JP7543143B2 - 早期発症型孤発性パーキンソン病の分子シグネチャの診断及び薬物スクリーニング - Google Patents
早期発症型孤発性パーキンソン病の分子シグネチャの診断及び薬物スクリーニング Download PDFInfo
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- JP7543143B2 JP7543143B2 JP2020560893A JP2020560893A JP7543143B2 JP 7543143 B2 JP7543143 B2 JP 7543143B2 JP 2020560893 A JP2020560893 A JP 2020560893A JP 2020560893 A JP2020560893 A JP 2020560893A JP 7543143 B2 JP7543143 B2 JP 7543143B2
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- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
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- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
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- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
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- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
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- G01N2333/91—Transferases (2.)
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- G01N2800/00—Detection or diagnosis of diseases
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024090584A JP2024126026A (ja) | 2018-04-30 | 2024-06-04 | 早期発症型孤発性パーキンソン病の分子シグネチャの診断及び薬物スクリーニング |
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862664888P | 2018-04-30 | 2018-04-30 | |
| US201862664827P | 2018-04-30 | 2018-04-30 | |
| US62/664,827 | 2018-04-30 | ||
| US62/664,888 | 2018-04-30 | ||
| US201862664942P | 2018-05-01 | 2018-05-01 | |
| US62/664,942 | 2018-05-01 | ||
| US201862755365P | 2018-11-02 | 2018-11-02 | |
| US62/755,365 | 2018-11-02 | ||
| US201962816795P | 2019-03-11 | 2019-03-11 | |
| US62/816,795 | 2019-03-11 | ||
| PCT/US2019/026195 WO2019212691A1 (en) | 2018-04-30 | 2019-04-05 | Diagnostic and drug screening for molecular signatures of early onset sporadic parkinson's disease |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024090584A Division JP2024126026A (ja) | 2018-04-30 | 2024-06-04 | 早期発症型孤発性パーキンソン病の分子シグネチャの診断及び薬物スクリーニング |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2021523700A JP2021523700A (ja) | 2021-09-09 |
| JP7543143B2 true JP7543143B2 (ja) | 2024-09-02 |
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Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020560893A Active JP7543143B2 (ja) | 2018-04-30 | 2019-04-05 | 早期発症型孤発性パーキンソン病の分子シグネチャの診断及び薬物スクリーニング |
| JP2020560894A Pending JP2021523888A (ja) | 2018-04-30 | 2019-04-05 | パーキンソン病におけるpkc経路 |
| JP2024038025A Pending JP2024073529A (ja) | 2018-04-30 | 2024-03-12 | パーキンソン病におけるpkc経路 |
| JP2024090584A Withdrawn JP2024126026A (ja) | 2018-04-30 | 2024-06-04 | 早期発症型孤発性パーキンソン病の分子シグネチャの診断及び薬物スクリーニング |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020560894A Pending JP2021523888A (ja) | 2018-04-30 | 2019-04-05 | パーキンソン病におけるpkc経路 |
| JP2024038025A Pending JP2024073529A (ja) | 2018-04-30 | 2024-03-12 | パーキンソン病におけるpkc経路 |
| JP2024090584A Withdrawn JP2024126026A (ja) | 2018-04-30 | 2024-06-04 | 早期発症型孤発性パーキンソン病の分子シグネチャの診断及び薬物スクリーニング |
Country Status (4)
| Country | Link |
|---|---|
| US (2) | US12564568B2 (https=) |
| EP (2) | EP3787613B1 (https=) |
| JP (4) | JP7543143B2 (https=) |
| WO (2) | WO2019212691A1 (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20190018000A1 (en) | 2016-01-12 | 2019-01-17 | Cedars-Sinai Medical Center | A method of non destructive monitoring of biological processes in microfluidic tissue culture systems |
| US11473061B2 (en) | 2016-02-01 | 2022-10-18 | Cedars-Sinai Medical Center | Systems and methods for growth of intestinal cells in microfluidic devices |
| WO2018140647A1 (en) | 2017-01-25 | 2018-08-02 | Cedars-Sinai Medical Center | In vitro induction of mammary-like differentiation from human pluripotent stem cells |
| US11767513B2 (en) | 2017-03-14 | 2023-09-26 | Cedars-Sinai Medical Center | Neuromuscular junction |
| US11414648B2 (en) | 2017-03-24 | 2022-08-16 | Cedars-Sinai Medical Center | Methods and compositions for production of fallopian tube epithelium |
| EP4700387A2 (en) | 2018-03-23 | 2026-02-25 | Cedars-Sinai Medical Center | Methods of use of islet cells |
| US11981918B2 (en) | 2018-04-06 | 2024-05-14 | Cedars-Sinai Medical Center | Differentiation technique to generate dopaminergic neurons from induced pluripotent stem cells |
| EP3775161A4 (en) | 2018-04-06 | 2022-04-06 | Cedars-Sinai Medical Center | NEURODEGENERATIVE DISEASE MODELS DERIVED FROM HUMAN PLURIPOTENTIC STEM CELLS ON A MICROFLUIDIC CHIP |
| EP3787613B1 (en) | 2018-04-30 | 2026-03-11 | Cedars-Sinai Medical Center | Pkc activation for use in treating early onset sporadic parkinson's disease |
| CN116635047A (zh) * | 2020-06-26 | 2023-08-22 | 米纳瓦生物技术公司 | 用于从多能干细胞衍生多巴胺能神经元的方法 |
| CA3183958A1 (en) * | 2020-06-26 | 2021-12-30 | Minerva Biotechnologies Corporation | Methods for deriving dopaminergic neurons from pluripotent stem cells |
| CN111808960A (zh) * | 2020-07-20 | 2020-10-23 | 山东大学齐鲁医院 | 一种用于诊治急性髓性白血病的药物和方法 |
| TW202300642A (zh) * | 2021-03-25 | 2023-01-01 | 美商藍岩醫療公司 | 獲得誘導型多能幹細胞之方法 |
| CN120420309A (zh) * | 2024-06-18 | 2025-08-05 | 山历叶生物科技(深圳)有限公司 | 巨大戟醇hep14在制备药物中的应用及其药物剂型和制备方法 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003511346A (ja) | 1999-03-09 | 2003-03-25 | ザ ユニヴァースティ コート オブ ザ ユニヴァースティ オブ グラスゴウ | 神経変性疾患関連遺伝子 |
Family Cites Families (130)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5610281A (en) | 1994-05-03 | 1997-03-11 | Brigham & Women's Hospital, Inc. | Antibodies for modulating heterotypic E-cadherin interactions with human T lymphocytes |
| WO2002038190A2 (en) | 2000-10-27 | 2002-05-16 | Beth Israel Deaconess Medical Center | Non-isotopic detection of osteoblastic activity in vivo using modified bisphosphonates |
| EP1385938A1 (en) * | 2001-04-23 | 2004-02-04 | Nsgene A/S | Method and culture medium for producing neural cells expressing tyrosine hydroxylase |
| US20080004332A1 (en) | 2002-03-07 | 2008-01-03 | Alkon Daniel L | Methods for alzheimer's disease treatment and cognitive enhancement |
| US20090030055A1 (en) * | 2002-07-02 | 2009-01-29 | Thomas Nelson | PKC activation as a means for enhancing sAPPALPHA secretion and improving cognition using bryostatin type compounds |
| US7635477B2 (en) | 2002-07-25 | 2009-12-22 | The General Hospital Corporation | Parathyroid hormone receptor activation and stem and progenitor cell expansion |
| CN1791421A (zh) | 2002-09-25 | 2006-06-21 | 医药研究加万研究院 | 诱导乳腺上皮细胞分化的方法 |
| US7960166B2 (en) | 2003-05-21 | 2011-06-14 | The General Hospital Corporation | Microfabricated compositions and processes for engineering tissues containing multiple cell types |
| EP1670901A4 (en) | 2003-08-29 | 2007-09-05 | Wisconsin Alumni Res Found | METHOD FOR IN VITRO DIFFERENTIATION OF NEURAL STEM CELLS, MOTOR NEURONES AND DOPAMINE NEURONES FROM EMBRYONAL PRIMATIVE STEM CELLS |
| DE102004061947A1 (de) | 2004-12-22 | 2006-07-06 | Ccs Cell Culture Service Gmbh | Verfahren zum Einfrieren und Lagern von Zellen |
| WO2007030469A2 (en) | 2005-09-06 | 2007-03-15 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Transplantable cell growth niche and related compositions and methods |
| US20070128722A1 (en) | 2005-12-05 | 2007-06-07 | Industrial Technology Research Institute | Human mesenchymal stem cells and culturing methods thereof |
| US8492150B2 (en) | 2006-02-03 | 2013-07-23 | President And Fellows Of Harvard College | Engineered cell growth on polymeric films and biotechnological applications thereof |
| US20080044847A1 (en) | 2006-06-23 | 2008-02-21 | Shusta Eric V | Blood-Brain Barrier Model |
| KR100790880B1 (ko) | 2006-07-05 | 2008-01-02 | 삼성전자주식회사 | 자성 비드가 결합되어 있는 소수성 다공성 중합체가 벽면에결합되어 있는 마이크로채널 또는 마이크로챔버를포함하는 미세유동장치 및 그를 이용하는 방법 |
| US11696908B2 (en) * | 2007-01-31 | 2023-07-11 | Biosuccess Biotech Co. Ltd. | Compositions and methods of use of phorbol esters |
| EP2139990A1 (en) | 2007-03-23 | 2010-01-06 | California Stem Cell, Inc. | Human late stage motor neuron progenitor cells and methods of making and using same |
| WO2008136729A1 (en) | 2007-05-04 | 2008-11-13 | Sundstroem Erik | Slicing device |
| JP2008307007A (ja) | 2007-06-15 | 2008-12-25 | Bayer Schering Pharma Ag | 出生後のヒト組織由来未分化幹細胞から誘導したヒト多能性幹細胞 |
| CA2691963A1 (en) | 2007-06-27 | 2008-12-31 | President And Fellows Of Harvard College | Neural stem cells |
| US20090075374A1 (en) | 2007-07-24 | 2009-03-19 | Palecek Sean P | Methods of generating epithelial lineage cells from embryoid bodies and pluripotent cells |
| US9381273B2 (en) | 2008-01-31 | 2016-07-05 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Scaffolds with oxygen carriers, and their use in tissue regeneration |
| JP2009247276A (ja) | 2008-04-04 | 2009-10-29 | Erii Kk | 生体供給用、生体移植用、生体添加用、生体投与用の解凍器官若しくは組織または解凍細胞群とその製造方法及びそれらに用いる過冷却液並びに製造装置 |
| WO2009128533A1 (ja) | 2008-04-18 | 2009-10-22 | 国立大学法人名古屋大学 | 間葉系幹細胞およびその生産方法 |
| CN104328050B (zh) | 2008-07-16 | 2017-12-15 | 儿童医疗中心有限公司 | 具有微通道的器官模仿装置及其使用和制造方法 |
| AU2015204375A1 (en) | 2008-07-16 | 2015-08-06 | Children's Medical Center Corporation | Organ mimic device with microchannels and methods of use and manufacturing thereof |
| WO2011109440A1 (en) | 2010-03-01 | 2011-09-09 | Caris Life Sciences Luxembourg Holdings | Biomarkers for theranostics |
| US9752124B2 (en) | 2009-02-03 | 2017-09-05 | Koninklijke Nederlandse Akademie Van Wetenschappen | Culture medium for epithelial stem cells and organoids comprising the stem cells |
| US8642334B2 (en) | 2009-02-17 | 2014-02-04 | Memorial Sloan Kettering Cancer Center | Methods of neural conversion of human embryonic stem cells |
| WO2010108005A2 (en) | 2009-03-18 | 2010-09-23 | University Of Georgia Research Foundation | Novel neural progenitors from pluripotent stem cells, methods of producing same and use to produce neural cells |
| KR20110134939A (ko) | 2009-04-03 | 2011-12-15 | 더 맥클린 하스피털 코퍼레이션 | 유도된 다능성 줄기 세포 |
| CN102573500A (zh) * | 2009-08-06 | 2012-07-11 | 纽拉尔图斯制药公司 | 巨噬细胞相关疾病的治疗 |
| US9708582B2 (en) | 2009-10-13 | 2017-07-18 | Stemcell Technologies Inc. | Method of differentiating stem cells |
| US9719068B2 (en) | 2010-05-06 | 2017-08-01 | Children's Hospital Medical Center | Methods and systems for converting precursor cells into intestinal tissues through directed differentiation |
| CA2808660A1 (en) * | 2010-08-19 | 2012-02-23 | Blanchette Rockefeller Neurosciences Institute | Treatment of cognitive disorders associated with abnormal dendritic spines using pkc activators |
| EP2636731B1 (en) | 2010-11-02 | 2016-07-13 | National University Corporation Kumamoto University | Method of producing intestinal cells |
| AU2010365057B2 (en) | 2010-12-08 | 2016-12-22 | Viacyte, Inc. | Agents and methods for inhibiting human pluripotent stem cell growth |
| ES2623538T3 (es) | 2010-12-13 | 2017-07-11 | TheraDep Technologies, Inc | Dispositivos médicos implantables |
| KR20140004724A (ko) | 2011-01-19 | 2014-01-13 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | 전분화능을 위한 선천적 잠재력을 갖는 체세포 |
| US20120211373A1 (en) | 2011-02-22 | 2012-08-23 | The Regents Of The University Of Michigan | Microfluidic system for measuring cell barrier function |
| KR102117921B1 (ko) | 2011-02-28 | 2020-06-03 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 세포 배양 시스템 |
| WO2012122405A2 (en) | 2011-03-08 | 2012-09-13 | The Trustees Of Columbia University In The City Of New York | Screening assays using stem cells and stem cell-derived neurons from mouse models of alzheimer's disease |
| CN103620024B (zh) | 2011-06-09 | 2016-06-22 | 弗·哈夫曼-拉罗切有限公司 | 用于使多能干细胞分化为血管床细胞的方法 |
| WO2012177997A1 (en) * | 2011-06-22 | 2012-12-27 | The General Hospital Corporation | Treatment of proteinopathies |
| CA2861668C (en) * | 2011-10-05 | 2021-09-07 | Blanchette Rockefeller Neurosciences Institute | Stimulus-elicited genomic profile markers of a neurodegenerative condition |
| WO2013056216A1 (en) | 2011-10-14 | 2013-04-18 | New York University | Micrornas and methods of using same |
| ES2741969T3 (es) | 2011-10-31 | 2020-02-12 | Riken | Método para el cultivo de células madre |
| JP6422778B2 (ja) * | 2011-11-13 | 2018-11-14 | ブランシェット・ロックフェラー・ニューロサイエンスィズ・インスティテュート | Pkcアクチベーターおよびその組合せ |
| US9725687B2 (en) | 2011-12-09 | 2017-08-08 | President And Fellows Of Harvard College | Integrated human organ-on-chip microphysiological systems |
| WO2013086502A1 (en) | 2011-12-09 | 2013-06-13 | President And Fellows Of Harvard College | Organ chips and uses thereof |
| US9149806B2 (en) | 2012-01-10 | 2015-10-06 | Biopico Systems Inc | Microfluidic devices and methods for cell sorting, cell culture and cells based diagnostics and therapeutics |
| US9828583B2 (en) | 2012-01-13 | 2017-11-28 | The General Hospital Corporation | Isolated human lung progenitor cells and uses thereof |
| EP2804598B1 (en) | 2012-01-17 | 2019-05-15 | Kyoto University | Prophylactic and therapeutic drug for amyotrophic lateral sclerosis and method of screening therefor |
| US9532997B2 (en) | 2012-04-03 | 2017-01-03 | Whitehead Institute For Biomedical Research | Compositions and methods for promoting intestinal stem cell function |
| US9468656B2 (en) | 2012-04-20 | 2016-10-18 | Medela Holding Ag | Stem cell preparations and methods of use |
| KR101200049B1 (ko) | 2012-05-14 | 2012-11-13 | 한국원자력연구원 | 테크네튬-99엠 트리카보닐 표지 글리신 단량체 또는 올리고머 활용 생리활성분자를 이용한 프로브의 제조방법 및 이를 포함하는 영상제 조성물 |
| US20150168375A1 (en) | 2012-06-04 | 2015-06-18 | Medimmune, Llc | Cancer stem cells and methods of using the same |
| EP2861612A4 (en) | 2012-06-13 | 2016-02-17 | Stemgent Inc | METHOD FOR PRODUCING PLURIPOTENT STEM CELLS |
| US9513280B2 (en) | 2012-08-28 | 2016-12-06 | University Of Utah Research Foundation | Microfluidic biological barrier model and associated method |
| GB201216796D0 (en) | 2012-09-20 | 2012-11-07 | Cambridge Entpr Ltd | In vitro pancreatic differentiation |
| US20140134732A1 (en) | 2012-11-14 | 2014-05-15 | Wisconsin Alumni Research Foundation | Simplified Compositions and Methods for Generating Neural Stem Cells From Human Pluripotent Stem Cells |
| US9932559B2 (en) | 2012-11-16 | 2018-04-03 | The Johns Hopkins University | Platform for creating an artificial blood brain barrier |
| US10160950B2 (en) | 2013-03-01 | 2018-12-25 | Wisconsin Alumni Research Foundation | Methods of maintaining, expanding and differentiating neuronal subtype specific progenitors |
| JP6112550B2 (ja) | 2013-03-08 | 2017-04-12 | 国立研究開発法人産業技術総合研究所 | 胃組織細胞の作製方法 |
| LT2970890T (lt) | 2013-03-14 | 2020-07-10 | The Brigham And Women`S Hospital, Inc. | Kompozicijos ir būdai, skirti epitelinių kamieninių ląstelių padauginimui ir kultivavimui |
| US10266807B2 (en) | 2013-04-03 | 2019-04-23 | FUJIFILM Cellular Dynamics, Inc. | Methods and compositions for culturing endoderm progenitor cells in suspension |
| US10638948B2 (en) | 2013-04-19 | 2020-05-05 | Cedars-Sinai Medical Center | Imaging biomarkers for the diagnosis and prognosis of back pain and related conditions |
| EP3498824A1 (en) | 2013-04-26 | 2019-06-19 | Memorial Sloan-Kettering Cancer Center | Cortical interneurons and other neuronal cells produced by the directed differentiation of pluripotent and multipotent cells |
| SG11201510177WA (en) | 2013-06-11 | 2016-01-28 | Harvard College | SC-β CELLS AND COMPOSITIONS AND METHODS FOR GENERATING THE SAME |
| WO2015006725A2 (en) | 2013-07-12 | 2015-01-15 | Cedars-Sinai Medical Center | Generation of induced pluripotent stem cells from normal human mammary epithelial cells |
| WO2015020234A1 (ja) | 2013-08-06 | 2015-02-12 | 武田薬品工業株式会社 | ドパミン神経細胞の製造方法 |
| GB201317869D0 (en) | 2013-10-09 | 2013-11-20 | Cambridge Entpr Ltd | In vitro production of foregut stem cells |
| WO2015057261A1 (en) | 2013-10-16 | 2015-04-23 | The Brigham And Women's Hospital, Inc. | Methods of generating intermediate mesoderm cells from human pluripotent stem cells |
| CA2934662C (en) | 2013-12-20 | 2024-02-20 | President And Fellows Of Harvard College | Low shear microfluidic devices and methods of use and manufacturing thereof |
| GB2583047B (en) | 2013-12-20 | 2021-03-24 | Harvard College | Organomimetic devices and methods of use and manufacturing thereof |
| US9695399B2 (en) | 2014-01-28 | 2017-07-04 | Northwestern University | 3D microphysiologic system |
| SG11201606832YA (en) | 2014-02-18 | 2016-09-29 | Massachusetts Inst Technology | Biophysically sorted osteoprogenitors from culture expanded bone marrow derived mesenchymal stromal cells (mscs) |
| WO2015143342A1 (en) * | 2014-03-21 | 2015-09-24 | Cellular Dynamics International, Inc. | Production of midbrain dopaminergic neurons and methods for the use thereof |
| AU2015241133B2 (en) | 2014-03-31 | 2019-11-28 | Brigham And Women's Hospital, Inc. | Systems and methods for biomimetic fluid processing |
| CN107075466A (zh) | 2014-04-23 | 2017-08-18 | 新加坡科技研究局 | 细胞重编程的方法 |
| US10006006B2 (en) | 2014-05-16 | 2018-06-26 | Janssen Biotech, Inc. | Use of small molecules to enhance MAFA expression in pancreatic endocrine cells |
| WO2015181253A1 (en) | 2014-05-27 | 2015-12-03 | Fundación Pública Andaluza Progreso Y Salud | Neural progenitor cell population |
| CN106661548B (zh) | 2014-05-28 | 2020-12-11 | 儿童医院医疗中心 | 用于经由定向分化将前体细胞转化为胃组织的方法和系统 |
| US20170107498A1 (en) | 2014-06-05 | 2017-04-20 | Cedars-Sinai Medical Center | Novel and efficient method for reprogramming immortalized lymphoblastoid cell lines to induced pluripotent stem cells |
| JP6804438B2 (ja) | 2014-10-17 | 2020-12-23 | チルドレンズ ホスピタル メディカル センター | 多能性幹細胞を使用するヒト小腸のin vivoモデル、並びにそれを作製、及び使用する方法 |
| WO2016063985A1 (ja) | 2014-10-24 | 2016-04-28 | 大日本住友製薬株式会社 | 神経組織の製造方法 |
| WO2016086040A1 (en) | 2014-11-25 | 2016-06-02 | Los Alamos National Security, Llc | Patterned neuromuscular junctions and methods of use |
| JP5777127B1 (ja) | 2014-12-09 | 2015-09-09 | 公立大学法人横浜市立大学 | 原始腸内胚葉細胞及びその作製方法 |
| WO2016114655A1 (en) * | 2015-01-12 | 2016-07-21 | Ry Pharma B.V. | Treating neuromuscular or neurologic disease through reducing gabaergic and/or glycinergic inhibitory neurotransmitter overstimulation |
| US9944894B2 (en) | 2015-01-16 | 2018-04-17 | General Electric Company | Pluripotent stem cell expansion and passage using a rocking platform bioreactor |
| JP6807853B2 (ja) | 2015-03-03 | 2021-01-06 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 機能的ヒト組織の作製方法 |
| CN107438669B (zh) | 2015-04-09 | 2022-09-27 | 拜奥拉米那公司 | 用于治疗神经退行性疾病的干细胞衍生多巴胺能细胞的生产方法和组合物 |
| WO2016183252A1 (en) * | 2015-05-11 | 2016-11-17 | Alkon, Daniel, L. | Treatment of neurodegenerative conditions using pkc activators after determining the presence of the apoe4 allele |
| WO2017035119A1 (en) | 2015-08-24 | 2017-03-02 | National University Of Singapore | Blood brain barrier model in a 3d co-culture microfluidic system |
| US12209253B2 (en) | 2016-08-29 | 2025-01-28 | EMULATE, Inc. | Development of spinal cord on a microfluidic chip |
| US20170226478A1 (en) | 2015-10-19 | 2017-08-10 | EMULATE, Inc. | Neuromuscular Junction: NMJ-ON-CHIP |
| AU2016341880B2 (en) | 2015-10-19 | 2021-01-21 | Cedars-Sinai Medical Center | Microfluidic model of the blood brain barrier |
| WO2017075271A1 (en) | 2015-10-29 | 2017-05-04 | The Regents Of The University Of Claifornia | Astrocyte differentiation protocol |
| CA3003152A1 (en) * | 2015-11-04 | 2017-05-11 | Fate Therapeutics, Inc. | Methods and compositions for inducing hematopoietic cell differentiation |
| WO2017112455A2 (en) | 2015-12-22 | 2017-06-29 | Corning Incorporated | Cell separation device and method for using same |
| US20190018000A1 (en) | 2016-01-12 | 2019-01-17 | Cedars-Sinai Medical Center | A method of non destructive monitoring of biological processes in microfluidic tissue culture systems |
| US11473061B2 (en) | 2016-02-01 | 2022-10-18 | Cedars-Sinai Medical Center | Systems and methods for growth of intestinal cells in microfluidic devices |
| WO2017143049A1 (en) | 2016-02-16 | 2017-08-24 | President And Fellows Of Harvard College | Improved blood-brain barrier endothelial cells derived from pluripotent stem cells for blood-brain barrier models |
| EP3423564A4 (en) | 2016-03-03 | 2019-08-21 | New York Stem Cell Foundation, Inc. | MICROGLIA DERIVED FROM PLURIPOTENTIAL STEM CELLS AND METHOD FOR THE PRODUCTION AND USE THEREOF |
| US10214724B2 (en) | 2016-04-05 | 2019-02-26 | Wisconsin Alumni Research Foundation | Methods for differentiation of human pluripotent stem cells to brain microvascular endothelial cells |
| WO2017200486A1 (en) | 2016-05-17 | 2017-11-23 | Agency For Science, Technology And Research | Human stem cell derived endothelial cells, endothelial- hepatocyte co-culture system and uses thereof |
| US10221395B2 (en) | 2016-06-16 | 2019-03-05 | Cedars-Sinai Medical Center | Efficient method for reprogramming blood to induced pluripotent stem cells |
| WO2018035214A1 (en) * | 2016-08-16 | 2018-02-22 | Cellular Dynamics International., Inc. | Methods for differentiating pluripotent cells |
| US12091650B2 (en) | 2016-08-29 | 2024-09-17 | EMULATE, Inc. | Development of spinal cord on a microfluidic chip |
| JP7068305B2 (ja) | 2016-12-05 | 2022-05-16 | チルドレンズ ホスピタル メディカル センター | 結腸オルガノイドならびにその作製方法および使用方法 |
| WO2018140647A1 (en) | 2017-01-25 | 2018-08-02 | Cedars-Sinai Medical Center | In vitro induction of mammary-like differentiation from human pluripotent stem cells |
| GB2575574B (en) | 2017-03-14 | 2022-08-17 | Cedars Sinai Medical Center | Neuromuscular junction |
| US11767513B2 (en) | 2017-03-14 | 2023-09-26 | Cedars-Sinai Medical Center | Neuromuscular junction |
| SG11201908359UA (en) | 2017-03-14 | 2019-10-30 | Emulate Inc | Neuromuscular junction: nmj-on-chip |
| JP7471084B2 (ja) | 2017-03-21 | 2024-04-19 | メモリアル スローン ケタリング キャンサー センター | 幹細胞由来星状細胞、作製方法および使用方法 |
| US11414648B2 (en) | 2017-03-24 | 2022-08-16 | Cedars-Sinai Medical Center | Methods and compositions for production of fallopian tube epithelium |
| WO2018213773A1 (en) | 2017-05-19 | 2018-11-22 | Cedars-Sinai Medical Center | Systems and methods for growth of intestinal cells |
| WO2019023793A1 (en) | 2017-08-04 | 2019-02-07 | University Health Network | GENERATION OF OLIGODENDROGENIC NEURON PROGENITOR CELLS |
| SG11202005063XA (en) | 2017-12-22 | 2020-06-29 | Tissuse Gmbh | NOVEL MULTI-ORGAN-CHIPS ESTABLISHING DIFFERENTIATION OF iPSC-DERIVED CELLS INTO ORGAN EQUIVALENTS |
| CN112074281A (zh) | 2018-03-02 | 2020-12-11 | 沃泰克斯药物股份有限公司 | 增强干细胞向β细胞分化的方法 |
| US12103004B2 (en) | 2018-03-12 | 2024-10-01 | Silicon Valley Scientific, Inc. | Method and apparatus for processing tissue and other samples encoding cellular spatial position information |
| US12258571B2 (en) | 2018-03-16 | 2025-03-25 | Cedars-Sinai Medical Center | Methods and compositions for inducible expression of neurotrophic factors |
| EP4700387A2 (en) | 2018-03-23 | 2026-02-25 | Cedars-Sinai Medical Center | Methods of use of islet cells |
| US11981918B2 (en) | 2018-04-06 | 2024-05-14 | Cedars-Sinai Medical Center | Differentiation technique to generate dopaminergic neurons from induced pluripotent stem cells |
| EP3775161A4 (en) | 2018-04-06 | 2022-04-06 | Cedars-Sinai Medical Center | NEURODEGENERATIVE DISEASE MODELS DERIVED FROM HUMAN PLURIPOTENTIC STEM CELLS ON A MICROFLUIDIC CHIP |
| EP3787613B1 (en) | 2018-04-30 | 2026-03-11 | Cedars-Sinai Medical Center | Pkc activation for use in treating early onset sporadic parkinson's disease |
| AU2020370288B2 (en) | 2019-10-22 | 2026-02-12 | Cedars-Sinai Medical Center | Cortical neural progenitor cells from iPSCs |
| WO2021081237A1 (en) | 2019-10-22 | 2021-04-29 | Cedars-Sinai Medical Center | Mesh chopping of neural progenitor cell aggregates |
| WO2021222724A1 (en) | 2020-05-01 | 2021-11-04 | Cedars-Sinai Medical Center | Multi-lineage cardiovascular microfluidic organ-chip |
| EP4217114A4 (en) | 2020-09-22 | 2024-10-23 | Cedars-Sinai Medical Center | COMPLEX MICROFLUIDIC MODELS FOR ALS INCLUDING NF BIOMARKERS FOR ALS RESEARCH AND DRUG DEVELOPMENT |
-
2019
- 2019-04-05 EP EP19796470.3A patent/EP3787613B1/en active Active
- 2019-04-05 WO PCT/US2019/026195 patent/WO2019212691A1/en not_active Ceased
- 2019-04-05 JP JP2020560893A patent/JP7543143B2/ja active Active
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- 2019-04-05 EP EP19796911.6A patent/EP3787649B1/en active Active
- 2019-04-05 US US17/043,344 patent/US12564568B2/en active Active
- 2019-04-05 WO PCT/US2019/026193 patent/WO2019212690A1/en not_active Ceased
- 2019-04-05 US US17/043,272 patent/US20210033628A1/en active Pending
-
2024
- 2024-03-12 JP JP2024038025A patent/JP2024073529A/ja active Pending
- 2024-06-04 JP JP2024090584A patent/JP2024126026A/ja not_active Withdrawn
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003511346A (ja) | 1999-03-09 | 2003-03-25 | ザ ユニヴァースティ コート オブ ザ ユニヴァースティ オブ グラスゴウ | 神経変性疾患関連遺伝子 |
Non-Patent Citations (6)
| Title |
|---|
| Cell Reports,2017年,21,p. 2304-2312及びSupplemental Information |
| Molecular Neurodegeneration,2017年,12:11,p. 1-18,DOI 10.1186/s13024-017-0154-3 |
| Stem Cell Reports,2016年,Vol. 6,p. 422-435及びSupplemental Information |
| STEM CELLS,2013年,31,p. 1548-1562 |
| STEM CELLS,2013年,31,p. 458-466, Supporting Information |
| 目的別で選べる細胞培養プロトコール,2012年,p. 210-211 |
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| EP3787649A1 (en) | 2021-03-10 |
| EP3787613A4 (en) | 2022-01-12 |
| JP2021523888A (ja) | 2021-09-09 |
| JP2024126026A (ja) | 2024-09-19 |
| EP3787613B1 (en) | 2026-03-11 |
| JP2021523700A (ja) | 2021-09-09 |
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| WO2019212691A1 (en) | 2019-11-07 |
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