JPH07228512A - Hair growing agent - Google Patents

Abstract

PURPOSE:To obtain a hair growing agent which contains the extract of Cola de cabalo (Epedra americana) or Pajaro bobo (Tessarium integrifola), a Peruvian crude drug, and has excellent depilation-preventing action and hair growing action. CONSTITUTION:The whole body of Cola de cabalo and/or Pajaro bobo is dried and extracted with hot water, a lower alcohol such as methanol or ethanol, an aqueous lower alcohol, a polyhydric alcohol such as propylene glycol or 1,3-butylene glycol, or an aqueous polyhydric alcohol to collect the extract. Such vegetable extract is added to a hair growing agent in an amount of 0.01 to 5wt.% on the dry basis to give the objective hair growing agent. This hair growing agent can be used in the form of a solution, emulsion, ointment or any other form which are applicable externally to skin. The hair growing agent is particularly used in medicines, quasi drugs or in the field of cosmetics.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a hair nourishing agent having excellent hair loss-preventing and hair-growing effects. The present invention is particularly used in the fields of medicines, quasi drugs, and cosmetics.

[0002]

2. Description of the Related Art Conventionally, the causes of baldness and hair loss are activation of male hormones in organs such as hair roots and sebaceous glands, decrease in blood flow to hair follicles, excessive secretion of sebum, and generation of peroxides. Abnormalities of the scalp are considered. For this reason, conventional hair nourishing agents are generally blended with compounds having the action of removing or reducing the above causes. For example, vitamins such as vitamin B and vitamin E, serine,
Prevents alopecia by blending amino acids such as methionine, vasodilators such as assembly extract and acetylcholine derivatives, purple root extract, anti-inflammatory agents such as hinokitiol, female hormone agents such as estradiol, and skin function enhancers such as cepharanthin. And used in therapy.

[0003]

However, in spite of various attempts as described above, conventional hair nourishing agents do not always have sufficient hair nourishing effects such as hair loss prevention and hair growth effects. It was This is probably because there are various causes of hair loss and the mechanism of hair growth is very complicated.

In view of the insufficient hair-feeding effect as described above, the present inventor searched for a substance which is effective for hair loss and has excellent hair-preventing and hair-growing effects. As a result, they have found that the extract of Cora decavalo and / or the extract of Pajarovobo has strong hair loss-preventing, hair-growing, and hair-growing actions, and completed the present invention.

[0005]

That is, according to the present invention,
A hair nourishing agent characterized by being blended with an extract of Cora de Cavaro and / or an extract of Pajarobobo.

The structure of the present invention will be described in detail below. As a plant of the plant extract used in the present invention, an extract of Cora decavallo of the Ephedra family, which is a Peru crude drug (regional name: C
ola de cabalo, scientific name: Epedra
americana H .; & B. ) And / or pajarobobo (local name: Pajaro bobo, scientific name: T
essaria integrafolia R. &
P. ) Whole grass dry matter is used.

The method for extracting the plant extract used in the present invention is to use plants as a solvent, for example, hot water, lower alcohols such as methanol and ethanol, hydrous lower alcohols, or polyhydric alcohols such as propylene glycol and 1-3 butylene glycol. Alternatively, it can be obtained by extraction with hydrous alcohol such as hydrous polyhydric alcohol.

The amount of the plant extract used in the present invention is 0.005 to 20% by weight, preferably 0.01 to 5% by weight, as a dried product, based on the total amount of the hair nourishing agent. 0.005
If it is less than 20% by weight, the effect of the present invention is not sufficiently exhibited, and if it exceeds 20% by weight, it is not preferable in terms of formulation.

In addition to the above-mentioned components, the hair nourishing agent according to the present invention,
Various components commonly used in cosmetics, quasi drugs, pharmaceuticals, etc., such as oil, higher fatty acids, solid paraffin, liquid paraffin, silicone oil, squalane, etc .; moisturizers such as hyaluronic acid, propylene glycol, maltitol, atelocollagen , Sodium lactate, etc .; thickeners, quince mucilages, carboxyvinyl polymers,
Xanthan gum, etc .; oil such as glyceryl monooleate, nicotinamide, benzyl nicotinate, vitamin E acetate, cembly extract, carpronium chloride,
Assembly extract, vasodilators such as acetylcholine derivatives, amino acids such as serine and methionine, vitamin B6
, Vitamin E and its derivatives, vitamins such as biotin, pantothenic acid and its derivatives glycyrrhetinic acid and its derivatives, nicotinic acid esters such as benzyl nicotinate, skin function enhancers such as cepharanthin, and female hormone agents such as estradiol. You may mix simultaneously. Furthermore, additives usually used for hair nourishing agents, for example, hinokitiol, hexachlorophene, benzalkonium chloride, cetylpyridinium chloride, undecylenic acid, trichlorocarbanilide and antibacterial agents such as biothionol, a refreshing agent such as menthol, salicylic acid, Drugs such as zinc and its derivatives, lactic acid and its alkyl esters, organic acids such as citric acid, amino acids such as arginine, olive oil, squalane, liquid paraffin, isopropyl myristate, oils such as higher fatty acids and higher alcohols, glycerin, propylene Polyhydric alcohol such as glycol, fragrance, antioxidant, ultraviolet absorber, dye,
Ethanol, water, a moisturizer, a thickener, etc. can be appropriately added within a range that does not impair the effects of the present invention.

The hair nourishing agent of the present invention may have any properties as long as it can be applied to the outer skin such as liquid, emulsion and ointment. The hair nourishing agent of the present invention is administered by percutaneous administration by directly applying or spraying on the skin. Further, the dose of the hair nourishing agent of the present invention cannot be clearly determined because it varies depending on age, individual differences, medical conditions, etc., but generally when administered to humans, the dose is 1 kg body weight and 0.01 to 100 mg per day,
It is preferably 0.1 to 10 mg, and this amount can be administered once a day or divided into 2 to 4 times.

[0011]

EXAMPLES Next, the production method and the hair-retaining action of the hair nourishing agent of the present invention will be described in more detail with reference to examples. The present invention is not limited to this. The blending amount is% by weight.

Example 1 To 90% of 70% ethanol, 1.0% of dried methanol extract of Coladecavalo, ion-exchanged water (residual) and 1.0% of hydrogenated castor oil ethylene oxide (40 mol) adduct were added and dissolved with stirring. Then, ion-exchanged water was added and mixed to obtain a liquid hair nourishing agent of Example 1.

Example 2 0.1% of dried 70% ethanol extract of Pajarobobo in 90% of 70% ethanol, deionized water (residual), sodium oleate 0.01%, dodecylbenzenesulfonic acid 0.49% and curing Castor oil ethylene oxide
(40 mol) 0.5% of an adduct was added and dissolved by stirring, and then ion-exchanged water was added and mixed to obtain a liquid hair nourishing agent of Example 2.

Example 3 To 90% of 70% ethanol, 0.05% of dried product of ethyl ester extract of coladecavalo, ion-exchanged water (residual), 0.1% of lauryldimethylamine oxide and hydrogenated castor oil ethylene oxide (60 mol) were added. Thing 0.9
%, And dissolved by stirring, and then ion-exchanged water was added and mixed to obtain a liquid hair nourishing agent of Example 3.

Example 4 90% 70% ethanol, 1.0% dry acetone extract of Pajarobobo, deionized water (residual), 0.4% sorbitan sesquioleate and hydrogenated castor oil ethylene oxide (40 mol) adduct 0 6% was added and dissolved by stirring, and then ion-exchanged water was added and mixed to obtain a liquid hair nourishing agent of Example 4.

Example 5 90% 70% ethanol, 0.3% 40% ethanol extract dry product of Cola de Cavaro, 0.3% 40% ethanol extract dry product of Pajarobobo, deionized water (residual),
Lauroyltaurine 0.1%, cetylpyridinium chloride 0.01% and hydrogenated castor oil ethylene oxide (40 mol) adduct 0.89% were added, dissolved by stirring, and then ion-exchanged water was added and mixed to obtain Example 5. To obtain a liquid hair nourishing agent.

Hair Growth Test The hair growth tests of Examples 1 to 5 and Comparative Example 1 were carried out using C3H / HeNCrJ mice in the resting phase of the hair cycle, by the method of Ogawa et al. (Normal and Abnormal Epidermal Difference [Normal and Abnormal Epi
dermal Differentiation], M. Seiji and IABernst
edited by ein, pp. 159-170, 1982, University of Tokyo). That is, one group of 10 mice was divided into 6 groups of Examples 1 to 5 and Comparative Example 1 (70% ethanol), the back of each mouse was shaved with a clipper and a shaver, and each sample was taken for 1 day. 0.1 ml each was applied once. The results of the hair regrowth area (after 25 days) of the samples of Examples 1 to 5 and Comparative Example 1 were as follows.

Sample Hair Regeneration Area Comparative Example 1 5.0% Example 1 85.5% Example 2 88.5% Example 3 86.0% Example 4 89.5% Example 5 92.0% As is clear from the above results, a significant effect on hair regrowth was observed in each Example (the present invention).

Hair nourishing test Next, in order to investigate the hair nourishing effects such as hair loss prevention and hair growth effect of the hair nourishing agent of the present invention, a trichogram test was carried out on humans. Example 1 and Comparative Example 1 were performed. The trichogram test is described below. The hair roots of the removed hair before and after the use of the hair nourishment were observed under a microscope, and the number of resting hair roots was counted from the form of the hair root, and the hair nourishing action of the hair nourishing agent was compared by increasing or decreasing the ratio. Resting hair roots are hair roots that have stopped growing, and it has been recognized that people who complain of hair loss have a higher proportion of resting hair roots than normal people. Each of the hair nourishing preparations of Example 1 and Comparative Example 1 was applied to a male subject.
It was applied to the scalp of 10 people twice a day, 2 ml each, continuously for 6 months, and 100 hairs were removed from each subject immediately before and 6 months after the application, and each hair root was examined. , The actual use test was done. The results are shown in Table 1.

[0020]

[Table 1]

As is clear from the results of Table 1, the hair-growth effect is excellent in Examples.

Example 6 (Phase A) Ethanol Extract Dried Product of Coladecavalo 1.0 Polyoxyethylene (60 mol) Addition-Cured Castor Oil 2.0 Glycerin 10.0 Dipropylene Glycol 10.0 1,3-Butylene Glycol 5.0 Polyethylene Glycol 1500 5.0 (Phase B) Cetyl isooctanoate 10.0 Squalane 5.0 Vaseline 2.0 Propylparaben 2.0 (C phase) Carboxyvinyl polymer 1% aqueous solution 30.0 Sodium hexametaphosphate 0.03 Ion exchanged water 8.35 (D phase) Ion exchanged water 4.5 (E phase) Causticari 0.12 Ion exchanged water 5.0 ( Manufacturing method) Phases A and B are each melted by heating at 60 ° C, mixed and treated with a homomixer to form a gel. D to this
Add the phases slowly and disperse with a homomixer. Next, dissolved C phase was added thereto, and finally dissolved E phase was added and emulsified with a homomixer to obtain an O / W emulsion type hair nourishing agent. When this hair nourishing agent was subjected to a practical use test to humans as in Example 1, it was confirmed that the hair nourishing action was excellent.

Example 7 (Phase A) Liquid Paraffin 5.0 Cetostearyl Alcohol 5.5 Glyceryl Monostearate 3.0 EO (20 mol) -2-Octyldodecyl Ether 3.0 Propylparaben 0.3 Perfume 0.1 (Phase B) Dried Pajalobobo Methanol Extract 5.0 Glycerin 8.0 Dipropylene glycol 20.0 Polyethylene glycol 4000 5.0 Sodium dodecyl sulfate 0.1 Sodium hexametaphosphate 0.005 Ion-exchanged water 45.095 (Production method) Phases A and B are dissolved by heating and mixed, respectively.
The mixture was emulsified with a homomixer to obtain a creamy hair nourishing agent. When this hair nourishing agent was subjected to a practical use test on humans as in Example 1, it was confirmed that the hair nourishing effect was excellent.

Example 8 Pajalobobo Ethanol Extract Dried Product 0.5 Coladecavalo Ethanol Extract Dried Product 0.5 Stearyl Dimethylamine Oxide 0.5 Hardened Castor Oil Ethylene Oxide (40 mol) Adduct 1.0 95% Ethanol 54.0 Ion Exchange Water Remainder (Production Method) 95% Ion-exchanged water is added to ethanol, hydrogenated castor oil ethylene oxide (40 mol) adduct and stearyl dimethylamine oxide are added thereto, and then each plant extract is added and dissolved by stirring. When this hair nourishment was subjected to an actual use test to a person in the same manner as in Example 1,
It was confirmed that the hair-growth effect was excellent.

Example 9 N-coconut lauryl-β-aminopropionate sodium 0.2 dried methanol extract of coladecavaro 1.0 dried methanol extract of pajarobobo 1.0 sodium dodecylbenzenesulfonate 0.5 hydrogenated castor oil ethylene oxide (40 mol) adduct 1.0 95% Ethanol 54.0 Ion-exchanged water balance (production method) Ion-exchanged water was added to 95% ethanol, and hydrogenated castor oil ethylene oxide (40 mol) adduct, sodium dodecylbenzenesulfonate and N-
After adding coconut lauryl-β-aminopropionate soda, each plant extract is added and dissolved by stirring. When this hair nourishing agent was subjected to a practical use test on humans as in Example 1, it was confirmed that the hair nourishing effect was excellent.

[0026]

The hair nourishing agent of the present invention is excellent in hair loss prevention effect, hair growth effect and the like.

Claims (1)

[Claims] 1. A hair nourishing agent comprising an extract of Cora decavallo and / or an extract of Pajarovobo.