JPH0610188B2 - １α，２５―ジヒドロキシル化ビタミンＤ▼下２▲化合物の前駆体 - Google Patents

１α，２５―ジヒドロキシル化ビタミンＤ▼下２▲化合物の前駆体

Info

Publication number
JPH0610188B2
JPH0610188B2 JP1338025A JP33802589A JPH0610188B2 JP H0610188 B2 JPH0610188 B2 JP H0610188B2 JP 1338025 A JP1338025 A JP 1338025A JP 33802589 A JP33802589 A JP 33802589A JP H0610188 B2 JPH0610188 B2 JP H0610188B2
Authority
JP
Japan
Prior art keywords
compound
vitamin
bone
compounds
dihydroxyvitamin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP1338025A
Other languages
English (en)
Japanese (ja)
Other versions
JPH02288854A (ja
Inventor
エフ．デルーカ ヘクター
ケー．シユノーズ ハインリツヒ
アール．シシンスキイ ラファル
洋子 田中
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wisconsin Alumni Research Foundation
Original Assignee
Wisconsin Alumni Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wisconsin Alumni Research Foundation filed Critical Wisconsin Alumni Research Foundation
Publication of JPH02288854A publication Critical patent/JPH02288854A/ja
Publication of JPH0610188B2 publication Critical patent/JPH0610188B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/24—Radicals substituted by singly bound oxygen or sulfur atoms esterified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0036—Nitrogen-containing hetero ring
    • C07J71/0042—Nitrogen only

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Nutrition Science (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
JP1338025A 1983-05-09 1989-12-26 １α，２５―ジヒドロキシル化ビタミンＤ▼下２▲化合物の前駆体 Expired - Fee Related JPH0610188B2 (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US49286383A 1983-05-09 1983-05-09
US492,863 1983-05-09
US60732784A 1984-05-04 1984-05-04
US607,327 1984-05-04

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP59502223A Division JPS60501261A (ja) 1983-05-09 1984-05-09 １α，２５―ジヒドロキシル化ビタミンＤ↓２化合物及びその製造方法

Publications (2)

Publication Number Publication Date
JPH02288854A JPH02288854A (ja) 1990-11-28
JPH0610188B2 true JPH0610188B2 (ja) 1994-02-09

Family

ID=27050897

Family Applications (3)

Application Number Title Priority Date Filing Date
JP1338025A Expired - Fee Related JPH0610188B2 (ja) 1983-05-09 1989-12-26 １α，２５―ジヒドロキシル化ビタミンＤ▼下２▲化合物の前駆体
JP1338024A Granted JPH02288873A (ja) 1983-05-09 1989-12-26 シクロビタミンｄ化合物
JP1338023A Expired - Lifetime JPH0651624B2 (ja) 1983-05-09 1989-12-26 骨の損耗の予防又は再生不調症の治療又は予防用薬剤

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP1338024A Granted JPH02288873A (ja) 1983-05-09 1989-12-26 シクロビタミンｄ化合物
JP1338023A Expired - Lifetime JPH0651624B2 (ja) 1983-05-09 1989-12-26 骨の損耗の予防又は再生不調症の治療又は予防用薬剤

Country Status (7)

Country Link
JP (3) JPH0610188B2 (enExample)
AU (1) AU568549B2 (enExample)
CH (1) CH665834A5 (enExample)
DE (4) DE3490215T (enExample)
DK (3) DK171397B1 (enExample)
NL (1) NL193245C (enExample)
WO (1) WO1984004527A1 (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62500301A (ja) * 1984-10-04 1987-02-05 ウイスコンシン　アラムナイ　リサ−チ　フオンデ−シヨン ２４―ホモビタミンｄ誘導体
EP0211863B1 (en) * 1985-01-17 1992-12-30 Wisconsin Alumni Research Foundation Vitamin d derivatives and methods for preparing same
US5104864A (en) * 1988-08-02 1992-04-14 Bone Care International, Inc. Method for treating and preventing loss of bone mass
CA1341408C (en) * 1988-08-02 2002-12-10 Charles W. Bishop Method for treating and preventing loss of bone mass
US4973584A (en) * 1989-03-09 1990-11-27 Deluca Hector F Novel 1α-hydroxyvitamin D2 epimer and derivatives
JP2645130B2 (ja) * 1989-03-31 1997-08-25 日清製粉株式会社 ステロイド誘導体
GB8914963D0 (en) * 1989-06-29 1989-08-23 Leo Pharm Prod Ltd Chemical compounds
IN171449B (enExample) * 1990-02-14 1992-10-17 Wisconsin Alumni Res Found
DK0600079T3 (da) * 1992-06-22 2002-04-15 Bone Care Int Inc Oral 1alpha-hydroxyprævitamin D
US5795882A (en) * 1992-06-22 1998-08-18 Bone Care International, Inc. Method of treating prostatic diseases using delayed and/or sustained release vitamin D formulations
US5763429A (en) 1993-09-10 1998-06-09 Bone Care International, Inc. Method of treating prostatic diseases using active vitamin D analogues
US6242434B1 (en) 1997-08-08 2001-06-05 Bone Care International, Inc. 24-hydroxyvitamin D, analogs and uses thereof
US6573256B2 (en) 1996-12-30 2003-06-03 Bone Care International, Inc. Method of inhibiting angiogenesis using active vitamin D analogues
US6503893B2 (en) 1996-12-30 2003-01-07 Bone Care International, Inc. Method of treating hyperproliferative diseases using active vitamin D analogues
US6566353B2 (en) 1996-12-30 2003-05-20 Bone Care International, Inc. Method of treating malignancy associated hypercalcemia using active vitamin D analogues
NZ336924A (en) 1997-02-13 2001-06-29 Bone Care Int Inc Targeted therapeutic delivery of vitamin D compounds via a Vitamin D conjugate
JP2004504295A (ja) 2000-07-18 2004-02-12 ボーン　ケア　インターナショナル　インコーポレイテッド 安定化１α−ヒドロキシビタミンＤ
US7148211B2 (en) 2002-09-18 2006-12-12 Genzyme Corporation Formulation for lipophilic agents
US7094775B2 (en) 2004-06-30 2006-08-22 Bone Care International, Llc Method of treating breast cancer using a combination of vitamin D analogues and other agents
JP5492099B2 (ja) 2008-03-12 2014-05-14 シトクロマ インコーポレイテッド 安定化１，２５−ジヒドロキシビタミンｄ２及びその製造方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4260549A (en) * 1979-05-21 1981-04-07 Wisconsin Alumni Research Foundation Process for preparing 1α-hydroxylated compounds
US4267117A (en) * 1978-06-19 1981-05-12 The Upjohn Company Compounds and process
US4269777A (en) * 1979-05-21 1981-05-26 Wisconsin Alumni Research Foundation Isotopically labeled vitamin D derivatives and processes for preparing same

Also Published As

Publication number Publication date
JPH0339505B2 (enExample) 1991-06-14
DE3448360C2 (enExample) 1991-10-02
CH665834A5 (de) 1988-06-15
DE3448412C2 (enExample) 1991-12-12
NL193245C (nl) 1999-04-02
AU3011584A (en) 1984-12-04
NL193245B (nl) 1998-12-01
JPH02288854A (ja) 1990-11-28
DK171397B1 (da) 1996-10-14
DK183291A (da) 1991-11-07
DK184588A (da) 1988-04-06
NL8420137A (nl) 1985-04-01
WO1984004527A1 (en) 1984-11-22
DK183291D0 (da) 1991-11-07
DK172733B1 (da) 1999-06-21
DK184588D0 (da) 1988-04-06
JPH0651624B2 (ja) 1994-07-06
DE3490215C2 (enExample) 1991-07-25
DK172567B1 (da) 1999-01-18
AU568549B2 (en) 1988-01-07
JPH02288873A (ja) 1990-11-28
DK8685A (da) 1985-01-08
DE3490215T (de) 1985-05-15
JPH02288829A (ja) 1990-11-28
DK8685D0 (da) 1985-01-08

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Legal Events

Date Code Title Description
LAPS Cancellation because of no payment of annual fees