DE3780704T2 - Verfahren zur herstellung von n-acyltetrahydroisochinoline. - Google Patents

Verfahren zur herstellung von n-acyltetrahydroisochinoline.

Info

Publication number
DE3780704T2
DE3780704T2 DE8787303217T DE3780704T DE3780704T2 DE 3780704 T2 DE3780704 T2 DE 3780704T2 DE 8787303217 T DE8787303217 T DE 8787303217T DE 3780704 T DE3780704 T DE 3780704T DE 3780704 T2 DE3780704 T2 DE 3780704T2
Authority
DE
Germany
Prior art keywords
acyltetrahydroisochinoline
producing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8787303217T
Other languages
English (en)
Other versions
DE3780704D1 (de
Inventor
Ryoji Noyori
Masato Kitamura
Hidemasa Takaya
Hidenori Kumobayashi
Susumu Akutagawa Sus Akutagawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takasago International Corp
Original Assignee
Takasago Perfumery Industry Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takasago Perfumery Industry Co filed Critical Takasago Perfumery Industry Co
Publication of DE3780704D1 publication Critical patent/DE3780704D1/de
Application granted granted Critical
Publication of DE3780704T2 publication Critical patent/DE3780704T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals
    • C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Catalysts (AREA)
DE8787303217T 1986-05-13 1987-04-13 Verfahren zur herstellung von n-acyltetrahydroisochinoline. Expired - Fee Related DE3780704T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP61108889A JPS62265266A (ja) 1986-05-13 1986-05-13 Ｎ−アシル−テトラヒドロイソキノリン類の製造法

Publications (2)

Publication Number Publication Date
DE3780704D1 DE3780704D1 (de) 1992-09-03
DE3780704T2 true DE3780704T2 (de) 1993-01-28

Family

ID=14496171

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8787303217T Expired - Fee Related DE3780704T2 (de) 1986-05-13 1987-04-13 Verfahren zur herstellung von n-acyltetrahydroisochinoline.

Country Status (4)

Country Link
US (1) US4851537A (de)
EP (1) EP0245960B1 (de)
JP (1) JPS62265266A (de)
DE (1) DE3780704T2 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0295531B1 (de) * 1987-06-16 1993-03-24 F. Hoffmann-La Roche Ag Hydrogenationsverfahren
DK168069B1 (da) * 1987-11-11 1994-01-31 Hoffmann La Roche Isoquinolinderivater og en fremgangsmaade til fremstilling af octahydroisoquinoliner ud fra derivaterne
JPH02276A (ja) * 1987-11-25 1990-01-05 Sankyo Co Ltd β−ラクタム化合物の製造法
DK0397042T3 (da) * 1989-05-10 1995-10-02 Hoffmann La Roche Fremstilling af isoquinolinderivater
US5362736A (en) * 1991-02-27 1994-11-08 Banyu Pharmaceutical Co., Ltd. Isoquinoline derivatives
US5238935A (en) * 1991-05-20 1993-08-24 Schering Corporation N-acyl-tetrahydroisoquinolines as inhibitors of acyl-coenzyme A: cholesterol acyl transferase
US5124337A (en) * 1991-05-20 1992-06-23 Schering Corporation N-acyl-tetrahydroisoquinolines as inhibitors of acyl-coenzyme a:cholesterol acyl transferase
CA2435883A1 (en) * 2001-01-26 2002-08-01 Sankyo Company, Limited Benzylamine analogue
MX2009006008A (es) * 2006-12-12 2009-06-16 Mallinckrodt Inc Preparacion de hexahidroisoquinolinas a partir de dihidroisoquinolinas.
BRPI0808272A2 (pt) * 2007-03-08 2014-07-08 Chemagis Ltd "método para cromatograficamente separar o isômero 1r-cis, 1´r-cis de uma mistura de isômeros de (1r-1'r) - atracúrio, besilato de cisatracúrio e isômero 1r-cis, 1'r-cis do besilato de cisatracúrio"
AU2008231470A1 (en) * 2007-03-26 2008-10-02 Chemagis Ltd. (1R,1'R)-atracurium salts separation process
EP2142510A1 (de) * 2007-05-01 2010-01-13 Chemagis Ltd. Neuartige isochinolin-verbindungen zur herstellung von cisatracurium und entsprechenden zwischenprodukten
CA2685491A1 (en) * 2007-05-01 2008-11-06 Chemagis Ltd. Process for producing cisatracurium compounds and associated intermediates
CA2687157A1 (en) * 2007-06-18 2008-12-24 Chemagis Ltd. (1r,1'r)-atracurium salts separation process
US20100256381A1 (en) * 2007-07-09 2010-10-07 Chemagis Ltd. Process for producing cisatracurium and associated intermediates
EP2197848A1 (de) * 2007-10-29 2010-06-23 Chemagis Ltd. Neuartige r,r'-atracurium-salze
CA2722651A1 (en) * 2008-05-01 2009-11-05 Chemagis Ltd. Cisatracurium derivatives, preparation and uses thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1250828B (de) * 1962-10-10 1967-09-28 Chinoin Gyogyszer es Vegyeszeti Termekek Gyära R.T., Budapest Verfahren zur Herstellung des spasmolytisch wirksamen 6,7,3',4' - Tetraäthoxy -l-benzyliden-1,2,3,4tetrahydroisochinolins und seiner Salze
JPS6163690A (ja) * 1984-09-04 1986-04-01 Takasago Corp ルテニウム−ホスフイン錯体

Also Published As

Publication number Publication date
EP0245960B1 (de) 1992-07-29
DE3780704D1 (de) 1992-09-03
JPS62265266A (ja) 1987-11-18
EP0245960A2 (de) 1987-11-19
EP0245960A3 (en) 1988-12-21
JPH0368022B2 (de) 1991-10-25
US4851537A (en) 1989-07-25

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee