JP7627042B2 - Ｏ－メチルリッチ完全安定化オリゴヌクレオチド - Google Patents

Ｏ－メチルリッチ完全安定化オリゴヌクレオチド Download PDF

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JP7627042B2
JP7627042B2 JP2021509991A JP2021509991A JP7627042B2 JP 7627042 B2 JP7627042 B2 JP 7627042B2 JP 2021509991 A JP2021509991 A JP 2021509991A JP 2021509991 A JP2021509991 A JP 2021509991A JP 7627042 B2 JP7627042 B2 JP 7627042B2
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nucleotides
strand
sirna
oligonucleotide
antisense strand
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JP2021533804A (ja
JPWO2020041769A5 (enExample
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アナスタシア・コボロバ
ジュリア・オルターマン
サラ・デイビス
アントン・トゥラノフ
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University of Massachusetts Amherst
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    • C12N2310/30—Chemical structure
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JP2021509991A 2018-08-23 2019-08-23 Ｏ－メチルリッチ完全安定化オリゴヌクレオチド Active JP7627042B2 (ja)

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US201862721993P 2018-08-23 2018-08-23
US62/721,993 2018-08-23
PCT/US2019/048027 WO2020041769A1 (en) 2018-08-23 2019-08-23 O-methyl rich fully stabilized oligonucleotides

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JP2021533804A JP2021533804A (ja) 2021-12-09
JPWO2020041769A5 JPWO2020041769A5 (enExample) 2022-08-31
JP7627042B2 true JP7627042B2 (ja) 2025-02-05

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US (2) US11279930B2 (enExample)
EP (1) EP3840759A4 (enExample)
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JP6892433B2 (ja) 2015-04-03 2021-06-23 ユニバーシティ・オブ・マサチューセッツＵｎｉｖｅｒｓｉｔｙ Ｏｆ Ｍａｓｓａｃｈｕｓｅｔｔｓ 十分に安定化された非対称ｓｉｒｎａ
US10633653B2 (en) 2015-08-14 2020-04-28 University Of Massachusetts Bioactive conjugates for oligonucleotide delivery
JP7749201B6 (ja) 2016-01-31 2025-10-21 ユニバーシティー オブ マサチューセッツ 分岐オリゴヌクレオチド
WO2018031933A2 (en) 2016-08-12 2018-02-15 University Of Massachusetts Conjugated oligonucleotides
US10844377B2 (en) 2017-06-23 2020-11-24 University Of Massachusetts Two-tailed self-delivering siRNA
WO2020041769A1 (en) 2018-08-23 2020-02-27 University Of Massachusetts O-methyl rich fully stabilized oligonucleotides
WO2020150636A1 (en) 2019-01-18 2020-07-23 University Of Massachusetts Dynamic pharmacokinetic-modifying anchors
MX2022001710A (es) 2019-08-09 2022-05-10 Univ Massachusetts Oligonucleótidos modificados químicamente dirigidos a los snp.
US20210115442A1 (en) * 2019-08-23 2021-04-22 University Of Massachusetts O-methyl rich fully stabilized oligonucleotides
US12365894B2 (en) 2019-09-16 2025-07-22 University Of Massachusetts Branched lipid conjugates of siRNA for specific tissue delivery
WO2021173984A2 (en) 2020-02-28 2021-09-02 University Of Massachusetts Oligonucleotides for prnp modulation
US20210363523A1 (en) * 2020-03-18 2021-11-25 University Of Massachusetts Oligonucleotides for mapt modulation
AU2021244600A1 (en) * 2020-03-26 2022-11-03 University Of Massachusetts Synthesis of modified oligonucleotides with increased stability
IL309334A (en) * 2021-06-23 2024-02-01 Univ Massachusetts Anti-FLT1 optimized oligonucleotide compounds for the treatment of preeclampsia and other angiogenic disorders
WO2023014654A2 (en) * 2021-08-02 2023-02-09 University Of Massachusetts Oligonucleotides for htt-1a modulation
US20250340883A1 (en) * 2021-11-18 2025-11-06 Resonance Health Analysis Services Pty Ltd Method For Treating Cyclophilin B Associated Diseases
CN118891366A (zh) * 2022-03-16 2024-11-01 第一三共株式会社 抑制转铁蛋白受体2的表达的siRNA
WO2025063238A1 (ja) * 2023-09-20 2025-03-27 第一三共株式会社 ホスホランバンの発現を抑制するｓｉＲＮＡ

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