JP7544597B2 - がんの診断及び療法 - Google Patents

がんの診断及び療法 Download PDF

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JP7544597B2
JP7544597B2 JP2020524340A JP2020524340A JP7544597B2 JP 7544597 B2 JP7544597 B2 JP 7544597B2 JP 2020524340 A JP2020524340 A JP 2020524340A JP 2020524340 A JP2020524340 A JP 2020524340A JP 7544597 B2 JP7544597 B2 JP 7544597B2
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cancer
tgf
expression level
antibody
individual
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JP2021502066A5 (https=
JP2021502066A (ja
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イングイ グアン，
ヤシン センババオグル，
シャノン ターリー，
ユイレイ ワン，
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Genentech Inc
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    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
    • A—HUMAN NECESSITIES
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
    • G01N33/57585—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites involving compounds identifiable in body fluids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2539/00—Reactions characterised by analysis of gene expression or genome comparison
    • C12Q2539/10—The purpose being sequence identification by analysis of gene expression or genome comparison characterised by
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/475—Assays involving growth factors
    • G01N2333/495—Transforming growth factor [TGF]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70596—Molecules with a "CD"-designation not provided for elsewhere in G01N2333/705
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

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  • Animal Behavior & Ethology (AREA)
  • Mycology (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2020524340A 2017-11-06 2018-11-05 がんの診断及び療法 Active JP7544597B2 (ja)

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Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201762582207P 2017-11-06 2017-11-06
US62/582,207 2017-11-06
US201762595957P 2017-12-07 2017-12-07
US62/595,957 2017-12-07
US201862657468P 2018-04-13 2018-04-13
US62/657,468 2018-04-13
PCT/US2018/059271 WO2019090263A1 (en) 2017-11-06 2018-11-05 Diagnostic and therapeutic methods for cancer

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JP2021502066A JP2021502066A (ja) 2021-01-28
JP2021502066A5 JP2021502066A5 (https=) 2021-12-16
JP7544597B2 true JP7544597B2 (ja) 2024-09-03

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US (2) US11473151B2 (https=)
EP (1) EP3707510B1 (https=)
JP (2) JP7544597B2 (https=)
KR (1) KR20200075860A (https=)
CN (1) CN111213059B (https=)
AU (1) AU2018359967A1 (https=)
CA (1) CA3077664A1 (https=)
ES (1) ES2984919T3 (https=)
IL (1) IL274246A (https=)
MX (1) MX2020004567A (https=)
PL (1) PL3707510T3 (https=)
TW (1) TW201923089A (https=)
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CN111729090A (zh) * 2013-12-20 2020-10-02 通用医疗公司 与循环肿瘤细胞相关的方法和测定法
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CN112367994A (zh) * 2018-06-27 2021-02-12 株式会社麦迪帕克特 诊断和治疗表达高水平TGF-β应答标记的癌症患者的方法
US20220249484A1 (en) * 2019-05-17 2022-08-11 Memorial Sloan Kettering Cancer Center Methods for predicting responsiveness of cancer to ferroptosis-inducing therapies
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TW202214287A (zh) * 2020-08-24 2022-04-16 大陸商江蘇恒瑞醫藥股份有限公司 TGF-β受體的融合蛋白與多靶點酪胺酸激酶抑制劑聯合在製備治療腫瘤藥物中的用途
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TWI907564B (zh) * 2020-11-16 2025-12-11 南韓商益免安協公司 用於預測對免疫抗癌劑的治療反應的生物標誌物及其用途
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