JPH0153276B2 - - Google Patents

Info

Publication number
JPH0153276B2
JPH0153276B2 JP54127427A JP12742779A JPH0153276B2 JP H0153276 B2 JPH0153276 B2 JP H0153276B2 JP 54127427 A JP54127427 A JP 54127427A JP 12742779 A JP12742779 A JP 12742779A JP H0153276 B2 JPH0153276 B2 JP H0153276B2
Authority
JP
Japan
Prior art keywords
group
atoms
formula
hydrogen atom
atom
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
JP54127427A
Other languages
English (en)
Japanese (ja)
Other versions
JPS5549374A (en
Inventor
Gugurierumetsutei Reonarudo
Ryuutei Kurisuteian
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of JPS5549374A publication Critical patent/JPS5549374A/ja
Publication of JPH0153276B2 publication Critical patent/JPH0153276B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/10—Radicals substituted by halogen atoms or nitro radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP12742779A 1978-10-04 1979-10-04 Manufacture of furanyllbenzazole Granted JPS5549374A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH1030478 1978-10-04

Publications (2)

Publication Number Publication Date
JPS5549374A JPS5549374A (en) 1980-04-09
JPH0153276B2 true JPH0153276B2 (OSRAM) 1989-11-13

Family

ID=4361752

Family Applications (1)

Application Number Title Priority Date Filing Date
JP12742779A Granted JPS5549374A (en) 1978-10-04 1979-10-04 Manufacture of furanyllbenzazole

Country Status (5)

Country Link
EP (1) EP0010063B1 (OSRAM)
JP (1) JPS5549374A (OSRAM)
BR (1) BR7906368A (OSRAM)
DE (1) DE2964427D1 (OSRAM)
ES (1) ES484676A1 (OSRAM)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2904829A1 (de) * 1979-02-08 1980-08-14 Bayer Ag Verfahren zur herstellung von benzimidazolylbenzofuran
US4542222A (en) * 1980-12-29 1985-09-17 Ciba-Ceigy Corporation Benzimidazoles
JPS615071A (ja) * 1984-06-15 1986-01-10 Fuji Photo Film Co Ltd ベンゾオキサゾ−ル誘導体
GB8417194D0 (en) * 1984-07-05 1984-08-08 Boots Co Plc Therapeutic agents
US4581457A (en) * 1984-09-21 1986-04-08 American Home Products Corporation Heterocyclic sulfonamides
DE4129603A1 (de) * 1991-09-06 1993-03-11 Thomae Gmbh Dr K Kondensierte 5-gliedrige heterocyclen, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
IT1272917B (it) * 1995-01-20 1997-07-01 3V Sigma Spa Derivati di benzossazolo,loro uso come filtri solari e composizioni cosmetiche che li contengono
AU773097B2 (en) * 1996-07-03 2004-05-13 Beckman Coulter, Inc. Automatic chemistry analyser
CA2363274A1 (en) 1999-12-27 2001-07-05 Japan Tobacco Inc. Fused-ring compounds and use thereof as drugs for hepatitis c
AU2002346216B2 (en) * 1999-12-27 2005-12-08 Japan Tobacco Inc. Fused cyclic compounds and medicinal use thereof
US6770666B2 (en) 1999-12-27 2004-08-03 Japan Tobacco Inc. Fused-ring compounds and use thereof as drugs
US6448281B1 (en) 2000-07-06 2002-09-10 Boehringer Ingelheim (Canada) Ltd. Viral polymerase inhibitors
AR035543A1 (es) * 2001-06-26 2004-06-16 Japan Tobacco Inc Agente terapeutico para la hepatitis c que comprende un compuesto de anillo condensado, compuesto de anillo condensado, composicion farmaceutica que lo comprende, compuestos de benzimidazol, tiazol y bifenilo utiles como intermediarios para producir dichos compuestos, uso del compuesto de anillo con
EP2335700A1 (en) 2001-07-25 2011-06-22 Boehringer Ingelheim (Canada) Ltd. Hepatitis C virus polymerase inhibitors with a heterobicylic structure
US7098231B2 (en) 2003-01-22 2006-08-29 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
US7223785B2 (en) 2003-01-22 2007-05-29 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
ZA200600424B (en) 2003-08-01 2007-05-30 Genelabs Tech Inc Bicyclic imidazol derivatives against flaviviridae
PL1718608T3 (pl) 2004-02-20 2013-11-29 Boehringer Ingelheim Int Inhibitory polimerazy wirusowej
CA2618682C (en) 2005-08-12 2011-06-21 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
SG177740A1 (en) * 2009-07-23 2012-02-28 Univ Vanderbilt Substituted benzoimidazolesulfonamides and substituted indolesulfonamides as mglur4 potentiators
WO2013102145A1 (en) 2011-12-28 2013-07-04 Global Blood Therapeutics, Inc. Substituted heteroaryl aldehyde compounds and methods for their use in increasing tissue oxygenation
JP6242810B2 (ja) 2011-12-28 2017-12-06 グローバル・ブラッド・セラピューティクス・インコーポレイテッドＧｌｏｂａｌ Ｂｌｏｏｄ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． 置換ベンズアルデヒド化合物および組織酸素化の増加におけるそれらの使用方法
US10100043B2 (en) 2013-03-15 2018-10-16 Global Blood Therapeutics, Inc. Substituted aldehyde compounds and methods for their use in increasing tissue oxygenation
US9458139B2 (en) 2013-03-15 2016-10-04 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
CN105246477A (zh) 2013-03-15 2016-01-13 全球血液疗法股份有限公司 化合物及其用于调节血红蛋白的用途
US9422279B2 (en) 2013-03-15 2016-08-23 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
EA037091B1 (ru) 2013-03-15 2021-02-04 Глобал Блад Терапьютикс, Инк. Соединения и их применения для модуляции гемоглобина
US8952171B2 (en) 2013-03-15 2015-02-10 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
MX379228B (es) 2013-03-15 2025-03-10 Global Blood Therapeutics Inc Compuestos y usos de estos para la modulación de la hemoglobina.
US9802900B2 (en) 2013-03-15 2017-10-31 Global Blood Therapeutics, Inc. Bicyclic heteroaryl compounds and uses thereof for the modulation of hemoglobin
US10266551B2 (en) 2013-03-15 2019-04-23 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US9604999B2 (en) 2013-03-15 2017-03-28 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US20140274961A1 (en) 2013-03-15 2014-09-18 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
EA201992707A1 (ru) 2013-11-18 2020-06-30 Глобал Блад Терапьютикс, Инк. Соединения и их применения для модуляции гемоглобина
CN114213390A (zh) 2014-02-07 2022-03-22 全球血液疗法股份有限公司 一种化合物的结晶多晶型物
MA41841A (fr) 2015-03-30 2018-02-06 Global Blood Therapeutics Inc Composés aldéhyde pour le traitement de la fibrose pulmonaire, de l'hypoxie, et de maladies auto-immunes et des tissus conjonctifs
FI3383392T3 (fi) 2015-12-04 2025-09-11 Global Blood Therapeutics Inc Annosteluohjelmat 2-hydroksi-6-((2-(1-isopropyyli-1h-pyratsol-5-yyli)pyridin-3-yyli)metoksi)bentsaldehydille
TWI752307B (zh) 2016-05-12 2022-01-11 美商全球血液治療公司 新穎化合物及製造化合物之方法
TWI778983B (zh) 2016-10-12 2022-10-01 美商全球血液治療公司 包含2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)吡啶-3-基)甲氧基)-苯甲醛之片劑
WO2020072377A1 (en) 2018-10-01 2020-04-09 Global Blood Therapeutics, Inc. Modulators of hemoglobin for the treatment of sickle cell disease

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE787580A (fr) * 1971-08-13 1973-02-14 Hoechst Ag Procede de preparation de derives du furanne
CH583723A5 (OSRAM) * 1972-12-18 1977-01-14 Hoechst Ag

Also Published As

Publication number Publication date
BR7906368A (pt) 1980-05-27
EP0010063B1 (de) 1982-12-29
EP0010063A3 (en) 1980-09-03
JPS5549374A (en) 1980-04-09
ES484676A1 (es) 1980-05-16
DE2964427D1 (en) 1983-02-03
EP0010063A2 (de) 1980-04-16

Similar Documents

Publication Publication Date Title
JPH0153276B2 (OSRAM)
CA1103246A (en) Thiazine derivatives
PL172035B1 (pl) Pochodne sulfonamidowe antagonisty endoteliny PL PL PL PL PL
JPH0314315B2 (OSRAM)
NO147879B (no) Analogifremgangsmaate for fremstilling av terapeutisk virksomme 2-substituerte benzimidazoler
JP2004518641A (ja) 化学方法及び新規中間体
PL119641B1 (en) Process for preparing novel,condensed derivatives of pyrimidine pirimidina
Cain et al. Potential antitumor agents. 19. Multiply substituted 4'-(9-acridinylamino) methanesulfonanilides
JP2019038987A (ja) 蛍光色素剤及びカルボスチリル化合物
US4082757A (en) Amides of 4-hydroxy-6H-thieno[2,3-b]thiopyran-5-carboxylic acid-7,7-dioxide
SE444314B (sv) Forfarande for framstellning av bensimidazolderivat
SU1340585A3 (ru) Способ получени производных тетразола
JP2002212181A (ja) ベンゾアゾール基含有トリアジン系化合物の製造方法
US3095421A (en) Bis-azolyl-tetrahydrothiophene compounds
CN110305128A (zh) 5-氨基苯并[b][1,8]萘啶类化合物的制备方法和应用
Lipunova et al. Novel pentacyclic fluoroquinolones
FI84477C (fi) Foerfarande foer framstaellning av farmakologiskt vaerdefulla diazin-etenylfenyloxamsyror.
FI65996B (fi) Foerfarande foer framstaellning av terapeutiskt anvaendbara n-2-furylmetyl)-5-sulfamoyl-ortanilsyror och deras salter
PL171318B1 (en) Method of obtaining benzo[b]naphtyridines
JPS6110548A (ja) スルホンアミド類
JP2002212170A (ja) トリアジン系トリスチリル化合物及びトリアジン系トリアルデヒド化合物
JPH01211580A (ja) 置換イミダゾール誘導体
Kaslow et al. Substituted Quinolines1, 2
JPH0140838B2 (OSRAM)
JPH0250904B2 (OSRAM)