AU2001295041A1 - Proteolysis targeting chimeric pharmaceutical - Google Patents

Proteolysis targeting chimeric pharmaceutical

Info

Publication number
AU2001295041A1
AU2001295041A1 AU2001295041A AU9504101A AU2001295041A1 AU 2001295041 A1 AU2001295041 A1 AU 2001295041A1 AU 2001295041 A AU2001295041 A AU 2001295041A AU 9504101 A AU9504101 A AU 9504101A AU 2001295041 A1 AU2001295041 A1 AU 2001295041A1
Authority
AU
Australia
Prior art keywords
targeting chimeric
proteolysis targeting
pharmaceutical
chimeric pharmaceutical
proteolysis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001295041A
Inventor
Craig Crews
Raymond J. Deshaies
Kathleen M. Sakamoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yale University
California Institute of Technology CalTech
University of California
Original Assignee
Yale University
California Institute of Technology CalTech
University of California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yale University, California Institute of Technology CalTech, University of California filed Critical Yale University
Publication of AU2001295041A1 publication Critical patent/AU2001295041A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5041Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects involving analysis of members of signalling pathways
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702Regulators; Modulating activity
    • C07K14/4703Inhibitors; Suppressors
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00Preparation of peptides or proteins
    • C12P21/06Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y304/00Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/11Aminopeptidases (3.4.11)
    • C12Y304/11018Methionyl aminopeptidase (3.4.11.18)
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
AU2001295041A 2000-09-08 2001-09-10 Proteolysis targeting chimeric pharmaceutical Abandoned AU2001295041A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US23135900P 2000-09-08 2000-09-08
US60/231,359 2000-09-08
PCT/US2001/042158 WO2002020740A2 (en) 2000-09-08 2001-09-10 Proteolysis targeting chimeric pharmaceutical

Publications (1)

Publication Number Publication Date
AU2001295041A1 true AU2001295041A1 (en) 2002-03-22

Family

ID=22868897

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001295041A Abandoned AU2001295041A1 (en) 2000-09-08 2001-09-10 Proteolysis targeting chimeric pharmaceutical

Country Status (4)

Country Link
US (1) US7041298B2 (en)
EP (1) EP1322750A4 (en)
AU (1) AU2001295041A1 (en)
WO (1) WO2002020740A2 (en)

Families Citing this family (90)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6306663B1 (en) * 1999-02-12 2001-10-23 Proteinex, Inc. Controlling protein levels in eucaryotic organisms
EP2802608A4 (en) 2012-01-12 2015-08-05 Univ Yale Compounds&methods for the enhanced degradation of targeted proteins&other polypeptides by an e3 ubiquitin ligase
SG10201709018QA (en) 2012-03-14 2017-11-29 Regeneron Pharma Multispecific antigen-binding molecules and uses thereof
GB201311888D0 (en) 2013-07-03 2013-08-14 Glaxosmithkline Ip Dev Ltd Novel compounds
GB201311891D0 (en) 2013-07-03 2013-08-14 Glaxosmithkline Ip Dev Ltd Novel compound
US10071164B2 (en) 2014-08-11 2018-09-11 Yale University Estrogen-related receptor alpha based protac compounds and associated methods of use
US9694084B2 (en) 2014-12-23 2017-07-04 Dana-Farber Cancer Institute, Inc. Methods to induce targeted protein degradation through bifunctional molecules
WO2016105518A1 (en) 2014-12-23 2016-06-30 Dana-Farber Cancer Institute, Inc. Methods to induce targeted protein degradation through bifunctional molecules
US20170327469A1 (en) 2015-01-20 2017-11-16 Arvinas, Inc. Compounds and methods for the targeted degradation of androgen receptor
KR20230119040A (en) 2015-01-20 2023-08-14 아비나스 오퍼레이션스, 인코포레이티드 Compounds and Methods for the Targeted Degradation of the Androgen Receptor
GB201504314D0 (en) 2015-03-13 2015-04-29 Univ Dundee Small molecules
BR112017019751A2 (en) 2015-03-18 2018-05-29 Arvinas Inc bifunctional compound, pharmaceutical composition, and methods for treating or preventing a disease or disorder, and for degrading a target protein in a cell
EP3302482A4 (en) 2015-06-05 2018-12-19 Arvinas, Inc. Tank-binding kinase-1 protacs and associated methods of use
CN105085620B (en) * 2015-06-25 2018-05-08 中山大学附属第一医院 A kind of compound for targeting ubiquitination degraded Smad3
EP3722318A1 (en) 2015-07-06 2020-10-14 Regeneron Pharmaceuticals, Inc. Multispecific antigen-binding molecules and uses thereof
WO2017007612A1 (en) 2015-07-07 2017-01-12 Dana-Farber Cancer Institute, Inc. Methods to induce targeted protein degradation through bifunctional molecules
AU2016301195B2 (en) 2015-08-06 2022-09-01 Dana-Farber Cancer Institute, Inc. Targeted protein degradation to attenuate adoptive T-cell therapy associated adverse inflammatory responses
WO2017030814A1 (en) 2015-08-19 2017-02-23 Arvinas, Inc. Compounds and methods for the targeted degradation of bromodomain-containing proteins
WO2017040982A1 (en) 2015-09-02 2017-03-09 The Regents Of The University Of California Her3 ligands and uses thereof
MX2018005340A (en) 2015-11-02 2018-05-17 Univ Yale Proteolysis targeting chimera compounds and methods of preparing and using same.
CA3021358A1 (en) 2016-04-22 2017-10-26 Dana-Farber Cancer Institute, Inc. Bifunctional molecules for degradation of egfr and methods of use
US11352446B2 (en) 2016-04-28 2022-06-07 Regeneron Pharmaceuticals, Inc. Methods of making multispecific antigen-binding molecules
EP3455218A4 (en) 2016-05-10 2019-12-18 C4 Therapeutics, Inc. C3-carbon linked glutarimide degronimers for target protein degradation
CN109562113A (en) 2016-05-10 2019-04-02 C4医药公司 Loop coil degron body for target protein degradation
EP3454856A4 (en) 2016-05-10 2019-12-25 C4 Therapeutics, Inc. Heterocyclic degronimers for target protein degradation
GB201610156D0 (en) 2016-06-10 2016-07-27 Otsuka Pharma Co Ltd Cliptac compositions
KR20230162137A (en) 2016-08-16 2023-11-28 베이진 스위찰랜드 게엠베하 (S)-7-(1-Acryloylpiperidin-4-yl)-2-(4-Phenoxyphenyl)-4,5,6,7-tetra-Hydrazolo[1,5-a]Pyrimidine-3-Carboxamide, Preparation, and Uses Thereof
TWI739887B (en) 2016-08-19 2021-09-21 英屬開曼群島商百濟神州有限公司 Treatment cancers using a combination comprising btk inhibitors
US20180072711A1 (en) 2016-09-15 2018-03-15 Arvinas, Inc. Indole derivatives as estrogen receptor degraders
WO2018064589A1 (en) 2016-09-29 2018-04-05 Dana-Farber Cancer Institute, Inc. Targeted protein degradation using a mutant e3 ubiquitin ligase
PL3660004T3 (en) 2016-10-11 2023-10-02 Arvinas Operations, Inc. Compounds and methods for the targeted degradation of androgen receptor
CN110234646A (en) 2016-11-01 2019-09-13 阿尔维纳斯股份有限公司 Target the Tau albumen and associated method of use of PROTAC
LT3689868T (en) 2016-12-01 2023-12-27 Arvinas Operations, Inc. Tetrahydronaphthalene and tetrahydroisoquinoline derivatives as estrogen receptor degraders
US10994015B2 (en) 2016-12-23 2021-05-04 Arvinas Operations, Inc. EGFR proteolysis targeting chimeric molecules and associated methods of use
WO2018118598A1 (en) 2016-12-23 2018-06-28 Arvinas, Inc. Compounds and methods for the targeted degradation of fetal liver kinase polypeptides
US11173211B2 (en) 2016-12-23 2021-11-16 Arvinas Operations, Inc. Compounds and methods for the targeted degradation of rapidly accelerated Fibrosarcoma polypeptides
BR112019012878A2 (en) 2016-12-23 2019-11-26 Arvinas Operations Inc compounds and methods for target degradation of rapidly accelerated fibrosarcoma polypeptides
US11191741B2 (en) 2016-12-24 2021-12-07 Arvinas Operations, Inc. Compounds and methods for the targeted degradation of enhancer of zeste homolog 2 polypeptide
WO2018140809A1 (en) 2017-01-26 2018-08-02 Arvinas, Inc. Modulators of estrogen receptor proteolysis and associated methods of use
EP3580212A4 (en) 2017-02-08 2021-03-17 Dana Farber Cancer Institute, Inc. Regulating chimeric antigen receptors
TW201902517A (en) 2017-04-28 2019-01-16 美商石英醫療公司 RAF degradation conjugate compound
CN110809583A (en) 2017-06-07 2020-02-18 瑞泽恩制药公司 Compositions and methods for internalizing enzymes
EP3641762A4 (en) 2017-06-20 2021-03-10 C4 Therapeutics, Inc. N/o-linked degrons and degronimers for protein degradation
CA3066518A1 (en) 2017-06-26 2019-01-03 Beigene, Ltd. Immunotherapy for hepatocellular carcinoma
CN111278816B (en) 2017-09-04 2024-03-15 C4医药公司 Dihydro quinolinones
WO2019043214A1 (en) 2017-09-04 2019-03-07 F. Hoffmann-La Roche Ag Glutarimide
CN111315735B (en) 2017-09-04 2024-03-08 C4医药公司 Dihydrobenzimidazolone
AU2018338314A1 (en) 2017-09-22 2020-04-09 Kymera Therapeutics, Inc Protein degraders and uses thereof
WO2019060693A1 (en) 2017-09-22 2019-03-28 Kymera Therapeutics, Inc. Crbn ligands and uses thereof
CN111372585A (en) 2017-11-16 2020-07-03 C4医药公司 Degradants and degreddeterminants for target protein degradation
WO2019099926A1 (en) 2017-11-17 2019-05-23 Arvinas, Inc. Compounds and methods for the targeted degradation of interleukin-1 receptor-associated kinase 4 polypeptides
US11786529B2 (en) 2017-11-29 2023-10-17 Beigene Switzerland Gmbh Treatment of indolent or aggressive B-cell lymphomas using a combination comprising BTK inhibitors
IL275649B2 (en) 2017-12-26 2023-12-01 Kymera Therapeutics Inc Irak degraders and uses thereof
EP3737666A4 (en) 2018-01-12 2022-01-05 Kymera Therapeutics, Inc. Protein degraders and uses thereof
EP3737675A4 (en) 2018-01-12 2022-01-05 Kymera Therapeutics, Inc. Crbn ligands and uses thereof
WO2019148055A1 (en) 2018-01-26 2019-08-01 Yale University Imide-based modulators of proteolysis and methods of use
KR20210018199A (en) 2018-03-26 2021-02-17 씨4 테라퓨틱스, 인코포레이티드 Cerevlon binder for decomposition of Ikaros
WO2019195609A2 (en) 2018-04-04 2019-10-10 Arvinas Operations, Inc. Modulators of proteolysis and associated methods of use
WO2019204354A1 (en) 2018-04-16 2019-10-24 C4 Therapeutics, Inc. Spirocyclic compounds
EP3578561A1 (en) 2018-06-04 2019-12-11 F. Hoffmann-La Roche AG Spiro compounds
JP2021527137A (en) * 2018-06-13 2021-10-11 アンフィスタ セラピューティクス リミテッド Bifunctional molecule for targeting Rpn11
EP3817748A4 (en) 2018-07-06 2022-08-24 Kymera Therapeutics, Inc. Tricyclic crbn ligands and uses thereof
JPWO2020027225A1 (en) 2018-07-31 2021-11-11 ファイメクス株式会社 Heterocyclic compound
EP3841100A1 (en) 2018-08-20 2021-06-30 Arvinas Operations, Inc. Proteolysis targeting chimeric (protac) compound with e3 ubiquitin ligase binding activity and targeting alpha-synuclein protein for treating neurodegenerative diseases
CA3119773A1 (en) 2018-11-30 2020-06-04 Kymera Therapeutics, Inc. Irak degraders and uses thereof
CN109762045A (en) * 2018-12-14 2019-05-17 中山大学附属第一医院 A kind of method and application thereof of double target spot building PROTAC
MX2021008712A (en) 2019-01-22 2021-08-19 Merck Patent Gmbh Heterocyclic derivatives.
EP3946360A4 (en) 2019-04-05 2023-05-10 Kymera Therapeutics, Inc. Stat degraders and uses thereof
GB201906705D0 (en) 2019-05-13 2019-06-26 Phoremost Ltd Methods
EP3976044A1 (en) * 2019-06-03 2022-04-06 Icahn School of Medicine at Mount Sinai Compounds and methods for inhibiting cancers via rest inhibition
WO2020264499A1 (en) 2019-06-28 2020-12-30 Kymera Therapeutics, Inc. Irak degraders and uses thereof
WO2021007286A1 (en) * 2019-07-08 2021-01-14 Board Of Regents, The University Of Texas System Compositions and methods for cancer therapy
CN114867727A (en) 2019-07-17 2022-08-05 阿尔维纳斯运营股份有限公司 TAU protein targeting compounds and related methods of use
CN112941634B (en) * 2019-12-10 2023-09-26 成都先导药物开发股份有限公司 Method for screening compounds simultaneously binding to multiple biological targets by DNA encoding compound library
WO2021127283A2 (en) 2019-12-17 2021-06-24 Kymera Therapeutics, Inc. Irak degraders and uses thereof
JP2023509366A (en) 2019-12-17 2023-03-08 カイメラ セラピューティクス, インコーポレイテッド IRAK dissolving agents and their uses
WO2021127443A1 (en) 2019-12-19 2021-06-24 Arvinas Operations, Inc. Compounds and methods for the targeted degradation of androgen receptor
KR20220151160A (en) 2019-12-23 2022-11-14 카이메라 쎄라퓨틱스 인코포레이티드 SMARCA disintegrant and its uses
WO2021188948A1 (en) 2020-03-19 2021-09-23 Kymera Therapeutics, Inc. Mdm2 degraders and uses thereof
TW202210483A (en) 2020-06-03 2022-03-16 美商凱麥拉醫療公司 Crystalline forms of irak degraders
WO2022120355A1 (en) 2020-12-02 2022-06-09 Ikena Oncology, Inc. Tead degraders and uses thereof
TW202237095A (en) 2020-12-03 2022-10-01 德商艾斯巴赫生物有限公司 Alc1 inhibitors and synergy with parpi
WO2023076161A1 (en) 2021-10-25 2023-05-04 Kymera Therapeutics, Inc. Tyk2 degraders and uses thereof
WO2023144053A1 (en) 2022-01-26 2023-08-03 Merck Patent Gmbh Heterocyclic derivatives
WO2023213833A1 (en) 2022-05-02 2023-11-09 Eisbach Bio Gmbh Use of alc1 inhibitors and synergy with parpi
WO2024006781A1 (en) 2022-06-27 2024-01-04 Relay Therapeutics, Inc. Estrogen receptor alpha degraders and use thereof
WO2024006776A1 (en) 2022-06-27 2024-01-04 Relay Therapeutics, Inc. Estrogen receptor alpha degraders and medical use thereof
WO2024050016A1 (en) 2022-08-31 2024-03-07 Oerth Bio Llc Compositions and methods for targeted inhibition and degradation of proteins in an insect cell
US11957759B1 (en) 2022-09-07 2024-04-16 Arvinas Operations, Inc. Rapidly accelerated fibrosarcoma (RAF) degrading compounds and associated methods of use
WO2024064358A1 (en) 2022-09-23 2024-03-28 Ifm Due, Inc. Compounds and compositions for treating conditions associated with sting activity

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6316003B1 (en) 1989-12-21 2001-11-13 Whitehead Institute For Biomedical Research Tat-derived transport polypeptides
US5292638A (en) * 1990-12-07 1994-03-08 The Regents Of The University Of California Method of determining functional estrogen receptors for prognosis of cancer
US6576469B1 (en) * 1997-09-10 2003-06-10 President And Fellows Of Harvard College Inducible methods for repressing gene function
WO2000022110A2 (en) * 1998-10-09 2000-04-20 President And Fellows Of Harvard College Targeted proteolysis by recruitment to ubiquitin protein ligases
US6306663B1 (en) 1999-02-12 2001-10-23 Proteinex, Inc. Controlling protein levels in eucaryotic organisms

Also Published As

Publication number Publication date
WO2002020740A2 (en) 2002-03-14
EP1322750A4 (en) 2004-09-29
US20020068063A1 (en) 2002-06-06
US7041298B2 (en) 2006-05-09
EP1322750A2 (en) 2003-07-02
WO2002020740A3 (en) 2002-08-08

Similar Documents

Publication Publication Date Title
AU2001295041A1 (en) Proteolysis targeting chimeric pharmaceutical
AU781269C (en) Pharmaceutical compositions
AU2002218250A1 (en) Medicament dispenser
AU2001250420A1 (en) Pharmaceutical compositions
AU2002223028A1 (en) Inhaler
AU2001274307A1 (en) Pharmaceutical compositions
AU2002221710A1 (en) Atomizer for liquids
WO2002006984A8 (en) Target rater
AU2001274548A1 (en) Syringe
AU4430701A (en) Compounds for targeting
AU2001263839A1 (en) Liquid formulations
AU2002223562A1 (en) Medicament dispenser
EP1414495A4 (en) Anti-microbial targeting chimeric pharmaceutical
AU2001273919A1 (en) Pharmaceutical compositions
AU3918501A (en) Atomiser
AU2001220281A1 (en) Rollerboard for road-skiing
AU2001232244A1 (en) Drug comprising combination
AU4085201A (en) Pharmaceutical composition
AU2001279748A1 (en) Herbicides
AU2001292578A1 (en) Pharmaceutical compounds
AU2002215902A1 (en) Medicament dispenser
AU2000271137A1 (en) Flame-sprayer for spraying curbs
AU2001278705A1 (en) Pharmaceutical composition
AU3586401A (en) Pharmaceutical composition
AU2001294341A1 (en) Targeting through integrins