JP7548992B2 - タウタンパク質標的化化合物および関連する使用方法 - Google Patents

タウタンパク質標的化化合物および関連する使用方法 Download PDF

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JP7548992B2
JP7548992B2 JP2022502929A JP2022502929A JP7548992B2 JP 7548992 B2 JP7548992 B2 JP 7548992B2 JP 2022502929 A JP2022502929 A JP 2022502929A JP 2022502929 A JP2022502929 A JP 2022502929A JP 7548992 B2 JP7548992 B2 JP 7548992B2
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disease
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tau
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JP2022540935A (ja
JP2022540935A5 (enExample
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クルー，アンドリュー・ピィ
バーリン，マイケル
ドン，ハンチン
イーシェンコ，アレクセイ
カカーチェ，アンジェラ・エム
チャンドラー，ジュリアン・ティ
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Arvinas Operations Inc
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JP2022502929A 2019-07-17 2020-07-17 タウタンパク質標的化化合物および関連する使用方法 Active JP7548992B2 (ja)

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JP2024178191A (ja) * 2019-07-17 2024-12-24 アルビナス・オペレーションズ・インコーポレイテッド タウタンパク質標的化化合物および関連する使用方法

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CA3161455A1 (en) 2019-11-13 2021-05-20 Aprinoia Therapeutics Limited Compounds for degrading tau protein aggregates and uses thereof
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TW202221000A (zh) 2020-09-30 2022-06-01 英屬開曼群島商百濟神州有限公司 用於降解ｅｇｆｒ之雙功能化合物及相關使用方法
CN117242060B (zh) 2021-01-13 2026-07-17 蒙特罗莎治疗股份有限公司 异吲哚啉酮化合物
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TW202317546A (zh) 2021-07-09 2023-05-01 美商普萊克斯姆公司 調節ikzf2之芳基化合物及醫藥組合物
JP2024539269A (ja) * 2021-10-22 2024-10-28 グルータクス セラピューティクス （シャンハイ） カンパニー、リミテッド Ｃｒｂｎ ｅ３リガーゼリガンド化合物、当該リガンド化合物に基づいて開発したタンパク質分解剤及びそれらの応用
US12662467B2 (en) 2022-04-18 2026-06-23 BioThery X, Inc. Isoindolinones, pharmaceutical compositions, and therapeutic applications
CN115385908B (zh) * 2022-07-26 2024-04-12 阿茨可利(杭州)医学科技有限公司 靶向促进tau蛋白去磷酸化的小分子嵌合体及其应用
CN115028679B (zh) * 2022-08-11 2022-11-15 深圳湾实验室 一种具有Cyclophilin A降解活性的PROTAC化合物及其制备方法与应用
WO2024097948A1 (en) 2022-11-04 2024-05-10 Roivant Discovery, Inc. Degraders of mdm2 and uses thereof
EP4644382A4 (en) * 2022-12-27 2026-04-01 Gluetacs Therapeutics Shanghai Co Ltd ISOINDOLINONE SKELETON-BASED COMPOUND WITH SULFUR/OXYGEN SUBSTITUTED GLUTARIMIDE AND ITS USE
PE20260006A1 (es) 2023-01-26 2026-01-06 Arvinas Operations Inc Protacs degradadores de kras basados en cereblon y usos relacionados con los mismos
CN120677149A (zh) * 2023-02-08 2025-09-19 细胞基因公司 用于选择性降解工程化蛋白的化合物和组合物
CN116283512B (zh) * 2023-02-24 2025-04-25 博诺康源(北京)药业科技有限公司 一种合成维兰特罗及其盐的方法
WO2024182633A2 (en) * 2023-03-01 2024-09-06 The Regents Of The University Of California Targeted dephosphorylation of tau
WO2024246838A1 (en) 2023-05-31 2024-12-05 Beigene Switzerland Gmbh Compounds for the degradation of egfr kinase
WO2025011624A1 (en) * 2023-07-11 2025-01-16 Etern Biopharma (Shanghai) Co., Ltd. Bifunctional compounds for androgen receptor degradation and methods of use
WO2025085387A1 (en) * 2023-10-16 2025-04-24 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Substituted-alkenyl-indazoles for imaging aggregated tau in tauopathies
WO2026026826A1 (en) * 2024-07-31 2026-02-05 Insilico Medicine Ip Limited Crbn-binding compounds and uses thereof
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