JP2019531728A5 - - Google Patents
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- JP2019531728A5 JP2019531728A5 JP2019516603A JP2019516603A JP2019531728A5 JP 2019531728 A5 JP2019531728 A5 JP 2019531728A5 JP 2019516603 A JP2019516603 A JP 2019516603A JP 2019516603 A JP2019516603 A JP 2019516603A JP 2019531728 A5 JP2019531728 A5 JP 2019531728A5
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- Prior art keywords
- seq
- cancer
- fusion protein
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- amino acid
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 102000037865 fusion proteins Human genes 0.000 claims 29
- 108020001507 fusion proteins Proteins 0.000 claims 29
- 239000013604 expression vector Substances 0.000 claims 15
- 239000002773 nucleotide Substances 0.000 claims 12
- 125000003729 nucleotide group Chemical group 0.000 claims 12
- 241000701161 unidentified adenovirus Species 0.000 claims 11
- 125000003275 alpha amino acid group Chemical group 0.000 claims 10
- 125000000539 amino acid group Chemical group 0.000 claims 9
- 206010028980 Neoplasm Diseases 0.000 claims 8
- 238000000034 method Methods 0.000 claims 7
- 210000004027 cell Anatomy 0.000 claims 5
- 102000003675 cytokine receptors Human genes 0.000 claims 5
- 108010057085 cytokine receptors Proteins 0.000 claims 5
- 241001135569 Human adenovirus 5 Species 0.000 claims 4
- 108060003951 Immunoglobulin Proteins 0.000 claims 4
- 230000007547 defect Effects 0.000 claims 4
- 102000018358 immunoglobulin Human genes 0.000 claims 4
- 238000003780 insertion Methods 0.000 claims 4
- 230000037431 insertion Effects 0.000 claims 4
- 238000011282 treatment Methods 0.000 claims 4
- 210000001744 T-lymphocyte Anatomy 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 230000007812 deficiency Effects 0.000 claims 3
- 201000010536 head and neck cancer Diseases 0.000 claims 3
- 208000014829 head and neck neoplasm Diseases 0.000 claims 3
- 208000032839 leukemia Diseases 0.000 claims 3
- 230000004614 tumor growth Effects 0.000 claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 2
- 208000026310 Breast neoplasm Diseases 0.000 claims 2
- 201000009030 Carcinoma Diseases 0.000 claims 2
- 206010008342 Cervix carcinoma Diseases 0.000 claims 2
- 108091007741 Chimeric antigen receptor T cells Proteins 0.000 claims 2
- 102000004127 Cytokines Human genes 0.000 claims 2
- 108090000695 Cytokines Proteins 0.000 claims 2
- 206010014733 Endometrial cancer Diseases 0.000 claims 2
- 206010014759 Endometrial neoplasm Diseases 0.000 claims 2
- 102000003839 Human Proteins Human genes 0.000 claims 2
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- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 2
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- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 2
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- 206010060862 Prostate cancer Diseases 0.000 claims 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 2
- 208000000453 Skin Neoplasms Diseases 0.000 claims 2
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 2
- 241000700605 Viruses Species 0.000 claims 2
- 201000010881 cervical cancer Diseases 0.000 claims 2
- 102000026898 cytokine binding proteins Human genes 0.000 claims 2
- 108091008470 cytokine binding proteins Proteins 0.000 claims 2
- 210000004602 germ cell Anatomy 0.000 claims 2
- 230000003463 hyperproliferative effect Effects 0.000 claims 2
- 208000015181 infectious disease Diseases 0.000 claims 2
- 230000004968 inflammatory condition Effects 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 201000005202 lung cancer Diseases 0.000 claims 2
- 208000020816 lung neoplasm Diseases 0.000 claims 2
- 210000004698 lymphocyte Anatomy 0.000 claims 2
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 244000309459 oncolytic virus Species 0.000 claims 2
- 201000002528 pancreatic cancer Diseases 0.000 claims 2
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 2
- 201000000849 skin cancer Diseases 0.000 claims 2
- 238000011144 upstream manufacturing Methods 0.000 claims 2
- 102000009027 Albumins Human genes 0.000 claims 1
- 108010088751 Albumins Proteins 0.000 claims 1
- 206010061424 Anal cancer Diseases 0.000 claims 1
- 208000007860 Anus Neoplasms Diseases 0.000 claims 1
- 208000005440 Basal Cell Neoplasms Diseases 0.000 claims 1
- 206010004146 Basal cell carcinoma Diseases 0.000 claims 1
- 206010004593 Bile duct cancer Diseases 0.000 claims 1
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 208000003174 Brain Neoplasms Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 206010051066 Gastrointestinal stromal tumour Diseases 0.000 claims 1
- 206010062878 Gastrooesophageal cancer Diseases 0.000 claims 1
- 241000701109 Human adenovirus 2 Species 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 206010025323 Lymphomas Diseases 0.000 claims 1
- 208000002030 Merkel cell carcinoma Diseases 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- 208000034578 Multiple myelomas Diseases 0.000 claims 1
- 101100012019 Mus musculus Etv4 gene Proteins 0.000 claims 1
- 206010029266 Neuroendocrine carcinoma of the skin Diseases 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 208000015634 Rectal Neoplasms Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 208000006265 Renal cell carcinoma Diseases 0.000 claims 1
- 206010039491 Sarcoma Diseases 0.000 claims 1
- 206010041067 Small cell lung cancer Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 208000024313 Testicular Neoplasms Diseases 0.000 claims 1
- 206010057644 Testis cancer Diseases 0.000 claims 1
- 208000024770 Thyroid neoplasm Diseases 0.000 claims 1
- 102000004887 Transforming Growth Factor beta Human genes 0.000 claims 1
- 108090001012 Transforming Growth Factor beta Proteins 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 208000002495 Uterine Neoplasms Diseases 0.000 claims 1
- 201000011165 anus cancer Diseases 0.000 claims 1
- 208000026900 bile duct neoplasm Diseases 0.000 claims 1
- 201000000220 brain stem cancer Diseases 0.000 claims 1
- 210000004899 c-terminal region Anatomy 0.000 claims 1
- 239000005018 casein Substances 0.000 claims 1
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 claims 1
- 235000021240 caseins Nutrition 0.000 claims 1
- 201000007455 central nervous system cancer Diseases 0.000 claims 1
- 238000002512 chemotherapy Methods 0.000 claims 1
- 208000006990 cholangiocarcinoma Diseases 0.000 claims 1
- 230000000112 colonic effect Effects 0.000 claims 1
- 208000017763 cutaneous neuroendocrine carcinoma Diseases 0.000 claims 1
- 230000009089 cytolysis Effects 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000000539 dimer Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 208000024519 eye neoplasm Diseases 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 201000006974 gastroesophageal cancer Diseases 0.000 claims 1
- 201000011243 gastrointestinal stromal tumor Diseases 0.000 claims 1
- 206010073071 hepatocellular carcinoma Diseases 0.000 claims 1
- 231100000844 hepatocellular carcinoma Toxicity 0.000 claims 1
- 238000001794 hormone therapy Methods 0.000 claims 1
- 230000002519 immonomodulatory effect Effects 0.000 claims 1
- 238000009169 immunotherapy Methods 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 230000000977 initiatory effect Effects 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 201000007270 liver cancer Diseases 0.000 claims 1
- 208000014018 liver neoplasm Diseases 0.000 claims 1
- 208000026045 malignant tumor of parathyroid gland Diseases 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 201000002120 neuroendocrine carcinoma Diseases 0.000 claims 1
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 1
- 201000008106 ocular cancer Diseases 0.000 claims 1
- 230000002611 ovarian Effects 0.000 claims 1
- 201000003913 parathyroid carcinoma Diseases 0.000 claims 1
- 208000017954 parathyroid gland carcinoma Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 235000018102 proteins Nutrition 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 108020003175 receptors Proteins 0.000 claims 1
- 102000005962 receptors Human genes 0.000 claims 1
- 206010038038 rectal cancer Diseases 0.000 claims 1
- 201000001275 rectum cancer Diseases 0.000 claims 1
- 208000015347 renal cell adenocarcinoma Diseases 0.000 claims 1
- 230000011664 signaling Effects 0.000 claims 1
- 201000010106 skin squamous cell carcinoma Diseases 0.000 claims 1
- 208000000587 small cell lung carcinoma Diseases 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 238000001356 surgical procedure Methods 0.000 claims 1
- 201000003120 testicular cancer Diseases 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 201000002510 thyroid cancer Diseases 0.000 claims 1
- 210000004881 tumor cell Anatomy 0.000 claims 1
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
- 206010046766 uterine cancer Diseases 0.000 claims 1
- 230000003612 virological effect Effects 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024003052A JP2024026738A (ja) | 2016-09-27 | 2024-01-12 | 免疫調節融合タンパク質 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662400338P | 2016-09-27 | 2016-09-27 | |
| US62/400,338 | 2016-09-27 | ||
| US201762484841P | 2017-04-12 | 2017-04-12 | |
| US62/484,841 | 2017-04-12 | ||
| PCT/US2017/053765 WO2018064190A1 (en) | 2016-09-27 | 2017-09-27 | Immunomodulatory fusion proteins |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024003052A Division JP2024026738A (ja) | 2016-09-27 | 2024-01-12 | 免疫調節融合タンパク質 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019531728A JP2019531728A (ja) | 2019-11-07 |
| JP2019531728A5 true JP2019531728A5 (enExample) | 2020-11-12 |
| JP7421338B2 JP7421338B2 (ja) | 2024-01-24 |
Family
ID=61763625
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019516603A Active JP7421338B2 (ja) | 2016-09-27 | 2017-09-27 | 免疫調節融合タンパク質 |
| JP2024003052A Pending JP2024026738A (ja) | 2016-09-27 | 2024-01-12 | 免疫調節融合タンパク質 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024003052A Pending JP2024026738A (ja) | 2016-09-27 | 2024-01-12 | 免疫調節融合タンパク質 |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US10906957B2 (enExample) |
| EP (1) | EP3519442A4 (enExample) |
| JP (2) | JP7421338B2 (enExample) |
| KR (2) | KR20240014617A (enExample) |
| CN (2) | CN118307682A (enExample) |
| AU (1) | AU2017336546C1 (enExample) |
| BR (1) | BR112019005964A2 (enExample) |
| CA (1) | CA3038526A1 (enExample) |
| IL (1) | IL265657A (enExample) |
| MX (1) | MX2019003445A (enExample) |
| WO (1) | WO2018064190A1 (enExample) |
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| CA3001131A1 (en) | 2015-11-02 | 2017-05-11 | Five Prime Therapeutics, Inc. | Cd80 extracellular domain polypeptides and their use in cancer treatment |
| US10906957B2 (en) | 2016-09-27 | 2021-02-02 | Epicentrx, Inc. | Immunomodulatory fusion proteins |
| JP7657548B2 (ja) | 2017-04-21 | 2025-04-07 | エランコ・ユーエス・インコーポレイテッド | 獣医学的使用のためのｉｌ４／ｉｌ１３受容体分子 |
| CN110546509A (zh) | 2017-04-28 | 2019-12-06 | 戊瑞治疗有限公司 | 用cd80细胞外结构域多肽进行治疗的方法 |
| LT3628049T (lt) | 2017-05-04 | 2023-08-25 | Acceleron Pharma Inc. | Tgf-beta ii tipo receptoriaus sulieti baltymai ir jų panaudojimo būdai |
| AU2018337671B2 (en) * | 2017-09-19 | 2021-03-04 | Paul Scherrer Institut | Transglutaminase conjugation method and linker |
| KR102757384B1 (ko) | 2017-09-27 | 2025-01-20 | 에피센트알엑스, 인코포레이티드 | 면역조절 융합 단백질 |
| CN112566650A (zh) | 2018-06-21 | 2021-03-26 | 沙塔克实验室有限公司 | 异二聚体蛋白及其用途 |
| JP2021528399A (ja) * | 2018-06-22 | 2021-10-21 | メルク パテント ゲーエムベーハー | 胆道癌を治療する際に使用するための標的ＴＧＦ−β阻害のための投薬計画 |
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| AU2020316002B2 (en) * | 2019-07-25 | 2026-05-07 | The University Of Chicago | Compositions and methods comprising protease-activated therapeutic agents |
| CN112574314A (zh) * | 2019-09-30 | 2021-03-30 | 和铂医药(苏州)有限公司 | 一种融合蛋白及其应用 |
| CN111000982A (zh) * | 2019-12-25 | 2020-04-14 | 沣潮医药科技（上海）有限公司 | Amhr2重组蛋白或融合蛋白在制备amh信号轴异常活化相关疾病治疗药物中的用途 |
| CN111154806A (zh) * | 2020-01-08 | 2020-05-15 | 深圳普菲科生命科技有限公司 | 一种嵌合外源超级细胞因子的溶瘤病毒载体系统及其在药物中的应用 |
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| CN111690070A (zh) * | 2020-05-13 | 2020-09-22 | 深圳市众循精准医学研究院 | 一种sPD-1-Fc-sTGFβRII融合蛋白及其应用 |
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| WO2010031168A1 (en) | 2008-09-17 | 2010-03-25 | National Research Council Of Canada | HETERO-MULTIVALENT BINDING AGENTS FOR MEMBERS OF THE TGFβ SUPERFAMILY |
| JP2011524741A (ja) | 2008-05-27 | 2011-09-08 | 協和発酵キリン株式会社 | インターロイキン１０受容体（ｉｌ−１０ｒ）抗体及び使用方法 |
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2017
- 2017-09-27 US US15/717,199 patent/US10906957B2/en active Active
- 2017-09-27 JP JP2019516603A patent/JP7421338B2/ja active Active
- 2017-09-27 KR KR1020247002333A patent/KR20240014617A/ko not_active Ceased
- 2017-09-27 AU AU2017336546A patent/AU2017336546C1/en not_active Ceased
- 2017-09-27 KR KR1020197012132A patent/KR20190128618A/ko not_active Ceased
- 2017-09-27 CN CN202410281185.1A patent/CN118307682A/zh active Pending
- 2017-09-27 EP EP17857347.3A patent/EP3519442A4/en active Pending
- 2017-09-27 CA CA3038526A patent/CA3038526A1/en active Pending
- 2017-09-27 MX MX2019003445A patent/MX2019003445A/es unknown
- 2017-09-27 BR BR112019005964-4A patent/BR112019005964A2/pt active Search and Examination
- 2017-09-27 CN CN201780073371.4A patent/CN110546168B/zh active Active
- 2017-09-27 WO PCT/US2017/053765 patent/WO2018064190A1/en not_active Ceased
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2019
- 2019-03-27 IL IL265657A patent/IL265657A/en unknown
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2021
- 2021-01-15 US US17/150,993 patent/US12054530B2/en active Active
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2024
- 2024-01-12 JP JP2024003052A patent/JP2024026738A/ja active Pending
- 2024-07-12 US US18/772,025 patent/US20250074967A1/en active Pending
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