JPH0643417B2 - インドリンおよび２−インドリノン誘導体 - Google Patents

インドリンおよび２−インドリノン誘導体

Info

Publication number
JPH0643417B2
JPH0643417B2 JP60102499A JP10249985A JPH0643417B2 JP H0643417 B2 JPH0643417 B2 JP H0643417B2 JP 60102499 A JP60102499 A JP 60102499A JP 10249985 A JP10249985 A JP 10249985A JP H0643417 B2 JPH0643417 B2 JP H0643417B2
Authority
JP
Japan
Prior art keywords
alkyl
hydrogen
methyl
oxo
indolinone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP60102499A
Other languages
English (en)
Japanese (ja)
Other versions
JPS6122080A (ja
Inventor
デビツド・ウエイン・ロバートソン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of JPS6122080A publication Critical patent/JPS6122080A/ja
Publication of JPH0643417B2 publication Critical patent/JPH0643417B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
JP60102499A 1984-05-14 1985-05-13 インドリンおよび２−インドリノン誘導体 Expired - Lifetime JPH0643417B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US61021084A 1984-05-14 1984-05-14
US610210 1984-05-14

Publications (2)

Publication Number Publication Date
JPS6122080A JPS6122080A (ja) 1986-01-30
JPH0643417B2 true JPH0643417B2 (ja) 1994-06-08

Family

ID=24444125

Family Applications (1)

Application Number Title Priority Date Filing Date
JP60102499A Expired - Lifetime JPH0643417B2 (ja) 1984-05-14 1985-05-13 インドリンおよび２−インドリノン誘導体

Country Status (20)

Country Link
EP (1) EP0161918B1 (enExample)
JP (1) JPH0643417B2 (enExample)
KR (1) KR870000274B1 (enExample)
AR (1) AR241531A1 (enExample)
AT (1) ATE54915T1 (enExample)
AU (1) AU577372B2 (enExample)
CA (1) CA1248099A (enExample)
DE (1) DE3578822D1 (enExample)
DK (1) DK207785A (enExample)
EG (1) EG17342A (enExample)
ES (1) ES8609308A1 (enExample)
GR (1) GR851121B (enExample)
HU (1) HU194873B (enExample)
IL (1) IL75122A (enExample)
MY (1) MY101520A (enExample)
NZ (1) NZ212023A (enExample)
PH (1) PH21862A (enExample)
PT (1) PT80414B (enExample)
SU (1) SU1486060A3 (enExample)
ZA (1) ZA853440B (enExample)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4591591A (en) * 1984-03-08 1986-05-27 Eli Lilly And Company Pyridazinone derivatives as inotropic agents
DE3631085A1 (de) * 1986-09-12 1988-03-24 Boehringer Mannheim Gmbh Heterocyclisch substituierte indolinone, verfahren zu ihrer herstellung, arzneimittel sowie zwischenprodukte
DE3706427A1 (de) * 1987-02-27 1988-09-08 Boehringer Mannheim Gmbh Neue substituierte 3h-indole, zwischenprodukte, verfahren zu ihrer herstellung sowie arzneimittel
US5196416A (en) * 1987-08-28 1993-03-23 Eli Lilly And Company Transdermal flux-enhancing pharmaceutical compositions comprising azone, ethanol and water
ES2037230T3 (es) * 1987-08-28 1993-06-16 Eli Lilly And Company Composiciones activadoras de la penetracion.
EP0326307B1 (en) * 1988-01-23 1994-08-17 Kyowa Hakko Kogyo Co., Ltd. Novel pyridazinone derivatives and pharmaceutical preparations containing them
GB8816944D0 (en) * 1988-07-15 1988-08-17 Sobio Lab Compounds
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
MX354786B (es) 2007-06-04 2018-03-21 Synergy Pharmaceuticals Inc Agonistas de guanilato ciclasa utiles para el tratamiento de trastornos gastrointestinales, inflamacion, cancer y otros trastornos.
CA2726917C (en) 2008-06-04 2018-06-26 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
EP2321341B1 (en) 2008-07-16 2017-02-22 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
EA201391254A1 (ru) 2011-03-01 2014-02-28 Синерджи Фармасьютикалз Инк. Способ получения агонистов гуанилатциклазы c
JP6499591B2 (ja) 2013-02-25 2019-04-10 シナジー ファーマシューティカルズ インコーポレイテッド 結腸洗浄において用いるためのグアニル酸シクラーゼ受容体アゴニスト
WO2014151200A2 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
JP2016514671A (ja) 2013-03-15 2016-05-23 シナジー ファーマシューティカルズ インコーポレイテッド グアニル酸シクラーゼのアゴニストおよびその使用
CN105764916B (zh) 2013-06-05 2021-05-18 博士医疗爱尔兰有限公司 鸟苷酸环化酶c的超纯激动剂、制备和使用所述激动剂的方法
EP3492106B1 (en) 2013-08-09 2021-02-17 Ardelyx, Inc. Compounds and methods for inhibiting phosphate transport
EP3972599B1 (en) 2019-05-21 2025-10-22 Ardelyx, Inc. Combination for lowering serum phosphate in a patient
JP2026508931A (ja) * 2023-03-10 2026-03-13 ゾエティス・サービシーズ・エルエルシー ホスホジエステラーゼ３（ｐｄｅ３）阻害剤

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES8101067A1 (es) * 1978-08-25 1980-12-01 Thomae Gmbh Dr K Procedimiento para la preparacion de nuevos bencimidazoles sustituidos en posicion 5 o 6 con un anillo de piridazinona
US4258185A (en) * 1978-10-17 1981-03-24 Yoshitomi Pharmaceutical Industries, Ltd. Pyridazinone compounds
DE3124699A1 (de) * 1981-06-24 1983-01-13 Basf Ag, 6700 Ludwigshafen Neue 2-aryl-3,4-diaza-bicyclo(4.n.0.)alken-(2)-one-(5),verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
JPS588016A (ja) * 1981-07-06 1983-01-18 Mitsubishi Chem Ind Ltd 強心剤

Also Published As

Publication number Publication date
DK207785A (da) 1985-11-15
ATE54915T1 (de) 1990-08-15
ES543078A0 (es) 1986-09-01
PT80414B (en) 1987-04-16
EP0161918A3 (en) 1986-11-20
DK207785D0 (da) 1985-05-10
CA1248099A (en) 1989-01-03
ZA853440B (en) 1986-12-30
EP0161918A2 (en) 1985-11-21
JPS6122080A (ja) 1986-01-30
SU1486060A3 (ru) 1989-06-07
KR850008166A (ko) 1985-12-13
PT80414A (en) 1985-06-01
AR241531A1 (es) 1992-08-31
IL75122A (en) 1989-02-28
EG17342A (en) 1991-03-30
GR851121B (enExample) 1985-11-25
ES8609308A1 (es) 1986-09-01
MY101520A (en) 1991-11-30
KR870000274B1 (ko) 1987-02-23
DE3578822D1 (de) 1990-08-30
PH21862A (en) 1988-03-25
NZ212023A (en) 1988-04-29
EP0161918B1 (en) 1990-07-25
HU194873B (en) 1988-03-28
HUT37783A (en) 1986-02-28
AU4240585A (en) 1985-11-21
AU577372B2 (en) 1988-09-22
IL75122A0 (en) 1985-09-29

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