JP7548696B2 - 疼痛関連障害を処置するための物質及び方法 - Google Patents

疼痛関連障害を処置するための物質及び方法 Download PDF

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JP7548696B2
JP7548696B2 JP2019500268A JP2019500268A JP7548696B2 JP 7548696 B2 JP7548696 B2 JP 7548696B2 JP 2019500268 A JP2019500268 A JP 2019500268A JP 2019500268 A JP2019500268 A JP 2019500268A JP 7548696 B2 JP7548696 B2 JP 7548696B2
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sequence
cells
composition
cell
scn9a
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JP2019520079A (ja
JP2019520079A5 (OSRAM
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スベン ランドバーグ アンテ
クルカーニー サマース
クレイン ローレンス
クマー パッドマナブハン ハリ
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Vertex Pharmaceuticals Inc
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JP2019500268A 2016-07-06 2017-07-06 疼痛関連障害を処置するための物質及び方法 Active JP7548696B2 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2022109956A JP7429264B2 (ja) 2016-07-06 2022-07-07 疼痛関連障害を処置するための物質及び方法
JP2024010029A JP7719222B2 (ja) 2016-07-06 2024-01-26 疼痛関連障害を処置するための物質及び方法
JP2025123989A JP2025146901A (ja) 2016-07-06 2025-07-24 疼痛関連障害を処置するための物質及び方法

Applications Claiming Priority (5)

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US201662358763P 2016-07-06 2016-07-06
US62/358,763 2016-07-06
US201762461874P 2017-02-22 2017-02-22
US62/461,874 2017-02-22
PCT/IB2017/054086 WO2018007980A1 (en) 2016-07-06 2017-07-06 Materials and methods for treatment of pain related disorders

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JP2019520079A JP2019520079A (ja) 2019-07-18
JP2019520079A5 JP2019520079A5 (OSRAM) 2020-08-13
JP7548696B2 true JP7548696B2 (ja) 2024-09-10

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JP2019500268A Active JP7548696B2 (ja) 2016-07-06 2017-07-06 疼痛関連障害を処置するための物質及び方法
JP2022109956A Active JP7429264B2 (ja) 2016-07-06 2022-07-07 疼痛関連障害を処置するための物質及び方法
JP2024010029A Active JP7719222B2 (ja) 2016-07-06 2024-01-26 疼痛関連障害を処置するための物質及び方法
JP2025123989A Pending JP2025146901A (ja) 2016-07-06 2025-07-24 疼痛関連障害を処置するための物質及び方法

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JP2022109956A Active JP7429264B2 (ja) 2016-07-06 2022-07-07 疼痛関連障害を処置するための物質及び方法
JP2024010029A Active JP7719222B2 (ja) 2016-07-06 2024-01-26 疼痛関連障害を処置するための物質及び方法
JP2025123989A Pending JP2025146901A (ja) 2016-07-06 2025-07-24 疼痛関連障害を処置するための物質及び方法

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US (2) US11459587B2 (OSRAM)
EP (1) EP3481857A1 (OSRAM)
JP (4) JP7548696B2 (OSRAM)
CN (2) CN109843914B (OSRAM)
AU (1) AU2017292173B2 (OSRAM)
CA (1) CA3029141A1 (OSRAM)
WO (1) WO2018007980A1 (OSRAM)

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CN109312343B (zh) 2015-12-14 2022-09-27 冷泉港实验室 用于治疗常染色体显性精神发育迟滞5型和Dravet综合征的反义寡聚体
US11801313B2 (en) 2016-07-06 2023-10-31 Vertex Pharmaceuticals Incorporated Materials and methods for treatment of pain related disorders
CN109843914B (zh) 2016-07-06 2024-03-15 沃泰克斯药物股份有限公司 用于治疗疼痛相关病症的材料和方法
IL315358A (en) * 2016-08-18 2024-11-01 Univ California CRISPR-CAS genome engineering using a modular AAV delivery system
SMT202400071T1 (it) 2017-08-25 2024-03-13 Stoke Therapeutics Inc Oligomeri antisenso per il trattamento di condizioni e malattie
MX2020008581A (es) * 2018-02-21 2020-09-21 Bristol Myers Squibb Co Oligonucleotidos antisentido de la proteina cinasa del tipo ii delta dependiente del calcio/calmodulina (camk2d) y sus usos.
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JP7455831B2 (ja) 2018-11-21 2024-03-26 アイオーニス ファーマシューティカルズ， インコーポレーテッド プリオン発現を低減するための化合物及び方法
CN113950526B (zh) * 2019-04-09 2025-03-21 加利福尼亚大学董事会 通过靶向体内表观遗传阻遏实现的持久镇痛
SG11202111270SA (en) 2019-04-12 2021-11-29 Vertex Pharma Gene-editing systems for modifying a scn9a or scn10a gene and methods of use thereof
CN118813654A (zh) * 2019-08-12 2024-10-22 生命编辑制药股份有限公司 Rna指导的核酸酶及其活性片段及变体以及使用方法
JP7528212B2 (ja) * 2019-11-26 2024-08-05 ディスアーム セラピューティクス， インコーポレイテッド 神経保護のための方法および組成物
AR120817A1 (es) * 2019-12-20 2022-03-23 Hoffmann La Roche Oligonucleótidos mejorados para inhibir la expresión de scn9a
TW202208626A (zh) 2020-04-24 2022-03-01 美商生命編輯公司 Rna引導核酸酶及其活性片段與變體，以及使用方法
CA3173647A1 (en) 2020-05-11 2021-11-18 Isabel AZNAREZ Opa1 antisense oligomers for treatment of conditions and diseases
WO2021247995A2 (en) * 2020-06-04 2021-12-09 Voyager Therapeutics, Inc. Compositions and methods of treating neuropathic pain
CN116368227A (zh) * 2020-07-22 2023-06-30 弗洛里神经科学与心理健康研究所 用于治疗与scn2a中功能失去突变相关的障碍的组合物和方法
US12152243B2 (en) 2020-09-17 2024-11-26 Quelltx, Inc. Therapeutic compositions for treating pain via multiple targets
WO2022147541A1 (en) * 2021-01-04 2022-07-07 Exicure Operating Company Compounds for modulating scn9a expression
WO2023010133A2 (en) * 2021-07-30 2023-02-02 Tune Therapeutics, Inc. Compositions and methods for modulating expression of frataxin (fxn)
GB202114871D0 (en) * 2021-10-18 2021-12-01 Ucl Business Ltd Guide RNA and uses thereof
AU2022421244A1 (en) 2021-12-22 2024-07-11 Camp4 Therapeutics Corporation Modulation of gene transcription using antisense oligonucleotides targeting regulatory rnas
CN115844918B (zh) * 2022-09-27 2024-11-22 首都医科大学附属北京天坛医院 一种miR-3131抑制剂在制备药物中的应用
WO2025106999A1 (en) * 2023-11-16 2025-05-22 The Johns Hopkins University Deprivation of human pluripotent stem cell-derived trpv1+, mrgprx1+ and scn9a+ sensory neurons and their functional characterization
WO2025128967A1 (en) * 2023-12-15 2025-06-19 Iowa State University Research Foundation, Inc. Compositions and methods for restoring susceptibility to pyrethroid insecticides in resistant populations

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