JP7453148B2 - 塩、結晶形態、およびその製造方法 - Google Patents

塩、結晶形態、およびその製造方法 Download PDF

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Publication number
JP7453148B2
JP7453148B2 JP2020543518A JP2020543518A JP7453148B2 JP 7453148 B2 JP7453148 B2 JP 7453148B2 JP 2020543518 A JP2020543518 A JP 2020543518A JP 2020543518 A JP2020543518 A JP 2020543518A JP 7453148 B2 JP7453148 B2 JP 7453148B2
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tpma
pyran
thieno
dihydro
disorder
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JP2021513975A (ja
JPWO2019161238A5 (fr
Inventor
アンドレア・バウアー
ナンドクマール・ニブリッティ・ボグル
シャオシア・チェン
シャーラ・ジャムザド
ロバート・ジョセフ・プリトコ
コスタス・サランテアス
ハロルド・スコット・ウィルキンソン
ハイタオ・ジャン
マイケル・ジョセフ・シゼンスキー
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Sunovion Pharmaceuticals Inc
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Sunovion Pharmaceuticals Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
JP2020543518A 2018-02-16 2019-02-15 塩、結晶形態、およびその製造方法 Active JP7453148B2 (ja)

Priority Applications (1)

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JP2024034508A JP2024063208A (ja) 2018-02-16 2024-03-07 塩、結晶形態、およびその製造方法

Applications Claiming Priority (3)

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US201862710416P 2018-02-16 2018-02-16
US62/710,416 2018-02-16
PCT/US2019/018265 WO2019161238A1 (fr) 2018-02-16 2019-02-15 Sels, formes cristallines et procédés de production associés

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JP2021513975A JP2021513975A (ja) 2021-06-03
JPWO2019161238A5 JPWO2019161238A5 (fr) 2022-02-22
JP7453148B2 true JP7453148B2 (ja) 2024-03-19

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JP2024034508A Pending JP2024063208A (ja) 2018-02-16 2024-03-07 塩、結晶形態、およびその製造方法

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US (3) US10815249B2 (fr)
EP (1) EP3752508A1 (fr)
JP (2) JP7453148B2 (fr)
KR (1) KR20200122345A (fr)
CN (1) CN112135827B (fr)
AU (2) AU2019222491B2 (fr)
CA (1) CA3091292A1 (fr)
EA (1) EA202091945A1 (fr)
IL (2) IL276692B (fr)
MX (2) MX2020008537A (fr)
PH (1) PH12020551256A1 (fr)
SG (1) SG11202007823PA (fr)
WO (1) WO2019161238A1 (fr)

Families Citing this family (13)

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RU2641648C1 (ru) 2009-12-04 2018-01-19 Суновион Фармасьютикалз, Инк. Полициклические соединения и способы их применения
SG10202100751YA (en) 2016-07-29 2021-03-30 Sunovion Pharmaceuticals Inc Compounds and compositions and uses thereof
US11129807B2 (en) 2017-02-16 2021-09-28 Sunovion Pharmaceuticals Inc. Methods of treating schizophrenia
BR112020001433A2 (pt) 2017-08-02 2020-07-28 Sunovion Pharmaceuticals Inc. compostos de isocromano e usos dos mesmos
AU2019222491B2 (en) 2018-02-16 2023-01-12 Sunovion Pharmaceuticals Inc. Salts, crystal forms, and production methods thereof
JP2022511509A (ja) 2018-12-06 2022-01-31 サノビオン ファーマシューティカルズ インク 神経障害および神経障害の処置方法
JP2023523569A (ja) 2020-04-14 2023-06-06 サノビオン ファーマシューティカルズ インク 神経学的および精神障害の治療方法
WO2022060758A1 (fr) * 2020-09-16 2022-03-24 Teva Pharmaceuticals International Gmbh Formes à l'état solide de sep-363856 et leur procédé de préparation
CA3233074A1 (fr) 2021-09-23 2023-03-30 Sumitomo Pharma America, Inc. Methodes de traitement de troubles metaboliques
WO2024050323A1 (fr) 2022-08-30 2024-03-07 Sunovion Pharmaceuticals Inc. Ulotaront pour le traitement adjuvant d'un trouble dépressif majeur
WO2024081828A1 (fr) 2022-10-13 2024-04-18 Sunovion Pharmaceuticals Inc. Méthodes de réduction de la dépendance physique aux traitements neuropsychiatriques
WO2024092070A1 (fr) 2022-10-28 2024-05-02 Sumitomo Pharma America, Inc. Ulotaront pour le traitement de l'anxiété et d'états associés
WO2024107681A1 (fr) 2022-11-15 2024-05-23 Sumitomo Pharma America, Inc. Procédés de commutation de médicaments neuropsychiatriques à l'aide d'ulotaront

Citations (1)

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Publication number Priority date Publication date Assignee Title
JP2013512926A (ja) 2009-12-04 2013-04-18 スノビオン プハルマセウトイカルス インコーポレイテッド 多環式化合物及びその使用方法

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