JPH062151B2 - コラーゲン／鉱質混合物のγ線照射 - Google Patents
コラーゲン／鉱質混合物のγ線照射Info
- Publication number
- JPH062151B2 JPH062151B2 JP62281930A JP28193087A JPH062151B2 JP H062151 B2 JPH062151 B2 JP H062151B2 JP 62281930 A JP62281930 A JP 62281930A JP 28193087 A JP28193087 A JP 28193087A JP H062151 B2 JPH062151 B2 JP H062151B2
- Authority
- JP
- Japan
- Prior art keywords
- collagen
- composition
- mineral
- irradiation
- mixture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 102000008186 Collagen Human genes 0.000 title claims description 120
- 108010035532 Collagen Proteins 0.000 title claims description 120
- 229920001436 collagen Polymers 0.000 title claims description 116
- 239000000203 mixture Substances 0.000 title claims description 87
- 229910052500 inorganic mineral Inorganic materials 0.000 title claims description 56
- 239000011707 mineral Substances 0.000 title claims description 56
- 238000000034 method Methods 0.000 claims description 55
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 50
- 238000002360 preparation method Methods 0.000 claims description 35
- 239000000463 material Substances 0.000 claims description 31
- 238000004132 cross linking Methods 0.000 claims description 24
- 210000000988 bone and bone Anatomy 0.000 claims description 23
- 239000001506 calcium phosphate Substances 0.000 claims description 18
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims description 18
- 229910000389 calcium phosphate Inorganic materials 0.000 claims description 16
- 235000011010 calcium phosphates Nutrition 0.000 claims description 16
- 238000010438 heat treatment Methods 0.000 claims description 12
- 239000000835 fiber Substances 0.000 claims description 9
- 230000036512 infertility Effects 0.000 claims description 6
- 230000001678 irradiating effect Effects 0.000 claims description 6
- 230000005855 radiation Effects 0.000 claims description 5
- 230000001954 sterilising effect Effects 0.000 description 22
- 238000004659 sterilization and disinfection Methods 0.000 description 20
- 238000011282 treatment Methods 0.000 description 16
- 102000004142 Trypsin Human genes 0.000 description 12
- 108090000631 Trypsin Proteins 0.000 description 12
- 239000012588 trypsin Substances 0.000 description 11
- 230000006835 compression Effects 0.000 description 8
- 238000007906 compression Methods 0.000 description 8
- 239000007943 implant Substances 0.000 description 8
- 230000001965 increasing effect Effects 0.000 description 8
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 8
- 230000000704 physical effect Effects 0.000 description 8
- 230000008569 process Effects 0.000 description 8
- 239000006185 dispersion Substances 0.000 description 7
- 229910052588 hydroxylapatite Inorganic materials 0.000 description 7
- 238000005259 measurement Methods 0.000 description 7
- 239000000047 product Substances 0.000 description 7
- 230000000694 effects Effects 0.000 description 6
- 230000008439 repair process Effects 0.000 description 6
- 230000035945 sensitivity Effects 0.000 description 6
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 5
- 239000011780 sodium chloride Substances 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 4
- 230000003416 augmentation Effects 0.000 description 4
- 239000000501 collagen implant Substances 0.000 description 4
- 238000001723 curing Methods 0.000 description 4
- 239000011521 glass Substances 0.000 description 4
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 3
- 150000001413 amino acids Chemical class 0.000 description 3
- 230000004071 biological effect Effects 0.000 description 3
- 239000012620 biological material Substances 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 244000309466 calf Species 0.000 description 3
- 230000015556 catabolic process Effects 0.000 description 3
- 230000007547 defect Effects 0.000 description 3
- 238000006731 degradation reaction Methods 0.000 description 3
- 238000001035 drying Methods 0.000 description 3
- 238000013467 fragmentation Methods 0.000 description 3
- 238000006062 fragmentation reaction Methods 0.000 description 3
- 239000012535 impurity Substances 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- 239000011148 porous material Substances 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- 238000010561 standard procedure Methods 0.000 description 3
- 239000000725 suspension Substances 0.000 description 3
- 230000007704 transition Effects 0.000 description 3
- 241000282693 Cercopithecidae Species 0.000 description 2
- 108010010803 Gelatin Proteins 0.000 description 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- 206010052428 Wound Diseases 0.000 description 2
- 208000027418 Wounds and injury Diseases 0.000 description 2
- 210000001909 alveolar process Anatomy 0.000 description 2
- 235000001014 amino acid Nutrition 0.000 description 2
- 239000012736 aqueous medium Substances 0.000 description 2
- 210000001185 bone marrow Anatomy 0.000 description 2
- 235000018417 cysteine Nutrition 0.000 description 2
- 150000001945 cysteines Chemical group 0.000 description 2
- 238000000113 differential scanning calorimetry Methods 0.000 description 2
- 239000011363 dried mixture Substances 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 239000000499 gel Substances 0.000 description 2
- 239000008273 gelatin Substances 0.000 description 2
- 229920000159 gelatin Polymers 0.000 description 2
- 235000019322 gelatine Nutrition 0.000 description 2
- 235000011852 gelatine desserts Nutrition 0.000 description 2
- 230000007062 hydrolysis Effects 0.000 description 2
- 238000006460 hydrolysis reaction Methods 0.000 description 2
- 230000005847 immunogenicity Effects 0.000 description 2
- 238000002513 implantation Methods 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- 239000012567 medical material Substances 0.000 description 2
- 230000003239 periodontal effect Effects 0.000 description 2
- 238000004886 process control Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 230000017423 tissue regeneration Effects 0.000 description 2
- 230000008733 trauma Effects 0.000 description 2
- 229910000391 tricalcium phosphate Inorganic materials 0.000 description 2
- 235000019731 tricalcium phosphate Nutrition 0.000 description 2
- 229940078499 tricalcium phosphate Drugs 0.000 description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 241000282472 Canis lupus familiaris Species 0.000 description 1
- 102000012422 Collagen Type I Human genes 0.000 description 1
- 108010022452 Collagen Type I Proteins 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- 102000004989 Hepsin Human genes 0.000 description 1
- 108090001101 Hepsin Proteins 0.000 description 1
- PMMYEEVYMWASQN-DMTCNVIQSA-N Hydroxyproline Chemical compound O[C@H]1CN[C@H](C(O)=O)C1 PMMYEEVYMWASQN-DMTCNVIQSA-N 0.000 description 1
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 description 1
- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 description 1
- 241000906034 Orthops Species 0.000 description 1
- 208000006735 Periostitis Diseases 0.000 description 1
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 description 1
- DUHSSNQZRMKHLD-UHFFFAOYSA-N [Ca].[Ca].[Ca].P(O)(O)(O)=O Chemical compound [Ca].[Ca].[Ca].P(O)(O)(O)=O DUHSSNQZRMKHLD-UHFFFAOYSA-N 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- -1 blood or bone marrow Chemical class 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 230000008468 bone growth Effects 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 239000000378 calcium silicate Substances 0.000 description 1
- 229910052918 calcium silicate Inorganic materials 0.000 description 1
- OYACROKNLOSFPA-UHFFFAOYSA-N calcium;dioxido(oxo)silane Chemical compound [Ca+2].[O-][Si]([O-])=O OYACROKNLOSFPA-UHFFFAOYSA-N 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 210000000845 cartilage Anatomy 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000003776 cleavage reaction Methods 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 239000000084 colloidal system Substances 0.000 description 1
- 239000013065 commercial product Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 238000002316 cosmetic surgery Methods 0.000 description 1
- 239000003431 cross linking reagent Substances 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000007598 dipping method Methods 0.000 description 1
- PMMYEEVYMWASQN-UHFFFAOYSA-N dl-hydroxyproline Natural products OC1C[NH2+]C(C([O-])=O)C1 PMMYEEVYMWASQN-UHFFFAOYSA-N 0.000 description 1
- 239000013013 elastic material Substances 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 210000002950 fibroblast Anatomy 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 239000010419 fine particle Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 description 1
- 238000013007 heat curing Methods 0.000 description 1
- 239000011796 hollow space material Substances 0.000 description 1
- 230000036571 hydration Effects 0.000 description 1
- 238000006703 hydration reaction Methods 0.000 description 1
- 239000012433 hydrogen halide Substances 0.000 description 1
- 229910000039 hydrogen halide Inorganic materials 0.000 description 1
- 229960002591 hydroxyproline Drugs 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 229960004194 lidocaine Drugs 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 230000013011 mating Effects 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 230000003278 mimic effect Effects 0.000 description 1
- 239000008239 natural water Substances 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 210000000963 osteoblast Anatomy 0.000 description 1
- 210000003460 periosteum Anatomy 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 229940085991 phosphate ion Drugs 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000002797 proteolythic effect Effects 0.000 description 1
- 230000005588 protonation Effects 0.000 description 1
- 238000011002 quantification Methods 0.000 description 1
- 238000005510 radiation hardening Methods 0.000 description 1
- 239000002516 radical scavenger Substances 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
- 229940125723 sedative agent Drugs 0.000 description 1
- 239000000932 sedative agent Substances 0.000 description 1
- 238000010206 sensitivity analysis Methods 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 239000008223 sterile water Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 210000002435 tendon Anatomy 0.000 description 1
- FGMPLJWBKKVCDB-UHFFFAOYSA-N trans-L-hydroxy-proline Natural products ON1CCCC1C(O)=O FGMPLJWBKKVCDB-UHFFFAOYSA-N 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
- 235000020302 vienna Nutrition 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
- A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
- A61L2/0029—Radiation
- A61L2/0035—Gamma radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
- A61L27/46—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S128/00—Surgery
- Y10S128/08—Collagen
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S623/00—Prosthesis, i.e. artificial body members, parts thereof, or aids and accessories therefor
- Y10S623/92—Method or apparatus for preparing or treating prosthetic
- Y10S623/923—Bone
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Inorganic Chemistry (AREA)
- Transplantation (AREA)
- Materials Engineering (AREA)
- Dermatology (AREA)
- Composite Materials (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Materials For Medical Uses (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US928,306 | 1986-11-06 | ||
| US06/928,306 US4865602A (en) | 1986-11-06 | 1986-11-06 | Gamma irradiation of collagen/mineral mixtures |
| CA000616394A CA1320451C (en) | 1986-11-06 | 1992-06-02 | Gamma irradiation of collagen/mineral mixtures |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP3343582A Division JPH0622571B2 (ja) | 1986-11-06 | 1991-12-25 | コラーゲン／鉱質混合物の水分含量調整法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS63132664A JPS63132664A (ja) | 1988-06-04 |
| JPH062151B2 true JPH062151B2 (ja) | 1994-01-12 |
Family
ID=25673243
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP62281930A Expired - Lifetime JPH062151B2 (ja) | 1986-11-06 | 1987-11-06 | コラーゲン／鉱質混合物のγ線照射 |
| JP3343582A Expired - Lifetime JPH0622571B2 (ja) | 1986-11-06 | 1991-12-25 | コラーゲン／鉱質混合物の水分含量調整法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP3343582A Expired - Lifetime JPH0622571B2 (ja) | 1986-11-06 | 1991-12-25 | コラーゲン／鉱質混合物の水分含量調整法 |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US4865602A (OSRAM) |
| EP (1) | EP0270254B1 (OSRAM) |
| JP (2) | JPH062151B2 (OSRAM) |
| AU (1) | AU603744B2 (OSRAM) |
| CA (1) | CA1320451C (OSRAM) |
| ES (1) | ES2053562T3 (OSRAM) |
| GR (1) | GR3007382T3 (OSRAM) |
Families Citing this family (101)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4888366A (en) * | 1984-10-24 | 1989-12-19 | Collagen Corporation | Inductive collagen-based bone repair preparations |
| US5001169A (en) * | 1984-10-24 | 1991-03-19 | Collagen Corporation | Inductive collagen-based bone repair preparations |
| US5246457A (en) * | 1985-03-28 | 1993-09-21 | Collagen Corporation | Xenogeneic collagen/mineral preparations in bone repair |
| US4865602A (en) * | 1986-11-06 | 1989-09-12 | Collagen Corporation | Gamma irradiation of collagen/mineral mixtures |
| GB8708009D0 (en) * | 1987-04-03 | 1987-05-07 | Clayton Found Res | Injectable soft tissue augmentation materials |
| US5735902A (en) * | 1987-07-20 | 1998-04-07 | Regen Biologics, Inc. | Hand implant device |
| US5306311A (en) * | 1987-07-20 | 1994-04-26 | Regen Corporation | Prosthetic articular cartilage |
| IT1215881B (it) * | 1988-02-16 | 1990-02-22 | Giancarlo Foresti | Sussidio chirurgico ad azione osteotropa. |
| DE68928975T2 (de) * | 1988-08-10 | 1999-10-28 | Nitta Gelatin Inc., Osaka | Aushärtender Werkstoff für ärztlichen und zahnärztlichen Gebrauch |
| US5643464A (en) * | 1988-11-21 | 1997-07-01 | Collagen Corporation | Process for preparing a sterile, dry crosslinking agent |
| CA2128783C (en) * | 1992-02-28 | 2004-10-12 | Donald G. Wallace | Injectable ceramic compositions and methods for their preparation and use |
| US5204382A (en) * | 1992-02-28 | 1993-04-20 | Collagen Corporation | Injectable ceramic compositions and methods for their preparation and use |
| US5358935A (en) * | 1992-11-19 | 1994-10-25 | Robert Allen Smith | Nonantigenic keratinous protein material |
| US20040067157A1 (en) * | 1993-07-22 | 2004-04-08 | Clearant, Inc. | Methods for sterilizing biological materials |
| US5362442A (en) | 1993-07-22 | 1994-11-08 | 2920913 Canada Inc. | Method for sterilizing products with gamma radiation |
| US5531791A (en) * | 1993-07-23 | 1996-07-02 | Bioscience Consultants | Composition for repair of defects in osseous tissues, method of making, and prosthesis |
| JP2775386B2 (ja) * | 1993-10-04 | 1998-07-16 | 科学技術庁無機材質研究所長 | アパタイト・有機物複合体とその製造法 |
| US5721150A (en) * | 1993-10-25 | 1998-02-24 | Lsi Logic Corporation | Use of silicon for integrated circuit device interconnection by direct writing of patterns therein |
| US5422068A (en) * | 1994-01-05 | 1995-06-06 | Shalaby; Shalaby W. | Radiochemical sterilization |
| US6337389B1 (en) * | 1995-03-17 | 2002-01-08 | Bioscience Consultants, L.L.C. | Method and process for the production of collagen preparations from invertebrate marine animals and compositions thereof |
| US5674292A (en) | 1995-06-07 | 1997-10-07 | Stryker Corporation | Terminally sterilized osteogenic devices and preparation thereof |
| US6436138B1 (en) | 1996-01-17 | 2002-08-20 | Osteotech, Inc. | Process for producing flexible sheets from demineralized, elongate, bone particles |
| US5788941A (en) * | 1996-01-31 | 1998-08-04 | Steris Corporation | Method of sterilization of bone tussue |
| US8865788B2 (en) * | 1996-02-13 | 2014-10-21 | The General Hospital Corporation | Radiation and melt treated ultra high molecular weight polyethylene prosthetic devices |
| US20020156536A1 (en) * | 1996-02-13 | 2002-10-24 | Harris William H. | Polyethylene hip joint prosthesis with extended range of motion |
| US8563623B2 (en) * | 1996-02-13 | 2013-10-22 | The General Hospital Corporation | Radiation melt treated ultra high molecular weight polyethylene prosthetic devices |
| US5792478A (en) * | 1996-07-08 | 1998-08-11 | Advanced Uro Science | Tissue injectable composition and method of use |
| US6083522A (en) * | 1997-01-09 | 2000-07-04 | Neucoll, Inc. | Devices for tissue repair and methods for preparation and use thereof |
| US6017366A (en) * | 1997-04-18 | 2000-01-25 | W. L. Gore & Associates, Inc. | Resorbable interposition arthroplasty implant |
| US5889075A (en) * | 1997-10-10 | 1999-03-30 | United States Surgical Corporation | Irradiated surgical suture and method for making same |
| US20040081704A1 (en) * | 1998-02-13 | 2004-04-29 | Centerpulse Biologics Inc. | Implantable putty material |
| US6706290B1 (en) | 1998-07-06 | 2004-03-16 | Olvai E. Kajander | Methods for eradication of nanobacteria |
| EP1094711B1 (en) * | 1998-07-06 | 2004-11-24 | Nanobac Oy | Methods for eradication of nanobacteria |
| FR2786400B1 (fr) * | 1998-11-30 | 2002-05-10 | Imedex Biomateriaux | Procede de preparation d'un materiau collagenique a vitesse de biodegradation in vivo controlee et materiaux obtenus |
| DE60006356T2 (de) | 1999-02-04 | 2004-09-09 | SDGI Holding, Inc., Wilmington | Hochmineralisierte osteogene schwammzusammensetzungen und ihre verwendung |
| AU770196B2 (en) * | 1999-02-04 | 2004-02-12 | Warsaw Orthopedic, Inc. | Osteogenic paste compositions and uses thereof |
| US20030228288A1 (en) | 1999-10-15 | 2003-12-11 | Scarborough Nelson L. | Volume maintaining osteoinductive/osteoconductive compositions |
| US20040086420A1 (en) * | 2000-03-23 | 2004-05-06 | Macphee Martin J. | Methods for sterilizing serum or plasma |
| EP1299131A4 (en) * | 2000-03-23 | 2003-06-18 | Clearant Inc | METHOD FOR STERILIZING BIOLOGICAL MATERIALS |
| US9387094B2 (en) * | 2000-07-19 | 2016-07-12 | Warsaw Orthopedic, Inc. | Osteoimplant and method of making same |
| JP4354181B2 (ja) | 2000-07-31 | 2009-10-28 | ザ・ジェネラル・ホスピタル・コーポレイション | 転位の危険性を減少させる改良された寛骨臼コンポーネント |
| US7323193B2 (en) | 2001-12-14 | 2008-01-29 | Osteotech, Inc. | Method of making demineralized bone particles |
| US20020114795A1 (en) | 2000-12-22 | 2002-08-22 | Thorne Kevin J. | Composition and process for bone growth and repair |
| US20020115742A1 (en) * | 2001-02-22 | 2002-08-22 | Trieu Hai H. | Bioactive nanocomposites and methods for their use |
| US6682695B2 (en) * | 2001-03-23 | 2004-01-27 | Clearant, Inc. | Methods for sterilizing biological materials by multiple rates |
| US6696060B2 (en) * | 2001-06-14 | 2004-02-24 | Clearant, Inc. | Methods for sterilizing preparations of monoclonal immunoglobulins |
| US7105182B2 (en) | 2001-07-25 | 2006-09-12 | Szymaitis Dennis W | Periodontal regeneration composition and method of using same |
| US20030026770A1 (en) * | 2001-07-25 | 2003-02-06 | Szymaitis Dennis W. | Periodontal regeneration composition and method of using same |
| US6946098B2 (en) | 2001-08-10 | 2005-09-20 | Clearant, Inc. | Methods for sterilizing biological materials |
| US7252799B2 (en) * | 2001-08-31 | 2007-08-07 | Clearant, Inc. | Methods for sterilizing preparations containing albumin |
| US6749851B2 (en) | 2001-08-31 | 2004-06-15 | Clearant, Inc. | Methods for sterilizing preparations of digestive enzymes |
| US20050152986A1 (en) * | 2001-09-06 | 2005-07-14 | Nicolaas Duneas | Cross-linked collagenous biomaterial |
| US20030095890A1 (en) * | 2001-09-24 | 2003-05-22 | Shirley Miekka | Methods for sterilizing biological materials containing non-aqueous solvents |
| US20110091353A1 (en) * | 2001-09-24 | 2011-04-21 | Wilson Burgess | Methods for Sterilizing Tissue |
| US20030185702A1 (en) * | 2002-02-01 | 2003-10-02 | Wilson Burgess | Methods for sterilizing tissue |
| KR20040047746A (ko) * | 2001-10-12 | 2004-06-05 | 오스테오테크, 인코포레이티드 | 향상된 골 이식물 |
| US20030124023A1 (en) * | 2001-12-21 | 2003-07-03 | Wilson Burgess | Method of sterilizing heart valves |
| US20030181371A1 (en) * | 2001-12-28 | 2003-09-25 | Angiotech Pharmaceuticals, Inc. | Compositions and methods of using collajolie |
| US20030180181A1 (en) * | 2002-02-01 | 2003-09-25 | Teri Greib | Methods for sterilizing tissue |
| US7455854B2 (en) * | 2002-04-18 | 2008-11-25 | University Of Florida Research Foundation, Inc. | Method for producing a mineral fiber |
| US7514249B2 (en) * | 2002-04-18 | 2009-04-07 | The University Of Florida Research Foundation, Inc. | Biomimetic organic/inorganic composites |
| US7514248B2 (en) | 2002-04-18 | 2009-04-07 | University Of Florida Research Foundation, Inc. | Process for making organic/inorganic composites |
| DK1523342T3 (da) * | 2002-04-29 | 2009-10-19 | Biomet Deutschland Gmbh | Struktureret komposit som matrix (Schaffold) for vævs- konstruktion af knogler |
| AU2003299486A1 (en) * | 2002-05-10 | 2004-06-03 | The Ohio State University | Flavin n-oxides: new anti-cancer agents and pathogen eradication agents |
| US7166133B2 (en) | 2002-06-13 | 2007-01-23 | Kensey Nash Corporation | Devices and methods for treating defects in the tissue of a living being |
| US20040013562A1 (en) * | 2002-07-18 | 2004-01-22 | Wilson Burgess | Methods for sterilizing milk. |
| US6908591B2 (en) * | 2002-07-18 | 2005-06-21 | Clearant, Inc. | Methods for sterilizing biological materials by irradiation over a temperature gradient |
| EP1605862A4 (en) * | 2003-02-28 | 2008-09-03 | Fibrogen Inc | COLLAGEN COMPOSITIONS AND BIOMATERIALS |
| KR20060031808A (ko) * | 2003-06-11 | 2006-04-13 | 오스테오테크, 인코포레이티드 | 뼈 임플란트 및 그의 제조 방법 |
| JP2005169008A (ja) * | 2003-12-15 | 2005-06-30 | Nipro Corp | 生体適合性材料の滅菌方法 |
| US20070190101A1 (en) * | 2004-03-31 | 2007-08-16 | Chunlin Yang | Flowable bone grafts |
| KR100974733B1 (ko) | 2004-04-28 | 2010-08-06 | 안지오디바이스 인터내셔널 게엠베하 | 가교된 생합성물질을 형성하기 위한 조성물 및 시스템, 및이와 관련된 제조 및 사용 방법 |
| US20050244450A1 (en) * | 2004-04-28 | 2005-11-03 | Reddi A H | Heat-treated implantable bone material |
| US7678385B2 (en) * | 2004-04-28 | 2010-03-16 | Biomet Manufacturing Corp. | Irradiated implantable bone material |
| US7722895B1 (en) | 2004-09-20 | 2010-05-25 | Warsaw Orthopedic, Inc. | Osteogenic implants with combined implant materials, and materials and methods for same |
| US7857853B2 (en) * | 2005-04-29 | 2010-12-28 | Sdgi Holdings, Inc | Synthetic loadbearing collagen-mineral composites useful for spinal implants, and methods of manufacture |
| US8506646B2 (en) * | 2005-04-29 | 2013-08-13 | Warsaw Orthopedic, Inc. | Multi-purpose medical implant devices |
| DE202005009755U1 (de) * | 2005-06-21 | 2005-09-08 | Cervitech, Inc. | Halter für Zwischenwirbelprothesen |
| US8920827B2 (en) | 2005-10-21 | 2014-12-30 | Wake Forest University Health Sciences | Keratin bioceramic compositions |
| WO2007056671A1 (en) * | 2005-11-02 | 2007-05-18 | Osteotech, Inc. | Hemostatic bone graft |
| US8048857B2 (en) | 2006-12-19 | 2011-11-01 | Warsaw Orthopedic, Inc. | Flowable carrier compositions and methods of use |
| US7718616B2 (en) | 2006-12-21 | 2010-05-18 | Zimmer Orthobiologics, Inc. | Bone growth particles and osteoinductive composition thereof |
| US20120195938A1 (en) * | 2007-05-30 | 2012-08-02 | James Louis Rutkowski | Formulations and methods for recovery from dental surgery |
| US9511076B2 (en) * | 2008-05-30 | 2016-12-06 | Clarion Research Group | Formulations and methods for recovery from dental surgery |
| US9616153B2 (en) | 2008-04-17 | 2017-04-11 | Warsaw Orthopedic, Inc. | Rigid bone graft substitute |
| US20090263507A1 (en) * | 2008-04-18 | 2009-10-22 | Warsaw Orthopedic, Inc. | Biological markers and response to treatment for pain, inflammation, neuronal or vascular injury and methods of use |
| KR20110086045A (ko) * | 2008-10-24 | 2011-07-27 | 오스테오테크, 인코포레이티드 | 뼈 형성 촉진용 조성물 및 뼈 형성 촉진방법 |
| US20130045923A1 (en) * | 2009-08-28 | 2013-02-21 | Tissue Science Laboratories Plc | Collagenous material |
| JP5967721B2 (ja) * | 2010-07-08 | 2016-08-10 | ライフセル コーポレーションＬｉｆｅＣｅｌｌ Ｃｏｒｐｏｒａｔｉｏｎ | 組織マトリックスの成形方法 |
| US8613938B2 (en) | 2010-11-15 | 2013-12-24 | Zimmer Orthobiologics, Inc. | Bone void fillers |
| EP2640408B1 (en) | 2010-11-17 | 2016-05-25 | Wake Forest University Health Sciences | Keratin compositions for treatment of bone deficiency or injury |
| US10016528B2 (en) * | 2013-09-09 | 2018-07-10 | Eran Rosines | Biologic prosthesis and methods of production and use |
| CZ307219B6 (cs) * | 2015-10-09 | 2018-04-04 | Ăšstav struktury a mechaniky hornin AVÄŚR, v.v.i. | Biomateriál na bázi želatiny pro výrobu kostních náhrad a výplní a způsob jeho přípravy |
| CN108697828A (zh) | 2016-02-11 | 2018-10-23 | 生命细胞公司 | 用于稳定包含胶原蛋白的组织产品防止酶降解的方法 |
| US10058159B2 (en) | 2016-12-01 | 2018-08-28 | Richard L. Kronenthal | Sterile compositions for human cosmetic products |
| IL275206B2 (en) | 2017-12-14 | 2023-04-01 | Geistlich Pharma Ag | Dry implant composition and aqueous injection formulation of the implant |
| AU2018382557B2 (en) | 2017-12-14 | 2024-05-02 | Geistlich Pharma Ag | Bone substitute material |
| WO2020004646A1 (ja) * | 2018-06-29 | 2020-01-02 | 国立研究開発法人量子科学技術研究開発機構 | 細胞培養用ハイドロゲル、ゲルキット、細胞培養物の製造方法、及び細胞培養用ハイドロゲルの製造方法 |
| RO134200B1 (ro) | 2018-11-23 | 2023-07-28 | Institutul Naţional De Cercetare-Dezvoltare Textile Pielărie - Sucursala Institutul De Cercetare Pielărie Încălţăminte | Procedeu de tratare şi piei conservate prin iradiere gama |
| CN114761048B (zh) | 2019-06-14 | 2023-05-02 | 盖斯特里希医药公司 | 骨替代材料的胶原基质或颗粒共混物 |
| EP3941542B1 (en) | 2019-06-14 | 2022-12-28 | Geistlich Pharma AG | Injectable aqueous implant formulation containing ascorbic acid |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3443261A (en) * | 1967-09-01 | 1969-05-13 | Fmc Corp | Prosthetic structures from microcrystalline collagen |
| US3767437A (en) * | 1971-10-20 | 1973-10-23 | Avicon Inc | Phosthetic structures derived from collagen |
| US3949073A (en) * | 1974-11-18 | 1976-04-06 | The Board Of Trustees Of Leland Stanford Junior University | Process for augmenting connective mammalian tissue with in situ polymerizable native collagen solution |
| CH615099A5 (OSRAM) * | 1975-08-07 | 1980-01-15 | Ulf Sven Erik Rothman | |
| CA1073360A (en) * | 1975-10-22 | 1980-03-11 | John R. Daniels | Non-antigenic collagen and articles of manufacture |
| DE2843963A1 (de) * | 1978-10-09 | 1980-04-24 | Merck Patent Gmbh | Im koerper resorbierbare geformte masse auf basis von kollagen und ihre verwendung in der medizin |
| US4349470A (en) * | 1979-09-14 | 1982-09-14 | Battista Orlando A | Protein polymer hydrogels |
| DE2967060D1 (en) * | 1979-12-18 | 1984-07-19 | Oscobal Ag | Bone replacement material and process for producing a bone replacement material |
| US4314380A (en) * | 1980-09-26 | 1982-02-09 | Koken Co., Ltd. | Artificial bone |
| JPS5841A (ja) * | 1981-06-22 | 1983-01-05 | Matsushita Electric Ind Co Ltd | パイプヒ−タ応用熱交換器 |
| DE3124981A1 (de) * | 1981-06-25 | 1983-01-13 | Dr. Ruhland Nachfolger GmbH, 8425 Neustadt | Wirkstoffhaltige kollageneinlage zum einfuehren in knochen oder weichteile und verfahren zu deren herstellung |
| JPS5858041A (ja) * | 1981-10-05 | 1983-04-06 | 三菱鉱業セメント株式会社 | 骨欠損部及び空隙部充てん材 |
| US4424208A (en) * | 1982-01-11 | 1984-01-03 | Collagen Corporation | Collagen implant material and method for augmenting soft tissue |
| US4409332A (en) * | 1982-01-12 | 1983-10-11 | Jefferies Steven R | Collagen-enzyme conjugates that exhibit no inflammatory response and method for making the same |
| US4582640A (en) * | 1982-03-08 | 1986-04-15 | Collagen Corporation | Injectable cross-linked collagen implant material |
| EP0108661A1 (en) * | 1982-10-04 | 1984-05-16 | Merck & Co. Inc. | Stabilized hydroxypropyl cellulose ophthalmic inserts and process to sterilize the same |
| EP0164483B1 (de) * | 1984-06-12 | 1989-08-16 | Oscobal Ag | Verfahren zur Herstellung von Knochenersatzmaterial |
| US4789663A (en) * | 1984-07-06 | 1988-12-06 | Collagen Corporation | Methods of bone repair using collagen |
| EP0169001A3 (en) * | 1984-07-17 | 1987-11-25 | Collagen Corporation | Collagen coated bone implants |
| US4553974A (en) * | 1984-08-14 | 1985-11-19 | Mayo Foundation | Treatment of collagenous tissue with glutaraldehyde and aminodiphosphonate calcification inhibitor |
| US4642117A (en) * | 1985-03-22 | 1987-02-10 | Collagen Corporation | Mechanically sheared collagen implant material and method |
| CA1260391A (en) * | 1985-03-28 | 1989-09-26 | Karl A. Piez | Xenogeneic collagen/mineral preparations in bone repair |
| US4992226A (en) * | 1985-03-28 | 1991-02-12 | Collagen Corporation | Method of making molds with xenogeneic collagen/mineral preparations for bone repair |
| EP0246638A3 (en) * | 1986-05-23 | 1989-03-15 | Cordis Corporation | Biologically modified synthetic grafts |
| US4865602A (en) * | 1986-11-06 | 1989-09-12 | Collagen Corporation | Gamma irradiation of collagen/mineral mixtures |
-
1986
- 1986-11-06 US US06/928,306 patent/US4865602A/en not_active Expired - Lifetime
-
1987
- 1987-11-04 AU AU80680/87A patent/AU603744B2/en not_active Ceased
- 1987-11-05 EP EP87309810A patent/EP0270254B1/en not_active Expired - Lifetime
- 1987-11-05 ES ES87309810T patent/ES2053562T3/es not_active Expired - Lifetime
- 1987-11-06 JP JP62281930A patent/JPH062151B2/ja not_active Expired - Lifetime
-
1989
- 1989-05-24 US US07/356,453 patent/US5035715A/en not_active Expired - Lifetime
-
1991
- 1991-01-29 US US07/647,758 patent/US5123925A/en not_active Expired - Lifetime
- 1991-12-25 JP JP3343582A patent/JPH0622571B2/ja not_active Expired - Lifetime
-
1992
- 1992-06-02 CA CA000616394A patent/CA1320451C/en not_active Expired - Lifetime
-
1993
- 1993-03-16 GR GR930400594T patent/GR3007382T3/el unknown
Non-Patent Citations (2)
| Title |
|---|
| 欧州特許出願公開第１０８６６１号公報 |
| 欧州特許出願公開第１９７６９３号公報 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP0270254A3 (en) | 1990-03-07 |
| AU8068087A (en) | 1988-05-12 |
| GR3007382T3 (OSRAM) | 1993-07-30 |
| ES2053562T3 (es) | 1994-08-01 |
| JPH0622571B2 (ja) | 1994-03-30 |
| US5123925A (en) | 1992-06-23 |
| CA1320451C (en) | 1993-07-20 |
| JPH05305133A (ja) | 1993-11-19 |
| EP0270254B1 (en) | 1993-03-10 |
| JPS63132664A (ja) | 1988-06-04 |
| US5035715A (en) | 1991-07-30 |
| AU603744B2 (en) | 1990-11-22 |
| EP0270254A2 (en) | 1988-06-08 |
| US4865602A (en) | 1989-09-12 |
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