JP7558156B2 - エキサテカン類似体のリガンド－薬物コンジュゲート、その調製方法およびその適用 - Google Patents

エキサテカン類似体のリガンド－薬物コンジュゲート、その調製方法およびその適用 Download PDF

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JP7558156B2
JP7558156B2 JP2021516798A JP2021516798A JP7558156B2 JP 7558156 B2 JP7558156 B2 JP 7558156B2 JP 2021516798 A JP2021516798 A JP 2021516798A JP 2021516798 A JP2021516798 A JP 2021516798A JP 7558156 B2 JP7558156 B2 JP 7558156B2
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cancer
antibody
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JP2022511351A (ja
JP2022511351A5 (https=
Inventor
ジェンイェン シイ
イン チャン
シャオファン ツァイ
ボーレイ チュー
ジンドン リャン
リアンシャン チャン
フェン ヘ
ウェイカン タオ
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Jiangsu Hengrui Medicine Co Ltd
Shanghai Hengrui Pharmaceutical Co Ltd
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Jiangsu Hengrui Medicine Co Ltd
Shanghai Hengrui Pharmaceutical Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
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    • A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
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  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2021516798A 2018-09-26 2019-09-25 エキサテカン類似体のリガンド－薬物コンジュゲート、その調製方法およびその適用 Active JP7558156B2 (ja)

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CN201811123833.1 2018-09-26
CN201811123833 2018-09-26
PCT/CN2019/107873 WO2020063676A1 (zh) 2018-09-26 2019-09-25 依喜替康类似物的配体-药物偶联物及其制备方法和应用

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JP2022511351A5 JP2022511351A5 (https=) 2022-10-03
JP7558156B2 true JP7558156B2 (ja) 2024-09-30

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EP (1) EP3858386A4 (https=)
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KR (1) KR20210066833A (https=)
CN (4) CN112512591B (https=)
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