic ethyl alkylamide melatonergic agents
FR2763335B1 (fr) * 1997-05-16 2000-11-24 Adir Nouveaux composes heterocycliques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
AU727654B2 (en) * 1997-06-13 2000-12-21 Yamanouchi Pharmaceutical Co., Ltd. Tricyclic pyrazole derivative
JP2002516859A (ja) * 1998-06-05 2002-06-11 ブリストルーマイヤーズ スクイブ カンパニー メラトニン作動性薬剤であるヘテロ環シスシクロプロパン誘導体
ES2213022T3 (es) 1999-06-30 2004-08-16 Bristol-Myers Squibb Company Derivados de aminopirrolidina heterociclicos utiles como agentes melatonergicos.
GB9918965D0 (en) * 1999-08-11 1999-10-13 Cerebrus Ltd Chemical compounds xxi
EP1213290B1 (en) 1999-08-20 2005-04-20 Takeda Pharmaceutical Company Limited Dihydrobenzofuran derivatives, process for the preparation thereof and agents
AU1603401A (en) * 2000-03-17 2001-10-03 Alcon Universal Ltd Pyranoindoles for treating glaucoma
US7012090B1 (en) 2000-03-17 2006-03-14 Alcon, Inc. Pyranoindoles for treating glaucoma
ES2172415B2 (es) 2000-07-28 2003-11-16 Univ Madrid Complutense Tratamiento del glaucoma y la hipertension ocular por medio de un analogo de la melatonina.
AU2002245104B2 (en) * 2000-12-11 2006-08-17 Testocreme, Llc Topical testosterone formulations and associated methods
US20030096379A1 (en) * 2001-03-28 2003-05-22 Kilgore James L. Method for producing tryptamine derivatives
US8273761B2 (en) * 2006-12-08 2012-09-25 Takeda Pharmaceutical Company Limited Tricyclic compound and medical use thereof
ES2331274B1 (es) * 2007-10-25 2010-10-21 Ferrer Internacional, S.A. Compuesto de indolina.
RU2011107443A (ru) * 2008-07-30 2012-09-10 Феррер Интернасионал С.А. (ES) Индаценовые соединения, фармацевтическая композиция и лекарственное средство на их основе, способ их получения и способ лечения или профилактики состояний, связанных с нарушением функционирования систем, регулируемых мелатонином, с их помощью
BR102016024814A2 (pt) 2016-10-24 2018-05-08 Aché Laboratórios Farmacêuticos S.A. composto, processo de obtenção do composto, composição farmacêutica, uso do composto e método de tratamento de desordens psiquiátricas e/ou distúrbios do sono

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2485539A1 (fr) * 1980-06-26 1981-12-31 Sori Soc Rech Ind Nouveau derive de pyranno-indole, son procede de preparation et son application en therapeutique
US4738972A (en) * 1985-05-21 1988-04-19 Pfizer Inc. Hypoglycemic thiazolidinediones
US4703052A (en) * 1985-05-21 1987-10-27 Pfizer Inc. Hypoglycemic thiazolidinediones

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007108442A1 (ja) * 2006-03-20 2007-09-27 Takeda Pharmaceutical Company Limited 過敏性腸症候群予防・治療薬
JP5219799B2 (ja) * 2006-03-20 2013-06-26 武田薬品工業株式会社 過敏性腸症候群予防・治療薬

Also Published As

Publication number Publication date
IS4244A (is) 1995-06-23
US5633276A (en) 1997-05-27
AP535A (en) 1996-09-16
WO1995017405A1 (en) 1995-06-29
IL112097A (en) 1998-06-15
ZA9410056B (en) 1995-10-18
MY131641A (en) 2007-08-30
SV1994000083A (es) 1995-07-24
EP0736028A1 (en) 1996-10-09
GB9326192D0 (en) 1994-02-23
CA2179402A1 (en) 1995-06-29
CO4340623A1 (es) 1996-07-30
IL112097A0 (en) 1995-03-15
AP9400706A0 (en) 1995-01-31
TW291479B (enExample) 1996-11-21
AU1274395A (en) 1995-07-10
AU684877B2 (en) 1998-01-08

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