JP7548992B2 - タウタンパク質標的化化合物および関連する使用方法 - Google Patents

タウタンパク質標的化化合物および関連する使用方法 Download PDF

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JP7548992B2
JP7548992B2 JP2022502929A JP2022502929A JP7548992B2 JP 7548992 B2 JP7548992 B2 JP 7548992B2 JP 2022502929 A JP2022502929 A JP 2022502929A JP 2022502929 A JP2022502929 A JP 2022502929A JP 7548992 B2 JP7548992 B2 JP 7548992B2
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disease
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tau
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JP2022540935A (ja
JP2022540935A5 (enExample
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クルー，アンドリュー・ピィ
バーリン，マイケル
ドン，ハンチン
イーシェンコ，アレクセイ
カカーチェ，アンジェラ・エム
チャンドラー，ジュリアン・ティ
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Arvinas Operations Inc
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JP2022502929A 2019-07-17 2020-07-17 タウタンパク質標的化化合物および関連する使用方法 Active JP7548992B2 (ja)

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PCT/US2020/042645 WO2021011913A1 (en) 2019-07-17 2020-07-17 Tau-protein targeting compounds and associated methods of use

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JP2024178191A (ja) * 2019-07-17 2024-12-24 アルビナス・オペレーションズ・インコーポレイテッド タウタンパク質標的化化合物および関連する使用方法

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EP4310496A3 (en) 2017-07-12 2024-12-04 Dana-Farber Cancer Institute, Inc. Compounds for tau protein degradation
CN119569702A (zh) 2018-04-04 2025-03-07 阿尔维纳斯运营股份有限公司 蛋白水解调节剂及相关使用方法
JP7293343B2 (ja) 2018-05-09 2023-06-19 アプリノイア セラピューティクス リミテッド ヘテロアリール化合物及びその使用
CA3161455A1 (en) 2019-11-13 2021-05-20 Aprinoia Therapeutics Limited Compounds for degrading tau protein aggregates and uses thereof
JP2023518202A (ja) * 2020-03-18 2023-04-28 ダナ－ファーバー キャンサー インスティテュート，インコーポレイテッド Ｐｅｔトレーサーｐｂｂ３に基づく異常タウの標的化ディグレーダー
AU2021337466A1 (en) 2020-09-01 2023-03-30 Enveric Biosciences Canada Inc. Halogenated psilocybin derivatives and methods of using
JP2024504932A (ja) 2021-01-13 2024-02-02 モンテ ローザ セラピューティクス， インコーポレイテッド イソインドリノン化合物
WO2022251614A1 (en) * 2021-05-28 2022-12-01 Beth Israel Deaconess Medical Center, Inc. Protacs with transcription factor targeting moieties
MX2024000313A (es) 2021-07-09 2024-03-06 Plexium Inc Compuestos de arilo y composiciones farmaceuticas que modulan la ikzf2.
KR20240110576A (ko) * 2021-10-22 2024-07-15 글루탁스 테라퓨틱스 (상하이) 씨오., 엘티디. Crbn e3 리가제 리간드 화합물, 리간드 화합물에 기초하여 개발된 단백질 분해제 및 이들의 응용
CN115385908B (zh) * 2022-07-26 2024-04-12 阿茨可利(杭州)医学科技有限公司 靶向促进tau蛋白去磷酸化的小分子嵌合体及其应用
CN115028679B (zh) * 2022-08-11 2022-11-15 深圳湾实验室 一种具有Cyclophilin A降解活性的PROTAC化合物及其制备方法与应用
WO2024097948A1 (en) 2022-11-04 2024-05-10 Roivant Discovery, Inc. Degraders of mdm2 and uses thereof
CN118556048A (zh) * 2022-12-27 2024-08-27 标新生物医药科技(上海)有限公司 基于硫/氧取代戊二酰亚胺基异吲哚啉酮骨架的化合物及其应用
CN121419983A (zh) 2023-01-26 2026-01-27 阿尔维纳斯运营股份有限公司 基于小脑蛋白的kras降解protac及其相关用途
AR131812A1 (es) * 2023-02-08 2025-05-07 Bristol Myers Squibb Co Compuestos y composiciones para la degradación selectiva de proteínas diseñadas
CN116283512B (zh) * 2023-02-24 2025-04-25 博诺康源(北京)药业科技有限公司 一种合成维兰特罗及其盐的方法
WO2024182633A2 (en) * 2023-03-01 2024-09-06 The Regents Of The University Of California Targeted dephosphorylation of tau
KR20260020383A (ko) 2023-05-31 2026-02-11 비원 메디슨즈 아이 게엠베하 Egfr 키나제의 분해를 위한 화합물
WO2025011624A1 (en) * 2023-07-11 2025-01-16 Etern Biopharma (Shanghai) Co., Ltd. Bifunctional compounds for androgen receptor degradation and methods of use
WO2025085387A1 (en) * 2023-10-16 2025-04-24 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Substituted-alkenyl-indazoles for imaging aggregated tau in tauopathies
CN119285633A (zh) * 2024-10-11 2025-01-10 中国药科大学 一种靶向降解Tau蛋白的疏水标签化合物及其制备和应用

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WO2018144649A1 (en) 2017-01-31 2018-08-09 Arvinas, Inc. Cereblon ligands and bifunctional compounds comprising the same
WO2019014429A1 (en) 2017-07-12 2019-01-17 Dana-Farber Cancer Institute, Inc. COMPOUNDS FOR THE DEGRADATION OF TAU PROTEIN

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