JP7829547B2 - 抗Ｎｏｔｃｈ２抗体及び使用方法 - Google Patents

抗Ｎｏｔｃｈ２抗体及び使用方法

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Publication number
JP7829547B2
JP7829547B2 JP2023502689A JP2023502689A JP7829547B2 JP 7829547 B2 JP7829547 B2 JP 7829547B2 JP 2023502689 A JP2023502689 A JP 2023502689A JP 2023502689 A JP2023502689 A JP 2023502689A JP 7829547 B2 JP7829547 B2 JP 7829547B2
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JP
Japan
Prior art keywords
seq
antibody
amino acid
cdr
acid sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
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JP2023502689A
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English (en)
Japanese (ja)
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JP2023534458A (ja
JP2023534458A5 (enExample
Inventor
セシリア プイ チー チウ，
ヤン ウー，
アデル マハムード エルソーリー，
ダニエル ジョージ ラフカス，
ジャン メヘル－ディーン パヤンデ，
シャオ－ピン ツァイ，
ホアンドゥン ダン ホー，
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genentech Inc
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Genentech Inc
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Application filed by Genentech Inc filed Critical Genentech Inc
Publication of JP2023534458A publication Critical patent/JP2023534458A/ja
Publication of JP2023534458A5 publication Critical patent/JP2023534458A5/ja
Priority to JP2026033054A priority Critical patent/JP2026102663A/ja
Application granted granted Critical
Publication of JP7829547B2 publication Critical patent/JP7829547B2/ja
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/35—Valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2023502689A 2020-07-17 2021-07-16 抗Ｎｏｔｃｈ２抗体及び使用方法 Active JP7829547B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2026033054A JP2026102663A (ja) 2020-07-17 2026-03-03 抗Ｎｏｔｃｈ２抗体及び使用方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063053034P 2020-07-17 2020-07-17
US63/053,034 2020-07-17
PCT/US2021/041935 WO2022016037A1 (en) 2020-07-17 2021-07-16 Anti-notch2 antibodies and methods of use

Related Child Applications (1)

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JP2026033054A Division JP2026102663A (ja) 2020-07-17 2026-03-03 抗Ｎｏｔｃｈ２抗体及び使用方法

Publications (3)

Publication Number Publication Date
JP2023534458A JP2023534458A (ja) 2023-08-09
JP2023534458A5 JP2023534458A5 (enExample) 2025-07-24
JP7829547B2 true JP7829547B2 (ja) 2026-03-13

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JP2023502689A Active JP7829547B2 (ja) 2020-07-17 2021-07-16 抗Ｎｏｔｃｈ２抗体及び使用方法
JP2026033054A Pending JP2026102663A (ja) 2020-07-17 2026-03-03 抗Ｎｏｔｃｈ２抗体及び使用方法

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Country Status (18)

Country Link
US (1) US20230303682A1 (enExample)
EP (1) EP4182348A1 (enExample)
JP (2) JP7829547B2 (enExample)
KR (1) KR20230038735A (enExample)
CN (1) CN116406377A (enExample)
AR (1) AR123001A1 (enExample)
AU (1) AU2021308653A1 (enExample)
BR (1) BR112023000839A2 (enExample)
CA (1) CA3185122A1 (enExample)
CL (3) CL2023000129A1 (enExample)
CO (1) CO2023000505A2 (enExample)
CR (1) CR20230087A (enExample)
IL (1) IL299799A (enExample)
MX (1) MX2023000617A (enExample)
PE (1) PE20231300A1 (enExample)
PH (1) PH12023550112A1 (enExample)
TW (1) TW202216780A (enExample)
WO (1) WO2022016037A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023141445A1 (en) * 2022-01-19 2023-07-27 Genentech, Inc. Anti-notch2 antibodies and conjugates and methods of use
CN121057747A (zh) * 2023-04-18 2025-12-02 上海洛启生物医药技术有限公司 抗Notch2纳米抗体及其应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012501625A (ja) 2008-07-08 2012-01-26 オンコメッド ファーマシューティカルズ インコーポレイテッド Ｎｏｔｃｈ結合剤およびアンタゴニストならびにその使用方法

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