JPH027314B2 - - Google Patents

Info

Publication number
JPH027314B2
JPH027314B2 JP57112040A JP11204082A JPH027314B2 JP H027314 B2 JPH027314 B2 JP H027314B2 JP 57112040 A JP57112040 A JP 57112040A JP 11204082 A JP11204082 A JP 11204082A JP H027314 B2 JPH027314 B2 JP H027314B2
Authority
JP
Japan
Prior art keywords
residue
chloroform
water
benzoxazine
difluoro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP57112040A
Other languages
English (en)
Japanese (ja)
Other versions
JPS591489A (ja
Inventor
Isao Hayakawa
Yoshiaki Tanaka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Daiichi Pharmaceutical Co Ltd
Original Assignee
Daiichi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Pharmaceutical Co Ltd filed Critical Daiichi Pharmaceutical Co Ltd
Priority to JP57112040A priority Critical patent/JPS591489A/ja
Priority to PH29040A priority patent/PH22140A/en
Priority to ZA834366A priority patent/ZA834366B/xx
Priority to FI832310A priority patent/FI74283C/fi
Priority to US06/507,652 priority patent/US4539401A/en
Priority to NO832329A priority patent/NO166227C/no
Priority to ES523664A priority patent/ES8504190A1/es
Priority to IE1503/83A priority patent/IE55532B1/en
Priority to DK297583A priority patent/DK158987C/da
Priority to GR71786A priority patent/GR77524B/el
Priority to CA000431290A priority patent/CA1203802A/en
Priority to AT83106341T priority patent/ATE24511T1/de
Priority to AU16368/83A priority patent/AU555103B2/en
Priority to KR1019830002940A priority patent/KR900004145B1/ko
Priority to EP83106341A priority patent/EP0101829B1/en
Priority to DE8383106341T priority patent/DE3368637D1/de
Publication of JPS591489A publication Critical patent/JPS591489A/ja
Publication of JPH027314B2 publication Critical patent/JPH027314B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/27—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups
    • C07C205/35—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C205/36—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system
    • C07C205/37—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system the oxygen atom of at least one of the etherified hydroxy groups being further bound to an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/58—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems with hetero atoms directly attached to the ring nitrogen atom
    • C07D215/60—N-oxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP57112040A 1982-06-29 1982-06-29 ピリドベンゾオキサジン誘導体 Granted JPS591489A (ja)

Priority Applications (16)

Application Number Priority Date Filing Date Title
JP57112040A JPS591489A (ja) 1982-06-29 1982-06-29 ピリドベンゾオキサジン誘導体
PH29040A PH22140A (en) 1982-06-29 1983-06-13 Tricyclic compounds
ZA834366A ZA834366B (en) 1982-06-29 1983-06-14 Tricyclic compounds
FI832310A FI74283C (fi) 1982-06-29 1983-06-23 Foerfarande foer framstaellning av nya antibakteriella 9-fluor-10-substituerad-3-metylen-7-oxo-2,3-dihydro- 7h-pyrido(1,2,3-de)-1,4-bensoxazin-6-karboxylsyror.
US06/507,652 US4539401A (en) 1982-06-29 1983-06-27 Pyridobenzoxazine derivatives useful as antibacterial agents
NO832329A NO166227C (no) 1982-06-29 1983-06-27 Analogifremgangsmaate for fremstilling av nye antibakterielle pyrido-benzoksazin-6-karboksylsyrer.
ES523664A ES8504190A1 (es) 1982-06-29 1983-06-28 Procedimiento para la preparacion de nuevos derivados del acido quinolicincarboxilico.
IE1503/83A IE55532B1 (en) 1982-06-29 1983-06-28 Tricyclic compounds,a process for their production and pharmaceutical compositions containing said compounds
DK297583A DK158987C (da) 1982-06-29 1983-06-28 Analogifremgangsmaade til fremstilling af pyrido(1,2,3-de)-1,4-benzoxaziner eller 6,7-dihydro-1h,5h-benzo(i,j)-quinoliziner
GR71786A GR77524B (enExample) 1982-06-29 1983-06-28
CA000431290A CA1203802A (en) 1982-06-29 1983-06-28 Tricyclic compounds
AT83106341T ATE24511T1 (de) 1982-06-29 1983-06-29 Tricyclische verbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen.
AU16368/83A AU555103B2 (en) 1982-06-29 1983-06-29 Tricyclic compounds
KR1019830002940A KR900004145B1 (ko) 1982-06-29 1983-06-29 트리사이클릭 화합물의 제조방법
EP83106341A EP0101829B1 (en) 1982-06-29 1983-06-29 Tricyclic compounds, a process for their production and pharmaceutical compositions containing said compounds
DE8383106341T DE3368637D1 (en) 1982-06-29 1983-06-29 Tricyclic compounds, a process for their production and pharmaceutical compositions containing said compounds

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP57112040A JPS591489A (ja) 1982-06-29 1982-06-29 ピリドベンゾオキサジン誘導体

Related Child Applications (3)

Application Number Title Priority Date Filing Date
JP20544189A Division JPH02138281A (ja) 1989-08-08 1989-08-08 ３‐置換ピリドベンゾオキサジン
JP20544089A Division JPH02138268A (ja) 1989-08-08 1989-08-08 ベンゾオキサジン化合物
JP20543989A Division JPH02152947A (ja) 1989-08-08 1989-08-08 ジフルオロフェノキシ化合物

Publications (2)

Publication Number Publication Date
JPS591489A JPS591489A (ja) 1984-01-06
JPH027314B2 true JPH027314B2 (enExample) 1990-02-16

Family

ID=14576505

Family Applications (1)

Application Number Title Priority Date Filing Date
JP57112040A Granted JPS591489A (ja) 1982-06-29 1982-06-29 ピリドベンゾオキサジン誘導体

Country Status (3)

Country Link
US (1) US4539401A (enExample)
JP (1) JPS591489A (enExample)
ZA (1) ZA834366B (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0670032B2 (ja) * 1984-11-22 1994-09-07 大日本製薬株式会社 アミノピロリジン誘導体、そのエステルおよびその塩
JPH0228178A (ja) * 1988-04-23 1990-01-30 Toyama Chem Co Ltd 新規なピリドンカルボン酸誘導体およびその塩並びにそれらの製造法
US5104868A (en) * 1988-06-21 1992-04-14 Pfizer Inc. Tricyclic derivatives of 7-substituted-6-fluoro-1,4-dihydroquinol-4-one-3-carboxylic acids and esters
AU1688499A (en) * 1997-12-24 1999-07-19 Sankyo Company Limited Fused-ring quinolinecarboxylic acid derivatives
JPWO2006009143A1 (ja) * 2004-07-21 2008-05-01 杏林製薬株式会社 （３ｓ）−３−ヒドロキシメチル−７−オキソピリドベンゾオキサジン−６−カルボン酸エステルの製造方法
US7282487B2 (en) * 2004-10-28 2007-10-16 Idexx Laboratories Method for treating bacterial infections in horses or pigs with tilmicosin
KR101419554B1 (ko) 2006-03-13 2014-07-17 교린 세이야꾸 가부시키 가이샤 Ｇｓｋ­３ 억제제로서 아미노퀴놀론
BRPI0816798A2 (pt) 2007-09-11 2016-10-11 Activx Biosciences Inc composto, composição farmacêutica, métodos para inibir a ação do glicogênio sintase cinase-3, e para tratar, prevenir ou melhorar uma doença, uso de um composto, e, artigo de fabricação
CN101855229A (zh) 2007-09-12 2010-10-06 埃迪威克斯生物科学公司 作为gsk-3抑制剂的螺环状氨基喹诺酮
BRPI1008974A2 (pt) 2009-03-11 2017-06-06 Kyorin Seiyaku Kk composto, composição farmacêutica, e, método para tratar, prevenir ou melhorar uma doença mediada com gsk-3
CN103755722B (zh) * 2013-12-06 2016-03-30 浙江大学 一种左旋氧氟沙星及氧氟沙星的合成方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5746986A (en) * 1980-09-02 1982-03-17 Dai Ichi Seiyaku Co Ltd Pyrido(1,2,3-de)(1,4)benzoxazine derivative

Also Published As

Publication number Publication date
US4539401A (en) 1985-09-03
ZA834366B (en) 1984-03-28
JPS591489A (ja) 1984-01-06

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