ES484676A1 - Procedimiento para la preparacion de furanil-benzazoles - Google Patents
Procedimiento para la preparacion de furanil-benzazolesInfo
- Publication number
- ES484676A1 ES484676A1 ES484676A ES484676A ES484676A1 ES 484676 A1 ES484676 A1 ES 484676A1 ES 484676 A ES484676 A ES 484676A ES 484676 A ES484676 A ES 484676A ES 484676 A1 ES484676 A1 ES 484676A1
- Authority
- ES
- Spain
- Prior art keywords
- unsubstituted
- substituted
- general formula
- see diagramm
- ring
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/12—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/10—Radicals substituted by halogen atoms or nitro radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Procedimiento para la preparación de furanil-benzazoles, caracterizado por condensarse un compuesto de o-hidroxicarbonilo que presenta un sistema cíclico aromático mononuclear o polinuclear con un 2-halhenmetil-benzazol, en presencia o ausencia de un agente de condensación debilmente básico.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH1030478 | 1978-10-04 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES484676A1 true ES484676A1 (es) | 1980-05-16 |
Family
ID=4361752
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES484676A Expired ES484676A1 (es) | 1978-10-04 | 1979-10-03 | Procedimiento para la preparacion de furanil-benzazoles |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0010063B1 (es) |
JP (1) | JPS5549374A (es) |
BR (1) | BR7906368A (es) |
DE (1) | DE2964427D1 (es) |
ES (1) | ES484676A1 (es) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2904829A1 (de) * | 1979-02-08 | 1980-08-14 | Bayer Ag | Verfahren zur herstellung von benzimidazolylbenzofuran |
US4542222A (en) * | 1980-12-29 | 1985-09-17 | Ciba-Ceigy Corporation | Benzimidazoles |
JPS615071A (ja) * | 1984-06-15 | 1986-01-10 | Fuji Photo Film Co Ltd | ベンゾオキサゾ−ル誘導体 |
GB8417194D0 (en) * | 1984-07-05 | 1984-08-08 | Boots Co Plc | Therapeutic agents |
US4581457A (en) * | 1984-09-21 | 1986-04-08 | American Home Products Corporation | Heterocyclic sulfonamides |
DE4129603A1 (de) * | 1991-09-06 | 1993-03-11 | Thomae Gmbh Dr K | Kondensierte 5-gliedrige heterocyclen, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
IT1272917B (it) * | 1995-01-20 | 1997-07-01 | 3V Sigma Spa | Derivati di benzossazolo,loro uso come filtri solari e composizioni cosmetiche che li contengono |
AU773097B2 (en) * | 1996-07-03 | 2004-05-13 | Beckman Coulter, Inc. | Automatic chemistry analyser |
AU763356C (en) | 1999-12-27 | 2004-08-26 | Japan Tobacco Inc. | Fused-ring compounds and use thereof as drugs |
US6770666B2 (en) | 1999-12-27 | 2004-08-03 | Japan Tobacco Inc. | Fused-ring compounds and use thereof as drugs |
AU2002346216B2 (en) * | 1999-12-27 | 2005-12-08 | Japan Tobacco Inc. | Fused cyclic compounds and medicinal use thereof |
US6448281B1 (en) | 2000-07-06 | 2002-09-10 | Boehringer Ingelheim (Canada) Ltd. | Viral polymerase inhibitors |
AR035543A1 (es) * | 2001-06-26 | 2004-06-16 | Japan Tobacco Inc | Agente terapeutico para la hepatitis c que comprende un compuesto de anillo condensado, compuesto de anillo condensado, composicion farmaceutica que lo comprende, compuestos de benzimidazol, tiazol y bifenilo utiles como intermediarios para producir dichos compuestos, uso del compuesto de anillo con |
EP2335700A1 (en) | 2001-07-25 | 2011-06-22 | Boehringer Ingelheim (Canada) Ltd. | Hepatitis C virus polymerase inhibitors with a heterobicylic structure |
US7223785B2 (en) | 2003-01-22 | 2007-05-29 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
US7098231B2 (en) | 2003-01-22 | 2006-08-29 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
TW200517381A (en) | 2003-08-01 | 2005-06-01 | Genelabs Tech Inc | Bicyclic heteroaryl derivatives |
ES2431314T3 (es) | 2004-02-20 | 2013-11-26 | Boehringer Ingelheim International Gmbh | Inhibidores de polimerasa vírica |
CA2618682C (en) | 2005-08-12 | 2011-06-21 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
SG177740A1 (en) * | 2009-07-23 | 2012-02-28 | Univ Vanderbilt | Substituted benzoimidazolesulfonamides and substituted indolesulfonamides as mglur4 potentiators |
WO2013102145A1 (en) | 2011-12-28 | 2013-07-04 | Global Blood Therapeutics, Inc. | Substituted heteroaryl aldehyde compounds and methods for their use in increasing tissue oxygenation |
ES2963218T3 (es) | 2011-12-28 | 2024-03-25 | Global Blood Therapeutics Inc | Productos intermedios para obtener compuestos de benzaldehído sustituidos y métodos para su uso en el aumento de la oxigenación tisular |
US9802900B2 (en) | 2013-03-15 | 2017-10-31 | Global Blood Therapeutics, Inc. | Bicyclic heteroaryl compounds and uses thereof for the modulation of hemoglobin |
US9458139B2 (en) | 2013-03-15 | 2016-10-04 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
CN111454200A (zh) | 2013-03-15 | 2020-07-28 | 全球血液疗法股份有限公司 | 化合物及其用于调节血红蛋白的用途 |
US9422279B2 (en) | 2013-03-15 | 2016-08-23 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
US9604999B2 (en) | 2013-03-15 | 2017-03-28 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
US20140274961A1 (en) | 2013-03-15 | 2014-09-18 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
WO2014145040A1 (en) | 2013-03-15 | 2014-09-18 | Global Blood Therapeutics, Inc. | Substituted aldehyde compounds and methods for their use in increasing tissue oxygenation |
US8952171B2 (en) | 2013-03-15 | 2015-02-10 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
CA2902711C (en) | 2013-03-15 | 2021-07-06 | Global Blood Therapeutics, Inc. | Substituted pyridinyl-6-methoxy-2-hydroxybenzaldehyde derivatives and pharmaceutical compositions thereof useful for the modulation of hemoglobin |
US10266551B2 (en) | 2013-03-15 | 2019-04-23 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
US20160083343A1 (en) | 2013-03-15 | 2016-03-24 | Global Blood Therapeutics, Inc | Compounds and uses thereof for the modulation of hemoglobin |
EA201992707A1 (ru) | 2013-11-18 | 2020-06-30 | Глобал Блад Терапьютикс, Инк. | Соединения и их применения для модуляции гемоглобина |
CA2916564C (en) | 2014-02-07 | 2023-02-28 | Global Blood Therapeutics, Inc. | Crystalline polymorphs of the free base of 2-hydroxy-6-((2-(1-isopropyl-1h-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde |
MA41841A (fr) | 2015-03-30 | 2018-02-06 | Global Blood Therapeutics Inc | Composés aldéhyde pour le traitement de la fibrose pulmonaire, de l'hypoxie, et de maladies auto-immunes et des tissus conjonctifs |
SG10201912511WA (en) | 2015-12-04 | 2020-02-27 | Global Blood Therapeutics Inc | Dosing regimens for 2-hydroxy-6-((2-(1-isopropyl-1h-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde |
TWI663160B (zh) | 2016-05-12 | 2019-06-21 | 全球血液治療公司 | 用於合成2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)-吡啶-3-基)甲氧基)苯甲醛之方法 |
TWI778983B (zh) | 2016-10-12 | 2022-10-01 | 美商全球血液治療公司 | 包含2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)吡啶-3-基)甲氧基)-苯甲醛之片劑 |
US11014884B2 (en) | 2018-10-01 | 2021-05-25 | Global Blood Therapeutics, Inc. | Modulators of hemoglobin |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE787580A (fr) * | 1971-08-13 | 1973-02-14 | Hoechst Ag | Procede de preparation de derives du furanne |
CH583723A5 (es) * | 1972-12-18 | 1977-01-14 | Hoechst Ag |
-
1979
- 1979-09-28 EP EP19790810104 patent/EP0010063B1/de not_active Expired
- 1979-09-28 DE DE7979810104T patent/DE2964427D1/de not_active Expired
- 1979-10-03 BR BR7906368A patent/BR7906368A/pt not_active IP Right Cessation
- 1979-10-03 ES ES484676A patent/ES484676A1/es not_active Expired
- 1979-10-04 JP JP12742779A patent/JPS5549374A/ja active Granted
Also Published As
Publication number | Publication date |
---|---|
DE2964427D1 (en) | 1983-02-03 |
EP0010063A2 (de) | 1980-04-16 |
JPH0153276B2 (es) | 1989-11-13 |
BR7906368A (pt) | 1980-05-27 |
EP0010063A3 (en) | 1980-09-03 |
EP0010063B1 (de) | 1982-12-29 |
JPS5549374A (en) | 1980-04-09 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC1A | Transfer granted |