JP7627042B2 - Ｏ－メチルリッチ完全安定化オリゴヌクレオチド - Google Patents

Ｏ－メチルリッチ完全安定化オリゴヌクレオチド Download PDF

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JP7627042B2
JP7627042B2 JP2021509991A JP2021509991A JP7627042B2 JP 7627042 B2 JP7627042 B2 JP 7627042B2 JP 2021509991 A JP2021509991 A JP 2021509991A JP 2021509991 A JP2021509991 A JP 2021509991A JP 7627042 B2 JP7627042 B2 JP 7627042B2
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nucleotides
strand
sirna
oligonucleotide
antisense strand
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JP2021533804A5 (enExample
JP2021533804A (ja
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アナスタシア・コボロバ
ジュリア・オルターマン
サラ・デイビス
アントン・トゥラノフ
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University of Massachusetts Amherst
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JP2021509991A 2018-08-23 2019-08-23 Ｏ－メチルリッチ完全安定化オリゴヌクレオチド Active JP7627042B2 (ja)

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US201862721993P 2018-08-23 2018-08-23
US62/721,993 2018-08-23
PCT/US2019/048027 WO2020041769A1 (en) 2018-08-23 2019-08-23 O-methyl rich fully stabilized oligonucleotides

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JP7627042B2 true JP7627042B2 (ja) 2025-02-05

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US (2) US11279930B2 (enExample)
EP (1) EP3840759A4 (enExample)
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EP3929293A3 (en) 2015-04-03 2022-03-16 University Of Massachusetts Fully stabilized asymmetric sirna
WO2017030973A1 (en) 2015-08-14 2017-02-23 University Of Massachusetts Bioactive conjugates for oligonucleotide delivery
WO2017132669A1 (en) 2016-01-31 2017-08-03 University Of Massachusetts Branched oligonucleotides
WO2018031933A2 (en) 2016-08-12 2018-02-15 University Of Massachusetts Conjugated oligonucleotides
WO2018237245A1 (en) 2017-06-23 2018-12-27 University Of Massachusetts TWO TAIL SELF-ADMINISTRATION SIRNA AND ASSOCIATED METHODS
BR112021002440A2 (pt) 2018-08-10 2021-05-04 University Of Massachusetts oligonucleotídeos modificados visando snps
WO2020041769A1 (en) 2018-08-23 2020-02-27 University Of Massachusetts O-methyl rich fully stabilized oligonucleotides
CN113614232A (zh) 2019-01-18 2021-11-05 马萨诸塞大学 动态药代动力学修饰锚
KR20220047989A (ko) 2019-08-09 2022-04-19 유니버시티 오브 매사추세츠 Snp를 표적화하는 화학적으로 변형된 올리고뉴클레오타이드
US20210115442A1 (en) * 2019-08-23 2021-04-22 University Of Massachusetts O-methyl rich fully stabilized oligonucleotides
US12365894B2 (en) 2019-09-16 2025-07-22 University Of Massachusetts Branched lipid conjugates of siRNA for specific tissue delivery
EP4110913A4 (en) * 2020-02-28 2024-07-24 University of Massachusetts OLIGONUCLEOTIDES FOR PRNP MODULATION
JP2023518439A (ja) * 2020-03-18 2023-05-01 ユニバーシティー オブ マサチューセッツ Ｍａｐｔ調節のためのオリゴヌクレオチド
AU2021244600A1 (en) * 2020-03-26 2022-11-03 University Of Massachusetts Synthesis of modified oligonucleotides with increased stability
CA3174079A1 (en) 2020-05-26 2021-12-02 Anastasia Khvorova Synthetic oligonucleotides having regions of block and cluster modifications
IL309334A (en) * 2021-06-23 2024-02-01 Univ Massachusetts Anti-FLT1 optimized oligonucleotide compounds for the treatment of preeclampsia and other angiogenic disorders
WO2023014654A2 (en) * 2021-08-02 2023-02-09 University Of Massachusetts Oligonucleotides for htt-1a modulation
WO2023081908A2 (en) 2021-11-08 2023-05-11 University Of Massachusetts Oligonucleotides for sod1 modulation
WO2023087062A1 (en) * 2021-11-18 2023-05-25 Resonance Health Analysis Services Pty Ltd Method for treating cyclophilin b associated diseases
IL315659A (en) * 2022-03-16 2024-11-01 Daiichi Sankyo Co Ltd siRNA FOR SUPPRESSING EXPRESSION OF TRANSFERRIN RECEPTOR-2
TW202528539A (zh) * 2023-09-20 2025-07-16 日商第一三共股份有限公司 抑制受磷蛋白之表現的siRNA

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