KR850001802A - 박테리아에서 l-아미노산을 제조하는 방법 - Google Patents

박테리아에서 l-아미노산을 제조하는 방법 Download PDF

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KR850001802A
KR850001802A KR1019840004879A KR840004879A KR850001802A KR 850001802 A KR850001802 A KR 850001802A KR 1019840004879 A KR1019840004879 A KR 1019840004879A KR 840004879 A KR840004879 A KR 840004879A KR 850001802 A KR850001802 A KR 850001802A
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amino acid
source
microorganism
produced
acid
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KR1019840004879A
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브라어안 로리스(외4) 버어질
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월터 에이취. 드래거
체넨메크 인코포레이리드
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Publication of KR850001802A publication Critical patent/KR850001802A/ko

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/22—Tryptophan; Tyrosine; Phenylalanine; 3,4-Dihydroxyphenylalanine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/22—Tryptophan; Tyrosine; Phenylalanine; 3,4-Dihydroxyphenylalanine
    • C12P13/222—Phenylalanine

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

내용 없음

Description

박테리아에서 L-아미노산을 제조하는 방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 발효조에서 정지기에 대장균 RV308 균주에 의한 페닐알라닌 생산도식임.

Claims (15)

  1. 최소 베지중에서 환원 동가체의 겸용 소오스 및 미생물이 유도에 반응하여서 적당한 특이성의 디히드로지나제와 트란스아미나제 효소를 생성하는 미생물 배양체의 존재하에 대응하는 α-캐토산을 암모니아와 반응시키는 L-아미노산 제조방법.
  2. 유도반응에 적합한 조건하에서, 유도반응에 응답하여 적당한 특이성을 가지는 디히드로지나제와 트란스아미나제 효소를 생성하는 미생물 배양체에 α-케토산, 암모니아 및 환원등가체의 소오스를 공급하여서 α-케토산을 대응하는 L-아미노산으로 전환시키는 방법.
  3. 유도반응에 응답해서 적당한 특이성을 가지는 디히드로지나제와 트란스아미나제 효소를 생성하는 미생물에 α-케토산, 암모니아 및 환원등가체의 겸용 소오스를 공급하여서 α-케토산을 대응하는 L-아미노산으로 전환시키는 방법.
  4. 대응하는 α-케토산을 환원등가체의 겸용 소오스와 유도반응에 적합한 조건하에서 배양시킨 미생물 존재하에 암모니아 반응시키는 L-아미노산의 제조방법.
  5. 제1-4항에 있어서, 미생물이 대장균 균주인 방법.
  6. 제1-4항에 있어서, L-아미노산이 페닐알라닌인 방법.
  7. 제5항에 있어서, L-아미노산이 페닐알라닌인 방법.
  8. 제1-4항에 있어서, 환원등가체 소오스가 글루코스인 방법.
  9. 제1-4항에 있어서, L-아미노산이 세포 배양체 리터당 20그람 이상의 양으로 생성되는 방법.
  10. 제1-4항에 있어서, L-아미노산이 10mg/ℓ/OD/시간 이상의 비율로 생성되는 방법.
  11. 제10항에 있어서, L-아미노산이 100mg/ℓ/OD/시간 이상의 비율로 생성되는 방법.
  12. 제1-4항에 있어서, α-케로산올 수올 50퍼센트 이상으로 대응하는 L-아미노산으로 전환시키는 방법.
  13. 제1-4항에 있어서, 미생물 배양체가 정지기에 있는 방법.
  14. 제1-4항의 방법을 행하는데에 유용한 미생물 또는 배양체.
  15. 제1-4항의 방법으로 생산된 L-아미노산.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019840004879A 1983-08-16 1984-08-14 박테리아에서 l-아미노산을 제조하는 방법 KR850001802A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US52353983A 1983-08-16 1983-08-16
US06/523539 1983-08-16

Publications (1)

Publication Number Publication Date
KR850001802A true KR850001802A (ko) 1985-04-01

Family

ID=24085429

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019840004879A KR850001802A (ko) 1983-08-16 1984-08-14 박테리아에서 l-아미노산을 제조하는 방법

Country Status (6)

Country Link
EP (1) EP0140503A1 (ko)
JP (1) JPS6091992A (ko)
KR (1) KR850001802A (ko)
AU (1) AU3187884A (ko)
IL (1) IL72700A0 (ko)
ZA (1) ZA846346B (ko)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4783403A (en) * 1984-02-08 1988-11-08 Kyowa Hakko Kogyo Co., Ltd. Process for producing l-phenylalanine
DE3533198A1 (de) * 1985-09-18 1987-03-19 Kernforschungsanlage Juelich Verfahren zur fermentativen herstellung von l-aminosaeuren aus (alpha)-ketocarbonsaeuren
JPH0785718B2 (ja) * 1986-03-07 1995-09-20 ダイセル化学工業株式会社 Ｄ−アミノ酸の製造方法
GB2196333A (en) * 1986-08-19 1988-04-27 Allelix Inc Continuous bioconversion process for the preparation of phenylalanine
CA2008702A1 (en) * 1989-02-27 1990-08-27 Ronald L. Hanson Process for transformation of hydroxyketo acids to hydroxyamino acids
US5169780A (en) * 1989-06-22 1992-12-08 Celgene Corporation Enantiomeric enrichment and stereoselective synthesis of chiral amines
US7420079B2 (en) 2002-12-09 2008-09-02 Bristol-Myers Squibb Company Methods and compounds for producing dipeptidyl peptidase IV inhibitors and intermediates thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4016037A (en) * 1975-10-15 1977-04-05 Ajinomoto Co., Inc. Method for producing L-amino acid
DE2930070A1 (de) * 1979-07-25 1981-02-19 Biotechnolog Forschung Gmbh Verfahren zur kontinuierlichen enzymatischen umwandlung von wasserloeslichen alpha -ketocarbonsaeuren in die entsprechenden aminosaeuren
DE3031151A1 (de) * 1980-08-18 1982-04-15 Basf Ag, 6700 Ludwigshafen Verfahren zur herstellung von d-n-carbamoyl-(alpha)-aminosaeuren und mikroorganismen dafuer

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Publication number Publication date
EP0140503A1 (en) 1985-05-08
ZA846346B (en) 1985-03-27
AU3187884A (en) 1985-02-21
IL72700A0 (en) 1984-11-30
JPS6091992A (ja) 1985-05-23

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