JPH01157385A - α−アミラーゼインヒビター - Google Patents
α−アミラーゼインヒビターInfo
- Publication number
- JPH01157385A JPH01157385A JP63164062A JP16406288A JPH01157385A JP H01157385 A JPH01157385 A JP H01157385A JP 63164062 A JP63164062 A JP 63164062A JP 16406288 A JP16406288 A JP 16406288A JP H01157385 A JPH01157385 A JP H01157385A
- Authority
- JP
- Japan
- Prior art keywords
- amylase
- inhibitor
- protein
- wheat flour
- barley
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003392 amylase inhibitor Substances 0.000 title claims abstract description 33
- 101710171801 Alpha-amylase inhibitor Proteins 0.000 title claims abstract description 21
- 108090000623 proteins and genes Proteins 0.000 claims abstract description 59
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- 102000004169 proteins and genes Human genes 0.000 claims abstract description 43
- 235000007340 Hordeum vulgare Nutrition 0.000 claims abstract description 38
- 239000003112 inhibitor Substances 0.000 claims abstract description 38
- QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 claims abstract description 13
- 235000013339 cereals Nutrition 0.000 claims abstract description 13
- 238000004587 chromatography analysis Methods 0.000 claims abstract description 9
- 101001123835 Thermoactinomyces vulgaris Neopullulanase 2 Proteins 0.000 claims abstract description 7
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- 244000063299 Bacillus subtilis Species 0.000 claims abstract description 6
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- 239000000284 extract Substances 0.000 claims abstract description 5
- 108091005658 Basic proteases Proteins 0.000 claims abstract description 4
- 108090000787 Subtilisin Proteins 0.000 claims abstract description 4
- 240000005979 Hordeum vulgare Species 0.000 claims abstract 4
- 150000003839 salts Chemical group 0.000 claims abstract 2
- 235000013312 flour Nutrition 0.000 claims description 47
- 235000018102 proteins Nutrition 0.000 claims description 41
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- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 claims description 2
- 108010073032 Grain Proteins Proteins 0.000 claims 2
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- 239000011780 sodium chloride Substances 0.000 description 5
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- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 3
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- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 239000000287 crude extract Substances 0.000 description 1
- 230000000593 degrading effect Effects 0.000 description 1
- 239000005547 deoxyribonucleotide Substances 0.000 description 1
- -1 deoxyribonucleotide triphosphates Chemical class 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- 239000005546 dideoxynucleotide Substances 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 238000009585 enzyme analysis Methods 0.000 description 1
- QPADNTZLUBYNEN-UHFFFAOYSA-N etallobarbital Chemical compound C=CCC1(CC)C(=O)NC(=O)NC1=O QPADNTZLUBYNEN-UHFFFAOYSA-N 0.000 description 1
- 210000003527 eukaryotic cell Anatomy 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 235000013373 food additive Nutrition 0.000 description 1
- 239000002778 food additive Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 229930182830 galactose Natural products 0.000 description 1
- 239000011544 gradient gel Substances 0.000 description 1
- 238000003306 harvesting Methods 0.000 description 1
- 229910001385 heavy metal Inorganic materials 0.000 description 1
- 238000009396 hybridization Methods 0.000 description 1
- 102000018358 immunoglobulin Human genes 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 108091006086 inhibitor proteins Proteins 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 108010034897 lentil lectin Proteins 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 108020004999 messenger RNA Proteins 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 238000002703 mutagenesis Methods 0.000 description 1
- 231100000350 mutagenesis Toxicity 0.000 description 1
- 230000035772 mutation Effects 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 229920001220 nitrocellulos Polymers 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 150000003833 nucleoside derivatives Chemical class 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 229950009506 penicillinase Drugs 0.000 description 1
- 102000013415 peroxidase activity proteins Human genes 0.000 description 1
- 108040007629 peroxidase activity proteins Proteins 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 102000020233 phosphotransferase Human genes 0.000 description 1
- 239000013600 plasmid vector Substances 0.000 description 1
- 238000002264 polyacrylamide gel electrophoresis Methods 0.000 description 1
- 239000001253 polyvinylpolypyrrolidone Substances 0.000 description 1
- 235000013809 polyvinylpolypyrrolidone Nutrition 0.000 description 1
- 229920000523 polyvinylpolypyrrolidone Polymers 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000002797 proteolythic effect Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000013605 shuttle vector Substances 0.000 description 1
- 238000002741 site-directed mutagenesis Methods 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 1
- 238000000638 solvent extraction Methods 0.000 description 1
- 230000003595 spectral effect Effects 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 239000010421 standard material Substances 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000012799 strong cation exchange Methods 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 239000001226 triphosphate Substances 0.000 description 1
- 235000011178 triphosphate Nutrition 0.000 description 1
- 239000002753 trypsin inhibitor Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Botany (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Bakery Products And Manufacturing Methods Therefor (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA540,780 | 1987-06-29 | ||
| CA540780 | 1987-06-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH01157385A true JPH01157385A (ja) | 1989-06-20 |
Family
ID=4135996
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP63164062A Pending JPH01157385A (ja) | 1987-06-29 | 1988-06-29 | α−アミラーゼインヒビター |
Country Status (3)
| Country | Link |
|---|---|
| US (2) | US4910297A (fr) |
| EP (1) | EP0297834A3 (fr) |
| JP (1) | JPH01157385A (fr) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005104875A (ja) * | 2003-09-29 | 2005-04-21 | Univ Kansai | 穀物種子抽出物およびその用途 |
| CN103349149A (zh) * | 2013-07-16 | 2013-10-16 | 浙江工商大学 | 利用稻米天然生物活性蛋白制备减肥食品的方法 |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3707150A1 (de) * | 1987-03-06 | 1988-09-15 | Hoechst Ag | Tendamistat-derivate |
| JP2757405B2 (ja) * | 1988-12-09 | 1998-05-25 | 日清製粉株式会社 | 小麦から得られるα−アミラーゼインヒビターを含有するダイエット剤 |
| GB9013017D0 (en) * | 1990-06-11 | 1990-08-01 | Mars Uk Ltd | Compounds |
| JPH05139985A (ja) * | 1991-11-18 | 1993-06-08 | Yakurigaku Chuo Kenkyusho:Kk | 糖尿病治療薬 |
| JP3195937B2 (ja) * | 1992-04-22 | 2001-08-06 | 日清製粉株式会社 | アミラーゼ阻害物質の取得方法 |
| US20030206982A1 (en) * | 2002-04-24 | 2003-11-06 | Antje Spors | Method of improving dietary balance using gustatory and olfactory aliesthesia |
| WO2004002239A2 (fr) * | 2002-06-28 | 2004-01-08 | Pharmachem Laboratories, Inc. | Inhibiteur d'amylase purifie et nouveau procede pour l'obtenir |
| US10611853B1 (en) | 2008-04-01 | 2020-04-07 | Ardent Mills, Llc | Assessing and improving wheat gluten quality with rheometric analysis |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL35986A (en) * | 1970-01-29 | 1974-10-22 | Bayer Ag | Amylase inhibitor,its production and use |
| US3950319A (en) * | 1970-01-29 | 1976-04-13 | Farbenfabriken Bayer Aktiengesellschaft | Amylase inhibitor from wheat gluten using alcohol |
| US3944537A (en) * | 1974-11-26 | 1976-03-16 | The United States Of America As Represented By The Secretary Of Agriculture | Preparation of alpha-amylase inhibitor |
| JPS57140727A (en) * | 1981-02-10 | 1982-08-31 | Nisshin Flour Milling Co Ltd | Novel alpha-amylase inhibitor substance |
| JPS5885899A (ja) * | 1981-11-16 | 1983-05-23 | Fujirebio Inc | アミラ−ゼインヒビタ−およびその製造法 |
-
1988
- 1988-06-16 US US07/207,669 patent/US4910297A/en not_active Expired - Fee Related
- 1988-06-29 JP JP63164062A patent/JPH01157385A/ja active Pending
- 1988-06-29 EP EP19880305881 patent/EP0297834A3/fr not_active Withdrawn
-
1990
- 1990-01-08 US US07/461,990 patent/US5047257A/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005104875A (ja) * | 2003-09-29 | 2005-04-21 | Univ Kansai | 穀物種子抽出物およびその用途 |
| JP4547545B2 (ja) * | 2003-09-29 | 2010-09-22 | 学校法人 関西大学 | 穀物種子抽出物およびその用途 |
| CN103349149A (zh) * | 2013-07-16 | 2013-10-16 | 浙江工商大学 | 利用稻米天然生物活性蛋白制备减肥食品的方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| US5047257A (en) | 1991-09-10 |
| US4910297A (en) | 1990-03-20 |
| EP0297834A2 (fr) | 1989-01-04 |
| EP0297834A3 (fr) | 1991-04-10 |
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