MX2022002390A - Sistema para regular la expresion genica. - Google Patents

Sistema para regular la expresion genica.

Info

Publication number
MX2022002390A
MX2022002390A MX2022002390A MX2022002390A MX2022002390A MX 2022002390 A MX2022002390 A MX 2022002390A MX 2022002390 A MX2022002390 A MX 2022002390A MX 2022002390 A MX2022002390 A MX 2022002390A MX 2022002390 A MX2022002390 A MX 2022002390A
Authority
MX
Mexico
Prior art keywords
gene expression
regulation
present disclosure
regulating gene
nucleic acid
Prior art date
Application number
MX2022002390A
Other languages
English (en)
Inventor
Laising Yen
Liming Luo
Jocelyn Duen-Ya Jea
Original Assignee
Baylor College Medicine
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baylor College Medicine filed Critical Baylor College Medicine
Publication of MX2022002390A publication Critical patent/MX2022002390A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/16—Aptamers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/50—Vector systems having a special element relevant for transcription regulating RNA stability, not being an intron, e.g. poly A signal

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Se describen composiciones y métodos relacionados con la regulación de la expresión génica. En algunas modalidades la presente descripción proporciona composiciones y métodos para la regulación de la expresión génica usando construcciones de ácidos nucleicos. En algunas modalidades, la presente descripción reconoce la utilidad del corte alternativo en la regulación de la expresión génica en una construcción de ácido nucleico. En algunas modalidades, la presente descripción reconoce la utilidad de la expresión génica reguladora que usa aptámeros de unión de ligando.
MX2022002390A 2019-08-30 2020-08-28 Sistema para regular la expresion genica. MX2022002390A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201962894611P 2019-08-30 2019-08-30
US201962904635P 2019-09-23 2019-09-23
US202063043504P 2020-06-24 2020-06-24
PCT/US2020/048561 WO2021041924A2 (en) 2019-08-30 2020-08-28 System for regulating gene expression

Publications (1)

Publication Number Publication Date
MX2022002390A true MX2022002390A (es) 2022-05-13

Family

ID=74683442

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2022002390A MX2022002390A (es) 2019-08-30 2020-08-28 Sistema para regular la expresion genica.

Country Status (11)

Country Link
US (1) US20220290147A1 (es)
EP (1) EP4022065A4 (es)
JP (1) JP2022546408A (es)
KR (1) KR20220049619A (es)
CN (1) CN115279902A (es)
AU (1) AU2020335909A1 (es)
BR (1) BR112022003512A2 (es)
CA (1) CA3152513A1 (es)
IL (1) IL290944A (es)
MX (1) MX2022002390A (es)
WO (1) WO2021041924A2 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20240053673A (ko) 2021-08-11 2024-04-24 사나 바이오테크놀로지, 인크. 저면역원성 세포 내 유전자 발현을 변경하기 위한 유도성 시스템

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2005222963B2 (en) * 2004-03-15 2009-10-29 Biogen Idec Ma Inc. Methods and constructs for expressing polypeptide multimers in eukaryotic cells using alternative splicing
EP1752536A4 (en) * 2004-05-11 2008-04-16 Alphagen Co Ltd POLYNUCLEOTIDE CAUSING RNA INTERFERENCE AND METHOD OF REGULATING GENE EXPRESSION WITH THE USE OF THE SAME
US8178503B2 (en) * 2006-03-03 2012-05-15 International Business Machines Corporation Ribonucleic acid interference molecules and binding sites derived by analyzing intergenic and intronic regions of genomes
US20150284738A1 (en) * 2006-12-29 2015-10-08 Rodina Holding S.A. Artificial dna sequence with optimized leader function in 5' (5'-utr) for the improved expression of heterologous proteins in plants
EP2812436A4 (en) * 2012-02-10 2016-05-11 Univ Leland Stanford Junior MINI-INTRONIC PLASMID VECTORS
JP2016522674A (ja) * 2012-05-16 2016-08-04 ラナ セラピューティクス インコーポレイテッド 遺伝子発現を調節するための組成物及び方法
WO2014025887A1 (en) * 2012-08-07 2014-02-13 The General Hospital Corporation Selective reactivation of genes on the inactive x chromosome
AU2016228751B2 (en) * 2015-03-11 2022-01-13 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Rp2 vectors for treating x-linked retinitis pigmentosa
ES2969015T3 (es) * 2015-11-12 2024-05-16 Baylor College Medicine Control exógeno de la expresión de genes de mamíferos mediante la modulación de la poliadenilación mediada por aptámeros

Also Published As

Publication number Publication date
WO2021041924A3 (en) 2021-04-08
CN115279902A (zh) 2022-11-01
JP2022546408A (ja) 2022-11-04
BR112022003512A2 (pt) 2022-05-17
KR20220049619A (ko) 2022-04-21
IL290944A (en) 2022-04-01
US20220290147A1 (en) 2022-09-15
WO2021041924A2 (en) 2021-03-04
CA3152513A1 (en) 2021-03-04
EP4022065A2 (en) 2022-07-06
EP4022065A4 (en) 2024-02-14
AU2020335909A1 (en) 2022-04-14

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