CA2098848A1 - Truncated interleukin-1 receptor gene for the treatment of arthritis - Google Patents
Truncated interleukin-1 receptor gene for the treatment of arthritisInfo
- Publication number
- CA2098848A1 CA2098848A1 CA002098848A CA2098848A CA2098848A1 CA 2098848 A1 CA2098848 A1 CA 2098848A1 CA 002098848 A CA002098848 A CA 002098848A CA 2098848 A CA2098848 A CA 2098848A CA 2098848 A1 CA2098848 A1 CA 2098848A1
- Authority
- CA
- Canada
- Prior art keywords
- interleukin
- gene
- receptor
- binding
- extracellular
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/13011—Gammaretrovirus, e.g. murine leukeamia virus
- C12N2740/13041—Use of virus, viral particle or viral elements as a vector
- C12N2740/13043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/13011—Gammaretrovirus, e.g. murine leukeamia virus
- C12N2740/13041—Use of virus, viral particle or viral elements as a vector
- C12N2740/13045—Special targeting system for viral vectors
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Public Health (AREA)
- Physics & Mathematics (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- Rheumatology (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Virology (AREA)
- Toxicology (AREA)
- Pain & Pain Management (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Plant Pathology (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63098190A | 1990-12-20 | 1990-12-20 | |
| US630,981 | 1990-12-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2098848A1 true CA2098848A1 (en) | 1992-06-21 |
Family
ID=24529337
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002098848A Abandoned CA2098848A1 (en) | 1990-12-20 | 1991-12-09 | Truncated interleukin-1 receptor gene for the treatment of arthritis |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP0563239A4 (de) |
| JP (1) | JPH06504440A (de) |
| CA (1) | CA2098848A1 (de) |
| WO (1) | WO1992011359A1 (de) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6159464A (en) * | 1990-12-20 | 2000-12-12 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Viral vectors to inhibit leukocyte infiltration or cartilage degradation of joints |
| US6228356B1 (en) | 1990-12-20 | 2001-05-08 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Viral vectors to inhibit leukocyte infiltration or cartilage degradation of joints |
| US6156304A (en) * | 1990-12-20 | 2000-12-05 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Gene transfer for studying and treating a connective tissue of a mammalian host |
| US5858355A (en) * | 1990-12-20 | 1999-01-12 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | IRAP gene as treatment for arthritis |
| US6413511B1 (en) * | 1990-12-20 | 2002-07-02 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Cartilage alterations by administering to joints chondrocytes comprising a heterologous polynucleotide |
| US5792751A (en) * | 1992-04-13 | 1998-08-11 | Baylor College Of Medicine | Tranformation of cells associated with fluid spaces |
| AU684050B2 (en) * | 1992-07-13 | 1997-12-04 | Baylor College Of Medicine | Targeting somatic gene therapy to joints |
| JPH08511507A (ja) * | 1993-03-08 | 1996-12-03 | ユニバーシティー オブ ピッツバーグ オブ ザ コモンウェルス システム オブ ハイヤー エデュケーション | 哺乳動物宿主の結合組織を処置するための遺伝子導入 |
| US5645829A (en) * | 1993-06-18 | 1997-07-08 | Beth Israel Hospital Association | Mesothelial cell gene therapy |
| WO1995003834A1 (en) * | 1993-07-28 | 1995-02-09 | The Government Of The United States Of America, Represented By The Secretary Of The Department Of Health And Human Services | PRE-BINDING OF RETROVIRAL VECTOR PARTICLES WITH COMPLEMENT COMPONENTS TO ENABLE THE PERFORMANCE OF HUMAN GENE THERAPY $i(IN VIVO) |
| AU1513495A (en) * | 1993-12-14 | 1995-07-03 | University Of Pittsburgh | Systemic gene treatment of connective tissue diseases |
| JPH083058A (ja) * | 1994-06-17 | 1996-01-09 | Hoechst Japan Ltd | 新規な骨代謝疾患治療剤 |
| CA2198462A1 (en) * | 1994-08-26 | 1996-03-07 | Hans-Harald Sedlacek | Genetic therapy of diseases caused by the immune system, said therapy using a cell-specific active substance regulated by the cell cycle |
| US6096728A (en) * | 1996-02-09 | 2000-08-01 | Amgen Inc. | Composition and method for treating inflammatory diseases |
| US6294170B1 (en) | 1997-08-08 | 2001-09-25 | Amgen Inc. | Composition and method for treating inflammatory diseases |
| WO1999011292A2 (en) * | 1997-09-02 | 1999-03-11 | Chiron Corporation | Compositions and methods for treating arthritis utilizing gene therapy |
| ES2312344T3 (es) | 1999-05-28 | 2009-03-01 | Targeted Genetics Corporation | Metodos y composiciones para disminuir el nivel de factor de necrosis tumoral (tnf) en trastornos asociados con tnf. |
| EP1939300A1 (de) | 1999-05-28 | 2008-07-02 | Targeted Genetics Corporation | Verfahren und Zusammensetzung zur Senkung des Spiegels des Tumornekrosefaktors (TNF) bei TNF-assoziierten Leiden |
| WO2001013960A1 (en) * | 1999-08-20 | 2001-03-01 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Methods for in vivo gene delivery to sites of cartilage damage |
| WO2002083080A2 (en) * | 2001-04-17 | 2002-10-24 | Genetix Pharmaceuticals, Inc. | Method of treating arthritis using lentiviral vectors in gene therapy |
| HUE040595T2 (hu) | 2004-04-02 | 2019-03-28 | Swedish Orphan Biovitrum Ab Publ | Eljárás IL-1ra aggregációjának csökkentésére |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4968607A (en) * | 1987-11-25 | 1990-11-06 | Immunex Corporation | Interleukin-1 receptors |
| WO1989004838A1 (en) * | 1987-11-25 | 1989-06-01 | Immunex Corporation | Interleukin-1 receptors |
-
1991
- 1991-12-09 CA CA002098848A patent/CA2098848A1/en not_active Abandoned
- 1991-12-09 EP EP19920902630 patent/EP0563239A4/de not_active Withdrawn
- 1991-12-09 WO PCT/US1991/009231 patent/WO1992011359A1/en not_active Application Discontinuation
- 1991-12-09 JP JP4502854A patent/JPH06504440A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP0563239A1 (de) | 1993-10-06 |
| WO1992011359A1 (en) | 1992-07-09 |
| EP0563239A4 (de) | 1994-10-12 |
| JPH06504440A (ja) | 1994-05-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |