JPH053453B2 - - Google Patents
Info
- Publication number
- JPH053453B2 JPH053453B2 JP59081649A JP8164984A JPH053453B2 JP H053453 B2 JPH053453 B2 JP H053453B2 JP 59081649 A JP59081649 A JP 59081649A JP 8164984 A JP8164984 A JP 8164984A JP H053453 B2 JPH053453 B2 JP H053453B2
- Authority
- JP
- Japan
- Prior art keywords
- extract
- lipid peroxide
- vivo
- rosemary
- allspice
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000000284 extract Substances 0.000 claims description 30
- -1 lipid peroxide Chemical class 0.000 claims description 28
- 238000001727 in vivo Methods 0.000 claims description 19
- 238000004519 manufacturing process Methods 0.000 claims description 19
- 239000000203 mixture Substances 0.000 claims description 12
- 240000008474 Pimenta dioica Species 0.000 claims description 11
- 235000006990 Pimenta dioica Nutrition 0.000 claims description 11
- 239000003112 inhibitor Substances 0.000 claims description 10
- 239000009724 Salvia extract Substances 0.000 claims description 5
- 229940092258 rosemary extract Drugs 0.000 claims description 5
- 235000020748 rosemary extract Nutrition 0.000 claims description 5
- 239000001233 rosmarinus officinalis l. extract Substances 0.000 claims description 5
- 238000002360 preparation method Methods 0.000 claims description 3
- 239000002552 dosage form Substances 0.000 claims description 2
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 22
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 9
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 8
- 241001529742 Rosmarinus Species 0.000 description 8
- 239000003814 drug Substances 0.000 description 8
- 229940079593 drug Drugs 0.000 description 8
- 239000002904 solvent Substances 0.000 description 8
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 6
- 241001072909 Salvia Species 0.000 description 6
- 235000017276 Salvia Nutrition 0.000 description 6
- 230000003078 antioxidant effect Effects 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 6
- VZGDMQKNWNREIO-UHFFFAOYSA-N tetrachloromethane Chemical compound ClC(Cl)(Cl)Cl VZGDMQKNWNREIO-UHFFFAOYSA-N 0.000 description 6
- 239000003963 antioxidant agent Substances 0.000 description 5
- 235000006708 antioxidants Nutrition 0.000 description 5
- 201000010099 disease Diseases 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 4
- 235000010323 ascorbic acid Nutrition 0.000 description 4
- 229960005070 ascorbic acid Drugs 0.000 description 4
- 239000011668 ascorbic acid Substances 0.000 description 4
- 238000000605 extraction Methods 0.000 description 4
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 210000004185 liver Anatomy 0.000 description 4
- 239000002798 polar solvent Substances 0.000 description 4
- 239000000843 powder Substances 0.000 description 4
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 3
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
- 206010067125 Liver injury Diseases 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 238000007796 conventional method Methods 0.000 description 3
- 231100000234 hepatic damage Toxicity 0.000 description 3
- 230000008818 liver damage Effects 0.000 description 3
- 239000003960 organic solvent Substances 0.000 description 3
- 229930003799 tocopherol Natural products 0.000 description 3
- 239000011732 tocopherol Substances 0.000 description 3
- 102000016938 Catalase Human genes 0.000 description 2
- 206010008570 Chloasma Diseases 0.000 description 2
- 108010024636 Glutathione Proteins 0.000 description 2
- 102000006587 Glutathione peroxidase Human genes 0.000 description 2
- 108700016172 Glutathione peroxidases Proteins 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 208000003351 Melanosis Diseases 0.000 description 2
- 241000700159 Rattus Species 0.000 description 2
- OUUQCZGPVNCOIJ-UHFFFAOYSA-M Superoxide Chemical compound [O-][O] OUUQCZGPVNCOIJ-UHFFFAOYSA-M 0.000 description 2
- 230000005856 abnormality Effects 0.000 description 2
- RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 description 2
- 235000021466 carotenoid Nutrition 0.000 description 2
- 150000001747 carotenoids Chemical class 0.000 description 2
- 208000026106 cerebrovascular disease Diseases 0.000 description 2
- 239000003925 fat Substances 0.000 description 2
- 229960003180 glutathione Drugs 0.000 description 2
- 235000003969 glutathione Nutrition 0.000 description 2
- 235000011187 glycerol Nutrition 0.000 description 2
- 239000008187 granular material Substances 0.000 description 2
- 241000411851 herbal medicine Species 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 229940057995 liquid paraffin Drugs 0.000 description 2
- 239000012454 non-polar solvent Substances 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 239000003208 petroleum Substances 0.000 description 2
- 201000011461 pre-eclampsia Diseases 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 235000019149 tocopherols Nutrition 0.000 description 2
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 2
- QUEDXNHFTDJVIY-UHFFFAOYSA-N γ-tocopherol Chemical class OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 QUEDXNHFTDJVIY-UHFFFAOYSA-N 0.000 description 2
- WSLDOOZREJYCGB-UHFFFAOYSA-N 1,2-Dichloroethane Chemical compound ClCCCl WSLDOOZREJYCGB-UHFFFAOYSA-N 0.000 description 1
- 206010002091 Anaesthesia Diseases 0.000 description 1
- 206010002383 Angina Pectoris Diseases 0.000 description 1
- 108010053835 Catalase Proteins 0.000 description 1
- 108030002440 Catalase peroxidases Proteins 0.000 description 1
- 206010014561 Emphysema Diseases 0.000 description 1
- 239000002714 Extracts of rosemary Substances 0.000 description 1
- 208000004930 Fatty Liver Diseases 0.000 description 1
- 201000005569 Gout Diseases 0.000 description 1
- 206010019708 Hepatic steatosis Diseases 0.000 description 1
- 206010019728 Hepatitis alcoholic Diseases 0.000 description 1
- 208000000563 Hyperlipoproteinemia Type II Diseases 0.000 description 1
- LPHGQDQBBGAPDZ-UHFFFAOYSA-N Isocaffeine Natural products CN1C(=O)N(C)C(=O)C2=C1N(C)C=N2 LPHGQDQBBGAPDZ-UHFFFAOYSA-N 0.000 description 1
- 102100024640 Low-density lipoprotein receptor Human genes 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 206010037765 Radiation pneumonitis Diseases 0.000 description 1
- 206010038933 Retinopathy of prematurity Diseases 0.000 description 1
- 208000000453 Skin Neoplasms Diseases 0.000 description 1
- 206010045261 Type IIa hyperlipidaemia Diseases 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 208000002353 alcoholic hepatitis Diseases 0.000 description 1
- 230000037005 anaesthesia Effects 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- 235000013361 beverage Nutrition 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000000601 blood cell Anatomy 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 210000005252 bulbus oculi Anatomy 0.000 description 1
- 229960001948 caffeine Drugs 0.000 description 1
- VJEONQKOZGKCAK-UHFFFAOYSA-N caffeine Natural products CN1C(=O)N(C)C(=O)C2=C1C=CN2C VJEONQKOZGKCAK-UHFFFAOYSA-N 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 229940084030 carboxymethylcellulose calcium Drugs 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 206010008118 cerebral infarction Diseases 0.000 description 1
- 208000019425 cirrhosis of liver Diseases 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 210000004087 cornea Anatomy 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 201000009101 diabetic angiopathy Diseases 0.000 description 1
- 201000002249 diabetic peripheral angiopathy Diseases 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 239000008157 edible vegetable oil Substances 0.000 description 1
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 235000019306 extracts of rosemary Nutrition 0.000 description 1
- 210000001508 eye Anatomy 0.000 description 1
- 201000001386 familial hypercholesterolemia Diseases 0.000 description 1
- 208000010706 fatty liver disease Diseases 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 235000013373 food additive Nutrition 0.000 description 1
- 239000002778 food additive Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- 239000007903 gelatin capsule Substances 0.000 description 1
- 235000021552 granulated sugar Nutrition 0.000 description 1
- 229960003132 halothane Drugs 0.000 description 1
- 210000002216 heart Anatomy 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 208000006454 hepatitis Diseases 0.000 description 1
- 231100000283 hepatitis Toxicity 0.000 description 1
- 235000012907 honey Nutrition 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 230000003859 lipid peroxidation Effects 0.000 description 1
- 210000005228 liver tissue Anatomy 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 150000004667 medium chain fatty acids Chemical class 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 239000011259 mixed solution Substances 0.000 description 1
- 208000010125 myocardial infarction Diseases 0.000 description 1
- 208000031225 myocardial ischemia Diseases 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 239000001566 pimenta officinalis powder Substances 0.000 description 1
- 210000003240 portal vein Anatomy 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- 201000000849 skin cancer Diseases 0.000 description 1
- 231100000240 steatosis hepatitis Toxicity 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 235000010384 tocopherol Nutrition 0.000 description 1
- 229960001295 tocopherol Drugs 0.000 description 1
- 239000000052 vinegar Substances 0.000 description 1
- 235000021419 vinegar Nutrition 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP59081649A JPS60224629A (ja) | 1984-04-23 | 1984-04-23 | 生体内過酸化脂質生成抑制剤組成物 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP59081649A JPS60224629A (ja) | 1984-04-23 | 1984-04-23 | 生体内過酸化脂質生成抑制剤組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS60224629A JPS60224629A (ja) | 1985-11-09 |
| JPH053453B2 true JPH053453B2 (fr) | 1993-01-14 |
Family
ID=13752183
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP59081649A Granted JPS60224629A (ja) | 1984-04-23 | 1984-04-23 | 生体内過酸化脂質生成抑制剤組成物 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS60224629A (fr) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010510271A (ja) * | 2006-11-24 | 2010-04-02 | ディーエスエム アイピー アセッツ ビー．ブイ． | ローズマリー抽出物、これらを含有する食品および医薬品組成物、ならびにその使用 |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3283274B2 (ja) * | 1991-06-15 | 2002-05-20 | サントリー株式会社 | 新規組成物 |
| WO1995005838A1 (fr) * | 1993-08-20 | 1995-03-02 | Scottish Agricultural College | Effets benefiques d'huiles volatiles d'origine vegetale |
| CN1068505C (zh) * | 1994-09-18 | 2001-07-18 | 陕西韩城花椒精厂 | 花椒精及其生产工艺 |
| JPH09308402A (ja) * | 1996-05-23 | 1997-12-02 | Pola Chem Ind Inc | 新規ブロードリーフセージ及びそのエッセンスを含有する組成物 |
| JPH10195433A (ja) * | 1996-12-27 | 1998-07-28 | Nippon Nouken:Kk | 抗酸化剤 |
| US6855349B2 (en) | 1998-12-07 | 2005-02-15 | Kemin Industries, Inc. | Method for simultaneous extraction of essential oils and antioxidants from Labiatae species and the extract products thereof |
| US6450935B1 (en) | 2000-10-13 | 2002-09-17 | Kemin Industries, Inc. | Method for removing essential oils and antioxidants from extract products of lamiaceae species using rolled film evaporation |
| WO2002062365A1 (fr) * | 2001-02-01 | 2002-08-15 | Meiji Seika Kaisha, Ltd. | Procede de production d'un extrait vegetal de lamiacee contenant des phenols, et utilisation de ce dernier |
| KR100478136B1 (ko) * | 2001-10-24 | 2005-03-21 | 주식회사 내츄로바이오텍 | 항산화 활성을 가지는 식물유래 추출물 |
| EP1515737B1 (fr) * | 2002-06-24 | 2005-10-12 | Anthony Devasia Joseph | Preparation nutraceutique ayurvedique |
| JP2007045751A (ja) * | 2005-08-10 | 2007-02-22 | Unitika Ltd | 肝機能賦活剤 |
| WO2014126199A1 (fr) * | 2013-02-18 | 2014-08-21 | アークレイ株式会社 | Agent augmentant l'activité protéine oxydée hydrolase |
| CN110974730A (zh) * | 2019-09-27 | 2020-04-10 | 中山大学新华学院 | 一种抗氧化的复方肉桂精油及应用 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5673025A (en) * | 1979-11-20 | 1981-06-17 | Osaka Chem Lab | Metabolism exciting agent |
| JPS57165400A (en) * | 1981-04-01 | 1982-10-12 | Osaka Chem Lab | Saponin of astragali radix and its separation |
| JPS5916830A (ja) * | 1982-07-19 | 1984-01-28 | Osaka Chem Lab | グルコ−ス吸収抑制剤 |
| JPS59145547A (ja) * | 1984-01-26 | 1984-08-21 | Denki Kagaku Kogyo Kk | 放熱シ−トの製造法 |
-
1984
- 1984-04-23 JP JP59081649A patent/JPS60224629A/ja active Granted
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5673025A (en) * | 1979-11-20 | 1981-06-17 | Osaka Chem Lab | Metabolism exciting agent |
| JPS57165400A (en) * | 1981-04-01 | 1982-10-12 | Osaka Chem Lab | Saponin of astragali radix and its separation |
| JPS5916830A (ja) * | 1982-07-19 | 1984-01-28 | Osaka Chem Lab | グルコ−ス吸収抑制剤 |
| JPS59145547A (ja) * | 1984-01-26 | 1984-08-21 | Denki Kagaku Kogyo Kk | 放熱シ−トの製造法 |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010510271A (ja) * | 2006-11-24 | 2010-04-02 | ディーエスエム アイピー アセッツ ビー．ブイ． | ローズマリー抽出物、これらを含有する食品および医薬品組成物、ならびにその使用 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS60224629A (ja) | 1985-11-09 |
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