JPH0220944B2 - - Google Patents
Info
- Publication number
- JPH0220944B2 JPH0220944B2 JP53144942A JP14494278A JPH0220944B2 JP H0220944 B2 JPH0220944 B2 JP H0220944B2 JP 53144942 A JP53144942 A JP 53144942A JP 14494278 A JP14494278 A JP 14494278A JP H0220944 B2 JPH0220944 B2 JP H0220944B2
- Authority
- JP
- Japan
- Prior art keywords
- antigen
- amount
- serum sample
- serum
- test
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 claims description 83
- 238000012360 testing method Methods 0.000 claims description 81
- 239000000427 antigen Substances 0.000 claims description 76
- 102000036639 antigens Human genes 0.000 claims description 76
- 108091007433 antigens Proteins 0.000 claims description 76
- 210000002966 serum Anatomy 0.000 claims description 61
- 201000005404 rubella Diseases 0.000 claims description 39
- 238000011002 quantification Methods 0.000 claims description 22
- 241000701022 Cytomegalovirus Species 0.000 claims description 19
- 238000003018 immunoassay Methods 0.000 claims description 17
- 239000000126 substance Substances 0.000 claims description 17
- 230000001900 immune effect Effects 0.000 claims description 15
- 229920001577 copolymer Polymers 0.000 claims description 11
- 108060003951 Immunoglobulin Proteins 0.000 claims description 10
- 102000018358 immunoglobulin Human genes 0.000 claims description 10
- 241000710799 Rubella virus Species 0.000 claims description 9
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 9
- 241000700605 Viruses Species 0.000 claims description 9
- 239000000463 material Substances 0.000 claims description 9
- 102000004169 proteins and genes Human genes 0.000 claims description 9
- 108090000623 proteins and genes Proteins 0.000 claims description 9
- 230000003612 virological effect Effects 0.000 claims description 9
- 241000589884 Treponema pallidum Species 0.000 claims description 8
- 239000011780 sodium chloride Substances 0.000 claims description 6
- 238000012546 transfer Methods 0.000 claims description 6
- 241000223997 Toxoplasma gondii Species 0.000 claims description 5
- 239000007850 fluorescent dye Substances 0.000 claims description 4
- 238000001215 fluorescent labelling Methods 0.000 claims description 3
- 244000045947 parasite Species 0.000 claims description 3
- 238000007654 immersion Methods 0.000 claims 4
- 241000351140 Allostoma pallidum Species 0.000 claims 2
- 208000009889 Herpes Simplex Diseases 0.000 claims 2
- 230000001580 bacterial effect Effects 0.000 claims 2
- 229940094342 human immunoglobulin m Drugs 0.000 claims 2
- 238000002372 labelling Methods 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
- 239000000243 solution Substances 0.000 description 17
- 239000000523 sample Substances 0.000 description 16
- 238000005259 measurement Methods 0.000 description 14
- 238000001035 drying Methods 0.000 description 7
- 238000003556 assay Methods 0.000 description 6
- 210000004027 cell Anatomy 0.000 description 6
- 108010073131 cystic fibrosis serum factor Proteins 0.000 description 6
- 229920001213 Polysorbate 20 Polymers 0.000 description 5
- 239000000872 buffer Substances 0.000 description 5
- 238000006243 chemical reaction Methods 0.000 description 5
- 230000000295 complement effect Effects 0.000 description 5
- 238000012937 correction Methods 0.000 description 5
- MHMNJMPURVTYEJ-UHFFFAOYSA-N fluorescein-5-isothiocyanate Chemical compound O1C(=O)C2=CC(N=C=S)=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 MHMNJMPURVTYEJ-UHFFFAOYSA-N 0.000 description 5
- 238000010211 hemagglutination inhibition (HI) assay Methods 0.000 description 5
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 5
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 5
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 4
- 238000002965 ELISA Methods 0.000 description 4
- 102000004190 Enzymes Human genes 0.000 description 4
- 108090000790 Enzymes Proteins 0.000 description 4
- 239000000020 Nitrocellulose Substances 0.000 description 4
- 241000700584 Simplexvirus Species 0.000 description 4
- FJWGYAHXMCUOOM-QHOUIDNNSA-N [(2s,3r,4s,5r,6r)-2-[(2r,3r,4s,5r,6s)-4,5-dinitrooxy-2-(nitrooxymethyl)-6-[(2r,3r,4s,5r,6s)-4,5,6-trinitrooxy-2-(nitrooxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-3,5-dinitrooxy-6-(nitrooxymethyl)oxan-4-yl] nitrate Chemical compound O([C@@H]1O[C@@H]([C@H]([C@H](O[N+]([O-])=O)[C@H]1O[N+]([O-])=O)O[C@H]1[C@@H]([C@@H](O[N+]([O-])=O)[C@H](O[N+]([O-])=O)[C@@H](CO[N+]([O-])=O)O1)O[N+]([O-])=O)CO[N+](=O)[O-])[C@@H]1[C@@H](CO[N+]([O-])=O)O[C@@H](O[N+]([O-])=O)[C@H](O[N+]([O-])=O)[C@H]1O[N+]([O-])=O FJWGYAHXMCUOOM-QHOUIDNNSA-N 0.000 description 4
- 230000004520 agglutination Effects 0.000 description 4
- 229940098773 bovine serum albumin Drugs 0.000 description 4
- 239000007975 buffered saline Substances 0.000 description 4
- 229920002301 cellulose acetate Polymers 0.000 description 4
- 238000010790 dilution Methods 0.000 description 4
- 239000012895 dilution Substances 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 210000003743 erythrocyte Anatomy 0.000 description 4
- 230000005764 inhibitory process Effects 0.000 description 4
- 229920001220 nitrocellulos Polymers 0.000 description 4
- 238000010998 test method Methods 0.000 description 4
- 241001494479 Pecora Species 0.000 description 3
- 210000001124 body fluid Anatomy 0.000 description 3
- 239000010839 body fluid Substances 0.000 description 3
- 230000002860 competitive effect Effects 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 229940072221 immunoglobulins Drugs 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- -1 polyethylene Polymers 0.000 description 3
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- 102000004506 Blood Proteins Human genes 0.000 description 2
- 108010017384 Blood Proteins Proteins 0.000 description 2
- 241000283973 Oryctolagus cuniculus Species 0.000 description 2
- 239000004793 Polystyrene Substances 0.000 description 2
- 241000223996 Toxoplasma Species 0.000 description 2
- 239000002390 adhesive tape Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 239000007853 buffer solution Substances 0.000 description 2
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 description 2
- 239000000969 carrier Substances 0.000 description 2
- 229920002678 cellulose Polymers 0.000 description 2
- 239000001913 cellulose Substances 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 239000012470 diluted sample Substances 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 238000007689 inspection Methods 0.000 description 2
- 238000006386 neutralization reaction Methods 0.000 description 2
- 229920002223 polystyrene Polymers 0.000 description 2
- 238000004445 quantitative analysis Methods 0.000 description 2
- 230000002285 radioactive effect Effects 0.000 description 2
- 230000000405 serological effect Effects 0.000 description 2
- 239000013076 target substance Substances 0.000 description 2
- 241001529453 unidentified herpesvirus Species 0.000 description 2
- 229920002554 vinyl polymer Polymers 0.000 description 2
- 235000012431 wafers Nutrition 0.000 description 2
- 239000011534 wash buffer Substances 0.000 description 2
- XNCSCQSQSGDGES-UHFFFAOYSA-N 2-[2-[bis(carboxymethyl)amino]propyl-(carboxymethyl)amino]acetic acid Chemical compound OC(=O)CN(CC(O)=O)C(C)CN(CC(O)=O)CC(O)=O XNCSCQSQSGDGES-UHFFFAOYSA-N 0.000 description 1
- QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 1
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
- 239000004215 Carbon black (E152) Substances 0.000 description 1
- 208000032170 Congenital Abnormalities Diseases 0.000 description 1
- 206010010356 Congenital anomaly Diseases 0.000 description 1
- 206010062343 Congenital infection Diseases 0.000 description 1
- 206010010619 Congenital rubella infection Diseases 0.000 description 1
- 101710107327 Endochitinase 1 Proteins 0.000 description 1
- 208000010201 Exanthema Diseases 0.000 description 1
- 241000701044 Human gammaherpesvirus 4 Species 0.000 description 1
- 102000004895 Lipoproteins Human genes 0.000 description 1
- 108090001030 Lipoproteins Proteins 0.000 description 1
- 239000004952 Polyamide Substances 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 229920001214 Polysorbate 60 Polymers 0.000 description 1
- 208000034712 Rickettsia Infections Diseases 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
- BZHJMEDXRYGGRV-UHFFFAOYSA-N Vinyl chloride Chemical compound ClC=C BZHJMEDXRYGGRV-UHFFFAOYSA-N 0.000 description 1
- 150000001252 acrylic acid derivatives Chemical class 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 230000001014 anti-treponemal effect Effects 0.000 description 1
- 230000000890 antigenic effect Effects 0.000 description 1
- 230000007698 birth defect Effects 0.000 description 1
- 230000023555 blood coagulation Effects 0.000 description 1
- 229920005549 butyl rubber Polymers 0.000 description 1
- 239000001110 calcium chloride Substances 0.000 description 1
- 229910001628 calcium chloride Inorganic materials 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 230000035606 childbirth Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000002405 diagnostic procedure Methods 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 239000013024 dilution buffer Substances 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 229920001971 elastomer Polymers 0.000 description 1
- 201000005884 exanthem Diseases 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 229920000578 graft copolymer Polymers 0.000 description 1
- 230000035931 haemagglutination Effects 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 238000010166 immunofluorescence Methods 0.000 description 1
- 229940027941 immunoglobulin g Drugs 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000002458 infectious effect Effects 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 150000002734 metacrylic acid derivatives Chemical class 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 229920002647 polyamide Polymers 0.000 description 1
- 229920001748 polybutylene Polymers 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000005180 public health Effects 0.000 description 1
- 238000000163 radioactive labelling Methods 0.000 description 1
- 206010037844 rash Diseases 0.000 description 1
- 239000005060 rubber Substances 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 229920000260 silastic Polymers 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 229920003051 synthetic elastomer Polymers 0.000 description 1
- 239000005061 synthetic rubber Substances 0.000 description 1
- 208000006379 syphilis Diseases 0.000 description 1
- 229910052715 tantalum Inorganic materials 0.000 description 1
- GUVRBAGPIYLISA-UHFFFAOYSA-N tantalum atom Chemical compound [Ta] GUVRBAGPIYLISA-UHFFFAOYSA-N 0.000 description 1
- 239000003656 tris buffered saline Substances 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/962—Prevention or removal of interfering materials or reactants or other treatment to enhance results, e.g. determining or preventing nonspecific binding
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US85461377A | 1977-11-25 | 1977-11-25 | |
| US05/943,314 US4294817A (en) | 1977-11-25 | 1978-09-18 | Method of fluoro immunoassay |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5486611A JPS5486611A (en) | 1979-07-10 |
| JPH0220944B2 true JPH0220944B2 (enExample) | 1990-05-11 |
Family
ID=27127243
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP14494278A Granted JPS5486611A (en) | 1977-11-25 | 1978-11-22 | Fluorescent immunological quantitative measuring method |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US4294817A (enExample) |
| JP (1) | JPS5486611A (enExample) |
| CA (1) | CA1111346A (enExample) |
| DE (1) | DE2851150C2 (enExample) |
| FR (1) | FR2410278A1 (enExample) |
| GB (1) | GB2008747B (enExample) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4540659A (en) * | 1981-04-17 | 1985-09-10 | Syva Company | Simultaneous calibration heterogeneous immunoassay |
| US5156953A (en) * | 1979-12-26 | 1992-10-20 | Syntex (U.S.A.) Inc. | Simultaneous calibration heterogeneous immunoassay |
| US4299916A (en) * | 1979-12-26 | 1981-11-10 | Syva Company | Preferential signal production on a surface in immunoassays |
| US5432057A (en) * | 1979-12-26 | 1995-07-11 | Syva Company | Simultaneous calibration heterogeneous immunoassay |
| NL8000173A (nl) * | 1980-01-11 | 1981-08-03 | Akzo Nv | Toepassing van in water dispergeerbare, hydrofobe kleurstoffen als label in immunochemische testen. |
| BR8108820A (pt) * | 1980-09-24 | 1982-08-24 | Cetus Corp | Processo e sonda de diagnostico |
| IL68506A (en) * | 1982-05-04 | 1988-06-30 | Syva Co | Simultaneous calibration heterogeneous immunoassay method and device and kit for use therein |
| JPS58206966A (ja) * | 1982-05-04 | 1983-12-02 | シバ・カンパニ− | 同時較正不均質イムノアツセイ |
| JPS58209994A (ja) * | 1982-05-10 | 1983-12-07 | Fujirebio Inc | 活性蛋白等固定化物を用いた抗原の測定方法 |
| JPS5934154A (ja) * | 1982-08-19 | 1984-02-24 | Konishiroku Photo Ind Co Ltd | 免疫分析素子測定法 |
| GB2157696A (en) * | 1982-11-12 | 1985-10-30 | California The Regents Of The | Recombinant dna derived antigens of treponema pallidum |
| US4614722A (en) * | 1983-11-01 | 1986-09-30 | Pasula Mark J | Method and apparatus for measuring the degree of reaction between antigens and leukocyte cellular antibodies |
| FR2563630B1 (fr) * | 1984-04-27 | 1988-02-19 | Pasteur Institut | Anticorps monoclonaux anticytomegalovirus et procedes pour le diagnostic in vitro des infections par les cytomegalovirus humains et d'une proteine-kinase inductible par les cytomegalovirus et susceptible d'etre reconnue par les susdits anticorps monoclonaux |
| SE458643B (sv) * | 1984-12-07 | 1989-04-17 | Pharmacia Ab | Anordning med kolonnelement uppdelat i provparti och referenspatri |
| US5879881A (en) * | 1985-04-04 | 1999-03-09 | Hybritech, Incorporated | Solid phase system for use in ligand-receptor assays |
| JPH0672883B2 (ja) * | 1985-06-19 | 1994-09-14 | コニカ株式会社 | 分析素子 |
| IT1206532B (it) * | 1985-10-15 | 1989-04-27 | Marcucci Francesco | Metodo allergodiagnostico mucosale e relativo dispositivo per il rilievo in vivo delle ige specifiche e totali |
| DK531185A (da) * | 1985-11-18 | 1987-05-19 | Radiometer As | Sensor til bestemmelse af koncentrationen af en biokemisk species |
| US4940670A (en) * | 1986-01-24 | 1990-07-10 | Rhodes Buck A | Method for compounding and testing patient specific monoclonal antibodies and monoclonal antibody fragments for in vivo use |
| DE3609217A1 (de) * | 1986-03-19 | 1987-09-24 | Boehringer Mannheim Gmbh | Verfahren und reagenz zur bestimmung eines reaktionspartners einer immunologischen reaktion |
| SE454465B (sv) * | 1986-04-15 | 1988-05-02 | Biopool Ab | Non kompetitiv fast-fas immunanalys med kompensation for ospecifik adsorption |
| US4762787A (en) * | 1986-11-21 | 1988-08-09 | Imre Corporation | Anti-human IGM immunoadsorbent and process for producing said immunoadsorbent |
| US4863869A (en) * | 1986-11-21 | 1989-09-05 | Imre Cororation | Anti-human IGM immunoadsorbent and process for producing said immunoadsorbent |
| US5250410A (en) * | 1987-01-27 | 1993-10-05 | Allegheny-Singer Research Institute | Rapid detection of herpes virus with lectin |
| US5447837A (en) * | 1987-08-05 | 1995-09-05 | Calypte, Inc. | Multi-immunoassay diagnostic system for antigens or antibodies or both |
| US4987086A (en) * | 1987-11-30 | 1991-01-22 | Becton, Dickinson And Company | Method for analysis of subpopulations of cells |
| US5064616A (en) * | 1987-11-30 | 1991-11-12 | Becton Dickinson And Company | Kit for analysis of subsets of subpopulations of leukocytes |
| JPH0743381B2 (ja) * | 1988-10-28 | 1995-05-15 | 株式会社日立製作所 | 光音響免疫分析方法及び装置 |
| US5420013A (en) * | 1991-05-10 | 1995-05-30 | Sangstat Medical Corporation | HLA typing |
| DE4434093A1 (de) * | 1994-09-23 | 1996-03-28 | Boehringer Mannheim Gmbh | Verfahren zum qualitativen oder/und quantitativen Nachweis einer zu bestimmenden Substanz |
| US6908770B1 (en) | 1998-07-16 | 2005-06-21 | Board Of Regents, The University Of Texas System | Fluid based analysis of multiple analytes by a sensor array |
| US7022517B1 (en) | 1999-07-16 | 2006-04-04 | Board Of Regents, The University Of Texas System | Method and apparatus for the delivery of samples to a chemical sensor array |
| EP1204859B1 (en) | 1999-07-16 | 2006-11-22 | The Board Of Regents, The University Of Texas System | Method and apparatus for the delivery of samples to a chemical sensor array |
| CA2401782A1 (en) | 2000-01-31 | 2001-08-02 | John T. Mcdevitt | Portable sensor array system |
| EP1502097A2 (en) * | 2002-04-26 | 2005-02-02 | Board of Regents, The University of Texas System | Method and system for the detection of cardiac risk factors |
| CA2549190A1 (en) | 2003-12-11 | 2005-06-30 | Board Of Regents, The University Of Texas System | Method and system for the analysis of saliva using a sensor array |
| WO2005061532A1 (es) * | 2003-12-23 | 2005-07-07 | Berthet Francois Xavier | Composiciones y procedimientos para detectar infección patógena |
| US8105849B2 (en) | 2004-02-27 | 2012-01-31 | Board Of Regents, The University Of Texas System | Integration of fluids and reagents into self-contained cartridges containing sensor elements |
| US8101431B2 (en) | 2004-02-27 | 2012-01-24 | Board Of Regents, The University Of Texas System | Integration of fluids and reagents into self-contained cartridges containing sensor elements and reagent delivery systems |
| US8377398B2 (en) | 2005-05-31 | 2013-02-19 | The Board Of Regents Of The University Of Texas System | Methods and compositions related to determination and use of white blood cell counts |
| GB0700133D0 (en) | 2007-01-04 | 2007-02-14 | Humabs Llc | Human cytomegalovirus neutralising antibodies and use thereof |
| US7947274B2 (en) | 2007-01-04 | 2011-05-24 | Humabs, LLC. | Human cytomegalovirus neutralising antibodies and use thereof |
| EP2352759B1 (en) | 2008-07-16 | 2017-11-01 | Institute for Research in Biomedicine | Human cytomegalovirus neutralizing antibodies and use thereof |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3777014A (en) * | 1971-02-02 | 1973-12-04 | Beckman Instruments Inc | Method and reagents for the diagnosis of viral diseases |
| US4011308A (en) * | 1974-01-04 | 1977-03-08 | General Electric Company | Method for surface immunological detection of biological particles by the use of tagged antibodies |
| GB1506017A (en) * | 1974-03-04 | 1978-04-05 | Int Diagnostic Tech | Fluorometric system and method for the detection of biologically derived substances |
| US3951748A (en) * | 1974-11-11 | 1976-04-20 | Medical Products, Inc. | Sensitized matrix for detection of disease |
| US4056724A (en) * | 1975-02-27 | 1977-11-01 | International Diagnostic Technology | Fluorometric system, method and test article |
| US3992631A (en) * | 1975-02-27 | 1976-11-16 | International Diagnostic Technology, Inc. | Fluorometric system, method and test article |
| JPS51114985A (en) * | 1975-04-01 | 1976-10-09 | Kyoto Daiichi Kagaku:Kk | Mothod to analyse urine, etc. |
| JPS605899B2 (ja) * | 1975-04-10 | 1985-02-14 | 中外製薬株式会社 | 免疫化学的定量法 |
| US3999948A (en) * | 1975-11-03 | 1976-12-28 | International Diagnostic Technology | Diagnostic reagent holder and method |
| JPS5819066B2 (ja) * | 1975-11-17 | 1983-04-15 | 武田薬品工業株式会社 | トガウ イルス ｈｉ反応方法 |
| US4020151A (en) * | 1976-02-17 | 1977-04-26 | International Diagnostic Technology, Inc. | Method for quantitation of antigens or antibodies on a solid surface |
| US4067959A (en) * | 1976-05-10 | 1978-01-10 | International Diagnostic Technology, Inc. | Indirect solid surface test for antigens or antibodies |
| US4025310A (en) * | 1976-05-28 | 1977-05-24 | International Diagnostic Technology, Inc. | Method for reading a wet fluorescent surface |
| US4135884A (en) * | 1977-08-29 | 1979-01-23 | Shen James T | Gamma stick |
| US4163779A (en) * | 1978-01-09 | 1979-08-07 | International Diagnostic Technology, Inc. | Test for quantitation of immunoglobulin and identification of abnormal immunoglobulin |
-
1978
- 1978-09-18 US US05/943,314 patent/US4294817A/en not_active Expired - Lifetime
- 1978-10-27 CA CA314,577A patent/CA1111346A/en not_active Expired
- 1978-11-22 JP JP14494278A patent/JPS5486611A/ja active Granted
- 1978-11-23 GB GB7845832A patent/GB2008747B/en not_active Expired
- 1978-11-24 FR FR7833216A patent/FR2410278A1/fr active Granted
- 1978-11-25 DE DE2851150A patent/DE2851150C2/de not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| US4294817A (en) | 1981-10-13 |
| JPS5486611A (en) | 1979-07-10 |
| GB2008747A (en) | 1979-06-06 |
| FR2410278B1 (enExample) | 1983-08-19 |
| FR2410278A1 (fr) | 1979-06-22 |
| GB2008747B (en) | 1982-09-02 |
| DE2851150C2 (de) | 1982-11-25 |
| CA1111346A (en) | 1981-10-27 |
| DE2851150A1 (de) | 1979-06-07 |
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