JP7737306B2 - Ｔ細胞に結合する多機能性分子および自己免疫障害を処置するためのその使用 - Google Patents

Ｔ細胞に結合する多機能性分子および自己免疫障害を処置するためのその使用

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JP7737306B2
JP7737306B2 JP2021549485A JP2021549485A JP7737306B2 JP 7737306 B2 JP7737306 B2 JP 7737306B2 JP 2021549485 A JP2021549485 A JP 2021549485A JP 2021549485 A JP2021549485 A JP 2021549485A JP 7737306 B2 JP7737306 B2 JP 7737306B2
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amino acid
acid sequence
seq
set forth
sequence set
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JPWO2020172598A5 (https=
JP2022522662A5 (https=
JP2022522662A (ja
Inventor
レーウ，アンドレアス
タン，セン－ライ
スー，ジョナサン
バシュ，ブライアン・エドワード
マイオッコ，ステファニー・ジェイ
マルホトラ，ニディ
カトラガッダ，マダン
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マレンゴ・セラピューティクス，インコーポレーテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
JP2021549485A 2019-02-21 2020-02-21 Ｔ細胞に結合する多機能性分子および自己免疫障害を処置するためのその使用 Active JP7737306B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2025056737A JP2025102876A (ja) 2019-02-21 2025-03-28 Ｔ細胞に結合する多機能性分子および自己免疫障害を処置するためのその使用

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962808713P 2019-02-21 2019-02-21
US62/808,713 2019-02-21
US202062957045P 2020-01-03 2020-01-03
US62/957,045 2020-01-03
PCT/US2020/019321 WO2020172598A1 (en) 2019-02-21 2020-02-21 Multifunctional molecules that bind to t cells and uses thereof to treat autoimmune disorders

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2025056737A Division JP2025102876A (ja) 2019-02-21 2025-03-28 Ｔ細胞に結合する多機能性分子および自己免疫障害を処置するためのその使用

Publications (4)

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JP2022522662A JP2022522662A (ja) 2022-04-20
JPWO2020172598A5 JPWO2020172598A5 (https=) 2023-06-05
JP2022522662A5 JP2022522662A5 (https=) 2023-06-05
JP7737306B2 true JP7737306B2 (ja) 2025-09-10

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JP2021549485A Active JP7737306B2 (ja) 2019-02-21 2020-02-21 Ｔ細胞に結合する多機能性分子および自己免疫障害を処置するためのその使用
JP2025056737A Pending JP2025102876A (ja) 2019-02-21 2025-03-28 Ｔ細胞に結合する多機能性分子および自己免疫障害を処置するためのその使用

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Country Status (9)

Country Link
US (1) US20210380691A1 (https=)
EP (1) EP3927745A1 (https=)
JP (2) JP7737306B2 (https=)
CN (2) CN114127112A (https=)
AU (2) AU2020224680B2 (https=)
CA (1) CA3130628A1 (https=)
GB (1) GB2599227B (https=)
SG (1) SG11202109033XA (https=)
WO (1) WO2020172598A1 (https=)

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EP3737692A4 (en) 2018-01-09 2021-09-29 Elstar Therapeutics, Inc. CALRETICULIN AND MODIFIED T-LYMPHOCYTES BINDING CONSTRUCTIONS FOR THE TREATMENT OF DISEASES
US12152073B2 (en) 2018-03-14 2024-11-26 Marengo Therapeutics, Inc. Multifunctional molecules that bind to calreticulin and uses thereof
EP3818083A2 (en) 2018-07-03 2021-05-12 Elstar Therapeutics, Inc. Anti-tcr antibody molecules and uses thereof
AU2020224681A1 (en) 2019-02-21 2021-09-16 Marengo Therapeutics, Inc. Antibody molecules that bind to NKp30 and uses thereof
JP7710373B2 (ja) 2019-02-21 2025-07-18 マレンゴ・セラピューティクス，インコーポレーテッド Ｔ細胞関連のがん細胞に結合する多機能性分子およびその使用
CN116234829A (zh) 2020-01-03 2023-06-06 马伦戈治疗公司 抗tcr抗体分子及其用途
CN116867519A (zh) * 2020-12-01 2023-10-10 约翰斯霍普金斯大学 治疗t细胞癌症的方法和材料
CA3214757A1 (en) * 2021-04-08 2022-10-13 Andreas Loew Multifuntional molecules binding to tcr and uses thereof
BR112023025331A2 (pt) * 2021-06-09 2024-02-27 Innate Pharma Proteína multiespecífica, composição farmacêutica, célula recombinante, ácido nucleico ou conjunto de ácidos nucleicos, uso de uma proteína ou composição, métodos ou uso
WO2025080685A2 (en) * 2023-10-10 2025-04-17 Marengo Therapeutics, Inc. Antibody molecules that bind to nkp30 and uses thereof

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