JP7737152B2 - 遺伝子発現を調節するためのシステム - Google Patents

遺伝子発現を調節するためのシステム

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Publication number
JP7737152B2
JP7737152B2 JP2022513155A JP2022513155A JP7737152B2 JP 7737152 B2 JP7737152 B2 JP 7737152B2 JP 2022513155 A JP2022513155 A JP 2022513155A JP 2022513155 A JP2022513155 A JP 2022513155A JP 7737152 B2 JP7737152 B2 JP 7737152B2
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Japan
Prior art keywords
polya
aptamer
ligand
double
shows
Prior art date
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JP2022513155A
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English (en)
Japanese (ja)
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JP2022546408A (ja
JP2022546408A5 (https=
Inventor
ライシン イェン，
リミン ルオ，
ジョスリン ドゥエン－ヤ ジェア，
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Baylor College of Medicine
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Baylor College of Medicine
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Publication date
Application filed by Baylor College of Medicine filed Critical Baylor College of Medicine
Publication of JP2022546408A publication Critical patent/JP2022546408A/ja
Publication of JP2022546408A5 publication Critical patent/JP2022546408A5/ja
Priority to JP2025073295A priority Critical patent/JP2025118711A/ja
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/16—Aptamers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/50—Vector systems having a special element relevant for transcription regulating RNA stability, not being an intron, e.g. poly A signal

Landscapes

  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2022513155A 2019-08-30 2020-08-28 遺伝子発現を調節するためのシステム Active JP7737152B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2025073295A JP2025118711A (ja) 2019-08-30 2025-04-25 遺伝子発現を調節するためのシステム

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201962894611P 2019-08-30 2019-08-30
US62/894,611 2019-08-30
US201962904635P 2019-09-23 2019-09-23
US62/904,635 2019-09-23
US202063043504P 2020-06-24 2020-06-24
US63/043,504 2020-06-24
PCT/US2020/048561 WO2021041924A2 (en) 2019-08-30 2020-08-28 System for regulating gene expression

Related Child Applications (1)

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JP2025073295A Division JP2025118711A (ja) 2019-08-30 2025-04-25 遺伝子発現を調節するためのシステム

Publications (3)

Publication Number Publication Date
JP2022546408A JP2022546408A (ja) 2022-11-04
JP2022546408A5 JP2022546408A5 (https=) 2023-09-05
JP7737152B2 true JP7737152B2 (ja) 2025-09-10

Family

ID=74683442

Family Applications (2)

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JP2022513155A Active JP7737152B2 (ja) 2019-08-30 2020-08-28 遺伝子発現を調節するためのシステム
JP2025073295A Pending JP2025118711A (ja) 2019-08-30 2025-04-25 遺伝子発現を調節するためのシステム

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2025073295A Pending JP2025118711A (ja) 2019-08-30 2025-04-25 遺伝子発現を調節するためのシステム

Country Status (11)

Country Link
US (1) US20220290147A1 (https=)
EP (1) EP4022065A4 (https=)
JP (2) JP7737152B2 (https=)
KR (1) KR20220049619A (https=)
CN (1) CN115279902A (https=)
AU (1) AU2020335909A1 (https=)
BR (1) BR112022003512A2 (https=)
CA (1) CA3152513A1 (https=)
IL (1) IL290944A (https=)
MX (1) MX2022002390A (https=)
WO (1) WO2021041924A2 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102904879B1 (ko) 2015-11-12 2025-12-30 베이롤 칼리지 오브 메드신 폴리아데닐화의 압타머 매개된 조정을 통한 포유류 유전자 발현의 외인성 제어
AU2022327174A1 (en) 2021-08-11 2024-02-15 Sana Biotechnology, Inc. Inducible systems for altering gene expression in hypoimmunogenic cells

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007529223A (ja) 2004-03-15 2007-10-25 バイオジェン・アイデック・エムエイ・インコーポレイテッド 選択的スプライシングを用いて真核細胞においてポリペプチドマルチマーを発現するための方法および構築物
WO2016126747A1 (en) 2015-02-02 2016-08-11 Meiragtx Uk Limited Regulation of gene expression by aptamer-mediated modulation of alternative splicing
JP2018533955A (ja) 2015-11-12 2018-11-22 ベイラー カレッジ オブ メディスンＢａｙｌｏｒ Ｃｏｌｌｅｇｅ Ｏｆ Ｍｅｄｉｃｉｎｅ ポリアデニル化のアプタマー介在型調節を通じた哺乳類遺伝子発現の外因的制御

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003295600A1 (en) * 2002-11-14 2004-06-15 Dharmacon, Inc. Functional and hyperfunctional sirna
WO2005106035A2 (en) * 2004-04-09 2005-11-10 Cornell Research Foundation, Inc. Modular design and construction of nucleic acid molecules, aptamer-derived nucleic acid constructs, rna scaffolds, their expression, and methods of use
WO2005116204A1 (ja) * 2004-05-11 2005-12-08 Rnai Co., Ltd. Ｒｎａ干渉を生じさせるポリヌクレオチド、および、これを用いた遺伝子発現抑制方法
US7825229B2 (en) * 2005-03-25 2010-11-02 Rosetta Genomics Ltd. Lung cancer-related nucleic acids
US8178503B2 (en) * 2006-03-03 2012-05-15 International Business Machines Corporation Ribonucleic acid interference molecules and binding sites derived by analyzing intergenic and intronic regions of genomes
US20150284738A1 (en) * 2006-12-29 2015-10-08 Rodina Holding S.A. Artificial dna sequence with optimized leader function in 5' (5'-utr) for the improved expression of heterologous proteins in plants
CN103108952A (zh) * 2010-09-01 2013-05-15 日本电气株式会社 检测目标物质的方法以及用于所述方法中的适体组、传感器和装置
EP2622084A1 (en) * 2010-10-01 2013-08-07 R1 B3 Holding B.V. Regulation of translation of expressed genes
WO2013119371A2 (en) * 2012-02-10 2013-08-15 The Board Of Trustees Of The Leland Stanford Junior University Mini-intronic plasmid vectors
US20150141320A1 (en) * 2012-05-16 2015-05-21 Rana Therapeutics, Inc. Compositions and methods for modulating gene expression
US9567581B2 (en) * 2012-08-07 2017-02-14 The General Hospital Corporation Selective reactivation of genes on the inactive X chromosome
EP3268481B1 (en) * 2015-03-11 2020-05-27 The United States of America, as represented by The Secretary, Department of Health and Human Services Rpgr vectors for treating x-linked retinitis pigmentosa

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007529223A (ja) 2004-03-15 2007-10-25 バイオジェン・アイデック・エムエイ・インコーポレイテッド 選択的スプライシングを用いて真核細胞においてポリペプチドマルチマーを発現するための方法および構築物
WO2016126747A1 (en) 2015-02-02 2016-08-11 Meiragtx Uk Limited Regulation of gene expression by aptamer-mediated modulation of alternative splicing
JP2018533955A (ja) 2015-11-12 2018-11-22 ベイラー カレッジ オブ メディスンＢａｙｌｏｒ Ｃｏｌｌｅｇｅ Ｏｆ Ｍｅｄｉｃｉｎｅ ポリアデニル化のアプタマー介在型調節を通じた哺乳類遺伝子発現の外因的制御

Also Published As

Publication number Publication date
AU2020335909A1 (en) 2022-04-14
US20220290147A1 (en) 2022-09-15
IL290944A (en) 2022-04-01
WO2021041924A2 (en) 2021-03-04
MX2022002390A (es) 2022-05-13
JP2025118711A (ja) 2025-08-13
JP2022546408A (ja) 2022-11-04
CN115279902A (zh) 2022-11-01
BR112022003512A2 (pt) 2022-05-17
KR20220049619A (ko) 2022-04-21
EP4022065A2 (en) 2022-07-06
WO2021041924A3 (en) 2021-04-08
EP4022065A4 (en) 2024-02-14
CA3152513A1 (en) 2021-03-04

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