JPH0649052A - 抗腫瘍剤 - Google Patents

抗腫瘍剤

Info

Publication number
JPH0649052A
JPH0649052A JP5051911A JP5191193A JPH0649052A JP H0649052 A JPH0649052 A JP H0649052A JP 5051911 A JP5051911 A JP 5051911A JP 5191193 A JP5191193 A JP 5191193A JP H0649052 A JPH0649052 A JP H0649052A
Authority
JP
Japan
Prior art keywords
carbonyl
amino
sulfonamide
mmol
chlorophenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP5051911A
Other languages
English (en)
Japanese (ja)
Inventor
Fariborz Mohamadi
ファリボルツ・モハマディ
Michael M Spees
マイケル・マリオット・スピーズ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of JPH0649052A publication Critical patent/JPH0649052A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Indole Compounds (AREA)
JP5051911A 1992-03-13 1993-03-12 抗腫瘍剤 Pending JPH0649052A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/850,531 US5169860A (en) 1992-03-13 1992-03-13 Antitumor compositions and methods of treatment
US850531 1992-03-13

Publications (1)

Publication Number Publication Date
JPH0649052A true JPH0649052A (ja) 1994-02-22

Family

ID=25308394

Family Applications (1)

Application Number Title Priority Date Filing Date
JP5051911A Pending JPH0649052A (ja) 1992-03-13 1993-03-12 抗腫瘍剤

Country Status (19)

Country Link
US (1) US5169860A (en:Method)
EP (1) EP0560554A2 (en:Method)
JP (1) JPH0649052A (en:Method)
KR (1) KR930019655A (en:Method)
CN (1) CN1076447A (en:Method)
AU (2) AU662605B2 (en:Method)
BR (1) BR9301137A (en:Method)
CA (1) CA2091207A1 (en:Method)
CZ (1) CZ36893A3 (en:Method)
FI (1) FI931085A7 (en:Method)
HU (1) HUT63830A (en:Method)
IL (1) IL104981A0 (en:Method)
MX (1) MX9301296A (en:Method)
MY (1) MY111178A (en:Method)
NO (1) NO930891L (en:Method)
NZ (1) NZ247083A (en:Method)
TW (1) TW215083B (en:Method)
YU (1) YU16893A (en:Method)
ZA (1) ZA931645B (en:Method)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000327674A (ja) * 1999-05-25 2000-11-28 Tosoh Corp ４−ハロベンゾフラン誘導体及びその製造方法
JP2019518071A (ja) * 2016-04-18 2019-06-27 アイエフエム トレ インコーポレイテッド Ｎｌｒｐ活性に関連する状態を処置するための化合物および組成物
JP2022505525A (ja) * 2018-10-24 2022-01-14 ノバルティス アーゲー Ｎｌｒｐ活性に関連する状態を治療するための化合物及び組成物

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5254582A (en) * 1992-02-05 1993-10-19 Eli Lilly And Company Antitumor compositions and methods
CA2110524A1 (en) * 1992-12-10 1994-06-11 Gerald Burr Grindey Antitumor compositions and methods of treatment
US5270329A (en) * 1992-12-10 1993-12-14 Eli Lilly And Company Antitumor compositions and methods of treatment
ZA941500B (en) * 1993-03-10 1995-09-04 Lilly Co Eli Antitumor compositions and methods of treatment
US5529999A (en) * 1994-03-04 1996-06-25 Eli Lilly And Company Antitumor compositions and methods of treatment
US5629425A (en) * 1994-09-19 1997-05-13 Eli Lilly And Company Haloalkyl hemisolvates of 6-hydroxy-2-(4-hydroxyphenyl)-3-[4-piperidinoethoxy)-benzoyl]benzo[b]thiophene
CO4410191A1 (es) 1994-09-19 1997-01-09 Lilly Co Eli SINTESIS DE 3-[4-(2-AMINOETOXI)BENZOIL]-2-ARIL-6- HIDROXIBENZO [b] TIOFENOS
US5863936A (en) * 1995-04-18 1999-01-26 Geron Corporation Telomerase inhibitors
JP2000506885A (ja) * 1996-03-19 2000-06-06 イーライ・リリー・アンド・カンパニー ３―［４―（２―アミノエトキシ）ベンゾイル］―２―アリール―６―ヒドロキシベンゾ［ｂ］チオフェンの合成
AU709107B2 (en) * 1996-08-22 1999-08-19 Dong Wha Pharmaceutical Industrial Co., Ltd. Arylsulfonylimidazolone derivatives as an antitumor agent
EP0929540A4 (en) * 1996-10-04 2001-12-12 Lilly Co Eli ANTI-TUMOR COMPOSITIONS AND THERAPEUTIC METHODS
JP2000247949A (ja) * 1999-02-26 2000-09-12 Eisai Co Ltd スルホンアミド含有インドール化合物
ES2156550B1 (es) * 1999-04-19 2002-02-01 Univ Navarra Publica Derivados de benzo(b) tiofenosulfonamida-1,1-dioxido y su uso como agentes antineoplasicos.
TWI281916B (en) * 2001-10-25 2007-06-01 Lilly Co Eli Antitumor compounds and methods
US20050119318A1 (en) * 2003-10-31 2005-06-02 Hudyma Thomas W. Inhibitors of HCV replication
BRPI0819883A2 (pt) 2007-11-28 2017-05-23 Sequoia Pharmaceuticals Inc composições e métodos para inibir citocromo p450 2d6
KR101300702B1 (ko) * 2011-01-20 2013-08-26 대우조선해양 주식회사 탈가스 장치
CN103450149B (zh) * 2012-06-01 2015-10-14 中国科学院上海有机化学研究所 苯基噻吩磺酰胺类化合物及其制备方法和用途
CN104564805B (zh) * 2013-10-29 2017-11-10 海尔集团公司 一种离心风机的扇叶结构、离心风机及嵌入式空调内机
CN113582889B (zh) * 2015-02-16 2024-09-20 昆士兰大学 磺酰脲和相关化合物及其用途
WO2019008025A1 (en) 2017-07-07 2019-01-10 Inflazome Limited NOVEL CARBOXAMIDE SULFONAMIDE COMPOUNDS
JP7412328B2 (ja) 2017-07-24 2024-01-12 ノバルティス アーゲー Ｎｌｒｐ活性に関連する状態を治療するための化合物及び組成物
WO2019034693A1 (en) 2017-08-15 2019-02-21 Inflazome Limited SULFONYLURATES AND SULFONYLTHIOURES AS INHIBITORS OF NLRP3
WO2019034692A1 (en) 2017-08-15 2019-02-21 Inflazome Limited SULFONYLURATES AND SULFONYLTHIOURES AS INHIBITORS OF NLRP3
BR112020003014A2 (pt) 2017-08-15 2020-07-28 Inflazome Limited sulfonilureias e sulfoniltioureias como inibidores de vnlrp3
US12221434B2 (en) 2017-11-09 2025-02-11 Inflazome Limited Sulfonamide carboxamide compounds
CA3078195A1 (en) 2017-11-09 2019-05-16 Inflazome Limited Novel sulfonamide carboxamide compounds
WO2019166619A1 (en) 2018-03-02 2019-09-06 Inflazome Limited Novel compounds
CN109384764B (zh) * 2018-12-12 2021-09-03 中国科学院上海有机化学研究所 苯基噻吩磺酰胺类化合物、药物组合物、其制备方法和应用
WO2022022646A1 (zh) * 2020-07-29 2022-02-03 南京明德新药研发有限公司 含硒五元杂芳环化合物

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3083207A (en) * 1963-03-26 Indolinesulfonylureas
DE1144259B (de) * 1956-05-29 1963-02-28 Hoechst Ag Verfahren zur Herstellung von Sulfonylharnstoffen
US3097242A (en) * 1960-06-29 1963-07-09 Olin Mathieson Hydrindene sulfonylureas
DE1240866B (de) * 1961-06-29 1967-05-24 Heyden Chem Fab Verfahren zur Herstellung von Indolin-6-sulfonylharnstoffen
US3102121A (en) * 1961-06-29 1963-08-27 Olin Mathieson Novel cumaransulfonylureas and 2,3-dihydrothionaphthenesulfonylureas
GB1050447A (en:Method) * 1962-04-11
US3849110A (en) * 1963-01-07 1974-11-19 Lilly Co Eli Herbicidal method employing aryl-sulfonylureas or salts thereof
US3736122A (en) * 1969-04-10 1973-05-29 C Tung Method of controlling plant growth
AU1862083A (en) * 1982-09-02 1984-03-08 Duphar International Research B.V. Tumor growth inhibitors
CA1208561A (en) * 1984-01-19 1986-07-29 Marius S. Brouwer Pharmaceutical compositions containing benzoylurea compounds
US4845128A (en) * 1984-06-27 1989-07-04 Eli Lilly And Company N([(4-trifluoromethylphenyl)amino]carbonyl)benzene sulfonamides
GR862353B (en) * 1985-09-23 1987-01-19 Lilly Co Eli Anti-tumor method and compounds
CA1331464C (en) * 1987-05-12 1994-08-16 Eli Lilly And Company Anti-tumor method and compounds
IL98784A0 (en) * 1990-07-17 1992-07-15 Lilly Co Eli Heterocyclyl sulfonamide derivatives,process for their preparation and pharmaceutical compositions containing them

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000327674A (ja) * 1999-05-25 2000-11-28 Tosoh Corp ４−ハロベンゾフラン誘導体及びその製造方法
JP2019518071A (ja) * 2016-04-18 2019-06-27 アイエフエム トレ インコーポレイテッド Ｎｌｒｐ活性に関連する状態を処置するための化合物および組成物
US11339136B2 (en) 2016-04-18 2022-05-24 Novartis Ag Compounds and compositions for treating conditions associated with NLRP activity
US11597706B2 (en) 2016-04-18 2023-03-07 Novartis Ag Compounds and compositions for treating conditions associated with NLRP activity
US11760735B2 (en) 2016-04-18 2023-09-19 Novartis Ag Compounds and compositions for treating conditions associated with NLRP activity
JP2022505525A (ja) * 2018-10-24 2022-01-14 ノバルティス アーゲー Ｎｌｒｐ活性に関連する状態を治療するための化合物及び組成物

Also Published As

Publication number Publication date
NZ247083A (en) 1995-09-26
TW215083B (en:Method) 1993-10-21
MX9301296A (es) 1993-10-01
EP0560554A3 (en:Method) 1994-01-19
EP0560554A2 (en) 1993-09-15
KR930019655A (ko) 1993-10-18
CN1076447A (zh) 1993-09-22
HU9300688D0 (en) 1993-05-28
CA2091207A1 (en) 1993-09-14
ZA931645B (en) 1994-09-08
BR9301137A (pt) 1993-09-28
FI931085L (fi) 1993-09-14
AU3519893A (en) 1993-09-16
NO930891D0 (no) 1993-03-11
AU4028995A (en) 1996-02-15
NO930891L (no) 1993-09-14
FI931085A0 (fi) 1993-03-11
AU662605B2 (en) 1995-09-07
IL104981A0 (en) 1993-07-08
CZ36893A3 (en) 1994-04-13
HUT63830A (en) 1993-10-28
FI931085A7 (fi) 1993-09-14
YU16893A (sh) 1996-07-24
US5169860A (en) 1992-12-08
MY111178A (en) 1999-09-30

Similar Documents

Publication Publication Date Title
JPH0649052A (ja) 抗腫瘍剤
EP0222475B1 (en) Sulfonyl ureas with anti-tumour activity
JPH0714881B2 (ja) ベンゼンスルホンアミド類およびその改良
JPH04234382A (ja) 抗腫瘍剤
US5254582A (en) Antitumor compositions and methods
US5594028A (en) Anti-tumor method and compounds
US5270329A (en) Antitumor compositions and methods of treatment
EP0291269A2 (en) Anti-tumour sulfonyl urea derivatives
RU2127259C1 (ru) Производные сульфонилмочевины или их фармацевтически приемлемые соли, способ их получения и фармацевтическая композиция на основе производных сульфонилмочевины, обладающая противоопухолевой активностью
EP0672662A1 (en) Quinoxaline derivative used in the treatment of tumours
CN1207740A (zh) 新的中间体及其制备n,n'-桥连的双吲哚基马来酰亚胺的用途
EP0546763A1 (en) Antitumor compositions and methods of treatment
US5827879A (en) Antitumor compositions and methods of treatment
CA1281333C (en) Sulfonylurea derivatives
US6174921B1 (en) Antitumor compositions and methods of treatment
JPH02290843A (ja) ナフチルアルキルアミノ置換スルフアモイル安息香酸誘導体

Legal Events

Date Code Title Description
A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20010410