JPH07501207A - アクレモニウム・クリソゲナムを使用するセファロスポリンｃの発酵生産方法 - Google Patents
アクレモニウム・クリソゲナムを使用するセファロスポリンｃの発酵生産方法Info
- Publication number
- JPH07501207A JPH07501207A JP5504067A JP50406792A JPH07501207A JP H07501207 A JPH07501207 A JP H07501207A JP 5504067 A JP5504067 A JP 5504067A JP 50406792 A JP50406792 A JP 50406792A JP H07501207 A JPH07501207 A JP H07501207A
- Authority
- JP
- Japan
- Prior art keywords
- fermentation
- cephalosporin
- filtrate
- fermenter
- acremonium chrysogenum
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 238000000034 method Methods 0.000 title claims description 16
- HOKIDJSKDBPKTQ-GLXFQSAKSA-N cephalosporin C Chemical compound S1CC(COC(=O)C)=C(C(O)=O)N2C(=O)[C@@H](NC(=O)CCC[C@@H](N)C(O)=O)[C@@H]12 HOKIDJSKDBPKTQ-GLXFQSAKSA-N 0.000 title claims description 8
- 241000228431 Acremonium chrysogenum Species 0.000 title claims description 6
- 238000012262 fermentative production Methods 0.000 title claims description 3
- 238000000855 fermentation Methods 0.000 claims description 21
- 230000004151 fermentation Effects 0.000 claims description 21
- 238000009295 crossflow filtration Methods 0.000 claims description 9
- 235000015097 nutrients Nutrition 0.000 claims description 7
- 239000000706 filtrate Substances 0.000 claims description 6
- 239000000047 product Substances 0.000 claims description 5
- 239000000919 ceramic Substances 0.000 claims description 3
- 229920000642 polymer Polymers 0.000 claims description 3
- 239000011148 porous material Substances 0.000 claims description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 3
- 238000001914 filtration Methods 0.000 description 11
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 6
- HOKIDJSKDBPKTQ-GLXFQSAKSA-M cephalosporin C(1-) Chemical compound S1CC(COC(=O)C)=C(C([O-])=O)N2C(=O)[C@@H](NC(=O)CCC[C@@H]([NH3+])C([O-])=O)[C@@H]12 HOKIDJSKDBPKTQ-GLXFQSAKSA-M 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 239000012528 membrane Substances 0.000 description 4
- USFZMSVCRYTOJT-UHFFFAOYSA-N Ammonium acetate Chemical compound N.CC(O)=O USFZMSVCRYTOJT-UHFFFAOYSA-N 0.000 description 3
- 239000005695 Ammonium acetate Substances 0.000 description 3
- 229940043376 ammonium acetate Drugs 0.000 description 3
- 235000019257 ammonium acetate Nutrition 0.000 description 3
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 description 3
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 3
- 235000019341 magnesium sulphate Nutrition 0.000 description 3
- 238000000746 purification Methods 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- SPFMQWBKVUQXJV-BTVCFUMJSA-N (2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanal;hydrate Chemical compound O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O SPFMQWBKVUQXJV-BTVCFUMJSA-N 0.000 description 2
- 235000017060 Arachis glabrata Nutrition 0.000 description 2
- 244000105624 Arachis hypogaea Species 0.000 description 2
- 235000010777 Arachis hypogaea Nutrition 0.000 description 2
- 235000018262 Arachis monticola Nutrition 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- 241000228417 Sarocladium strictum Species 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 229930006000 Sucrose Natural products 0.000 description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
- 229910052925 anhydrite Inorganic materials 0.000 description 2
- 230000003115 biocidal effect Effects 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 2
- 239000013256 coordination polymer Substances 0.000 description 2
- NNQIJOYQWYKBOW-VMAXQDLPSA-N deacetoxycephalosporin-c Chemical compound S1CC(C)=C(C(O)=O)N2C(=O)[C@@H](NC(=O)CCC[C@H](N)C(O)=O)[C@H]12 NNQIJOYQWYKBOW-VMAXQDLPSA-N 0.000 description 2
- 238000006731 degradation reaction Methods 0.000 description 2
- 235000012054 meals Nutrition 0.000 description 2
- 235000020232 peanut Nutrition 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 238000001179 sorption measurement Methods 0.000 description 2
- 239000005720 sucrose Substances 0.000 description 2
- 241001019659 Acremonium <Plectosphaerellaceae> Species 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 229920002261 Corn starch Polymers 0.000 description 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000371 Esterases Proteins 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 240000005979 Hordeum vulgare Species 0.000 description 1
- 235000007340 Hordeum vulgare Nutrition 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 239000004952 Polyamide Substances 0.000 description 1
- 235000019764 Soybean Meal Nutrition 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 238000005273 aeration Methods 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 239000002518 antifoaming agent Substances 0.000 description 1
- 125000003460 beta-lactamyl group Chemical group 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 239000001110 calcium chloride Substances 0.000 description 1
- 229910001628 calcium chloride Inorganic materials 0.000 description 1
- 229920002301 cellulose acetate Polymers 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- 239000010941 cobalt Substances 0.000 description 1
- 229910017052 cobalt Inorganic materials 0.000 description 1
- GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 239000008120 corn starch Substances 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 239000012531 culture fluid Substances 0.000 description 1
- NNQIJOYQWYKBOW-UHFFFAOYSA-N desacetoxycephalosphorin G Natural products S1CC(C)=C(C(O)=O)N2C(=O)C(NC(=O)CCCC(N)C(O)=O)C12 NNQIJOYQWYKBOW-UHFFFAOYSA-N 0.000 description 1
- 239000008121 dextrose Substances 0.000 description 1
- ZPWVASYFFYYZEW-UHFFFAOYSA-L dipotassium hydrogen phosphate Chemical compound [K+].[K+].OP([O-])([O-])=O ZPWVASYFFYYZEW-UHFFFAOYSA-L 0.000 description 1
- 229910000396 dipotassium phosphate Inorganic materials 0.000 description 1
- 235000019797 dipotassium phosphate Nutrition 0.000 description 1
- QYDYPVFESGNLHU-UHFFFAOYSA-N elaidic acid methyl ester Natural products CCCCCCCCC=CCCCCCCCC(=O)OC QYDYPVFESGNLHU-UHFFFAOYSA-N 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000003925 fat Substances 0.000 description 1
- 235000013861 fat-free Nutrition 0.000 description 1
- 239000012510 hollow fiber Substances 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- -1 mankan Chemical compound 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000012533 medium component Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- FFEARJCKVFRZRR-UHFFFAOYSA-N methionine Chemical compound CSCCC(N)C(O)=O FFEARJCKVFRZRR-UHFFFAOYSA-N 0.000 description 1
- QYDYPVFESGNLHU-KHPPLWFESA-N methyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC QYDYPVFESGNLHU-KHPPLWFESA-N 0.000 description 1
- 229940073769 methyl oleate Drugs 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 235000013379 molasses Nutrition 0.000 description 1
- XONPDZSGENTBNJ-UHFFFAOYSA-N molecular hydrogen;sodium Chemical compound [Na].[H][H] XONPDZSGENTBNJ-UHFFFAOYSA-N 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- TWNQGVIAIRXVLR-UHFFFAOYSA-N oxo(oxoalumanyloxy)alumane Chemical compound O=[Al]O[Al]=O TWNQGVIAIRXVLR-UHFFFAOYSA-N 0.000 description 1
- RVTZCBVAJQQJTK-UHFFFAOYSA-N oxygen(2-);zirconium(4+) Chemical group [O-2].[O-2].[Zr+4] RVTZCBVAJQQJTK-UHFFFAOYSA-N 0.000 description 1
- 229920002492 poly(sulfone) Polymers 0.000 description 1
- 229920002647 polyamide Polymers 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 235000015424 sodium Nutrition 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000007928 solubilization Effects 0.000 description 1
- 238000005063 solubilization Methods 0.000 description 1
- 239000004455 soybean meal Substances 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 238000011146 sterile filtration Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- SRVJKTDHMYAMHA-WUXMJOGZSA-N thioacetazone Chemical compound CC(=O)NC1=CC=C(\C=N\NC(N)=S)C=C1 SRVJKTDHMYAMHA-WUXMJOGZSA-N 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 238000000108 ultra-filtration Methods 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910001928 zirconium oxide Inorganic materials 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
- C12P35/06—Cephalosporin C; Derivatives thereof
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Cephalosporin Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Soy Sauces And Products Related Thereto (AREA)
- Data Exchanges In Wide-Area Networks (AREA)
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3-10770 | 1991-01-31 | ||
| JP3-55020 | 1991-03-19 | ||
| JP3-134745 | 1991-06-06 | ||
| JP3-143350 | 1991-06-14 | ||
| JP3-168038 | 1991-07-09 | ||
| JP3-208262 | 1991-08-20 | ||
| DE4127648.5 | 1991-08-21 | ||
| DE4127648A DE4127648C1 (https=) | 1991-08-21 | 1991-08-21 | |
| PCT/EP1992/001811 WO1993004188A1 (de) | 1991-08-21 | 1992-08-08 | Verfahren zur fermentativen herstellung von cephalosporin c mit acremonium chrysogenum |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPWO1992014321A1 JPWO1992014321A1 (ja) | 1993-02-04 |
| JPH07501207A true JPH07501207A (ja) | 1995-02-09 |
Family
ID=6438749
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP5504067A Withdrawn JPH07501207A (ja) | 1991-08-21 | 1992-08-08 | アクレモニウム・クリソゲナムを使用するセファロスポリンｃの発酵生産方法 |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP0599891B1 (https=) |
| JP (1) | JPH07501207A (https=) |
| CN (1) | CN1045008C (https=) |
| AT (1) | ATE130038T1 (https=) |
| AU (1) | AU663519B2 (https=) |
| CA (1) | CA2116019A1 (https=) |
| CZ (1) | CZ281698B6 (https=) |
| DE (2) | DE4127648C1 (https=) |
| DK (1) | DK0599891T3 (https=) |
| ES (1) | ES2079882T3 (https=) |
| FI (1) | FI103988B1 (https=) |
| HU (1) | HU213570B (https=) |
| NO (1) | NO940565L (https=) |
| PT (1) | PT100796B (https=) |
| RU (1) | RU2094463C1 (https=) |
| SK (1) | SK279794B6 (https=) |
| TW (1) | TW317572B (https=) |
| WO (1) | WO1993004188A1 (https=) |
| ZA (1) | ZA926271B (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100446110B1 (ko) * | 1997-10-24 | 2004-10-28 | 씨제이 주식회사 | 세팔로스포린 c 생산 미생물 |
| ATE226954T1 (de) * | 1998-03-27 | 2002-11-15 | Dsm Nv | Verfahren zur fermentativen herstellung von cephalosporin |
| ATE243739T1 (de) * | 1998-04-14 | 2003-07-15 | Dsm Nv | Membranfiltration |
| RU2319574C1 (ru) * | 2006-07-11 | 2008-03-20 | Федеральное государственнное унитарное предприятие "Всероссийский научно-исследовательский институт авиационных материалов" (ФГУП "ВИАМ") | Способ изготовления составного керамического стержня для литья полых изделий |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS57106683A (en) * | 1980-12-24 | 1982-07-02 | Takeda Chem Ind Ltd | Method for concentrating beta-lactam antibiotic substance |
| DE3307095A1 (de) * | 1983-03-01 | 1984-09-06 | Degussa Ag, 6000 Frankfurt | Mikrobiologisch hergestellte l-phenylalanin-dehydrogenase, verfahren zu ihrer gewinnung und ihre verwendung |
| CS244333B1 (en) * | 1984-11-02 | 1986-07-17 | Jan Rakyta | Method of c-cephalosporine fermentation production with utilization of fats as limitating carbonaceous substrate by means of acromonium chrysogenum strain |
-
1991
- 1991-08-21 DE DE4127648A patent/DE4127648C1/de not_active Expired - Fee Related
-
1992
- 1992-08-08 SK SK197-94A patent/SK279794B6/sk unknown
- 1992-08-08 RU RU9294015848A patent/RU2094463C1/ru active
- 1992-08-08 JP JP5504067A patent/JPH07501207A/ja not_active Withdrawn
- 1992-08-08 ES ES92916796T patent/ES2079882T3/es not_active Expired - Lifetime
- 1992-08-08 EP EP92916796A patent/EP0599891B1/de not_active Expired - Lifetime
- 1992-08-08 AU AU24024/92A patent/AU663519B2/en not_active Ceased
- 1992-08-08 AT AT92916796T patent/ATE130038T1/de not_active IP Right Cessation
- 1992-08-08 CZ CZ94366A patent/CZ281698B6/cs not_active IP Right Cessation
- 1992-08-08 WO PCT/EP1992/001811 patent/WO1993004188A1/de not_active Ceased
- 1992-08-08 HU HU9400463A patent/HU213570B/hu not_active IP Right Cessation
- 1992-08-08 DK DK92916796.3T patent/DK0599891T3/da active
- 1992-08-08 CA CA002116019A patent/CA2116019A1/en not_active Abandoned
- 1992-08-08 DE DE59204277T patent/DE59204277D1/de not_active Expired - Fee Related
- 1992-08-20 PT PT100796A patent/PT100796B/pt not_active IP Right Cessation
- 1992-08-20 ZA ZA926271A patent/ZA926271B/xx unknown
- 1992-08-21 CN CN92110651A patent/CN1045008C/zh not_active Expired - Fee Related
- 1992-08-22 TW TW081106636A patent/TW317572B/zh active
-
1994
- 1994-02-18 FI FI940778A patent/FI103988B1/fi active
- 1994-02-18 NO NO940565A patent/NO940565L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| HU213570B (en) | 1997-08-28 |
| CN1045008C (zh) | 1999-09-08 |
| ZA926271B (en) | 1993-04-28 |
| FI103988B (fi) | 1999-10-29 |
| SK19794A3 (en) | 1994-08-10 |
| PT100796A (pt) | 1993-09-30 |
| HUT69767A (en) | 1995-09-28 |
| EP0599891A1 (de) | 1994-06-08 |
| FI103988B1 (fi) | 1999-10-29 |
| WO1993004188A1 (de) | 1993-03-04 |
| DE4127648C1 (https=) | 1993-01-14 |
| FI940778L (fi) | 1994-03-16 |
| CZ36694A3 (en) | 1994-07-13 |
| FI940778A0 (fi) | 1994-02-18 |
| ATE130038T1 (de) | 1995-11-15 |
| NO940565D0 (no) | 1994-02-18 |
| HU9400463D0 (en) | 1994-06-28 |
| CN1071953A (zh) | 1993-05-12 |
| DE59204277D1 (de) | 1995-12-14 |
| RU2094463C1 (ru) | 1997-10-27 |
| PT100796B (pt) | 1999-07-30 |
| TW317572B (https=) | 1997-10-11 |
| NO940565L (no) | 1994-02-18 |
| DK0599891T3 (da) | 1996-02-26 |
| SK279794B6 (sk) | 1999-03-12 |
| CZ281698B6 (cs) | 1996-12-11 |
| CA2116019A1 (en) | 1993-03-04 |
| EP0599891B1 (de) | 1995-11-08 |
| AU2402492A (en) | 1993-03-16 |
| ES2079882T3 (es) | 1996-01-16 |
| AU663519B2 (en) | 1995-10-12 |
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