JPH0651624B2 - 骨の損耗の予防又は再生不調症の治療又は予防用薬剤 - Google Patents
骨の損耗の予防又は再生不調症の治療又は予防用薬剤Info
- Publication number
- JPH0651624B2 JPH0651624B2 JP1338023A JP33802389A JPH0651624B2 JP H0651624 B2 JPH0651624 B2 JP H0651624B2 JP 1338023 A JP1338023 A JP 1338023A JP 33802389 A JP33802389 A JP 33802389A JP H0651624 B2 JPH0651624 B2 JP H0651624B2
- Authority
- JP
- Japan
- Prior art keywords
- vitamin
- dihydroxy
- compound
- trans
- prevention
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
- C07D317/24—Radicals substituted by singly bound oxygen or sulfur atoms esterified
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0036—Nitrogen-containing hetero ring
- C07J71/0042—Nitrogen only
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Nutrition Science (AREA)
- Urology & Nephrology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US49286383A | 1983-05-09 | 1983-05-09 | |
US492,863 | 1983-05-09 | ||
US60732784A | 1984-05-04 | 1984-05-04 | |
US607,327 | 1984-05-04 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP59502223A Division JPS60501261A (ja) | 1983-05-09 | 1984-05-09 | 1α,25―ジヒドロキシル化ビタミンD↓2化合物及びその製造方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH02288829A JPH02288829A (ja) | 1990-11-28 |
JPH0651624B2 true JPH0651624B2 (ja) | 1994-07-06 |
Family
ID=27050897
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP1338023A Expired - Lifetime JPH0651624B2 (ja) | 1983-05-09 | 1989-12-26 | 骨の損耗の予防又は再生不調症の治療又は予防用薬剤 |
JP1338024A Granted JPH02288873A (ja) | 1983-05-09 | 1989-12-26 | シクロビタミンd化合物 |
JP1338025A Expired - Fee Related JPH0610188B2 (ja) | 1983-05-09 | 1989-12-26 | 1α,25―ジヒドロキシル化ビタミンD▼下2▲化合物の前駆体 |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP1338024A Granted JPH02288873A (ja) | 1983-05-09 | 1989-12-26 | シクロビタミンd化合物 |
JP1338025A Expired - Fee Related JPH0610188B2 (ja) | 1983-05-09 | 1989-12-26 | 1α,25―ジヒドロキシル化ビタミンD▼下2▲化合物の前駆体 |
Country Status (7)
Country | Link |
---|---|
JP (3) | JPH0651624B2 (da) |
AU (1) | AU568549B2 (da) |
CH (1) | CH665834A5 (da) |
DE (4) | DE3448412C2 (da) |
DK (3) | DK171397B1 (da) |
NL (1) | NL193245C (da) |
WO (1) | WO1984004527A1 (da) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL8520265A (nl) * | 1984-10-04 | 1986-09-01 | Wisconsin Alumni Res Found | Derivaten van vitamine d en werkwijzen voor het bereiden daarvan. |
DE3687377T2 (de) * | 1985-01-17 | 1993-04-29 | Wisconsin Alumni Res Found | Vitamin-d-abkoemmlinge und deren herstellungsverfahren. |
CA1341408C (en) * | 1988-08-02 | 2002-12-10 | Charles W. Bishop | Method for treating and preventing loss of bone mass |
US5104864A (en) * | 1988-08-02 | 1992-04-14 | Bone Care International, Inc. | Method for treating and preventing loss of bone mass |
US4973584A (en) * | 1989-03-09 | 1990-11-27 | Deluca Hector F | Novel 1α-hydroxyvitamin D2 epimer and derivatives |
JP2645130B2 (ja) * | 1989-03-31 | 1997-08-25 | 日清製粉株式会社 | ステロイド誘導体 |
GB8914963D0 (en) * | 1989-06-29 | 1989-08-23 | Leo Pharm Prod Ltd | Chemical compounds |
IN171426B (da) * | 1990-02-14 | 1992-10-10 | Wisconsin Alumni Res Found | |
NZ254424A (en) * | 1992-06-22 | 1997-09-22 | Lunar Corp | Pharmaceutical composition and use of 1 alpha hydroxy-pre-vitamin d |
US5795882A (en) * | 1992-06-22 | 1998-08-18 | Bone Care International, Inc. | Method of treating prostatic diseases using delayed and/or sustained release vitamin D formulations |
US5763429A (en) * | 1993-09-10 | 1998-06-09 | Bone Care International, Inc. | Method of treating prostatic diseases using active vitamin D analogues |
US6573256B2 (en) | 1996-12-30 | 2003-06-03 | Bone Care International, Inc. | Method of inhibiting angiogenesis using active vitamin D analogues |
US6566353B2 (en) | 1996-12-30 | 2003-05-20 | Bone Care International, Inc. | Method of treating malignancy associated hypercalcemia using active vitamin D analogues |
US6503893B2 (en) | 1996-12-30 | 2003-01-07 | Bone Care International, Inc. | Method of treating hyperproliferative diseases using active vitamin D analogues |
NZ336924A (en) | 1997-02-13 | 2001-06-29 | Bone Care Int Inc | Targeted therapeutic delivery of vitamin D compounds via a Vitamin D conjugate |
JP5492099B2 (ja) | 2008-03-12 | 2014-05-14 | シトクロマ インコーポレイテッド | 安定化1,25−ジヒドロキシビタミンd2及びその製造方法 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4260549A (en) | 1979-05-21 | 1981-04-07 | Wisconsin Alumni Research Foundation | Process for preparing 1α-hydroxylated compounds |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4267117A (en) * | 1978-06-19 | 1981-05-12 | The Upjohn Company | Compounds and process |
US4269777A (en) * | 1979-05-21 | 1981-05-26 | Wisconsin Alumni Research Foundation | Isotopically labeled vitamin D derivatives and processes for preparing same |
-
1984
- 1984-05-09 DE DE3448412A patent/DE3448412C2/de not_active Expired - Lifetime
- 1984-05-09 NL NL8420137A patent/NL193245C/nl not_active IP Right Cessation
- 1984-05-09 DE DE3448360A patent/DE3448360C2/de not_active Expired - Lifetime
- 1984-05-09 CH CH145/85A patent/CH665834A5/de not_active IP Right Cessation
- 1984-05-09 DE DE3490215A patent/DE3490215C2/de not_active Expired - Lifetime
- 1984-05-09 AU AU30115/84A patent/AU568549B2/en not_active Ceased
- 1984-05-09 WO PCT/US1984/000714 patent/WO1984004527A1/en active Application Filing
- 1984-05-09 DE DE19843490215 patent/DE3490215T/de active Pending
-
1985
- 1985-01-08 DK DK008685A patent/DK171397B1/da not_active IP Right Cessation
-
1988
- 1988-04-06 DK DK198801845A patent/DK172567B1/da not_active IP Right Cessation
-
1989
- 1989-12-26 JP JP1338023A patent/JPH0651624B2/ja not_active Expired - Lifetime
- 1989-12-26 JP JP1338024A patent/JPH02288873A/ja active Granted
- 1989-12-26 JP JP1338025A patent/JPH0610188B2/ja not_active Expired - Fee Related
-
1991
- 1991-11-07 DK DK199101832A patent/DK172733B1/da not_active IP Right Cessation
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4260549A (en) | 1979-05-21 | 1981-04-07 | Wisconsin Alumni Research Foundation | Process for preparing 1α-hydroxylated compounds |
Also Published As
Publication number | Publication date |
---|---|
DK183291D0 (da) | 1991-11-07 |
DK8685D0 (da) | 1985-01-08 |
DE3490215T (de) | 1985-05-15 |
DK8685A (da) | 1985-01-08 |
NL193245B (nl) | 1998-12-01 |
JPH02288854A (ja) | 1990-11-28 |
DK172567B1 (da) | 1999-01-18 |
DE3448412C2 (da) | 1991-12-12 |
WO1984004527A1 (en) | 1984-11-22 |
JPH02288829A (ja) | 1990-11-28 |
DE3490215C2 (da) | 1991-07-25 |
JPH0339505B2 (da) | 1991-06-14 |
DK184588D0 (da) | 1988-04-06 |
DK171397B1 (da) | 1996-10-14 |
NL8420137A (nl) | 1985-04-01 |
CH665834A5 (de) | 1988-06-15 |
NL193245C (nl) | 1999-04-02 |
DK172733B1 (da) | 1999-06-21 |
DK184588A (da) | 1988-04-06 |
AU568549B2 (en) | 1988-01-07 |
JPH0610188B2 (ja) | 1994-02-09 |
JPH02288873A (ja) | 1990-11-28 |
DK183291A (da) | 1991-11-07 |
DE3448360C2 (da) | 1991-10-02 |
AU3011584A (en) | 1984-12-04 |
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