JPH06504440A - 関節炎治療用切形インターロイキン−１受容体遺伝子 - Google Patents
関節炎治療用切形インターロイキン−１受容体遺伝子Info
- Publication number
- JPH06504440A JPH06504440A JP4502854A JP50285491A JPH06504440A JP H06504440 A JPH06504440 A JP H06504440A JP 4502854 A JP4502854 A JP 4502854A JP 50285491 A JP50285491 A JP 50285491A JP H06504440 A JPH06504440 A JP H06504440A
- Authority
- JP
- Japan
- Prior art keywords
- interleukin
- receptor
- gene
- cells
- retroviral
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- C07—ORGANIC CHEMISTRY
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- C12N2740/13043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/13011—Gammaretrovirus, e.g. murine leukeamia virus
- C12N2740/13041—Use of virus, viral particle or viral elements as a vector
- C12N2740/13045—Special targeting system for viral vectors
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pain & Pain Management (AREA)
- Virology (AREA)
- Cell Biology (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Microbiology (AREA)
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- Physics & Mathematics (AREA)
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- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63098190A | 1990-12-20 | 1990-12-20 | |
| US630,981 | 1990-12-20 | ||
| PCT/US1991/009231 WO1992011359A1 (en) | 1990-12-20 | 1991-12-09 | A truncated interleukin-1 receptor gene for the treatment of arthritis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH06504440A true JPH06504440A (ja) | 1994-05-26 |
Family
ID=24529337
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP4502854A Pending JPH06504440A (ja) | 1990-12-20 | 1991-12-09 | 関節炎治療用切形インターロイキン−１受容体遺伝子 |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP0563239A4 (de) |
| JP (1) | JPH06504440A (de) |
| CA (1) | CA2098848A1 (de) |
| WO (1) | WO1992011359A1 (de) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5858355A (en) * | 1990-12-20 | 1999-01-12 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | IRAP gene as treatment for arthritis |
| US6159464A (en) * | 1990-12-20 | 2000-12-12 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Viral vectors to inhibit leukocyte infiltration or cartilage degradation of joints |
| US6156304A (en) * | 1990-12-20 | 2000-12-05 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Gene transfer for studying and treating a connective tissue of a mammalian host |
| US6228356B1 (en) | 1990-12-20 | 2001-05-08 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Viral vectors to inhibit leukocyte infiltration or cartilage degradation of joints |
| US6413511B1 (en) * | 1990-12-20 | 2002-07-02 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Cartilage alterations by administering to joints chondrocytes comprising a heterologous polynucleotide |
| US5792751A (en) * | 1992-04-13 | 1998-08-11 | Baylor College Of Medicine | Tranformation of cells associated with fluid spaces |
| JPH07508988A (ja) * | 1992-07-13 | 1995-10-05 | ベイラー・カレッジ・オブ・メディシン | 体細胞遺伝子治療の関節への標的化 |
| WO1994020517A1 (en) * | 1993-03-08 | 1994-09-15 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Gene transfer for treating a connective tissue of a mammalian host |
| US5645829A (en) * | 1993-06-18 | 1997-07-08 | Beth Israel Hospital Association | Mesothelial cell gene therapy |
| AU7516594A (en) * | 1993-07-28 | 1995-02-28 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Pre-binding of retroviral vector particles with complement components to enable the performance of human gene therapy (in vivo) |
| EP0690673A4 (de) * | 1993-12-14 | 1996-05-29 | Univ Pittsburgh | Systemische genetische behandlung von bindegewebeerkrankungen |
| JPH083058A (ja) * | 1994-06-17 | 1996-01-09 | Hoechst Japan Ltd | 新規な骨代謝疾患治療剤 |
| DK0807183T3 (da) * | 1994-08-26 | 2001-03-05 | Aventis Pharma Gmbh | Genterapi af sygdomme, der fremkaldes af immunsystemet, ved hjælp af et cellespecifikt aktivt stof, der reguleres af cellec |
| US6096728A (en) * | 1996-02-09 | 2000-08-01 | Amgen Inc. | Composition and method for treating inflammatory diseases |
| US6294170B1 (en) | 1997-08-08 | 2001-09-25 | Amgen Inc. | Composition and method for treating inflammatory diseases |
| WO1999011292A2 (en) * | 1997-09-02 | 1999-03-11 | Chiron Corporation | Compositions and methods for treating arthritis utilizing gene therapy |
| EP1939300A1 (de) | 1999-05-28 | 2008-07-02 | Targeted Genetics Corporation | Verfahren und Zusammensetzung zur Senkung des Spiegels des Tumornekrosefaktors (TNF) bei TNF-assoziierten Leiden |
| EP1180159B1 (de) | 1999-05-28 | 2008-09-03 | Targeted Genetics Corporation | Methoden und zusammensetzungen zur reduktion des tumor-nekrosis-faktor-spiegels (tnf) bei tnf-assoziierten erkrankungen |
| WO2001013960A1 (en) * | 1999-08-20 | 2001-03-01 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Methods for in vivo gene delivery to sites of cartilage damage |
| AU2002311777A1 (en) * | 2001-04-17 | 2002-10-28 | Genetix Pharmaceuticals, Inc. | Method of treating arthritis using lentiviral vectors in gene therapy |
| CA2557910C (en) | 2004-04-02 | 2012-05-29 | Amgen Inc. | Methods of reducing aggregation of il-1ra |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1989004838A1 (en) * | 1987-11-25 | 1989-06-01 | Immunex Corporation | Interleukin-1 receptors |
| US4968607A (en) * | 1987-11-25 | 1990-11-06 | Immunex Corporation | Interleukin-1 receptors |
-
1991
- 1991-12-09 JP JP4502854A patent/JPH06504440A/ja active Pending
- 1991-12-09 CA CA002098848A patent/CA2098848A1/en not_active Abandoned
- 1991-12-09 EP EP19920902630 patent/EP0563239A4/de not_active Withdrawn
- 1991-12-09 WO PCT/US1991/009231 patent/WO1992011359A1/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0563239A4 (de) | 1994-10-12 |
| CA2098848A1 (en) | 1992-06-21 |
| WO1992011359A1 (en) | 1992-07-09 |
| EP0563239A1 (de) | 1993-10-06 |
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