JPH0368022B2 - - Google Patents

Info

Publication number
JPH0368022B2
JPH0368022B2 JP61108889A JP10888986A JPH0368022B2 JP H0368022 B2 JPH0368022 B2 JP H0368022B2 JP 61108889 A JP61108889 A JP 61108889A JP 10888986 A JP10888986 A JP 10888986A JP H0368022 B2 JPH0368022 B2 JP H0368022B2
Authority
JP
Japan
Prior art keywords
group
mmol
binap
yield
tetrahydroisoquinoline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP61108889A
Other languages
English (en)
Japanese (ja)
Other versions
JPS62265266A (ja
Inventor
Ryoji Noyori
Masahito Kitamura
Hidemasa Takatani
Hidenori Kumobayashi
Susumu Akutagawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takasago International Corp
Original Assignee
Takasago Perfumery Industry Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takasago Perfumery Industry Co filed Critical Takasago Perfumery Industry Co
Priority to JP61108889A priority Critical patent/JPS62265266A/ja
Priority to DE8787303217T priority patent/DE3780704T2/de
Priority to EP87303217A priority patent/EP0245960B1/en
Priority to US07/038,571 priority patent/US4851537A/en
Publication of JPS62265266A publication Critical patent/JPS62265266A/ja
Publication of JPH0368022B2 publication Critical patent/JPH0368022B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals
    • C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)
JP61108889A 1986-05-13 1986-05-13 Ｎ−アシル−テトラヒドロイソキノリン類の製造法 Granted JPS62265266A (ja)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP61108889A JPS62265266A (ja) 1986-05-13 1986-05-13 Ｎ−アシル−テトラヒドロイソキノリン類の製造法
DE8787303217T DE3780704T2 (de) 1986-05-13 1987-04-13 Verfahren zur herstellung von n-acyltetrahydroisochinoline.
EP87303217A EP0245960B1 (en) 1986-05-13 1987-04-13 Process for preparing n-acyltetrahydroisoquinoline
US07/038,571 US4851537A (en) 1986-05-13 1987-04-15 Process for preparing N-acyltetrahydroisoquinoline

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP61108889A JPS62265266A (ja) 1986-05-13 1986-05-13 Ｎ−アシル−テトラヒドロイソキノリン類の製造法

Publications (2)

Publication Number Publication Date
JPS62265266A JPS62265266A (ja) 1987-11-18
JPH0368022B2 true JPH0368022B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1991-10-25

Family

ID=14496171

Family Applications (1)

Application Number Title Priority Date Filing Date
JP61108889A Granted JPS62265266A (ja) 1986-05-13 1986-05-13 Ｎ−アシル−テトラヒドロイソキノリン類の製造法

Country Status (4)

Country Link
US (1) US4851537A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EP (1) EP0245960B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JPS62265266A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE3780704T2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3879551T2 (de) * 1987-06-16 1993-07-08 Hoffmann La Roche Hydrogenationsverfahren.
DK168069B1 (da) * 1987-11-11 1994-01-31 Hoffmann La Roche Isoquinolinderivater og en fremgangsmaade til fremstilling af octahydroisoquinoliner ud fra derivaterne
JPH02276A (ja) * 1987-11-25 1990-01-05 Sankyo Co Ltd β−ラクタム化合物の製造法
DK0397042T3 (da) * 1989-05-10 1995-10-02 Hoffmann La Roche Fremstilling af isoquinolinderivater
US5362736A (en) * 1991-02-27 1994-11-08 Banyu Pharmaceutical Co., Ltd. Isoquinoline derivatives
US5238935A (en) * 1991-05-20 1993-08-24 Schering Corporation N-acyl-tetrahydroisoquinolines as inhibitors of acyl-coenzyme A: cholesterol acyl transferase
US5124337A (en) * 1991-05-20 1992-06-23 Schering Corporation N-acyl-tetrahydroisoquinolines as inhibitors of acyl-coenzyme a:cholesterol acyl transferase
ATE380172T1 (de) * 2001-01-26 2007-12-15 Btg Int Ltd Benzylaminanalogen
AU2007332772B2 (en) * 2006-12-12 2012-08-30 SpecGx LLC Preparation of tetrahydroisoquinolines from dihydroisoquinolines
BRPI0808272A2 (pt) * 2007-03-08 2014-07-08 Chemagis Ltd "método para cromatograficamente separar o isômero 1r-cis, 1´r-cis de uma mistura de isômeros de (1r-1'r) - atracúrio, besilato de cisatracúrio e isômero 1r-cis, 1'r-cis do besilato de cisatracúrio"
AU2008231470A1 (en) * 2007-03-26 2008-10-02 Chemagis Ltd. (1R,1'R)-atracurium salts separation process
AU2008273724B2 (en) * 2007-05-01 2013-05-23 Chemagis Ltd. Process for Producing Cisatracurium and Associated Intermediates
EP2155684B1 (en) * 2007-05-01 2014-04-09 Chemagis Ltd. Process for producing cisatracurium compounds and associated intermediates
AU2008264802A1 (en) * 2007-06-18 2008-12-24 Chemagis Ltd. (1R,1'R)-atracurium salts separation process
EP2176227A1 (en) * 2007-07-09 2010-04-21 Chemagis Ltd. Process for producing cisatracurium and associated intermediates
WO2009057086A1 (en) * 2007-10-29 2009-05-07 Chemagis Ltd. Novel r,r'-atracurium salts
EP2283005A4 (en) * 2008-05-01 2011-08-31 Chemagis Ltd CISATRACURIUM DERIVATIVES, PREPARATION AND USES THEREOF

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1250828B (de) * 1962-10-10 1967-09-28 Chinoin Gyogyszer es Vegyeszeti Termekek Gyära R.T., Budapest Verfahren zur Herstellung des spasmolytisch wirksamen 6,7,3',4' - Tetraäthoxy -l-benzyliden-1,2,3,4tetrahydroisochinolins und seiner Salze
JPS6163690A (ja) * 1984-09-04 1986-04-01 Takasago Corp ルテニウム−ホスフイン錯体

Also Published As

Publication number Publication date
US4851537A (en) 1989-07-25
EP0245960B1 (en) 1992-07-29
DE3780704T2 (de) 1993-01-28
DE3780704D1 (de) 1992-09-03
EP0245960A2 (en) 1987-11-19
EP0245960A3 (en) 1988-12-21
JPS62265266A (ja) 1987-11-18

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