DE3586935D1 - Hemmungsstoffe enkephalinase-b deren herstellung und deren pharmazeutische zusammensetzungen. - Google Patents

Hemmungsstoffe enkephalinase-b deren herstellung und deren pharmazeutische zusammensetzungen.

Info

Publication number
DE3586935D1
DE3586935D1 DE8585307127T DE3586935T DE3586935D1 DE 3586935 D1 DE3586935 D1 DE 3586935D1 DE 8585307127 T DE8585307127 T DE 8585307127T DE 3586935 T DE3586935 T DE 3586935T DE 3586935 D1 DE3586935 D1 DE 3586935D1
Authority
DE
Germany
Prior art keywords
inhibitors
inkephalinase
production
pharmaceutical compositions
kitasatosporia
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8585307127T
Other languages
English (en)
Other versions
DE3586935T2 (de
Inventor
Yoshinori Inaoka
Shuji Takahashi
Hidetsune Tamaoki
Ryuzo Enokita
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Application granted granted Critical
Publication of DE3586935D1 publication Critical patent/DE3586935D1/de
Publication of DE3586935T2 publication Critical patent/DE3586935T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE8585307127T 1984-10-04 1985-10-04 Hemmungsstoffe enkephalinase-b deren herstellung und deren pharmazeutische zusammensetzungen. Expired - Fee Related DE3586935T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP59208789A JPS6188884A (ja) 1984-10-04 1984-10-04 エンケフアリナ−ゼｂ阻害物質およびその製法

Publications (2)

Publication Number Publication Date
DE3586935D1 true DE3586935D1 (de) 1993-02-11
DE3586935T2 DE3586935T2 (de) 1993-07-22

Family

ID=16562134

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8585307127T Expired - Fee Related DE3586935T2 (de) 1984-10-04 1985-10-04 Hemmungsstoffe enkephalinase-b deren herstellung und deren pharmazeutische zusammensetzungen.

Country Status (7)

Country Link
US (1) US4804676A (de)
EP (1) EP0177366B1 (de)
JP (1) JPS6188884A (de)
AT (1) ATE84045T1 (de)
CA (1) CA1277623C (de)
DE (1) DE3586935T2 (de)
ES (1) ES8701228A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2746372B2 (ja) * 1988-03-11 1998-05-06 科研製薬株式会社 Ｆ−０３６８物質
US6583139B1 (en) * 1997-07-31 2003-06-24 Eugene D. Thorsett Compounds which inhibit leukocyte adhesion mediated by VLA-4
US6939855B2 (en) 1997-07-31 2005-09-06 Elan Pharmaceuticals, Inc. Anti-inflammatory compositions and method
US6492421B1 (en) 1997-07-31 2002-12-10 Athena Neurosciences, Inc. Substituted phenylalanine type compounds which inhibit leukocyte adhesion mediated by VLA-4
US6423688B1 (en) * 1997-07-31 2002-07-23 Athena Neurosciences, Inc. Dipeptide and related compounds which inhibit leukocyte adhesion mediated by VLA-4
US6559127B1 (en) 1997-07-31 2003-05-06 Athena Neurosciences, Inc. Compounds which inhibit leukocyte adhesion mediated by VLA-4
US7030114B1 (en) 1997-07-31 2006-04-18 Elan Pharmaceuticals, Inc. Compounds which inhibit leukocyte adhesion mediated by VLA-4
US6362341B1 (en) 1997-07-31 2002-03-26 Athena Neurosciences, Inc. Benzyl compounds which inhibit leukocyte adhesion mediated by VLA-4
US6797820B2 (en) 1999-12-17 2004-09-28 Vicuron Pharmaceuticals Inc. Succinate compounds, compositions and methods of use and preparation
CA2393825A1 (en) * 1999-12-17 2001-06-21 Versicor, Inc. Novel succinate compounds, compositions and methods of use and preparation
US20040006093A1 (en) * 2000-10-17 2004-01-08 Thorsett Eugene D. Compounds which inhibit leukocyte adhesion mediated by VLA-4
PT1406893E (pt) * 2001-06-15 2007-07-12 Vicuron Pharm Inc Compostos bicíclicos de pirrolidina
AR036053A1 (es) * 2001-06-15 2004-08-04 Versicor Inc Compuestos de n-formil-hidroxilamina, un proceso para su preparacion y composiciones farmaceuticas
GB0509223D0 (en) 2005-05-05 2005-06-15 Chroma Therapeutics Ltd Enzyme inhibitors
IL262472B1 (en) 2016-04-21 2024-08-01 4TEEN4 Pharmaceuticals GmbH DPP3 inhibitors for use in the treatment of diseases associated with necrosis
KR20200083509A (ko) 2017-10-25 2020-07-08 4틴4 파마슈티컬스 게엠베하 특이적 dpp3-에피토프에 대하여 지시되고 이에 결합하는 dpp3 결합제 및 산화적 스트레스와 연관되는 질환 / 급성 병태의 예방 또는 치료에서의 그의 용도
JP2023518731A (ja) 2020-03-16 2023-05-08 ４ティーン４ ファーマシューティカルズ ゲゼルシャフト ミット ベシュレンクテル ハフツング コロナウイルスに感染した患者におけるｄｐｐ３
EP3922993A1 (de) 2020-06-12 2021-12-15 4TEEN4 Pharmaceuticals GmbH Dpp3 bei patienten, die mit coronavirus infiziert sind
WO2024126793A1 (en) 2022-12-15 2024-06-20 4TEEN4 Pharmaceuticals GmbH Dpp3 inhibitor for improvement of pulmonary function in critically ill patients

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4284561A (en) * 1979-12-03 1981-08-18 E. R. Squibb & Sons, Inc. Hydroxamic acid derivatives of mercaptoacyl amino acids
JPS5697266A (en) * 1979-12-28 1981-08-05 Tanabe Seiyaku Co Ltd Proline derivative and its preparation
JPS56139455A (en) * 1980-04-02 1981-10-30 Santen Pharmaceut Co Ltd Sulfur-containing acylaminoacid
FR2518088B1 (fr) * 1981-12-16 1987-11-27 Roques Bernard Nouveaux derives d'aminoacides, et leur application therapeutique
JPS6115840A (ja) * 1984-07-03 1986-01-23 Microbial Chem Res Found 免疫賦活剤

Also Published As

Publication number Publication date
DE3586935T2 (de) 1993-07-22
EP0177366A3 (en) 1988-08-10
EP0177366A2 (de) 1986-04-09
JPS6188884A (ja) 1986-05-07
EP0177366B1 (de) 1992-12-30
ES8701228A1 (es) 1986-11-16
ES547630A0 (es) 1986-11-16
JPH0413358B2 (de) 1992-03-09
ATE84045T1 (de) 1993-01-15
CA1277623C (en) 1990-12-11
US4804676A (en) 1989-02-14

Similar Documents

Publication Publication Date Title
DE3586935D1 (de) Hemmungsstoffe enkephalinase-b deren herstellung und deren pharmazeutische zusammensetzungen.
YU174490A (sh) Novi estri tienil-karboksilne kiseline sa aminoalkoholima, njihova kvaterna jedinjenja kao i pripremanje i primena tih jedinjenja
GEP20012580B (en) Substituted 4-Hydroxy-Phenylalcanoic Acid Derivatives With Agonist Activity to PPAR-Gamma, Methods for Their Production, Pharmaceutical Conposition and Methods for Treatment
DE69939532D1 (de) Gamma-aminobuttersäurederivate enthaltende, feste arzneimittel und verfahren zu ihrer herstellung
AR031828A2 (es) Procedimientos para la preparacion de compuestos espiro-azabiciclicos utiles en terapia
FR2692264B1 (fr) Nouvelles piperazines 1,4-disubstituees, leur procede de preparation et les compositions pharmaceutiques les contenant.
ATE229017T1 (de) Farnesyltransferase-inhibitoren mit piperidinstruktur und verfahren zu ihrer herstellung
BG60102B2 (bg) Метод за получаване на 5-флуор-2(((4-циклопропил- метокси-2-пиридинил)метил)тионил)-1н-бензимидазол
OA09039A (fr) Acides 3-alcenyl-1-azabicyclo(3.2.0)hep-2-ene-2carboxyliques
GB2071088B (en) Indane derivatives
ES449162A1 (es) Un procedimiento para la preparacion de un compuesto racemi-co u 8r-antimerico.
FR2601259B1 (fr) Nouvelles compositions tensio-actives a base d'esters phosphoriques leur procede de preparation et leur application a la formulation de matieres actives.
DE69818286D1 (de) Pyridylverbindungen und diese enthaltende pharmazeutische zubereitungen
GEP20043162B (en) Derivatives of Isosorbid Mononitrate, Utilization as Vasodilator Agents with Reduced Tolerance
ES8702427A1 (es) Un procedimiento para preparar derivados de 1,3-difosfonato
ES2143833T3 (es) Acidos y esteres de la diosmetina y composiciones farmaceuticas que los contienen.
ATE27270T1 (de) Thioester von acetylsalicylsaeure, ein verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen.
IT1164387B (it) Derivati n-sostituiti dell'1-(4'-alchilsulfonilfenil)-2-ammino-1,3-propandiolo
ES8505332A1 (es) Procedimiento para la fabricacion de derivados del acido benzoico con actividad antimicrobiana
FR2597097B1 (fr) Derives de benzothiazepine-1, 5, leur preparation et leur application en therapeutique
DE3570249D1 (en) Enzyme-inhibitory griseolic acid derivatives, and their use
ATE50248T1 (de) Ein imidazolidintrion-derivat oder ein seiner pharmazeutisch akzeptierbaren salze enthaltende pharmazeutische zusammenstellung.
FR2540498B1 (fr) Nouveaux medicaments derives d'amides d'acide mercaptoacetique et de l'acide 3-mercaptopropionique et les compositions pharmaceutiques les renfermant
DE3466981D1 (de) 1-(4'-alkylthiophenyl)-2-amino-1,3-propanediol n-substituted derivatives
IT1228537B (it) Derivati della cisteina ad azione espettorante

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee