JPH0347279B2 - - Google Patents

Info

Publication number
JPH0347279B2
JPH0347279B2 JP57189467A JP18946782A JPH0347279B2 JP H0347279 B2 JPH0347279 B2 JP H0347279B2 JP 57189467 A JP57189467 A JP 57189467A JP 18946782 A JP18946782 A JP 18946782A JP H0347279 B2 JPH0347279 B2 JP H0347279B2
Authority
JP
Japan
Prior art keywords
culture
solution
administration
medium
dose
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP57189467A
Other languages
English (en)
Japanese (ja)
Other versions
JPS5978190A (ja
Inventor
Shinzo Ishii
Shigeo Katsumata
Takemitsu Arai
Tadashi Ashizawa
Makoto Morimoto
Kimikatsu Shirahata
Yutaka Saito
Kazumichi Kono
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KH Neochem Co Ltd
Original Assignee
Kyowa Hakko Kogyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Co Ltd filed Critical Kyowa Hakko Kogyo Co Ltd
Priority to JP57189467A priority Critical patent/JPS5978190A/ja
Priority to DE8383306551T priority patent/DE3381470D1/de
Priority to US06/546,142 priority patent/US4563462A/en
Priority to EP83306551A priority patent/EP0110563B1/en
Publication of JPS5978190A publication Critical patent/JPS5978190A/ja
Publication of JPH0347279B2 publication Critical patent/JPH0347279B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/16—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/182—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP57189467A 1982-10-28 1982-10-28 新規物質ａｘ―２ Granted JPS5978190A (ja)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP57189467A JPS5978190A (ja) 1982-10-28 1982-10-28 新規物質ａｘ―２
DE8383306551T DE3381470D1 (de) 1982-10-28 1983-10-27 Anti-tumor-verbindung aus streptomyces.
US06/546,142 US4563462A (en) 1982-10-28 1983-10-27 Substance AX-2, a process for producing the same and an antitumor composition containing the same
EP83306551A EP0110563B1 (en) 1982-10-28 1983-10-27 Antitumour substance from streptomyces

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP57189467A JPS5978190A (ja) 1982-10-28 1982-10-28 新規物質ａｘ―２

Publications (2)

Publication Number Publication Date
JPS5978190A JPS5978190A (ja) 1984-05-04
JPH0347279B2 true JPH0347279B2 (enExample) 1991-07-18

Family

ID=16241755

Family Applications (1)

Application Number Title Priority Date Filing Date
JP57189467A Granted JPS5978190A (ja) 1982-10-28 1982-10-28 新規物質ａｘ―２

Country Status (4)

Country Link
US (1) US4563462A (enExample)
EP (1) EP0110563B1 (enExample)
JP (1) JPS5978190A (enExample)
DE (1) DE3381470D1 (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5220026A (en) * 1990-11-22 1993-06-15 Kyowa Hakko Kogyo Co., Ltd. Pyrazoloacridone derivatives

Also Published As

Publication number Publication date
JPS5978190A (ja) 1984-05-04
DE3381470D1 (de) 1990-05-23
EP0110563B1 (en) 1990-04-18
EP0110563A3 (en) 1986-06-25
EP0110563A2 (en) 1984-06-13
US4563462A (en) 1986-01-07

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