JPH0481992B2 - - Google Patents

Info

Publication number
JPH0481992B2
JPH0481992B2 JP60003696A JP369685A JPH0481992B2 JP H0481992 B2 JPH0481992 B2 JP H0481992B2 JP 60003696 A JP60003696 A JP 60003696A JP 369685 A JP369685 A JP 369685A JP H0481992 B2 JPH0481992 B2 JP H0481992B2
Authority
JP
Japan
Prior art keywords
piperazine
benzhydryl
pharmaceutically acceptable
addition salt
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP60003696A
Other languages
English (en)
Japanese (ja)
Other versions
JPS61161272A (ja
Inventor
Hiroshi Ootaka
Toshiro Kanazawa
Keizo Ito
Goro Tsukamoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kanebo Ltd
Original Assignee
Kanebo Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kanebo Ltd filed Critical Kanebo Ltd
Priority to JP60003696A priority Critical patent/JPS61161272A/ja
Priority to NO855383A priority patent/NO164170C/no
Priority to US06/815,452 priority patent/US4703048A/en
Priority to EP86100017A priority patent/EP0187639B1/en
Priority to CA000498854A priority patent/CA1255313A/en
Priority to AT86100017T priority patent/ATE63114T1/de
Priority to DE8686100017T priority patent/DE3678970D1/de
Priority to GR860045A priority patent/GR860045B/el
Priority to FI860098A priority patent/FI860098A7/fi
Priority to ES550781A priority patent/ES8708213A1/es
Publication of JPS61161272A publication Critical patent/JPS61161272A/ja
Publication of JPH0481992B2 publication Critical patent/JPH0481992B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP60003696A 1985-01-11 1985-01-11 新規なピペラジン誘導体および該化合物を有効成分とする医薬組成物 Granted JPS61161272A (ja)

Priority Applications (10)

Application Number Priority Date Filing Date Title
JP60003696A JPS61161272A (ja) 1985-01-11 1985-01-11 新規なピペラジン誘導体および該化合物を有効成分とする医薬組成物
NO855383A NO164170C (no) 1985-01-11 1985-12-30 Analogifremgangsmaate for fremstilling av terapeutisk aktive 1-benzhydryl-4-cinnamyl-piperazinderivater.
US06/815,452 US4703048A (en) 1985-01-11 1985-12-31 Novel 1-benzhydryl-4-cinnamylpiperazine derivatives, and pharmaceutical compositions comprising said compounds as active ingredient for treating a cerebrovascular disease
EP86100017A EP0187639B1 (en) 1985-01-11 1986-01-02 Novel piperazine derivatives, processes for production thereof, and pharmaceutical compositions comprising said compounds as active ingredient
CA000498854A CA1255313A (en) 1985-01-11 1986-01-02 Piperazines derivatives, processes for production thereof, and pharmaceutical compositions comprising said compounds as active ingredient
AT86100017T ATE63114T1 (de) 1985-01-11 1986-01-02 Piperazinderivate, verfahren zu ihrer herstellung und diese als wirkstoffe enthaltende pharmazeutische zusammensetzungen.
DE8686100017T DE3678970D1 (de) 1985-01-11 1986-01-02 Piperazinderivate, verfahren zu ihrer herstellung und diese als wirkstoffe enthaltende pharmazeutische zusammensetzungen.
GR860045A GR860045B (en) 1985-01-11 1986-01-09 Novel piperazine derivatives processes for production thereof and pharmaceutical compositions comprising said compounds as active ingredient
FI860098A FI860098A7 (fi) 1985-01-11 1986-01-09 Uusia piperatsiinijohdannaisia, menetelmä niiden valmistamiseksi ja farmaseuttiset koostumukset, jotkasisältävät näitä yhdisteitä.
ES550781A ES8708213A1 (es) 1985-01-11 1986-01-10 Un procedimiento para preparar un derivado de 1-benzhidril--4-cinamilpiperazina

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP60003696A JPS61161272A (ja) 1985-01-11 1985-01-11 新規なピペラジン誘導体および該化合物を有効成分とする医薬組成物

Publications (2)

Publication Number Publication Date
JPS61161272A JPS61161272A (ja) 1986-07-21
JPH0481992B2 true JPH0481992B2 (en, 2012) 1992-12-25

Family

ID=11564541

Family Applications (1)

Application Number Title Priority Date Filing Date
JP60003696A Granted JPS61161272A (ja) 1985-01-11 1985-01-11 新規なピペラジン誘導体および該化合物を有効成分とする医薬組成物

Country Status (10)

Country Link
US (1) US4703048A (en, 2012)
EP (1) EP0187639B1 (en, 2012)
JP (1) JPS61161272A (en, 2012)
AT (1) ATE63114T1 (en, 2012)
CA (1) CA1255313A (en, 2012)
DE (1) DE3678970D1 (en, 2012)
ES (1) ES8708213A1 (en, 2012)
FI (1) FI860098A7 (en, 2012)
GR (1) GR860045B (en, 2012)
NO (1) NO164170C (en, 2012)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62277370A (ja) * 1986-02-04 1987-12-02 Terumo Corp ジエン誘導体およびこれを含有する血管拡張剤
IT1197348B (it) * 1986-09-30 1988-11-30 Boehringer Biochemia Srl Cinnamilammine, processo per la loro preparazione e composizioni farmaceutiche che le contengono
FR2614021B1 (fr) * 1987-04-14 1991-03-01 Andre Buzas Derives de la 1-((1,1-diphenyl)-1-alcenyl)-piperazine, procede d'obtention et compositions pharmaceutiques les contenant
EP3670498A1 (en) * 2018-12-17 2020-06-24 Gottfried Wilhelm Leibniz Universität Hannover Compounds for treatment of hepaci virus infection and method for determining therapy of hepaci virus infection, in particular, hcv infection

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE556791A (en, 2012) *
GB809760A (en) * 1956-04-20 1959-03-04 Lab Pharmaceutica Dr C Janssen Improvements in or relating to pharmacologically active piperazine derivatives and processes for preparing them
FR805M (en, 2012) * 1960-06-30 1961-09-01
FR1303080A (fr) * 1961-07-25 1962-09-07 Science Union Et Compagnie Soc Pipérazines disubstituées
US3773939A (en) * 1971-11-24 1973-11-20 Janssen Pharmaceutica Nv N-arallyl-n'-aralkyl piperazine pharmaceutical compositions
JPS5331159B2 (en, 2012) * 1973-08-08 1978-08-31
JPS606946B2 (ja) * 1974-03-12 1985-02-21 東京田辺製薬株式会社 Ｎ−（３，３−ジフエニルプロピル）−ｎ’−アラルキル置換ピペラジンおよびその塩の製法
DE2502679C3 (de) * 1975-01-23 1981-07-23 Ludwig Merckle Kg Chem. Pharm. Fabrik, 7902 Blaubeuren Phenoxyalkancarbonsäurederivate, Verfahren zu ihrer Herstellung und Arzneimittel
CH605873A5 (en) * 1975-12-02 1978-10-13 Chemosynth Ag Antihistaminic 1-benzhydryl-4-cinnamyl-piperazine prodn.
JPS59101475A (ja) * 1982-12-02 1984-06-12 Nippon Chemiphar Co Ltd 新規ピペラジン誘導体およびその製造法ならびにこれを含有する脳循環改善剤
IT1213131B (it) * 1984-02-02 1989-12-14 Yason Srl Composto ad attivita' calcio antagonista periferica, anticonvulsivante ed eumetabolica cerebrale,metodo per la sua preparazione e composizioni farmaceutiche.
JPS60222472A (ja) * 1984-03-30 1985-11-07 Kanebo Ltd 新規なピペラジン誘導体および該化合物を有効成分とする医薬組成物

Also Published As

Publication number Publication date
NO164170C (no) 1990-09-05
GR860045B (en) 1986-05-12
NO855383L (no) 1986-07-14
US4703048A (en) 1987-10-27
FI860098A0 (fi) 1986-01-09
FI860098L (fi) 1986-07-12
EP0187639B1 (en) 1991-05-02
DE3678970D1 (de) 1991-06-06
ES550781A0 (es) 1987-10-01
ATE63114T1 (de) 1991-05-15
JPS61161272A (ja) 1986-07-21
FI860098A7 (fi) 1986-07-12
CA1255313A (en) 1989-06-06
EP0187639A1 (en) 1986-07-16
NO164170B (no) 1990-05-28
ES8708213A1 (es) 1987-10-01

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