JPH0474338B2 - - Google Patents

Info

Publication number
JPH0474338B2
JPH0474338B2 JP59159281A JP15928184A JPH0474338B2 JP H0474338 B2 JPH0474338 B2 JP H0474338B2 JP 59159281 A JP59159281 A JP 59159281A JP 15928184 A JP15928184 A JP 15928184A JP H0474338 B2 JPH0474338 B2 JP H0474338B2
Authority
JP
Japan
Prior art keywords
hemoglobin
liposomes
solution
dialysis
inhibitor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP59159281A
Other languages
English (en)
Japanese (ja)
Other versions
JPS6137735A (ja
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Priority to JP15928184A priority Critical patent/JPS6137735A/ja
Priority to EP85109515A priority patent/EP0170247B1/en
Priority to DE8585109515T priority patent/DE3579865D1/de
Publication of JPS6137735A publication Critical patent/JPS6137735A/ja
Publication of JPH0474338B2 publication Critical patent/JPH0474338B2/ja
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/41—Porphyrin- or corrin-ring-containing peptides
    • A61K38/42—Haemoglobins; Myoglobins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dispersion Chemistry (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP15928184A 1984-07-31 1984-07-31 ヘモグロビン含有リポソ−ムおよびその製造方法 Granted JPS6137735A (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP15928184A JPS6137735A (ja) 1984-07-31 1984-07-31 ヘモグロビン含有リポソ−ムおよびその製造方法
EP85109515A EP0170247B1 (en) 1984-07-31 1985-07-29 Hemoglobin-containing liposomes and process for preparing the same
DE8585109515T DE3579865D1 (de) 1984-07-31 1985-07-29 Haemoglobin-enthaltende liposomen und ein verfahren zu ihrer herstellung.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP15928184A JPS6137735A (ja) 1984-07-31 1984-07-31 ヘモグロビン含有リポソ−ムおよびその製造方法

Publications (2)

Publication Number Publication Date
JPS6137735A JPS6137735A (ja) 1986-02-22
JPH0474338B2 true JPH0474338B2 (https=) 1992-11-26

Family

ID=15690365

Family Applications (1)

Application Number Title Priority Date Filing Date
JP15928184A Granted JPS6137735A (ja) 1984-07-31 1984-07-31 ヘモグロビン含有リポソ−ムおよびその製造方法

Country Status (3)

Country Link
EP (1) EP0170247B1 (https=)
JP (1) JPS6137735A (https=)
DE (1) DE3579865D1 (https=)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2597367B1 (fr) * 1986-04-22 1988-07-15 Oreal Procede pour faciliter la formation de spherules lipidiques en dispersion dans une phase aqueuse et pour ameliorer leur stabilite et leur taux d'encapsulation, et dispersions correspondantes.
US4776991A (en) * 1986-08-29 1988-10-11 The United States Of America As Represented By The Secretary Of The Navy Scaled-up production of liposome-encapsulated hemoglobin
JPS63211230A (ja) * 1987-02-27 1988-09-02 Terumo Corp ヘモグロビン含有リポソ−ム
JPS6461426A (en) * 1987-08-31 1989-03-08 Terumo Corp Artificial erythrocyte
JP2916684B2 (ja) * 1988-03-04 1999-07-05 武田薬品工業株式会社 リポソーム製剤の精製法
JPH0661459B2 (ja) * 1988-09-26 1994-08-17 テルモ株式会社 リポソームおよびその製法
EP0615747B1 (en) * 1993-03-18 1999-09-29 Terumo Kabushiki Kaisha Hemoglobin-encapsulating liposome and method for making the same
US5674528A (en) * 1994-06-15 1997-10-07 Terumo Kabushiki Kaisha Hemoglobin-encapsulated liposome
KR100674690B1 (ko) * 1999-07-01 2007-01-25 시스멕스 가부시키가이샤 헤모글로빈 안정화수단
US20040077604A1 (en) 2001-12-19 2004-04-22 Lenard Lichtenberger Method and compositions employing formulations of lecithin oils and nsaids for protecting the gastrointestinal tract and providingenhanced therapeutic activity
GB0111279D0 (en) * 2001-05-10 2001-06-27 Nycomed Imaging As Radiolabelled liposomes
EP1585504A4 (en) * 2002-11-06 2009-07-15 Azaya Therapeutics Inc Protein stabilized liposomal formulations of pharmaceutical active ingredients
JP2004307404A (ja) 2003-04-08 2004-11-04 Nipro Corp 人工酸素運搬体を含む医薬組成物
CN104261576A (zh) * 2014-09-30 2015-01-07 北京建筑材料科学研究总院有限公司 一种洗灰水在蒸发结晶器中的阻垢防垢方法及装置

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB658060A (en) * 1948-06-23 1951-10-03 Sharp & Dohme Inc Pharmaceutical compositions and their preparation
GB1578776A (en) * 1976-06-10 1980-11-12 Univ Illinois Hemoglobin liposome and method of making the same

Also Published As

Publication number Publication date
JPS6137735A (ja) 1986-02-22
EP0170247A2 (en) 1986-02-05
EP0170247B1 (en) 1990-09-26
DE3579865D1 (de) 1990-10-31
EP0170247A3 (en) 1986-05-14

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