JP7421338B2 - 免疫調節融合タンパク質 - Google Patents

免疫調節融合タンパク質 Download PDF

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JP7421338B2
JP7421338B2 JP2019516603A JP2019516603A JP7421338B2 JP 7421338 B2 JP7421338 B2 JP 7421338B2 JP 2019516603 A JP2019516603 A JP 2019516603A JP 2019516603 A JP2019516603 A JP 2019516603A JP 7421338 B2 JP7421338 B2 JP 7421338B2
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cancer
fusion protein
expression vector
certain embodiments
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JP2019531728A (ja
JP2019531728A5 (enExample
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ラーソン，クリストファー
リード，トニー
オロンスキー，ブライアン，ティー．
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エピセントアールエックス，インコーポレイテッド
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    • C07—ORGANIC CHEMISTRY
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/179—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
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    • A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
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    • A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
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    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • C07—ORGANIC CHEMISTRY
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    • C07K2319/00—Fusion polypeptide
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    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
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JP2019516603A 2016-09-27 2017-09-27 免疫調節融合タンパク質 Active JP7421338B2 (ja)

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US201662400338P 2016-09-27 2016-09-27
US62/400,338 2016-09-27
US201762484841P 2017-04-12 2017-04-12
US62/484,841 2017-04-12
PCT/US2017/053765 WO2018064190A1 (en) 2016-09-27 2017-09-27 Immunomodulatory fusion proteins

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JP2019531728A5 JP2019531728A5 (enExample) 2020-11-12
JP7421338B2 true JP7421338B2 (ja) 2024-01-24

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US (3) US10906957B2 (enExample)
EP (1) EP3519442A4 (enExample)
JP (2) JP7421338B2 (enExample)
KR (2) KR20190128618A (enExample)
CN (2) CN118307682A (enExample)
AU (1) AU2017336546C1 (enExample)
BR (1) BR112019005964A2 (enExample)
CA (1) CA3038526A1 (enExample)
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