JP7624690B2 - Ｗｄｒ５タンパク質－タンパク質結合の阻害剤 - Google Patents

Ｗｄｒ５タンパク質－タンパク質結合の阻害剤 Download PDF

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JP7624690B2
JP7624690B2 JP2018546618A JP2018546618A JP7624690B2 JP 7624690 B2 JP7624690 B2 JP 7624690B2 JP 2018546618 A JP2018546618 A JP 2018546618A JP 2018546618 A JP2018546618 A JP 2018546618A JP 7624690 B2 JP7624690 B2 JP 7624690B2
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fluoro
phenyl
alkyl
carboxamide
trifluoromethyl
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JP2019512482A5 (enExample
JP2019512482A (ja
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アル－アワ，リマ
アルマンド ゼペダ－ベラスケス，カルロス
ポダ，ゲンナゲィー
アイザック，メスヴィン
ユーリン，デイビッド
ウィルソン，ブライアン
ジョセフ，バブ
リュウ，ヤン
スブラマニアン，パンディアラシュ
ママイ，アフメド
プラケシュ，マイケル
カスリーン スティル，ジュリア
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プロペロン セラピューティクス インコーポレイテッド
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
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  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrrole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
JP2018546618A 2016-03-01 2017-03-01 Ｗｄｒ５タンパク質－タンパク質結合の阻害剤 Active JP7624690B2 (ja)

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JP2022028700A JP2022071046A (ja) 2016-03-01 2022-02-25 Ｗｄｒ５タンパク質－タンパク質結合の阻害剤
JP2024071190A JP2024102151A (ja) 2016-03-01 2024-04-25 Ｗｄｒ５タンパク質－タンパク質結合の阻害剤

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US201662301673P 2016-03-01 2016-03-01
US62/301,673 2016-03-01
PCT/CA2017/050269 WO2017147700A1 (en) 2016-03-01 2017-03-01 Inhibitors of wdr5 protein-protein binding

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JP2022028700A Pending JP2022071046A (ja) 2016-03-01 2022-02-25 Ｗｄｒ５タンパク質－タンパク質結合の阻害剤
JP2024071190A Pending JP2024102151A (ja) 2016-03-01 2024-04-25 Ｗｄｒ５タンパク質－タンパク質結合の阻害剤

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JP2024071190A Pending JP2024102151A (ja) 2016-03-01 2024-04-25 Ｗｄｒ５タンパク質－タンパク質結合の阻害剤

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US (2) US11319299B2 (enExample)
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KR (1) KR20180120720A (enExample)
CN (1) CN109195965B (enExample)
AU (1) AU2017226004B2 (enExample)
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JP2019507179A (ja) 2016-03-01 2019-03-14 プロペロン セラピューティックス インコーポレイテッド Ｗｄｒ５タンパク質−タンパク質結合の阻害剤
BR112018067392A2 (pt) * 2016-03-01 2019-01-02 Propellon Therapeutics Inc inibidores de ligação entre proteínas wdr5
SG11201903483VA (en) 2016-10-28 2019-05-30 Icahn School Med Mount Sinai Compositions and methods for treating ezh2-mediated cancer
AU2017370694A1 (en) 2016-12-08 2019-07-25 Icahn School Of Medicine At Mount Sinai Compositions and methods for treating CDK4/6-mediated cancer
EP3601233B1 (en) 2017-03-27 2024-08-14 Hydro-Québec Salts for use in electrolyte compositions or as electrode additives
JP2020532561A (ja) * 2017-09-06 2020-11-12 プロペロン セラピューティクス インコーポレイテッド Ｗｄｒ５タンパク質−タンパク質結合の阻害剤
US10501466B2 (en) 2017-09-19 2019-12-10 Vanderbilt University WDR5 inhibitors and modulators
CN111566086B (zh) * 2018-01-04 2023-08-01 北京大学深圳研究生院 同时抑制lsd1和hdac靶点的化合物及其应用
JP2021515013A (ja) 2018-03-06 2021-06-17 アイカーン スクール オブ メディスン アット マウント シナイ セリンスレオニンキナーゼ（ａｋｔ）分解／破壊化合物および使用方法
CN108715585A (zh) * 2018-04-23 2018-10-30 中国药科大学 苯基联三氮唑类mll1-wdr5蛋白-蛋白相互作用抑制剂
US10844044B2 (en) 2018-06-14 2020-11-24 Vanderbilt University WDR5 inhibitors and modulators
EP3810145A4 (en) 2018-06-21 2022-06-01 Icahn School of Medicine at Mount Sinai Wd40 repeat domain protein 5 (wdr5) degradation / disruption compounds and methods of use
US10807959B2 (en) 2018-08-16 2020-10-20 Vanderbilt University WDR5-MLL1 inhibitors and modulators
CN109734674B (zh) 2019-02-26 2022-08-26 中国药科大学 苯胺类wdr5蛋白-蛋白相互作用抑制剂及其制法和用途
CN113543852A (zh) 2019-03-06 2021-10-22 第一三共株式会社 吡咯并吡唑衍生物
CN118908962A (zh) 2019-05-06 2024-11-08 西奈山伊坎医学院 作为hpk1的降解剂的异双功能化合物
CN111039860B (zh) * 2019-12-02 2022-09-13 河北科技大学 2-羟基-n-(4’-氯联苯-2-基)烟酰胺的合成方法及应用
CN113024538B (zh) * 2019-12-24 2022-09-09 南开大学 吡唑酰胺类化合物及其制备和在防治植物病菌病和杀虫中的应用
US12103924B2 (en) 2020-06-01 2024-10-01 Icahn School Of Medicine At Mount Sinai Mitogen-activated protein kinase kinase (MEK) degradation compounds and methods of use
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