JPH09249554A - 安定な水性ソリュビリゼート及びその製法 - Google Patents
安定な水性ソリュビリゼート及びその製法Info
- Publication number
- JPH09249554A JPH09249554A JP9050801A JP5080197A JPH09249554A JP H09249554 A JPH09249554 A JP H09249554A JP 9050801 A JP9050801 A JP 9050801A JP 5080197 A JP5080197 A JP 5080197A JP H09249554 A JPH09249554 A JP H09249554A
- Authority
- JP
- Japan
- Prior art keywords
- solubilizate
- vitamins
- carotenoids
- content
- vitamin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- 210000002443 helper t lymphocyte Anatomy 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 208000010125 myocardial infarction Diseases 0.000 description 1
- 229960003966 nicotinamide Drugs 0.000 description 1
- 235000005152 nicotinamide Nutrition 0.000 description 1
- 239000011570 nicotinamide Substances 0.000 description 1
- 239000007800 oxidant agent Substances 0.000 description 1
- 235000016236 parenteral nutrition Nutrition 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 235000019234 riboflavin-5-sodium phosphate Nutrition 0.000 description 1
- 150000003839 salts Chemical group 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 230000007928 solubilization Effects 0.000 description 1
- 238000005063 solubilization Methods 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
- 229940033663 thimerosal Drugs 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 235000019156 vitamin B Nutrition 0.000 description 1
- 239000011720 vitamin B Substances 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Dispersion Chemistry (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Nutrition Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19609477A DE19609477A1 (de) | 1996-03-11 | 1996-03-11 | Stabile wäßrige Solubilisate von Carotinoiden und Vitamine |
| DE19609477.1 | 1996-03-11 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH09249554A true JPH09249554A (ja) | 1997-09-22 |
| JPH09249554A5 JPH09249554A5 (enExample) | 2004-12-16 |
Family
ID=7787924
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP9050801A Pending JPH09249554A (ja) | 1996-03-11 | 1997-03-06 | 安定な水性ソリュビリゼート及びその製法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US5891907A (enExample) |
| EP (1) | EP0800825A1 (enExample) |
| JP (1) | JPH09249554A (enExample) |
| CN (1) | CN1096264C (enExample) |
| AU (1) | AU1620497A (enExample) |
| CA (1) | CA2199415A1 (enExample) |
| DE (1) | DE19609477A1 (enExample) |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2000178187A (ja) * | 1998-12-15 | 2000-06-27 | Sanochemia Pharmazeutika Ag | βカロテンの水性調合物 |
| JP2001011441A (ja) * | 1999-05-28 | 2001-01-16 | Johnson & Johnson Consumer Co Inc | 酸素不安定種を安定化する組成物および方法 |
| JP2007270073A (ja) * | 2006-03-31 | 2007-10-18 | Fujifilm Corp | エマルジョン組成物 |
| JP2008169117A (ja) * | 2007-01-05 | 2008-07-24 | Fujifilm Corp | 分散組成物及びスキンケア用化粧料並びに分散組成物の製造方法 |
| JP2009007289A (ja) * | 2007-06-27 | 2009-01-15 | Fujifilm Corp | 分散組成物及びスキンケア用化粧料並びに分散組成物の製造方法 |
| JP2009013129A (ja) * | 2007-07-06 | 2009-01-22 | Fujifilm Corp | 化粧品組成物 |
| JP2010518829A (ja) * | 2007-02-23 | 2010-06-03 | ビーエーエスエフ ソシエタス・ヨーロピア | 味覚変容物質としての水分散性カロテノイドナノ粒子の使用、水分散性カロテノイドナノ粒子を含む味覚変容物質、および味覚変容方法 |
| JP2013501752A (ja) * | 2009-08-11 | 2013-01-17 | ピエール、ファーブル、メディカマン | Ｄｈａエステルを含む非経口投与のための医薬組成物 |
| JP2022509196A (ja) * | 2018-11-26 | 2022-01-20 | オルファニクス ゲゼルシャフト ミット ベシュレンクテル ハフツング | 水性の小児用レチノール製剤 |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19653410A1 (de) | 1996-12-20 | 1998-06-25 | Basf Ag | Verwendung von Carotinoid-Solubilisaten zum Färben von Lebensmitteln und pharmazeutischen Zubereitungen |
| WO1998045241A2 (en) | 1997-04-04 | 1998-10-15 | Henkel Corporation | Lutein esters having high bioavailability |
| JP2003511348A (ja) * | 1999-04-13 | 2003-03-25 | レオ・ファーマ・アクティーゼルスカブ | 可溶化された非経口投与用の医薬組成物 |
| US6582721B1 (en) | 1999-09-17 | 2003-06-24 | Alcon, Inc. | Stable carotene-xanthophyll beadlet compositions and methods of use |
| US8137699B2 (en) * | 2002-03-29 | 2012-03-20 | Trustees Of Princeton University | Process and apparatuses for preparing nanoparticle compositions with amphiphilic copolymers and their use |
| DE10126446A1 (de) * | 2001-05-31 | 2002-12-05 | Cognis Deutschland Gmbh | Haarpflegemittel mit natürlichen Ölen |
| US6635293B2 (en) * | 2001-10-23 | 2003-10-21 | Kemin Foods, L.C. | Finely dispersed carotenoid suspensions for use in foods and a process for their preparation |
| DE10221212A1 (de) * | 2002-05-13 | 2003-11-27 | Andreas Maack | Sporopollenin enthaltende lösliche Zusammensetzung und Verwendung |
| EP1526837A1 (de) * | 2002-07-24 | 2005-05-04 | Basf Aktiengesellschaft | Suspensionen von salzen der ascorbinsäure und ihre verwendung als antioxidantien |
| US20050148517A1 (en) * | 2002-07-29 | 2005-07-07 | Lockwood Samuel F. | Carotenoid ether analogs or derivatives for controlling connexin 43 expression |
| US7345091B2 (en) * | 2002-07-29 | 2008-03-18 | Cardax Pharmaceuticals, Inc. | Carotenoid ether analogs or derivatives for the inhibition and amelioration of disease |
| US20050004235A1 (en) * | 2002-07-29 | 2005-01-06 | Lockwood Samuel Fournier | Carotenoid analogs or derivatives for the inhibition and amelioration of liver disease |
| BRPI0313155B8 (pt) | 2002-07-29 | 2021-05-25 | Cardax Pharmaceuticals Inc | composto químico derivado ou análogo de carotenóide, composição farmacêutica, e, uso do composto |
| US7763649B2 (en) * | 2002-07-29 | 2010-07-27 | Cardax Pharmaceuticals, Inc. | Carotenoid analogs or derivatives for controlling connexin 43 expression |
| US20050059635A1 (en) * | 2002-07-29 | 2005-03-17 | Lockwood Samuel Fournier | Carotenoid ester analogs or derivatives for controlling C-reactive protein levels |
| US7320997B2 (en) * | 2002-07-29 | 2008-01-22 | Cardax Pharmaceuticals, Inc. | Pharmaceutical compositions including carotenoid ester analogs or derivatives for the inhibition and amelioration of disease |
| US20050026874A1 (en) * | 2002-07-29 | 2005-02-03 | Lockwood Samuel Fournier | Carotenoid ether analogs or derivatives for the inhibition and amelioration of liver disease |
| US20050049248A1 (en) * | 2002-07-29 | 2005-03-03 | Lockwood Samuel Fournier | Carotenoid ether analogs or derivatives for controlling C-reactive protein levels |
| US20050009788A1 (en) * | 2002-07-29 | 2005-01-13 | Lockwood Samuel Fournier | Carotenoid ester analogs or derivatives for controlling connexin 43 expression |
| US7521584B2 (en) * | 2002-07-29 | 2009-04-21 | Cardax Pharmaceuticals, Inc. | Carotenoid analogs or derivatives for the inhibition and amelioration of disease |
| US7723327B2 (en) * | 2002-07-29 | 2010-05-25 | Cardax Pharmaceuticals, Inc. | Carotenoid ester analogs or derivatives for the inhibition and amelioration of liver disease |
| US20050143475A1 (en) * | 2002-07-29 | 2005-06-30 | Lockwood Samuel F. | Carotenoid analogs or derivatives for the inhibition and amelioration of ischemic reperfusion injury |
| US7375133B2 (en) * | 2002-07-29 | 2008-05-20 | Cardax Pharmaceuticals, Inc. | Pharmaceutical compositions including carotenoid ether analogs or derivatives for the inhibition and amelioration of disease |
| US20050059659A1 (en) * | 2002-07-29 | 2005-03-17 | Lockwood Samuel Fournier | Carotenoid analogs or derivatives for controlling C-reactive protein levels |
| GB0218932D0 (en) * | 2002-08-14 | 2002-09-25 | Zoolife Internat Ltd | Composition for dietary enrichment |
| DE10243437A1 (de) * | 2002-09-18 | 2004-04-29 | Pm-International Ag | Kosmetische Formulierung |
| US20050037115A1 (en) * | 2003-08-15 | 2005-02-17 | Linda Fullmer | Carotenoid nanodispersions for use in water-based systems and a process for their preparation |
| US20060058269A1 (en) * | 2004-04-14 | 2006-03-16 | Lockwood Samuel F | Carotenoid analogs or derivatives for the inhibition and amelioration of inflammation |
| WO2005102356A1 (en) * | 2004-04-14 | 2005-11-03 | Hawaii Biotech, Inc. | Carotenoid analogs or derivatives for the inhibition and amelioration of inflammation |
| US7351424B2 (en) * | 2004-07-22 | 2008-04-01 | Bio Lut S.A. De C.V. | Enhanced purity trans-lutein-ester compositions and methods of making same |
| WO2006047475A2 (en) * | 2004-10-25 | 2006-05-04 | Sytera, Inc. | Detection and analysis of ophthalmically-relevant fluorescent molecules |
| US20070065487A1 (en) * | 2005-09-21 | 2007-03-22 | Bio Lut S.A. De C.V. | Trans-lutein xantophyll ester of high purity and high bioavailability in micellar solution and a process for the preparation thereof |
| US7435846B2 (en) | 2006-08-18 | 2008-10-14 | Industrial Organica, S.A. De C.V. | Absorption and bioavailability of carotenoids, formulations and applications |
| JP5368316B2 (ja) | 2007-01-16 | 2013-12-18 | ビーエーエスエフ ソシエタス・ヨーロピア | カロテノイドを含有する液体製剤 |
| ATE494800T1 (de) * | 2007-02-23 | 2011-01-15 | Brain Biotechnology Res & Information Network Ag | Verfahren zur geschmacksmodulation von stofflichen zusammensetzungen, die mindestens einen high intensity sweetener (his) enthalten |
| DE202008006492U1 (de) | 2007-02-23 | 2008-08-21 | Basf Se | Verwendung von wasserdispergierbaren Carotinoid-Nanopartikeln als Geschmacksmodulatoren, Geschmacksmodulatoren, enthaltend wasserdispergierbare Carotinoid-Nanopartikel |
| CN105077203A (zh) | 2007-11-29 | 2015-11-25 | 巴斯夫欧洲公司 | 用于饮料着色的粉状类胡萝卜素制剂 |
| JP5728152B2 (ja) * | 2008-07-07 | 2015-06-03 | 株式会社ファンケル | 乾燥リポソーム製剤 |
| EP2151231B1 (de) * | 2008-08-05 | 2017-08-02 | PM-International AG | Kosmetische Formulierung |
| ES2563640T5 (es) | 2008-10-07 | 2021-11-22 | Basf Se | Emulsión estable, lista para usar |
| EP2192160B1 (de) * | 2008-12-01 | 2016-08-17 | Aquanova Ag | Micellar integrierter Oxidationsschutz für natürliche Farbstoffe |
| US20120157547A1 (en) | 2010-12-21 | 2012-06-21 | Ricardo Montoya-Olvera | Compositions and applications of carotenoids of improved absorption and bioavailability |
| HK1211836A1 (en) | 2013-03-28 | 2016-06-03 | Omniactive Health Technologies Limited | Neuroprotective effect of carotenoids in brain |
| AT514764A1 (de) * | 2013-09-02 | 2015-03-15 | Sanochemia Ag | Beta-Carotin Zubereitung |
| US9622970B2 (en) * | 2014-05-08 | 2017-04-18 | Yaguang Liu | Pharmaceutical composition containing lutein and antioxidant for treating and preventing human disease |
| AT521983A1 (de) * | 2018-11-26 | 2020-06-15 | Orphanix Gmbh | Wässrige pädiatrische Retinolpräparate |
| CN111568858A (zh) * | 2020-04-30 | 2020-08-25 | 佛山科学技术学院 | 一种虾青素水溶液的制备方法 |
| CN111991301A (zh) * | 2020-09-21 | 2020-11-27 | 四川梅奥由享生物科技有限公司 | 具有抗炎美白修复保湿多重功效的乳液 |
| CN114081069A (zh) * | 2021-11-11 | 2022-02-25 | 光明乳业股份有限公司 | 一种含虾青素的乳制品及其制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3048000A1 (de) * | 1980-12-19 | 1982-07-15 | Basf Ag | Stabile injizierbare (beta)-carotin-solubilisate und verfahren zu ihrer herstellung |
| DE4031094A1 (de) * | 1990-10-02 | 1992-04-09 | Basf Ag | Verfahren zur herstellung von stabilen injizierbaren (beta)-carotin-solubilisaten |
| GB9219524D0 (en) * | 1992-09-15 | 1992-10-28 | Smithkline Beecham Plc | Novel composition |
| CH685325A5 (de) * | 1994-01-04 | 1995-06-15 | Marigen Sa | Ultramikroemulsionen aus spontan dispergierbaren Konzentraten mit schwer löslichen Carotinen. |
-
1996
- 1996-03-11 DE DE19609477A patent/DE19609477A1/de not_active Ceased
-
1997
- 1997-03-04 EP EP97103484A patent/EP0800825A1/de not_active Withdrawn
- 1997-03-06 JP JP9050801A patent/JPH09249554A/ja active Pending
- 1997-03-06 CA CA002199415A patent/CA2199415A1/en not_active Abandoned
- 1997-03-07 AU AU16204/97A patent/AU1620497A/en not_active Abandoned
- 1997-03-10 US US08/813,978 patent/US5891907A/en not_active Expired - Fee Related
- 1997-03-11 CN CN97109610A patent/CN1096264C/zh not_active Expired - Fee Related
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2000178187A (ja) * | 1998-12-15 | 2000-06-27 | Sanochemia Pharmazeutika Ag | βカロテンの水性調合物 |
| JP2001011441A (ja) * | 1999-05-28 | 2001-01-16 | Johnson & Johnson Consumer Co Inc | 酸素不安定種を安定化する組成物および方法 |
| JP2007270073A (ja) * | 2006-03-31 | 2007-10-18 | Fujifilm Corp | エマルジョン組成物 |
| JP2008169117A (ja) * | 2007-01-05 | 2008-07-24 | Fujifilm Corp | 分散組成物及びスキンケア用化粧料並びに分散組成物の製造方法 |
| JP2010518829A (ja) * | 2007-02-23 | 2010-06-03 | ビーエーエスエフ ソシエタス・ヨーロピア | 味覚変容物質としての水分散性カロテノイドナノ粒子の使用、水分散性カロテノイドナノ粒子を含む味覚変容物質、および味覚変容方法 |
| JP2009007289A (ja) * | 2007-06-27 | 2009-01-15 | Fujifilm Corp | 分散組成物及びスキンケア用化粧料並びに分散組成物の製造方法 |
| JP2009013129A (ja) * | 2007-07-06 | 2009-01-22 | Fujifilm Corp | 化粧品組成物 |
| JP2013501752A (ja) * | 2009-08-11 | 2013-01-17 | ピエール、ファーブル、メディカマン | Ｄｈａエステルを含む非経口投与のための医薬組成物 |
| JP2022509196A (ja) * | 2018-11-26 | 2022-01-20 | オルファニクス ゲゼルシャフト ミット ベシュレンクテル ハフツング | 水性の小児用レチノール製剤 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP0800825A1 (de) | 1997-10-15 |
| CN1096264C (zh) | 2002-12-18 |
| CN1165653A (zh) | 1997-11-26 |
| CA2199415A1 (en) | 1997-09-11 |
| DE19609477A1 (de) | 1997-09-18 |
| US5891907A (en) | 1999-04-06 |
| AU1620497A (en) | 1997-09-18 |
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