JPH0258280B2 - - Google Patents
Info
- Publication number
- JPH0258280B2 JPH0258280B2 JP59100441A JP10044184A JPH0258280B2 JP H0258280 B2 JPH0258280 B2 JP H0258280B2 JP 59100441 A JP59100441 A JP 59100441A JP 10044184 A JP10044184 A JP 10044184A JP H0258280 B2 JPH0258280 B2 JP H0258280B2
- Authority
- JP
- Japan
- Prior art keywords
- phoroximitin
- culture
- medium
- cultured
- growth
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
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- GMKMEZVLHJARHF-UHFFFAOYSA-N 2,6-diaminopimelic acid Chemical compound OC(=O)C(N)CCCC(N)C(O)=O GMKMEZVLHJARHF-UHFFFAOYSA-N 0.000 description 4
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- 229930006000 Sucrose Natural products 0.000 description 4
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- FGIUAXJPYTZDNR-UHFFFAOYSA-N potassium nitrate Chemical compound [K+].[O-][N+]([O-])=O FGIUAXJPYTZDNR-UHFFFAOYSA-N 0.000 description 4
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- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 3
- SRBFZHDQGSBBOR-HWQSCIPKSA-N L-arabinopyranose Chemical compound O[C@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-HWQSCIPKSA-N 0.000 description 3
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- XEEYBQQBJWHFJM-UHFFFAOYSA-N iron Substances [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 3
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- BBBFYZOJHSYQMW-LGDQNDJISA-N (2s)-2,4-diamino-4-oxobutanoic acid;(2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanal Chemical compound OC(=O)[C@@H](N)CC(N)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O BBBFYZOJHSYQMW-LGDQNDJISA-N 0.000 description 2
- UQZSVIGPZAULMV-DKWTVANSSA-N (2s)-2,4-diamino-4-oxobutanoic acid;propane-1,2,3-triol Chemical compound OCC(O)CO.OC(=O)[C@@H](N)CC(N)=O UQZSVIGPZAULMV-DKWTVANSSA-N 0.000 description 2
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- 239000012491 analyte Substances 0.000 description 1
- 230000003276 anti-hypertensive effect Effects 0.000 description 1
- 239000002246 antineoplastic agent Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 239000011425 bamboo Substances 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 239000005018 casein Substances 0.000 description 1
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
- 235000021240 caseins Nutrition 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
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- 235000017803 cinnamon Nutrition 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 238000012136 culture method Methods 0.000 description 1
- MGNCLNQXLYJVJD-UHFFFAOYSA-N cyanuric chloride Chemical compound ClC1=NC(Cl)=NC(Cl)=N1 MGNCLNQXLYJVJD-UHFFFAOYSA-N 0.000 description 1
- 229940127089 cytotoxic agent Drugs 0.000 description 1
- 230000034994 death Effects 0.000 description 1
- 231100000517 death Toxicity 0.000 description 1
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- 229940079593 drug Drugs 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
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- 238000000921 elemental analysis Methods 0.000 description 1
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- 229940125532 enzyme inhibitor Drugs 0.000 description 1
- 239000002532 enzyme inhibitor Substances 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 239000004467 fishmeal Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 235000021312 gluten Nutrition 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
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- 229920003303 ion-exchange polymer Polymers 0.000 description 1
- 239000007951 isotonicity adjuster Substances 0.000 description 1
- BJHIKXHVCXFQLS-UYFOZJQFSA-N keto-D-fructose Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)C(=O)CO BJHIKXHVCXFQLS-UYFOZJQFSA-N 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
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- 231100000053 low toxicity Toxicity 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 1
- 235000019341 magnesium sulphate Nutrition 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 238000004949 mass spectrometry Methods 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
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- 210000004080 milk Anatomy 0.000 description 1
- 235000013379 molasses Nutrition 0.000 description 1
- LPUQAYUQRXPFSQ-UHFFFAOYSA-M monosodium glutamate Chemical compound [Na+].[O-]C(=O)C(N)CCC(O)=O LPUQAYUQRXPFSQ-UHFFFAOYSA-M 0.000 description 1
- 239000004081 narcotic agent Substances 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 230000003472 neutralizing effect Effects 0.000 description 1
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- 235000014593 oils and fats Nutrition 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 235000020232 peanut Nutrition 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 229910052697 platinum Inorganic materials 0.000 description 1
- 238000000425 proton nuclear magnetic resonance spectrum Methods 0.000 description 1
- 238000004445 quantitative analysis Methods 0.000 description 1
- 235000011121 sodium hydroxide Nutrition 0.000 description 1
- 239000004317 sodium nitrate Substances 0.000 description 1
- 235000010344 sodium nitrate Nutrition 0.000 description 1
- 239000012064 sodium phosphate buffer Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000011877 solvent mixture Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06086—Dipeptides with the first amino acid being basic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/465—Streptomyces
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Behavior & Ethology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- General Engineering & Computer Science (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Description
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Claims (1)
- ãç¹èš±è«æ±ã®ç¯å²ã ïŒ æ¬¡åŒ ã§è¡šããããæã¢ã³ãžãªãã³ã·ã³å€æé µçŽ æŽ»æ§
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ã³çç£èãå¹é€ããŠãæ¬¡åŒ ã§è¡šããããçç掻æ§ç©è³ªãã«ãªãã·ããã³ãå¹
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é æ³ã ïŒ æ¬¡åŒ ã§è¡šããããçç掻æ§ç©è³ªãã«ãªãã·ããã³åã¯
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Priority Applications (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP59100441A JPS60246399A (ja) | 1984-05-21 | 1984-05-21 | æ°çç掻æ§ç©è³ªãã«ãªãã·ããã³ããã®è£œé æ³ããã³çšé |
| HU851822A HUT38971A (en) | 1984-05-21 | 1985-05-14 | Microbiological process for preparing phoroxymytine and pharmaceutical compositions containing this compound |
| EP85106066A EP0162422A2 (en) | 1984-05-21 | 1985-05-17 | The novel physiologically active substance foroxymithine, a process and microorganisms for its production and its use as medicament |
| GR851217A GR851217B (ja) | 1984-05-21 | 1985-05-20 | |
| ES543289A ES8605584A1 (es) | 1984-05-21 | 1985-05-20 | Un procedimiento para preparar foroximitina |
| DK223385A DK223385A (da) | 1984-05-21 | 1985-05-20 | Foroxymithin, fremgangsmaade og mikroorganismer til dets fremstillingog dets anvendelse som laegemiddel |
| ZA853779A ZA853779B (en) | 1984-05-21 | 1985-05-20 | The novel physiologically active substance foroxymithine,a process and microorganisms for its production and its use as medicament |
| PT80496A PT80496B (en) | 1984-05-21 | 1985-05-21 | The novel physiologically active substance foroxymithine a process ane microorganisms for its production and its use as medicament |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP59100441A JPS60246399A (ja) | 1984-05-21 | 1984-05-21 | æ°çç掻æ§ç©è³ªãã«ãªãã·ããã³ããã®è£œé æ³ããã³çšé |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS60246399A JPS60246399A (ja) | 1985-12-06 |
| JPH0258280B2 true JPH0258280B2 (ja) | 1990-12-07 |
Family
ID=14274018
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP59100441A Granted JPS60246399A (ja) | 1984-05-21 | 1984-05-21 | æ°çç掻æ§ç©è³ªãã«ãªãã·ããã³ããã®è£œé æ³ããã³çšé |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP0162422A2 (ja) |
| JP (1) | JPS60246399A (ja) |
| DK (1) | DK223385A (ja) |
| ES (1) | ES8605584A1 (ja) |
| GR (1) | GR851217B (ja) |
| HU (1) | HUT38971A (ja) |
| PT (1) | PT80496B (ja) |
| ZA (1) | ZA853779B (ja) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115340961B (zh) * | 2022-04-26 | 2023-05-16 | æµæ±åžèå€§åŠ | æ®ææ°Žçš»ç»èæ§æ¡æç èçæ²é¿éçŽ éŸéèåå ¶åºçš |
-
1984
- 1984-05-21 JP JP59100441A patent/JPS60246399A/ja active Granted
-
1985
- 1985-05-14 HU HU851822A patent/HUT38971A/hu unknown
- 1985-05-17 EP EP85106066A patent/EP0162422A2/en not_active Withdrawn
- 1985-05-20 ZA ZA853779A patent/ZA853779B/xx unknown
- 1985-05-20 GR GR851217A patent/GR851217B/el unknown
- 1985-05-20 ES ES543289A patent/ES8605584A1/es not_active Expired
- 1985-05-20 DK DK223385A patent/DK223385A/da not_active Application Discontinuation
- 1985-05-21 PT PT80496A patent/PT80496B/pt unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES8605584A1 (es) | 1986-03-16 |
| ES543289A0 (es) | 1986-03-16 |
| EP0162422A2 (en) | 1985-11-27 |
| JPS60246399A (ja) | 1985-12-06 |
| DK223385D0 (da) | 1985-05-20 |
| PT80496A (en) | 1985-06-01 |
| GR851217B (ja) | 1985-11-25 |
| DK223385A (da) | 1985-11-22 |
| PT80496B (en) | 1987-06-03 |
| ZA853779B (en) | 1986-01-29 |
| HUT38971A (en) | 1986-07-28 |
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| EXPY | Cancellation because of completion of term |