JPH0413358B2 - - Google Patents

Info

Publication number
JPH0413358B2
JPH0413358B2 JP59208789A JP20878984A JPH0413358B2 JP H0413358 B2 JPH0413358 B2 JP H0413358B2 JP 59208789 A JP59208789 A JP 59208789A JP 20878984 A JP20878984 A JP 20878984A JP H0413358 B2 JPH0413358 B2 JP H0413358B2
Authority
JP
Japan
Prior art keywords
propioxatin
enkephalinase
solution
kitasatosporia
manufactured
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP59208789A
Other languages
English (en)
Japanese (ja)
Other versions
JPS6188884A (ja
Inventor
Yoshinori Inaoka
Hideji Takahashi
Hidetsune Tamaoki
Ryuzo Enokida
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Priority to JP59208789A priority Critical patent/JPS6188884A/ja
Priority to US06/782,524 priority patent/US4804676A/en
Priority to ES547630A priority patent/ES8701228A1/es
Priority to DE8585307127T priority patent/DE3586935T2/de
Priority to EP85307127A priority patent/EP0177366B1/en
Priority to AT85307127T priority patent/ATE84045T1/de
Priority to CA000492328A priority patent/CA1277623C/en
Publication of JPS6188884A publication Critical patent/JPS6188884A/ja
Publication of JPH0413358B2 publication Critical patent/JPH0413358B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP59208789A 1984-10-04 1984-10-04 エンケフアリナ−ゼｂ阻害物質およびその製法 Granted JPS6188884A (ja)

Priority Applications (7)

Application Number Priority Date Filing Date Title
JP59208789A JPS6188884A (ja) 1984-10-04 1984-10-04 エンケフアリナ−ゼｂ阻害物質およびその製法
US06/782,524 US4804676A (en) 1984-10-04 1985-10-01 Enkephalinase B inhibitors, their preparation, and pharmaceutical compositions containing the same
ES547630A ES8701228A1 (es) 1984-10-04 1985-10-04 Un metodo para producir una propioxantina
DE8585307127T DE3586935T2 (de) 1984-10-04 1985-10-04 Hemmungsstoffe enkephalinase-b deren herstellung und deren pharmazeutische zusammensetzungen.
EP85307127A EP0177366B1 (en) 1984-10-04 1985-10-04 Enkephalinase b inhibitors, their preparation, and pharmaceutical compositions containing the same
AT85307127T ATE84045T1 (de) 1984-10-04 1985-10-04 Hemmungsstoffe enkephalinase-b deren herstellung und deren pharmazeutische zusammensetzungen.
CA000492328A CA1277623C (en) 1984-10-04 1985-10-04 Enkephalinase b inhibitors, their preparation, and pharmaceutical compositions containing the same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP59208789A JPS6188884A (ja) 1984-10-04 1984-10-04 エンケフアリナ−ゼｂ阻害物質およびその製法

Publications (2)

Publication Number Publication Date
JPS6188884A JPS6188884A (ja) 1986-05-07
JPH0413358B2 true JPH0413358B2 (enExample) 1992-03-09

Family

ID=16562134

Family Applications (1)

Application Number Title Priority Date Filing Date
JP59208789A Granted JPS6188884A (ja) 1984-10-04 1984-10-04 エンケフアリナ−ゼｂ阻害物質およびその製法

Country Status (7)

Country Link
US (1) US4804676A (enExample)
EP (1) EP0177366B1 (enExample)
JP (1) JPS6188884A (enExample)
AT (1) ATE84045T1 (enExample)
CA (1) CA1277623C (enExample)
DE (1) DE3586935T2 (enExample)
ES (1) ES8701228A1 (enExample)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2746372B2 (ja) * 1988-03-11 1998-05-06 科研製薬株式会社 Ｆ−０３６８物質
US6559127B1 (en) * 1997-07-31 2003-05-06 Athena Neurosciences, Inc. Compounds which inhibit leukocyte adhesion mediated by VLA-4
US6939855B2 (en) 1997-07-31 2005-09-06 Elan Pharmaceuticals, Inc. Anti-inflammatory compositions and method
US6583139B1 (en) * 1997-07-31 2003-06-24 Eugene D. Thorsett Compounds which inhibit leukocyte adhesion mediated by VLA-4
US6423688B1 (en) * 1997-07-31 2002-07-23 Athena Neurosciences, Inc. Dipeptide and related compounds which inhibit leukocyte adhesion mediated by VLA-4
US6492421B1 (en) 1997-07-31 2002-12-10 Athena Neurosciences, Inc. Substituted phenylalanine type compounds which inhibit leukocyte adhesion mediated by VLA-4
US7030114B1 (en) 1997-07-31 2006-04-18 Elan Pharmaceuticals, Inc. Compounds which inhibit leukocyte adhesion mediated by VLA-4
US6362341B1 (en) 1997-07-31 2002-03-26 Athena Neurosciences, Inc. Benzyl compounds which inhibit leukocyte adhesion mediated by VLA-4
EP1237862A1 (en) * 1999-12-17 2002-09-11 Versicor, Inc. Succinate compounds, compositions and methods of use and preparation
US6797820B2 (en) 1999-12-17 2004-09-28 Vicuron Pharmaceuticals Inc. Succinate compounds, compositions and methods of use and preparation
US20040006093A1 (en) * 2000-10-17 2004-01-08 Thorsett Eugene D. Compounds which inhibit leukocyte adhesion mediated by VLA-4
AR036053A1 (es) * 2001-06-15 2004-08-04 Versicor Inc Compuestos de n-formil-hidroxilamina, un proceso para su preparacion y composiciones farmaceuticas
EP1406893B1 (en) * 2001-06-15 2007-04-18 Vicuron Pharmaceuticals, Inc. Pyrrolidine bicyclic compounds
GB0509223D0 (en) 2005-05-05 2005-06-15 Chroma Therapeutics Ltd Enzyme inhibitors
CH713803B1 (de) 2016-04-21 2023-08-15 4TEEN4 Pharmaceuticals GmbH Verfahren zur Diagnose durch Bestimmung von DPP3, Hemmer der Aktivität von DPP3 und Zusammensetzung mit einem Hemmer.
MY202502A (en) 2017-10-25 2024-05-01 4TEEN4 Pharmaceuticals GmbH Dpp3 binder directed to and binding to specific dpp3-epitopes and its use in the prevention or treatment of diseases / acute conditions that are associated with oxidative stress
EP3922993A1 (en) 2020-06-12 2021-12-15 4TEEN4 Pharmaceuticals GmbH Dpp3 in patients infected with coronavirus
MX2022011583A (es) 2020-03-16 2022-10-18 4TEEN4 Pharmaceuticals GmbH Dpp3 en pacientes infectados con coronavirus.
JP2025541138A (ja) 2022-12-15 2025-12-18 ４ティーン４ ファーマシューティカルズ ゲゼルシャフト ミット ベシュレンクテル ハフツング 重篤な患者における肺機能の改善のためのｄｐｐ３阻害剤
EP4687942A1 (en) 2023-03-29 2026-02-11 4TEEN4 Pharmaceuticals GmbH Dpp3 inhibitor for myocardial protection and prevention of myocardial injury in critically ill patients with blood pressure decline
WO2025248139A1 (en) 2024-05-31 2025-12-04 4TEEN4 Pharmaceuticals GmbH Use of adrenomedullin or fragments thereof in the treatment of a patient in need thereof
WO2026046968A1 (en) 2024-08-26 2026-03-05 4TEEN4 Pharmaceuticals GmbH Dpp3 binders for the treatment of endothelial dysfunction

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4284561A (en) * 1979-12-03 1981-08-18 E. R. Squibb & Sons, Inc. Hydroxamic acid derivatives of mercaptoacyl amino acids
JPS5697266A (en) * 1979-12-28 1981-08-05 Tanabe Seiyaku Co Ltd Proline derivative and its preparation
JPS56139455A (en) * 1980-04-02 1981-10-30 Santen Pharmaceut Co Ltd Sulfur-containing acylaminoacid
FR2518088B1 (fr) * 1981-12-16 1987-11-27 Roques Bernard Nouveaux derives d'aminoacides, et leur application therapeutique
JPS6115840A (ja) * 1984-07-03 1986-01-23 Microbial Chem Res Found 免疫賦活剤

Also Published As

Publication number Publication date
CA1277623C (en) 1990-12-11
ES547630A0 (es) 1986-11-16
EP0177366A2 (en) 1986-04-09
DE3586935D1 (de) 1993-02-11
EP0177366B1 (en) 1992-12-30
ATE84045T1 (de) 1993-01-15
EP0177366A3 (en) 1988-08-10
ES8701228A1 (es) 1986-11-16
US4804676A (en) 1989-02-14
JPS6188884A (ja) 1986-05-07
DE3586935T2 (de) 1993-07-22

Similar Documents

Publication Publication Date Title
JPH0413358B2 (enExample)
CA2310400C (en) Novel physiologically active substance sulphostin, process for producing the same, and use thereof
JPWO1999025719A1 (ja) 新規生理活性物質スルフォスチン、その製造法及びその用途
JPH02204499A (ja) ペプチド誘導体
EP0822260B1 (en) Substance fa-70d, process for producing the same, and uses thereof
US4014860A (en) Plasminostreptin (enzyme inhibitor) and method for producing it from streptomyces
JPWO1997031122A1 (ja) Ｆａ−７０ｄ物質、その製造法及びその用途
US5087614A (en) Enzyme inhibitor and method of producing the same
JP2810752B2 (ja) 新規生理活性物質サイクロオクタチン、その製造法およびその用途
JPH0144198B2 (enExample)
JP3092877B2 (ja) 新規ペプチドｓｎａ−１１５及びｓｎａ−１１５ｔ、その製造法及び新規ペプチド産生菌株
JP2858939B2 (ja) 抗生物質ａｂ３２１７ａ、ａｂ３２１７ｂ及びａｂ３２１７ｃとそれらの製造法
JP3686693B2 (ja) 新規生理活性物質ベラクチンａおよびｂとその製造法
JP3448334B2 (ja) 新規生理活性物質ピペラスタチンａおよびその製造法
JP3063941B2 (ja) ジデメチルアロサミジン及びその製造法
EP0162422A2 (en) The novel physiologically active substance foroxymithine, a process and microorganisms for its production and its use as medicament
JP3638341B2 (ja) 新規生理活性物質ＡＨＰＡ−Ｖａｌ−Ｐｈｅ、その製造法およびその用途
FI106026B (fi) Menetelmä lääkeaineena käyttökelpoisen 2-amino-4-(hydroksimetyyli)-3a,5,6,6a-tetrahydro-4H-syklopent[d]oksatsoli-4,5,6-triolin valmistamiseksi
JPS6258991A (ja) 新規抗生物質ｍｄ９４４−ａｆ１およびその製造法
JPH01272553A (ja) カルボン酸誘導体
JPS61115100A (ja) Ｄｃ−７９およびその製造法
JPH0140840B2 (enExample)
JPH01249799A (ja) 新規生理活性物質リスタチン及びその製造法
JPS6339898A (ja) 新規なペプチドｍｒ−３３−ａ物質及びその製造法
JPH03148227A (ja) 鎮痛剤