JPH022595B2 - - Google Patents
Info
- Publication number
- JPH022595B2 JPH022595B2 JP55101444A JP10144480A JPH022595B2 JP H022595 B2 JPH022595 B2 JP H022595B2 JP 55101444 A JP55101444 A JP 55101444A JP 10144480 A JP10144480 A JP 10144480A JP H022595 B2 JPH022595 B2 JP H022595B2
- Authority
- JP
- Japan
- Prior art keywords
- formate
- substrate
- membrane
- dehydrogenase
- mmol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000012528 membrane Substances 0.000 claims description 49
- 239000000758 substrate Substances 0.000 claims description 38
- 239000000243 solution Substances 0.000 claims description 25
- 238000006243 chemical reaction Methods 0.000 claims description 23
- 108090000698 Formate Dehydrogenases Proteins 0.000 claims description 20
- -1 polyoxyethylene Polymers 0.000 claims description 16
- 238000000034 method Methods 0.000 claims description 12
- 229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 claims description 12
- BAWFJGJZGIEFAR-NNYOXOHSSA-N NAD zwitterion Chemical compound NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](COP([O-])(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 BAWFJGJZGIEFAR-NNYOXOHSSA-N 0.000 claims description 11
- 230000000694 effects Effects 0.000 claims description 11
- 229950006238 nadide Drugs 0.000 claims description 11
- BOPGDPNILDQYTO-NNYOXOHSSA-N nicotinamide-adenine dinucleotide Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 BOPGDPNILDQYTO-NNYOXOHSSA-N 0.000 claims description 11
- 101710088194 Dehydrogenase Proteins 0.000 claims description 10
- 239000000706 filtrate Substances 0.000 claims description 9
- 239000002253 acid Substances 0.000 claims description 8
- 150000001413 amino acids Chemical class 0.000 claims description 8
- BDAGIHXWWSANSR-UHFFFAOYSA-M Formate Chemical compound [O-]C=O BDAGIHXWWSANSR-UHFFFAOYSA-M 0.000 claims description 7
- 238000000108 ultra-filtration Methods 0.000 claims description 5
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims description 4
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 4
- VZTDIZULWFCMLS-UHFFFAOYSA-N ammonium formate Chemical compound [NH4+].[O-]C=O VZTDIZULWFCMLS-UHFFFAOYSA-N 0.000 claims description 4
- 150000007513 acids Chemical class 0.000 claims description 3
- 239000007864 aqueous solution Substances 0.000 claims description 3
- 230000002255 enzymatic effect Effects 0.000 claims description 3
- 230000001172 regenerating effect Effects 0.000 claims description 2
- 150000003839 salts Chemical class 0.000 claims description 2
- 229920003169 water-soluble polymer Polymers 0.000 claims description 2
- 108010031025 Alanine Dehydrogenase Proteins 0.000 description 12
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 12
- QNAYBMKLOCPYGJ-UHFFFAOYSA-N D-alpha-Ala Natural products CC([NH3+])C([O-])=O QNAYBMKLOCPYGJ-UHFFFAOYSA-N 0.000 description 10
- QNAYBMKLOCPYGJ-UWTATZPHSA-N L-Alanine Natural products C[C@@H](N)C(O)=O QNAYBMKLOCPYGJ-UWTATZPHSA-N 0.000 description 10
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 10
- 229960003767 alanine Drugs 0.000 description 10
- 239000005515 coenzyme Substances 0.000 description 10
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 9
- 235000011187 glycerol Nutrition 0.000 description 6
- 239000012510 hollow fiber Substances 0.000 description 6
- 239000000047 product Substances 0.000 description 6
- DAEPDZWVDSPTHF-UHFFFAOYSA-M sodium pyruvate Chemical compound [Na+].CC(=O)C([O-])=O DAEPDZWVDSPTHF-UHFFFAOYSA-M 0.000 description 6
- 229940024606 amino acid Drugs 0.000 description 5
- 235000001014 amino acid Nutrition 0.000 description 5
- 108090000790 Enzymes Proteins 0.000 description 4
- 102000004190 Enzymes Human genes 0.000 description 4
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 4
- 239000011541 reaction mixture Substances 0.000 description 4
- LCTONWCANYUPML-UHFFFAOYSA-M Pyruvate Chemical compound CC(=O)C([O-])=O LCTONWCANYUPML-UHFFFAOYSA-M 0.000 description 3
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 3
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 3
- 235000011130 ammonium sulphate Nutrition 0.000 description 3
- 238000006911 enzymatic reaction Methods 0.000 description 3
- 230000007717 exclusion Effects 0.000 description 3
- 229910000403 monosodium phosphate Inorganic materials 0.000 description 3
- 235000019799 monosodium phosphate Nutrition 0.000 description 3
- 229940076788 pyruvate Drugs 0.000 description 3
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 3
- 235000011121 sodium hydroxide Nutrition 0.000 description 3
- 229940054269 sodium pyruvate Drugs 0.000 description 3
- 239000007921 spray Substances 0.000 description 3
- 230000001954 sterilising effect Effects 0.000 description 3
- 238000004659 sterilization and disinfection Methods 0.000 description 3
- BKAJNAXTPSGJCU-UHFFFAOYSA-N 4-methyl-2-oxopentanoic acid Chemical compound CC(C)CC(=O)C(O)=O BKAJNAXTPSGJCU-UHFFFAOYSA-N 0.000 description 2
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 2
- 235000019454 L-leucine Nutrition 0.000 description 2
- 239000004395 L-leucine Substances 0.000 description 2
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 239000008098 formaldehyde solution Substances 0.000 description 2
- 229960003136 leucine Drugs 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 2
- 239000011148 porous material Substances 0.000 description 2
- 235000018102 proteins Nutrition 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- KDVFRMMRZOCFLS-UHFFFAOYSA-N 2-oxopentanoic acid Chemical compound CCCC(=O)C(O)=O KDVFRMMRZOCFLS-UHFFFAOYSA-N 0.000 description 1
- QHKABHOOEWYVLI-UHFFFAOYSA-N 3-methyl-2-oxobutanoic acid Chemical compound CC(C)C(=O)C(O)=O QHKABHOOEWYVLI-UHFFFAOYSA-N 0.000 description 1
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 description 1
- NOWKCMXCCJGMRR-UHFFFAOYSA-N Aziridine Chemical compound C1CN1 NOWKCMXCCJGMRR-UHFFFAOYSA-N 0.000 description 1
- 244000063299 Bacillus subtilis Species 0.000 description 1
- 235000014469 Bacillus subtilis Nutrition 0.000 description 1
- 241000382839 Cupriavidus oxalaticus Species 0.000 description 1
- 238000006088 Dimroth rearrangement reaction Methods 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 description 1
- 229930182844 L-isoleucine Natural products 0.000 description 1
- 239000004952 Polyamide Substances 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 239000004280 Sodium formate Substances 0.000 description 1
- SMEGJBVQLJJKKX-HOTMZDKISA-N [(2R,3S,4S,5R,6R)-5-acetyloxy-3,4,6-trihydroxyoxan-2-yl]methyl acetate Chemical compound CC(=O)OC[C@@H]1[C@H]([C@@H]([C@H]([C@@H](O1)O)OC(=O)C)O)O SMEGJBVQLJJKKX-HOTMZDKISA-N 0.000 description 1
- 241000222124 [Candida] boidinii Species 0.000 description 1
- 229940081735 acetylcellulose Drugs 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 150000001718 carbodiimides Chemical class 0.000 description 1
- 229920002301 cellulose acetate Polymers 0.000 description 1
- 230000021615 conjugation Effects 0.000 description 1
- 238000010924 continuous production Methods 0.000 description 1
- 238000007872 degassing Methods 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 235000019253 formic acid Nutrition 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 229960000310 isoleucine Drugs 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 229920002492 poly(sulfone) Polymers 0.000 description 1
- 229920002647 polyamide Polymers 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
- WFIZEGIEIOHZCP-UHFFFAOYSA-M potassium formate Chemical compound [K+].[O-]C=O WFIZEGIEIOHZCP-UHFFFAOYSA-M 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- HLBBKKJFGFRGMU-UHFFFAOYSA-M sodium formate Chemical compound [Na+].[O-]C=O HLBBKKJFGFRGMU-UHFFFAOYSA-M 0.000 description 1
- 235000019254 sodium formate Nutrition 0.000 description 1
- 229960004295 valine Drugs 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/06—Alanine; Leucine; Isoleucine; Serine; Homoserine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
- C12P19/30—Nucleotides
- C12P19/36—Dinucleotides, e.g. nicotineamide-adenine dinucleotide phosphate
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/813—Continuous fermentation
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Mycology (AREA)
- Molecular Biology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19792930070 DE2930070A1 (de) | 1979-07-25 | 1979-07-25 | Verfahren zur kontinuierlichen enzymatischen umwandlung von wasserloeslichen alpha -ketocarbonsaeuren in die entsprechenden aminosaeuren |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5664792A JPS5664792A (en) | 1981-06-02 |
| JPH022595B2 true JPH022595B2 (cg-RX-API-DMAC7.html) | 1990-01-18 |
Family
ID=6076684
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP10144480A Granted JPS5664792A (en) | 1979-07-25 | 1980-07-25 | Continuous enzymatic conversion of water soluble alphaaketocarboxylic acid to corresponding to amino acid |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US4304858A (cg-RX-API-DMAC7.html) |
| EP (1) | EP0023346B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JPS5664792A (cg-RX-API-DMAC7.html) |
| CA (1) | CA1139697A (cg-RX-API-DMAC7.html) |
| DE (2) | DE2930070A1 (cg-RX-API-DMAC7.html) |
| SU (1) | SU1069622A3 (cg-RX-API-DMAC7.html) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4481292A (en) * | 1980-07-01 | 1984-11-06 | The Coca-Cola Company | Process for the generation of acetaldehyde from ethanol |
| EP0076266B1 (en) * | 1981-04-08 | 1988-11-09 | GORTON, Lo | Electrode for the electrochemical regeneration of co-enzyme, a method of making said electrode, and the use thereof |
| US4451566A (en) * | 1981-12-04 | 1984-05-29 | Spencer Donald B | Methods and apparatus for enzymatically producing ethanol |
| DE3247981A1 (de) * | 1982-12-24 | 1984-06-28 | Degussa Ag, 6000 Frankfurt | Verfahren zur gewinnung von l-aepfelsaeure |
| US4600692A (en) * | 1983-02-10 | 1986-07-15 | Purification Engineering, Inc. | Immobilized cells for preparing phenylalanine |
| DE3307095A1 (de) * | 1983-03-01 | 1984-09-06 | Degussa Ag, 6000 Frankfurt | Mikrobiologisch hergestellte l-phenylalanin-dehydrogenase, verfahren zu ihrer gewinnung und ihre verwendung |
| DE3307094A1 (de) * | 1983-03-01 | 1984-09-06 | Degussa Ag, 6000 Frankfurt | Verfahren zur kontinuierlichen enzymatischen umwandlung von (alpha)-hydroxycarbonsaeuren in entsprechende optisch aktive (alpha)-aminocarbonsaeuren |
| US4728611A (en) * | 1983-07-29 | 1988-03-01 | Purification Engineering, Inc. | Production of phenylalanine with immobilized cells |
| EP0137646A1 (en) * | 1983-08-16 | 1985-04-17 | Genentech, Inc. | Recombinant process for preparing L-amino acids, recombinant expression vectors and transformed microorganisms for use in the process |
| KR850001802A (ko) * | 1983-08-16 | 1985-04-01 | 월터 에이취. 드래거 | 박테리아에서 l-아미노산을 제조하는 방법 |
| US4518692A (en) * | 1983-09-01 | 1985-05-21 | Genetics Institute, Inc. | Production of L-amino acids by transamination |
| US4525454A (en) * | 1983-09-01 | 1985-06-25 | Genetics Institute, Inc. | Production of L-4-phenyl-2-aminobutanoic acid by transamination |
| JPS60184393A (ja) * | 1984-03-02 | 1985-09-19 | Ajinomoto Co Inc | アラニンの製造法 |
| US4657862A (en) * | 1984-07-31 | 1987-04-14 | International Flavors & Fragrances Inc. | Preparation of naturally-occurring C2-C5 alkyl esters of C4-C5 carboxylic acids by means of fermentation of C5-C6 amino acids in the presence of C2-C5 alcohols |
| JPS6198962U (cg-RX-API-DMAC7.html) * | 1984-12-05 | 1986-06-25 | ||
| DE3446304A1 (de) * | 1984-12-19 | 1986-07-10 | Degussa Ag, 6000 Frankfurt | Verfahren zur gewinnung von phenylalanin-dehydrogenase enthaltenden mikroorganismen, mikroorganismen, die in ihnen enthaltene phenylalanin-dehydrogenase und deren verwendung zur herstellung von l-(alpha)-aminosaeuren |
| JPS61185195A (ja) * | 1985-02-13 | 1986-08-18 | Mitsui Toatsu Chem Inc | アミノ酸の製造法 |
| JPS61185194A (ja) * | 1985-02-13 | 1986-08-18 | Mitsui Toatsu Chem Inc | アミノ酸の生産法 |
| JPS6236196A (ja) * | 1985-04-15 | 1987-02-17 | Ajinomoto Co Inc | アラニンの製造法 |
| US4849345A (en) * | 1985-04-17 | 1989-07-18 | Sagami Chemical Research Center | L-phenylalanine dehydrogenase and use thereof |
| FR2583432B1 (fr) * | 1985-06-13 | 1988-11-04 | Inst Francais Du Petrole | Procede de production enzymatique de l-a-aminoacides a partir d'a-cetoacides |
| JPS6261594A (ja) * | 1985-09-11 | 1987-03-18 | Kuraray Co Ltd | Ｌ−フエニルアラニンの製造方法 |
| US4826766A (en) * | 1985-09-23 | 1989-05-02 | Genetics Institute, Inc. | Production of amino acids using coupled aminotransferases |
| DE3733198A1 (de) * | 1987-10-01 | 1989-04-13 | Kernforschungsanlage Juelich | Enzymatisches verfahren zur herstellung von dipeptiden |
| DE3842025A1 (de) * | 1988-12-14 | 1990-07-05 | Hoechst Ag | Verfahren zur herstellung von l-phosphinothricin |
| CA2008702A1 (en) * | 1989-02-27 | 1990-08-27 | Ronald L. Hanson | Process for transformation of hydroxyketo acids to hydroxyamino acids |
| CA2069008A1 (en) * | 1990-09-20 | 1992-03-21 | Yasuo Kato | Process for producing l-beta-haloalanine |
| ES2100819B1 (es) * | 1995-11-27 | 1997-12-16 | Univ Murcia | Metodo de rentencion de nad (p) (h) en estado nativo con membranas de ultrafiltracion no cargadas. |
| US6432688B1 (en) * | 1999-01-18 | 2002-08-13 | Daicel Chemical Industries, Ltd. | Amino alcohol dehydrogenase converts keto alcohol to amino alcohol and amino alcohol to keto alcohol |
| DE19926770A1 (de) | 1999-06-11 | 2000-12-14 | Basf Ag | Nukleinsäurefragment und Vektor, enthaltend eine Halogenase, sowie ein Verfahren zur Halogenierung chemischer Verbindungen |
| WO2011035978A1 (de) | 2009-09-23 | 2011-03-31 | Basf Se | Oligosaccharide und deren herstellung durch saure hydrolyse von stärke |
| EP3330380A1 (en) * | 2016-12-05 | 2018-06-06 | Evonik Degussa GmbH | Process for producing l-methionine from methional |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3183170A (en) * | 1961-10-03 | 1965-05-11 | Sanraku Ocean Kabushiki Kaisha | Method of l-amino acid manufacture |
| DE2008842A1 (de) * | 1969-02-27 | 1970-11-05 | Kyowa Hakko Kogyo Co., Ltd., Tokio | Verfahren und Vorrichtung zur kontinuierlichen Durchführung von Enzymreaktionen |
| FR2217296A1 (en) * | 1972-10-10 | 1974-09-06 | Inst Francais Du Petrole | Organic cpds. prepn. by co-enzymatic reduction - with continuous regeneration of the oxidised coenzyme with a reducing agent |
| US3915799A (en) * | 1974-07-05 | 1975-10-28 | Dow Chemical Co | Method of minimizing cofactor loss in enzymatic reactors |
| IL46178A (en) * | 1974-12-03 | 1978-10-31 | Rehovot Res Prod | Method for the performance of enzymatic reactions |
| FR2398046A1 (fr) * | 1977-07-18 | 1979-02-16 | Inst Francais Du Petrole | Synthese enzymatique de la l-carnitine |
| US4251631A (en) * | 1978-02-23 | 1981-02-17 | Research Products Rehovot Ltd. | Cross-linked enzyme membrane |
-
1979
- 1979-07-25 DE DE19792930070 patent/DE2930070A1/de not_active Withdrawn
-
1980
- 1980-07-24 EP EP80104345A patent/EP0023346B1/de not_active Expired
- 1980-07-24 DE DE8080104345T patent/DE3064127D1/de not_active Expired
- 1980-07-24 SU SU802954169A patent/SU1069622A3/ru active
- 1980-07-24 CA CA000356910A patent/CA1139697A/en not_active Expired
- 1980-07-25 US US06/172,446 patent/US4304858A/en not_active Expired - Lifetime
- 1980-07-25 JP JP10144480A patent/JPS5664792A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| EP0023346A3 (en) | 1981-05-13 |
| EP0023346A2 (de) | 1981-02-04 |
| DE2930070A1 (de) | 1981-02-19 |
| SU1069622A3 (ru) | 1984-01-23 |
| EP0023346B1 (de) | 1983-07-13 |
| JPS5664792A (en) | 1981-06-02 |
| CA1139697A (en) | 1983-01-18 |
| DE3064127D1 (en) | 1983-08-18 |
| US4304858A (en) | 1981-12-08 |
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| JPH022595B2 (cg-RX-API-DMAC7.html) | ||
| JPS6335B2 (cg-RX-API-DMAC7.html) | ||
| EP0132999B1 (en) | Process and compositions for preparing phenylalanine | |
| IE58779B1 (en) | Process for the microbiological production of l-carnitine | |
| US4335209A (en) | Process for preparation of L-tryptophan by enzyme | |
| JPH0516833B2 (cg-RX-API-DMAC7.html) | ||
| Fukui et al. | Comparative Studies on the Properties of Tryptophanase and Tyrosine Phenol‐lyase Immobilized Directly on Sepharose or by Use of Sepharose‐Bound Pyridoxal 5′‐Phosphate | |
| Wandrey et al. | Continuous cofactor regeneration Utilization of polymer bound NAD (H) for the production of optically active acids | |
| Schmidt‐Steffen et al. | Ultrafiltration membranes for chemical bonding of urease | |
| US4782020A (en) | Process for the continuous enzymatic conversion of alpha-hydrocarboxylic acids into the corresponding optically active alpha-aminocarboxylic acids | |
| US6653112B2 (en) | Method for producing L-carnitine from crotonobetaine using a two stage continuous cell-recycle reactor | |
| WO2001062948A2 (en) | Method and catalyst system for stereoselectively inverting a chiral center of a chemical compound | |
| JPH01100193A (ja) | ポリマーに固定されたコフアクターを有する酵素リアクター | |
| JP3279642B2 (ja) | アルギナーゼバッチおよびオルニチンの酵素的製造方法 | |
| EP0349204A2 (en) | Use and regeneration of reagents using coupled reactions and permselective barriers | |
| US4728611A (en) | Production of phenylalanine with immobilized cells | |
| JPS62253388A (ja) | Ｌ−カルニチンの改良された製造方法 | |
| JPH0269178A (ja) | 生育促進剤 | |
| CA1178910A (en) | Process for production of l-amino acids using immobilized microorganisms | |
| Dolabdjian et al. | Soluble Nad+-Derivatives of High Molecular Weight in Enzymic Recycling Systems | |
| Wandrey | Synthesis of L-amino acids by isolated enzymes and microorganisms | |
| Yamamoto et al. | Repeated batch production of theanine by coupled fermentation with energy transfer using membrane-enclosed γ-glutamylmethylamide synthetase and dried yeast cells | |
| CHENAULT et al. | for use in Organic Synthesis | |
| EP0295622A2 (en) | Process for producing L-Tryptophan | |
| JPS62208290A (ja) | ギ酸デヒドロゲナ−ゼを用いる共役反応方法 |