CN1047596C - β-氨基烷基和β-N-肽基氨基烷基硼酸 - Google Patents

β-氨基烷基和β-N-肽基氨基烷基硼酸 Download PDF

Info

Publication number
CN1047596C
CN1047596C CN93117839A CN93117839A CN1047596C CN 1047596 C CN1047596 C CN 1047596C CN 93117839 A CN93117839 A CN 93117839A CN 93117839 A CN93117839 A CN 93117839A CN 1047596 C CN1047596 C CN 1047596C
Authority
CN
China
Prior art keywords
alkyl
acid
compound
composition
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN93117839A
Other languages
English (en)
Chinese (zh)
Other versions
CN1090850A (zh
Inventor
D·W·比约奎斯特
R·K·彭南迪卡
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Procter and Gamble Co
Original Assignee
Procter and Gamble Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter and Gamble Co filed Critical Procter and Gamble Co
Publication of CN1090850A publication Critical patent/CN1090850A/zh
Application granted granted Critical
Publication of CN1047596C publication Critical patent/CN1047596C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/38—Products with no well-defined composition, e.g. natural products
    • C11D3/386—Preparations containing enzymes, e.g. protease or amylase
    • C11D3/38663—Stabilised liquid enzyme compositions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Wood Science & Technology (AREA)
  • Detergent Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN93117839A 1992-08-14 1993-08-14 β-氨基烷基和β-N-肽基氨基烷基硼酸 Expired - Fee Related CN1047596C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/931,809 US5442100A (en) 1992-08-14 1992-08-14 β-aminoalkyl and β-N-peptidylaminoalkyl boronic acids
US931,809 1992-08-14

Publications (2)

Publication Number Publication Date
CN1090850A CN1090850A (zh) 1994-08-17
CN1047596C true CN1047596C (zh) 1999-12-22

Family

ID=25461390

Family Applications (1)

Application Number Title Priority Date Filing Date
CN93117839A Expired - Fee Related CN1047596C (zh) 1992-08-14 1993-08-14 β-氨基烷基和β-N-肽基氨基烷基硼酸

Country Status (10)

Country Link
US (2) US5442100A (enExample)
EP (1) EP0655067B1 (enExample)
JP (1) JPH08500113A (enExample)
CN (1) CN1047596C (enExample)
AT (1) ATE159945T1 (enExample)
AU (1) AU4799793A (enExample)
DE (1) DE69315079T2 (enExample)
MX (1) MX9304970A (enExample)
TW (1) TW251274B (enExample)
WO (1) WO1994004542A1 (enExample)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0583536B1 (en) * 1992-08-14 1997-03-05 The Procter & Gamble Company Liquid detergents containing an alpha-amino boronic acid
BR9407048A (pt) * 1993-07-09 1996-08-13 Novo Nordisk As Composiçao liquida
US5834415A (en) * 1994-04-26 1998-11-10 Novo Nordisk A/S Naphthalene boronic acids
DE4422433A1 (de) * 1994-06-28 1996-01-04 Cognis Bio Umwelt Mehrenzymgranulat
US5731439A (en) * 1995-03-24 1998-03-24 The Dupont Merck Pharmaceutical Company Piperidine containing aminobornic acids
CA2221635A1 (en) 1995-06-05 1996-12-12 Creative Products Resource, Inc. Dry-cleaning kit for in-dryer use
US6036727A (en) 1995-06-05 2000-03-14 Creative Products Resource, Inc. Anhydrous dry-cleaning compositions containing polysulfonic acid, and dry-cleaning kits for delicate fabrics
US5658651A (en) 1995-09-29 1997-08-19 Creative Products Resource, Inc. Fabric treatment and softener system for in-dryer use
US6086634A (en) 1995-06-05 2000-07-11 Custom Cleaner, Inc. Dry-cleaning compositions containing polysulfonic acid
JP3895377B2 (ja) * 1995-06-13 2007-03-22 ノボザイムス アクティーゼルスカブ 酵素安定剤としての４−置換フェニルボロン酸
US6727368B1 (en) * 1999-06-14 2004-04-27 Wisconsin Alumni Research Foundation Oligomers and polymers of cyclic imino carboxylic acids
CN101014691A (zh) * 2004-09-08 2007-08-08 宝洁公司 具有改善的气味的衣物处理组合物
RU2470069C2 (ru) 2008-01-04 2012-12-20 Дзе Проктер Энд Гэмбл Компани Композиция средства для стирки, содержащая гликозилгидролазу
US20090209447A1 (en) * 2008-02-15 2009-08-20 Michelle Meek Cleaning compositions
EP4545638A3 (en) 2008-06-06 2025-07-16 The Procter & Gamble Company Detergent composition comprising a variant of a family 44 xyloglucanase
SI2318419T2 (sl) 2008-06-17 2025-10-30 Takeda Pharmaceutical Company Limited Spojine boronat estra in njihovi farmacevtski sestavki
JP2012532246A (ja) 2009-07-09 2012-12-13 ザ プロクター アンド ギャンブル カンパニー 比較的低濃度の水溶性電解質を含む触媒性洗濯洗剤組成物
MX2012000480A (es) 2009-07-09 2012-01-27 Procter & Gamble Composiciones detergente catalitica de lavanderia que comprende niveles relativamente bajos de electrolitos solubles en agua.
US20110166370A1 (en) * 2010-01-12 2011-07-07 Charles Winston Saunders Scattered Branched-Chain Fatty Acids And Biological Production Thereof
JP5758412B2 (ja) 2010-03-12 2015-08-05 ザ プロクター アンド ギャンブルカンパニー 消費者製品組成物で使用するジアミドゲル化剤
CA2792759C (en) 2010-03-12 2014-07-08 The Procter & Gamble Company Liquid detergent compositions comprising ph tuneable amido-gellants, and processes for making
RU2599791C2 (ru) 2010-08-10 2016-10-20 Ремпекс Фармасьютикэлз, Инч. Циклические бороновые кислотно-эфирные производные и их использование в терапии
CN103380204B (zh) 2011-02-17 2016-02-03 宝洁公司 包含c10-c13烷基苯基磺酸盐的混合物的组合物
WO2012112828A1 (en) 2011-02-17 2012-08-23 The Procter & Gamble Company Bio-based linear alkylphenyl sulfonates
US8921299B2 (en) 2011-07-25 2014-12-30 The Procter & Gamble Company Detergents having acceptable color
US20130303427A1 (en) 2011-09-13 2013-11-14 Susana Fernandez Prieto MICROCAPSULE COMPOSITIONS COMPRISING pH TUNEABLE DI-AMIDO GELLANTS
WO2013104897A1 (en) * 2012-01-09 2013-07-18 University of Tromsø Therapeutic boron-containing compounds
EP2716644B1 (en) 2012-10-03 2017-04-05 The Procter and Gamble Company A stable enzyme stabilizer premix
AU2014204045B2 (en) 2013-01-04 2018-10-18 Rempex Pharmaceuticals, Inc. Boronic acid derivatives and therapeutic uses thereof
US9241947B2 (en) 2013-01-04 2016-01-26 Rempex Pharmaceuticals, Inc. Boronic acid derivatives and therapeutic uses thereof
US20160024440A1 (en) 2013-03-14 2016-01-28 Novozymes A/S Enzyme and Inhibitor Containing Water-Soluble Films
CN105164244B (zh) 2013-05-03 2019-08-20 诺维信公司 洗涤剂酶的微囊化
WO2015171398A1 (en) 2014-05-05 2015-11-12 Rempex Pharmaceuticals, Inc. Salts and polymorphs of cyclic boronic acid ester derivatives and therapeutic uses thereof
US10385074B2 (en) 2014-05-05 2019-08-20 Rempex Pharmaceuticals, Inc. Synthesis of boronate salts and uses thereof
AU2015264418A1 (en) 2014-05-19 2016-11-10 Rempex Pharmaceuticals, Inc. Boronic acid derivatives and therapeutic uses thereof
UA121389C2 (uk) 2014-05-20 2020-05-25 Мілленніум Фармасьютікалз, Інк. Борвмісні інгібітори протеасом для застосування після первинної протиракової терапії
AU2015284307A1 (en) 2014-07-01 2017-02-02 Rempex Pharmaceuticals, Inc. Boronic acid derivatives and therapeutic uses thereof
WO2016001319A1 (en) 2014-07-03 2016-01-07 Novozymes A/S Improved stabilization of non-protease enzyme
WO2016081297A1 (en) 2014-11-18 2016-05-26 Rempex Pharmaceuticals, Inc. Cyclic boronic acid ester derivatives and therapeutic uses thereof
ES2761778T3 (es) 2014-12-19 2020-05-21 Rempex Pharmaceuticals Inc Aparato y proceso de flujo continuo para la producción de derivados de ácido borónico
WO2016097352A1 (en) 2014-12-19 2016-06-23 Novozymes A/S Protease variants and polynucleotides encoding same
WO2016149393A1 (en) 2015-03-17 2016-09-22 Rempex Pharmaceuticals, Inc. Boronic acid derivatives and therapeutic uses thereof
CN114292829A (zh) 2015-07-06 2022-04-08 诺维信公司 脂肪酶变体以及编码它们的多核苷酸
US10675589B2 (en) 2015-10-14 2020-06-09 Novozymes A/S Cleaning of water filtration membranes
AU2017290060B2 (en) 2016-06-30 2021-07-22 Qpex Biopharma, Inc Boronic acid derivatives and therapeutic uses thereof
WO2018202846A1 (en) 2017-05-05 2018-11-08 Novozymes A/S Compositions comprising lipase and sulfite
US20200181542A1 (en) 2017-06-30 2020-06-11 Novozymes A/S Enzyme Slurry Composition
BR112020007138B1 (pt) 2017-10-11 2023-03-21 Qpex Biopharma, Inc Derivados de ácido borônico, métodos de síntese, composição farmacêutica e uso dos mesmos
US20200291330A1 (en) 2017-11-01 2020-09-17 Novozymes A/S Polypeptides and Compositions Comprising Such Polypeptides
WO2019086530A1 (en) 2017-11-01 2019-05-09 Novozymes A/S Polypeptides and compositions comprising such polypeptides
EP3765185B1 (en) 2018-03-13 2023-07-19 Novozymes A/S Microencapsulation using amino sugar oligomers
CN112424209A (zh) 2018-04-20 2021-02-26 Qpex生物制药有限公司 硼酸衍生物及其治疗用途
ES2981999T3 (es) 2018-10-31 2024-10-14 Henkel Ag & Co Kgaa Composiciones limpiadoras que contienen dispersinas V
EP3647397A1 (en) 2018-10-31 2020-05-06 Henkel AG & Co. KGaA Cleaning compositions containing dispersins iv
US12636297B2 (en) 2019-06-19 2026-05-26 Qpex Biopharma, Inc. Boronic acid derivatives and therapeutic uses thereof
US11879110B2 (en) 2019-11-27 2024-01-23 The Procter & Gamble Company Alkylbenzenesulfonate surfactants
EP4077656A2 (en) 2019-12-20 2022-10-26 Novozymes A/S Polypeptides having proteolytic activity and use thereof
US12637481B2 (en) 2020-03-18 2026-05-26 Qpex Biopharma, Inc. Boronic acid derivatives and therapeutic uses thereof
IL297458A (en) 2020-05-05 2022-12-01 Qpex Biopharma Inc Boronic acid derivatives and their synthesis, polymorphic forms and medicinal uses
EP4305146A1 (en) 2021-03-12 2024-01-17 Novozymes A/S Polypeptide variants
KR20250130619A (ko) 2022-12-23 2025-09-02 노보자임스 에이/에스 카탈라제 및 아밀라제를 포함하는 세제 조성물

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0371467A2 (de) * 1988-12-01 1990-06-06 Hoechst Aktiengesellschaft Beta-Amino-Boronsäure-Derivate

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2872479A (en) * 1955-06-30 1959-02-03 Callery Chemical Co Preparation of organoboron compounds
US3912595A (en) * 1974-02-25 1975-10-14 Us Health Method of purifying enzymes using boronic acids covalently bonded to an insoluble support
IT1129814B (it) * 1980-07-02 1986-06-11 Unilever Nv Composizione detergente enzimatica liquida
US4462922A (en) * 1981-11-19 1984-07-31 Lever Brothers Company Enzymatic liquid detergent composition
GB8311314D0 (en) * 1983-04-26 1983-06-02 Unilever Plc Aqueous enzyme-containing compositions
US4652394A (en) * 1983-05-31 1987-03-24 Colgate Palmolive Co. Built single phase liquid anionic detergent compositions containing stabilized enzymes
DE3413571A1 (de) * 1984-04-11 1985-10-24 Hoechst Ag, 6230 Frankfurt Verwendung von kristallinen schichtfoermigen natriumsilikaten zur wasserenthaertung und verfahren zur wasserenthaertung
US4537707A (en) * 1984-05-14 1985-08-27 The Procter & Gamble Company Liquid detergents containing boric acid and formate to stabilize enzymes
US4566985A (en) * 1984-09-19 1986-01-28 Applied Biochemists, Inc. Method of cleaning using liquid compositions comprising stabilized mixtures of enzymes
US4747977A (en) * 1984-11-09 1988-05-31 The Procter & Gamble Company Ethanol-free liquid laundry detergent compositions
US4900475A (en) * 1985-07-26 1990-02-13 Colgate-Palmolive Co. Stabilized built liquid detergent composition containing enzyme
US4842769A (en) * 1985-07-26 1989-06-27 Colgate-Palmolive Co. Stabilized fabric softening built detergent composition containing enzymes
EP0218272B1 (en) * 1985-08-09 1992-03-18 Gist-Brocades N.V. Novel lipolytic enzymes and their use in detergent compositions
EG18543A (en) * 1986-02-20 1993-07-30 Albright & Wilson Protected enzyme systems
US4842758A (en) * 1986-10-31 1989-06-27 Colgate-Palmolive Company Stabilized enzyme system for use in aqueous liquid built detergent compositions
US4704233A (en) * 1986-11-10 1987-11-03 The Procter & Gamble Company Detergent compositions containing ethylenediamine-N,N'-disuccinic acid
US5187157A (en) * 1987-06-05 1993-02-16 Du Pont Merck Pharmaceutical Company Peptide boronic acid inhibitors of trypsin-like proteases
DK571587D0 (da) * 1987-11-02 1987-11-02 Novo Industri As Enzymatisk detergentsammensaetning
EP0315574A3 (de) * 1987-11-05 1990-08-22 Hoechst Aktiengesellschaft Renin-Inhibitoren
GB8810822D0 (en) * 1988-05-06 1988-06-08 Unilever Plc Liquid detergent compositions
US4963655A (en) * 1988-05-27 1990-10-16 Mayo Foundation For Medical Education And Research Boron analogs of amino acid/peptide protease inhibitors
US5039446A (en) * 1988-07-01 1991-08-13 Genencor International, Inc. Liquid detergent with stabilized enzyme
AU4724989A (en) * 1988-12-30 1990-07-05 Unilever Plc Enzymatic liquid detergent composition
US4959179A (en) * 1989-01-30 1990-09-25 Lever Brothers Company Stabilized enzymes liquid detergent composition containing lipase and protease
US4908150A (en) * 1989-02-02 1990-03-13 Lever Brothers Company Stabilized lipolytic enzyme-containing liquid detergent composition
EP0385401A1 (en) * 1989-02-27 1990-09-05 Occidental Chemical Corporation Unique Microbial lipases with activity at temperatures and pHs suitable for use in detergents
EP0399681B1 (en) * 1989-05-15 2000-01-19 The Clorox Company Method of laundering fabrics
EP0450702A3 (en) * 1990-04-06 1993-06-02 Unilever N.V. Process for preparing liquid enzymatic detergent compositions
EP0478050A1 (en) * 1990-09-24 1992-04-01 Unilever N.V. Detergent composition
EP0486073B1 (en) * 1990-11-14 1996-07-24 The Procter & Gamble Company Liquid detergent composition containing lipase and protease

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0371467A2 (de) * 1988-12-01 1990-06-06 Hoechst Aktiengesellschaft Beta-Amino-Boronsäure-Derivate

Also Published As

Publication number Publication date
US5442100A (en) 1995-08-15
JPH08500113A (ja) 1996-01-09
MX9304970A (es) 1994-05-31
ATE159945T1 (de) 1997-11-15
CN1090850A (zh) 1994-08-17
TW251274B (enExample) 1995-07-11
DE69315079D1 (de) 1997-12-11
EP0655067A1 (en) 1995-05-31
US5488157A (en) 1996-01-30
AU4799793A (en) 1994-03-15
WO1994004542A1 (en) 1994-03-03
EP0655067B1 (en) 1997-11-05
DE69315079T2 (de) 1998-06-04

Similar Documents

Publication Publication Date Title
CN1041435C (zh) 含有蛋白酶和某些β-氨基烷基硼酸和其酯的液体洗涤剂组合物
CN1046761C (zh) 一种抑制蛋白酶的新的邻位取代的苯基硼酸和含有该化合物的液体洗涤剂
CN1031589C (zh) 含有一种芳基硼酸以抑制蛋白水解酶的液体洗涤剂
US5442100A (en) β-aminoalkyl and β-N-peptidylaminoalkyl boronic acids
CN1034021C (zh) 加有抑制蛋白水解酶的硼-多羟基化合物配合物助洗剂的液体洗涤剂
CN1113089C (zh) 含有蛋白酶和蛋白酶抑制剂的液体洗涤剂
CN1113088C (zh) 含有蛋白酶和蛋白酶抑制剂的液体洗涤剂
CN1085943A (zh) 含有肽醛的液体洗涤剂
CN1238001A (zh) 含有蛋白水解酶、肽醛和钙离子的液体洗涤剂
CN1238002A (zh) 含有蛋白水解酶、肽醛和硼酸源的液体洗涤剂
CN1238003A (zh) 含有蛋白酶和蛋白酶抑制剂的液体洗衣洗涤剂组合物
CN1067264A (zh) 抑制蛋白分解酶的芳族硼酸酯液体洗涤剂
US5422030A (en) Liquid detergents with aromatic borate ester to inhibit proteolytic enzyme
JP3285866B2 (ja) ペプチドトリフルオロメチルケトンを含有する液体洗剤
CN1090851A (zh) 合成β氨基烷基硼酸及酯的方法

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C19 Lapse of patent right due to non-payment of the annual fee
CF01 Termination of patent right due to non-payment of annual fee