JPH08500113A - β‐アミノアルキルおよびβ‐Ｎ‐ペプチジルアミノアルキルボロニン酸 - Google Patents

β‐アミノアルキルおよびβ‐Ｎ‐ペプチジルアミノアルキルボロニン酸

Info

Publication number
JPH08500113A
JPH08500113A JP6506312A JP50631294A JPH08500113A JP H08500113 A JPH08500113 A JP H08500113A JP 6506312 A JP6506312 A JP 6506312A JP 50631294 A JP50631294 A JP 50631294A JP H08500113 A JPH08500113 A JP H08500113A
Authority
JP
Japan
Prior art keywords
acid
alkyl
group
compound
aryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP6506312A
Other languages
English (en)
Japanese (ja)
Inventor
ウイリアム ブヨルキスト，デイビッド
ケシャブ パナンディカー，ラジャン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Procter and Gamble Co
Original Assignee
Procter and Gamble Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter and Gamble Co filed Critical Procter and Gamble Co
Publication of JPH08500113A publication Critical patent/JPH08500113A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/38—Products with no well-defined composition, e.g. natural products
    • C11D3/386—Preparations containing enzymes, e.g. protease or amylase
    • C11D3/38663—Stabilised liquid enzyme compositions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Detergent Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP6506312A 1992-08-14 1993-08-03 β‐アミノアルキルおよびβ‐Ｎ‐ペプチジルアミノアルキルボロニン酸 Pending JPH08500113A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US07/931,809 US5442100A (en) 1992-08-14 1992-08-14 β-aminoalkyl and β-N-peptidylaminoalkyl boronic acids
US07/931,809 1992-08-14
PCT/US1993/007276 WO1994004542A1 (en) 1992-08-14 1993-08-03 β-AMINOALKYL AND β-N-PEPTIDYLAMINOALKYL BORONIC ACIDS

Publications (1)

Publication Number Publication Date
JPH08500113A true JPH08500113A (ja) 1996-01-09

Family

ID=25461390

Family Applications (1)

Application Number Title Priority Date Filing Date
JP6506312A Pending JPH08500113A (ja) 1992-08-14 1993-08-03 β‐アミノアルキルおよびβ‐Ｎ‐ペプチジルアミノアルキルボロニン酸

Country Status (10)

Country Link
US (2) US5442100A (enExample)
EP (1) EP0655067B1 (enExample)
JP (1) JPH08500113A (enExample)
CN (1) CN1047596C (enExample)
AT (1) ATE159945T1 (enExample)
AU (1) AU4799793A (enExample)
DE (1) DE69315079T2 (enExample)
MX (1) MX9304970A (enExample)
TW (1) TW251274B (enExample)
WO (1) WO1994004542A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008512522A (ja) * 2004-09-08 2008-04-24 ザ プロクター アンド ギャンブル カンパニー 臭いが改良された洗濯処理組成物

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0583536B1 (en) * 1992-08-14 1997-03-05 The Procter & Gamble Company Liquid detergents containing an alpha-amino boronic acid
CN1127014A (zh) * 1993-07-09 1996-07-17 诺沃挪第克公司 作为酶稳定剂的一烃基硼酸或二烃基硼酸衍生物
US5834415A (en) * 1994-04-26 1998-11-10 Novo Nordisk A/S Naphthalene boronic acids
DE4422433A1 (de) * 1994-06-28 1996-01-04 Cognis Bio Umwelt Mehrenzymgranulat
US5731439A (en) * 1995-03-24 1998-03-24 The Dupont Merck Pharmaceutical Company Piperidine containing aminobornic acids
EP0830473A4 (en) 1995-06-05 1999-01-07 Creative Prod Resource Inc CHEMICAL CLEANING KIT FOR USE IN DRYER
US5658651A (en) 1995-09-29 1997-08-19 Creative Products Resource, Inc. Fabric treatment and softener system for in-dryer use
US6086634A (en) 1995-06-05 2000-07-11 Custom Cleaner, Inc. Dry-cleaning compositions containing polysulfonic acid
US6036727A (en) 1995-06-05 2000-03-14 Creative Products Resource, Inc. Anhydrous dry-cleaning compositions containing polysulfonic acid, and dry-cleaning kits for delicate fabrics
CN1103810C (zh) * 1995-06-13 2003-03-26 诺沃奇梅兹有限公司 含苯基硼酸衍生物酶稳定剂的液冻组合物
JP2003502316A (ja) * 1999-06-14 2003-01-21 ウィスコンシン アルムニ リサーチ ファウンデイション 環状イミノカルボン酸のオリゴマー及びポリマー
RU2470069C2 (ru) 2008-01-04 2012-12-20 Дзе Проктер Энд Гэмбл Компани Композиция средства для стирки, содержащая гликозилгидролазу
US20090209447A1 (en) * 2008-02-15 2009-08-20 Michelle Meek Cleaning compositions
MY159940A (en) 2008-06-06 2017-02-15 Procter & Gamble Detergent composition comprising a variant of a family 44 xyloglucanase
HRP20150592T4 (hr) * 2008-06-17 2025-02-14 Millennium Pharmaceuticals, Inc Organoborni esterski spojevi i njihove farmaceutske kompozicije
BR112012000531A2 (pt) 2009-07-09 2019-09-24 Procter & Gamble composição detergente para lavagem de roupas catalítica que compreende teores relativamente baixos de eletrólito solúvel em água
CN102471729A (zh) 2009-07-09 2012-05-23 宝洁公司 包含较低含量水溶性电解质的催化性衣物洗涤剂组合物
US8933131B2 (en) * 2010-01-12 2015-01-13 The Procter & Gamble Company Intermediates and surfactants useful in household cleaning and personal care compositions, and methods of making the same
MX2012010571A (es) 2010-03-12 2012-10-09 Procter & Gamble Composiciones detergentes fluidas que comprenden un gelificante de diamida y procesos para fabricarlas.
WO2011112910A1 (en) 2010-03-12 2011-09-15 The Procter & Gamble Company Liquid detergent compositions comprising ph tuneable amido-gellants, and processes for making
PL3412676T3 (pl) 2010-08-10 2021-04-06 Melinta Therapeutics, Inc. Cykliczne pochodne estrowe kwasu boronowego, sposób otrzymywania oraz ich zastosowania terapeutyczne
MX2013009546A (es) 2011-02-17 2013-11-22 Procter & Gamble Alquilfenil sulfonatos lineales de base biologica.
WO2012138423A1 (en) 2011-02-17 2012-10-11 The Procter & Gamble Company Compositions comprising mixtures of c10-c13 alkylphenyl sulfonates
EP2737043B1 (en) 2011-07-25 2017-01-04 The Procter and Gamble Company Detergents having acceptable color
US20130303427A1 (en) 2011-09-13 2013-11-14 Susana Fernandez Prieto MICROCAPSULE COMPOSITIONS COMPRISING pH TUNEABLE DI-AMIDO GELLANTS
US20150018311A1 (en) * 2012-01-09 2015-01-15 University of Tromsø Therapeutic boron-containing compounds
EP2716644B1 (en) 2012-10-03 2017-04-05 The Procter and Gamble Company A stable enzyme stabilizer premix
EP2941246A4 (en) 2013-01-04 2016-12-21 Rempex Pharmaceuticals Inc BORONIC ACID DERIVATIVES AND THEIR THERAPEUTIC USES
US9241947B2 (en) 2013-01-04 2016-01-26 Rempex Pharmaceuticals, Inc. Boronic acid derivatives and therapeutic uses thereof
EP2970830B1 (en) 2013-03-14 2017-12-13 Novozymes A/S Enzyme and inhibitor contained in water-soluble films
EP2992076B1 (en) 2013-05-03 2018-10-24 Novozymes A/S Microencapsulation of detergent enzymes
EP3140310B1 (en) 2014-05-05 2019-08-07 Rempex Pharmaceuticals, Inc. Synthesis of boronate salts and uses thereof
US9687497B1 (en) 2014-05-05 2017-06-27 Rempex Pharmaceuticals, Inc. Salts and polymorphs of cyclic boronic acid ester derivatives and therapeutic uses thereof
AU2015264418A1 (en) 2014-05-19 2016-11-10 Rempex Pharmaceuticals, Inc. Boronic acid derivatives and therapeutic uses thereof
SG10202003693RA (en) 2014-05-20 2020-05-28 Millennium Pharm Inc Boron-containing proteasome inhibitors for use after primary cancer therapy
US10206937B2 (en) 2014-07-01 2019-02-19 Qpex Biopharma, Inc. Boronic acid derivatives and therapeutic uses thereof
WO2016001319A1 (en) 2014-07-03 2016-01-07 Novozymes A/S Improved stabilization of non-protease enzyme
WO2016081297A1 (en) 2014-11-18 2016-05-26 Rempex Pharmaceuticals, Inc. Cyclic boronic acid ester derivatives and therapeutic uses thereof
US10364257B2 (en) 2014-12-19 2019-07-30 Rempex Pharmaceuticals, Inc. Apparatus and continuous flow process for production of boronic acid derivatives
WO2016097352A1 (en) 2014-12-19 2016-06-23 Novozymes A/S Protease variants and polynucleotides encoding same
US20180051041A1 (en) 2015-03-17 2018-02-22 Rempex Pharmaceuticals, Inc. Boronic acid derivatives and therapeutic uses thereof
EP3320089B1 (en) 2015-07-06 2021-06-16 Novozymes A/S Lipase variants and polynucleotides encoding same
CN108367251A (zh) 2015-10-14 2018-08-03 诺维信公司 滤水膜的清洁
MY196909A (en) 2016-06-30 2023-05-09 Qpex Biopharma Inc Boronic acid derivatives and therapeutic uses thereof
CN110651038B (zh) 2017-05-05 2025-02-18 诺维信公司 包含脂肪酶和亚硫酸根的组合物
EP3645692B1 (en) 2017-06-30 2025-12-31 Novozymes A/S ENZYMATIC SUSPENSION COMPOSITION
EP3694864B1 (en) 2017-10-11 2025-03-05 Qpex Biopharma, Inc. Boronic acid derivatives and synthesis thereof
CN111479919A (zh) 2017-11-01 2020-07-31 诺维信公司 多肽以及包含此类多肽的组合物
BR112020008737A2 (pt) 2017-11-01 2020-10-13 Novozymes A/S polipeptídeos e composições que compreendam tais polipeptídeos
US20210002588A1 (en) 2018-03-13 2021-01-07 Novozymes A/S Microencapsulation Using Amino Sugar Oligomers
AU2019256351B2 (en) 2018-04-20 2024-02-29 Qpex Biopharma, Inc. Boronic acid derivatives and therapeutic uses thereof
EP3647397A1 (en) 2018-10-31 2020-05-06 Henkel AG & Co. KGaA Cleaning compositions containing dispersins iv
ES2981999T3 (es) 2018-10-31 2024-10-14 Henkel Ag & Co Kgaa Composiciones limpiadoras que contienen dispersinas V
CN114667335B (zh) 2019-11-27 2025-07-08 宝洁公司 改进的烷基苯磺酸盐表面活性剂
EP4077656A2 (en) 2019-12-20 2022-10-26 Novozymes A/S Polypeptides having proteolytic activity and use thereof
US12552815B2 (en) 2020-05-05 2026-02-17 Qpex Biopharma, Inc. Boronic acid derivatives and synthesis, polymorphic forms, and therapeutic uses thereof
EP4305146A1 (en) 2021-03-12 2024-01-17 Novozymes A/S Polypeptide variants
JP2026501223A (ja) 2022-12-23 2026-01-14 ノボザイムス アクティーゼルスカブ カタラーゼ及びアミラーゼを含む洗剤組成物

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2872479A (en) * 1955-06-30 1959-02-03 Callery Chemical Co Preparation of organoboron compounds
US3912595A (en) * 1974-02-25 1975-10-14 Us Health Method of purifying enzymes using boronic acids covalently bonded to an insoluble support
IT1129814B (it) * 1980-07-02 1986-06-11 Unilever Nv Composizione detergente enzimatica liquida
US4462922A (en) * 1981-11-19 1984-07-31 Lever Brothers Company Enzymatic liquid detergent composition
GB8311314D0 (en) * 1983-04-26 1983-06-02 Unilever Plc Aqueous enzyme-containing compositions
US4652394A (en) * 1983-05-31 1987-03-24 Colgate Palmolive Co. Built single phase liquid anionic detergent compositions containing stabilized enzymes
DE3413571A1 (de) * 1984-04-11 1985-10-24 Hoechst Ag, 6230 Frankfurt Verwendung von kristallinen schichtfoermigen natriumsilikaten zur wasserenthaertung und verfahren zur wasserenthaertung
US4537707A (en) * 1984-05-14 1985-08-27 The Procter & Gamble Company Liquid detergents containing boric acid and formate to stabilize enzymes
US4566985A (en) * 1984-09-19 1986-01-28 Applied Biochemists, Inc. Method of cleaning using liquid compositions comprising stabilized mixtures of enzymes
US4747977A (en) * 1984-11-09 1988-05-31 The Procter & Gamble Company Ethanol-free liquid laundry detergent compositions
US4842769A (en) * 1985-07-26 1989-06-27 Colgate-Palmolive Co. Stabilized fabric softening built detergent composition containing enzymes
US4900475A (en) * 1985-07-26 1990-02-13 Colgate-Palmolive Co. Stabilized built liquid detergent composition containing enzyme
WO1987000859A1 (en) * 1985-08-09 1987-02-12 Gist-Brocades N.V. Novel lipolytic enzymes and their use in detergent compositions
EG18543A (en) * 1986-02-20 1993-07-30 Albright & Wilson Protected enzyme systems
US4842758A (en) * 1986-10-31 1989-06-27 Colgate-Palmolive Company Stabilized enzyme system for use in aqueous liquid built detergent compositions
US4704233A (en) * 1986-11-10 1987-11-03 The Procter & Gamble Company Detergent compositions containing ethylenediamine-N,N'-disuccinic acid
US5187157A (en) * 1987-06-05 1993-02-16 Du Pont Merck Pharmaceutical Company Peptide boronic acid inhibitors of trypsin-like proteases
DK571587D0 (da) * 1987-11-02 1987-11-02 Novo Industri As Enzymatisk detergentsammensaetning
EP0315574A3 (de) * 1987-11-05 1990-08-22 Hoechst Aktiengesellschaft Renin-Inhibitoren
GB8810822D0 (en) * 1988-05-06 1988-06-08 Unilever Plc Liquid detergent compositions
US4963655A (en) * 1988-05-27 1990-10-16 Mayo Foundation For Medical Education And Research Boron analogs of amino acid/peptide protease inhibitors
US5039446A (en) * 1988-07-01 1991-08-13 Genencor International, Inc. Liquid detergent with stabilized enzyme
DE3840452A1 (de) * 1988-12-01 1990-06-07 Hoechst Ag (beta)-amino-boronsaeure-derivate
AU4724989A (en) * 1988-12-30 1990-07-05 Unilever Plc Enzymatic liquid detergent composition
US4959179A (en) * 1989-01-30 1990-09-25 Lever Brothers Company Stabilized enzymes liquid detergent composition containing lipase and protease
US4908150A (en) * 1989-02-02 1990-03-13 Lever Brothers Company Stabilized lipolytic enzyme-containing liquid detergent composition
CA2010986A1 (en) * 1989-02-27 1990-08-27 George E. Pierce Unique microbial lipases with activity at high temperatures and phs suitable for use in detergents
DE69033423T2 (de) * 1989-05-15 2000-05-25 The Clorox Co., Oakland Wäschewaschverfahren
EP0450702A3 (en) * 1990-04-06 1993-06-02 Unilever N.V. Process for preparing liquid enzymatic detergent compositions
EP0478050A1 (en) * 1990-09-24 1992-04-01 Unilever N.V. Detergent composition
DK0486073T3 (da) * 1990-11-14 1996-12-09 Procter & Gamble Væskeformig detergentsammensætning, der indeholder lipase og protease

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008512522A (ja) * 2004-09-08 2008-04-24 ザ プロクター アンド ギャンブル カンパニー 臭いが改良された洗濯処理組成物

Also Published As

Publication number Publication date
TW251274B (enExample) 1995-07-11
MX9304970A (es) 1994-05-31
US5442100A (en) 1995-08-15
DE69315079T2 (de) 1998-06-04
WO1994004542A1 (en) 1994-03-03
EP0655067B1 (en) 1997-11-05
CN1047596C (zh) 1999-12-22
AU4799793A (en) 1994-03-15
DE69315079D1 (de) 1997-12-11
CN1090850A (zh) 1994-08-17
ATE159945T1 (de) 1997-11-15
US5488157A (en) 1996-01-30
EP0655067A1 (en) 1995-05-31

Similar Documents

Publication Publication Date Title
JPH08500147A (ja) プロテアーゼおよび特定のβ‐アミノアルキルボロニン酸およびエステルを含有する液体洗剤組成物
US5442100A (en) β-aminoalkyl and β-N-peptidylaminoalkyl boronic acids
US5431842A (en) Liquid detergents with ortho-substituted phenylboronic acids for inhibition of proteolytic enzyme
JP3219765B2 (ja) タンパク分解酵素を阻害するためのホウ酸系物質−ポリオール複合体を有するビルダー入り液体洗剤
CN1039431C (zh) 含有肽醛的液体洗涤剂
CN1113089C (zh) 含有蛋白酶和蛋白酶抑制剂的液体洗涤剂
CN1113088C (zh) 含有蛋白酶和蛋白酶抑制剂的液体洗涤剂
JP3046071B2 (ja) ポリヒドロキシ脂肪酸アミド界面活性剤とアルキルエステルスルホネート界面活性剤とを含有する洗剤組成物
JP2000506933A (ja) タンパク質分解酵素、ペプチドアルデヒドおよびホウ酸源を含有した液体洗剤
JPH08500145A (ja) アルファ‐アミノボロニン酸を含む液体洗剤組成物
JPH06507199A (ja) タンパク質分解酵素阻害芳香族ホウ酸エステル含有液体洗剤
RU2105791C1 (ru) Жидкая моющая композиция и гранулированная моющая композиция
JP3285866B2 (ja) ペプチドトリフルオロメチルケトンを含有する液体洗剤
JPH08500114A (ja) β‐アミノアルキルボロニン酸及びエステルの合成方法
JPH06508394A (ja) ポリヒドロキシ脂肪酸アミドと不溶性エトキシ化アルコールとを含有する洗濯洗剤