JPH02288873A - シクロビタミンｄ化合物 - Google Patents

シクロビタミンｄ化合物

Info

Publication number
JPH02288873A
JPH02288873A JP1338024A JP33802489A JPH02288873A JP H02288873 A JPH02288873 A JP H02288873A JP 1338024 A JP1338024 A JP 1338024A JP 33802489 A JP33802489 A JP 33802489A JP H02288873 A JPH02288873 A JP H02288873A
Authority
JP
Japan
Prior art keywords
compound
vitamin
bone
formula
acyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP1338024A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0339505B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html
Inventor
Hector F Deluca
ヘクター　エフ．デルーカ
Heinrich K Schnoes
ハインリッヒ　ケー．シユノーズ
Rafal R Sicinski
ラファル　アール．シシンスキイ
Yoko Tanaka
洋子 田中
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wisconsin Alumni Research Foundation
Original Assignee
Wisconsin Alumni Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wisconsin Alumni Research Foundation filed Critical Wisconsin Alumni Research Foundation
Publication of JPH02288873A publication Critical patent/JPH02288873A/ja
Publication of JPH0339505B2 publication Critical patent/JPH0339505B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/24—Radicals substituted by singly bound oxygen or sulfur atoms esterified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0036—Nitrogen-containing hetero ring
    • C07J71/0042—Nitrogen only

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Nutrition Science (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
JP1338024A 1983-05-09 1989-12-26 シクロビタミンｄ化合物 Granted JPH02288873A (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US49286383A 1983-05-09 1983-05-09
US492,863 1983-05-09
US60732784A 1984-05-04 1984-05-04
US607,327 1984-05-04

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP59502223A Division JPS60501261A (ja) 1983-05-09 1984-05-09 １α，２５―ジヒドロキシル化ビタミンＤ↓２化合物及びその製造方法

Publications (2)

Publication Number Publication Date
JPH02288873A true JPH02288873A (ja) 1990-11-28
JPH0339505B2 JPH0339505B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1991-06-14

Family

ID=27050897

Family Applications (3)

Application Number Title Priority Date Filing Date
JP1338024A Granted JPH02288873A (ja) 1983-05-09 1989-12-26 シクロビタミンｄ化合物
JP1338023A Expired - Lifetime JPH0651624B2 (ja) 1983-05-09 1989-12-26 骨の損耗の予防又は再生不調症の治療又は予防用薬剤
JP1338025A Expired - Fee Related JPH0610188B2 (ja) 1983-05-09 1989-12-26 １α，２５―ジヒドロキシル化ビタミンＤ▼下２▲化合物の前駆体

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP1338023A Expired - Lifetime JPH0651624B2 (ja) 1983-05-09 1989-12-26 骨の損耗の予防又は再生不調症の治療又は予防用薬剤
JP1338025A Expired - Fee Related JPH0610188B2 (ja) 1983-05-09 1989-12-26 １α，２５―ジヒドロキシル化ビタミンＤ▼下２▲化合物の前駆体

Country Status (7)

Country Link
JP (3) JPH02288873A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (1) AU568549B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CH (1) CH665834A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (4) DE3448360C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DK (3) DK171397B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NL (1) NL193245C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
WO (1) WO1984004527A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0197949A1 (en) * 1984-10-04 1986-10-22 Wisconsin Alumni Research Foundation Vitamin d derivatives and methods for preparing same
DE3687377T2 (de) * 1985-01-17 1993-04-29 Wisconsin Alumni Res Found Vitamin-d-abkoemmlinge und deren herstellungsverfahren.
CA1341408C (en) * 1988-08-02 2002-12-10 Charles W. Bishop Method for treating and preventing loss of bone mass
US5104864A (en) * 1988-08-02 1992-04-14 Bone Care International, Inc. Method for treating and preventing loss of bone mass
US4973584A (en) * 1989-03-09 1990-11-27 Deluca Hector F Novel 1α-hydroxyvitamin D2 epimer and derivatives
JP2645130B2 (ja) * 1989-03-31 1997-08-25 日清製粉株式会社 ステロイド誘導体
GB8914963D0 (en) * 1989-06-29 1989-08-23 Leo Pharm Prod Ltd Chemical compounds
IN171449B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * 1990-02-14 1992-10-17 Wisconsin Alumni Res Found
ES2170069T3 (es) * 1992-06-22 2002-08-01 Bone Care Int Inc 1-alfa-hidroxiprevitamina d para administracion oral.
US5795882A (en) * 1992-06-22 1998-08-18 Bone Care International, Inc. Method of treating prostatic diseases using delayed and/or sustained release vitamin D formulations
US5763429A (en) * 1993-09-10 1998-06-09 Bone Care International, Inc. Method of treating prostatic diseases using active vitamin D analogues
US6242434B1 (en) 1997-08-08 2001-06-05 Bone Care International, Inc. 24-hydroxyvitamin D, analogs and uses thereof
US6573256B2 (en) 1996-12-30 2003-06-03 Bone Care International, Inc. Method of inhibiting angiogenesis using active vitamin D analogues
US6566353B2 (en) 1996-12-30 2003-05-20 Bone Care International, Inc. Method of treating malignancy associated hypercalcemia using active vitamin D analogues
US6503893B2 (en) 1996-12-30 2003-01-07 Bone Care International, Inc. Method of treating hyperproliferative diseases using active vitamin D analogues
PL336231A1 (en) 1997-02-13 2000-06-19 Bone Care International System for aimed therapeutic delivery of vitamin d compounds
IL153378A0 (en) 2000-07-18 2003-07-06 Bone Care Internat Inc STABILIZED 1alpha-HYDROXY VITAMIN D
US7148211B2 (en) 2002-09-18 2006-12-12 Genzyme Corporation Formulation for lipophilic agents
US7094775B2 (en) 2004-06-30 2006-08-22 Bone Care International, Llc Method of treating breast cancer using a combination of vitamin D analogues and other agents
CN104761480A (zh) 2008-03-12 2015-07-08 赛特克罗公司 稳定化的1,25-二羟基维生素d2和其制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4260549A (en) * 1979-05-21 1981-04-07 Wisconsin Alumni Research Foundation Process for preparing 1α-hydroxylated compounds
US4267117A (en) * 1978-06-19 1981-05-12 The Upjohn Company Compounds and process
US4269777A (en) * 1979-05-21 1981-05-26 Wisconsin Alumni Research Foundation Isotopically labeled vitamin D derivatives and processes for preparing same

Also Published As

Publication number Publication date
DK183291D0 (da) 1991-11-07
DK183291A (da) 1991-11-07
NL8420137A (nl) 1985-04-01
CH665834A5 (de) 1988-06-15
DK184588D0 (da) 1988-04-06
JPH0651624B2 (ja) 1994-07-06
JPH02288829A (ja) 1990-11-28
AU568549B2 (en) 1988-01-07
NL193245C (nl) 1999-04-02
WO1984004527A1 (en) 1984-11-22
JPH0339505B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1991-06-14
DE3490215C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1991-07-25
NL193245B (nl) 1998-12-01
DK172567B1 (da) 1999-01-18
DK184588A (da) 1988-04-06
DE3490215T (de) 1985-05-15
DK8685A (da) 1985-01-08
DK171397B1 (da) 1996-10-14
DE3448360C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1991-10-02
DK172733B1 (da) 1999-06-21
JPH0610188B2 (ja) 1994-02-09
AU3011584A (en) 1984-12-04
JPH02288854A (ja) 1990-11-28
DK8685D0 (da) 1985-01-08
DE3448412C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1991-12-12

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