JP7402804B2 - ピラゾール化合物及びその調製 - Google Patents
ピラゾール化合物及びその調製 Download PDFInfo
- Publication number
- JP7402804B2 JP7402804B2 JP2020541983A JP2020541983A JP7402804B2 JP 7402804 B2 JP7402804 B2 JP 7402804B2 JP 2020541983 A JP2020541983 A JP 2020541983A JP 2020541983 A JP2020541983 A JP 2020541983A JP 7402804 B2 JP7402804 B2 JP 7402804B2
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- methyl
- alkyl
- difluoromethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J23/00—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00
- B01J23/70—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of the iron group metals or copper
- B01J23/72—Copper
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J27/00—Catalysts comprising the elements or compounds of halogens, sulfur, selenium, tellurium, phosphorus or nitrogen; Catalysts comprising carbon compounds
- B01J27/06—Halogens; Compounds thereof
- B01J27/08—Halides
- B01J27/122—Halides of copper
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/18—One oxygen or sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Materials Engineering (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN201811003855 | 2018-02-01 | ||
| IN201811003855 | 2018-02-01 | ||
| IN201811003859 | 2018-02-01 | ||
| IN201811003859 | 2018-02-01 | ||
| IN201711042921 | 2018-05-30 | ||
| IN201711042921 | 2018-05-30 | ||
| PCT/IN2019/050076 WO2019150392A1 (en) | 2018-02-01 | 2019-02-01 | Pyrazole compounds and preparation thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021512127A JP2021512127A (ja) | 2021-05-13 |
| JP2021512127A5 JP2021512127A5 (https=) | 2022-01-27 |
| JP7402804B2 true JP7402804B2 (ja) | 2023-12-21 |
Family
ID=67478207
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020541983A Active JP7402804B2 (ja) | 2018-02-01 | 2019-02-01 | ピラゾール化合物及びその調製 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US11873289B2 (https=) |
| EP (1) | EP3746434A4 (https=) |
| JP (1) | JP7402804B2 (https=) |
| KR (1) | KR102951622B1 (https=) |
| CN (1) | CN111670184A (https=) |
| AU (1) | AU2019213854C1 (https=) |
| BR (1) | BR112020015692A2 (https=) |
| CA (1) | CA3090204A1 (https=) |
| IL (1) | IL276410B2 (https=) |
| MA (1) | MA54677A (https=) |
| MX (2) | MX2020008151A (https=) |
| MY (1) | MY209060A (https=) |
| SG (1) | SG11202007328UA (https=) |
| WO (1) | WO2019150392A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3090204A1 (en) | 2018-02-01 | 2019-08-08 | MyoKardia, Inc. | Pyrazole compounds and preparation thereof |
| WO2025244956A1 (en) * | 2024-05-20 | 2025-11-27 | MyoKardia, Inc. | Methods of manufacturing danicamtiv |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007284386A (ja) | 2006-04-18 | 2007-11-01 | Kumiai Chem Ind Co Ltd | ３−ピラゾリルフェニルスルフィド誘導体及びそれを有効成分として含有する殺虫・殺ダニ・殺線虫剤 |
| WO2012166415A1 (en) | 2011-05-27 | 2012-12-06 | Amira Pharmaceuticals, Inc. | Heterocyclic autotaxin inhibitors and uses thereof |
| WO2016118774A1 (en) | 2015-01-22 | 2016-07-28 | MyoKardia, Inc. | 4-methylsulfonyl-substituted piperidine urea compounds for the treatment of dilated cardiomyopathy (dcm) |
| WO2018132372A1 (en) | 2017-01-10 | 2018-07-19 | Sanford Burnham Prebys Medical Discovery Institute | Small molecule activators of nicotinamide phosphoribosyltransferase (nampt) and uses thereof |
| WO2018191283A1 (en) | 2017-04-11 | 2018-10-18 | Oric Pharmaceuticals, Inc. | Glucocorticoid receptor modulators |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8324178B2 (en) * | 2008-10-31 | 2012-12-04 | The Regents Of The University Of California | Method of treatment using alpha-1-adrenergic agonist compounds |
| BR112015004097B1 (pt) | 2012-08-30 | 2020-02-18 | Bayer Cropscience Ag | Procedimento para a descarboxilação de derivados do ácido 3,5-bis (haloalquil) -pirazol-4-carboxílico |
| CN104968664A (zh) | 2012-12-12 | 2015-10-07 | 山东亨利医药科技有限责任公司 | 作为酪氨酸激酶抑制剂的并环化合物 |
| EP3063134B1 (en) | 2013-11-01 | 2020-08-12 | Srf Limited | Process for the preparation of pyrazole derivatives |
| EP3015458A1 (en) | 2014-11-03 | 2016-05-04 | Bayer CropScience AG | Process for preparing 3,5-bis(haloalkyl)pyrazole derivatives from a,a-dihaloamines and ketimines |
| CA3090204A1 (en) | 2018-02-01 | 2019-08-08 | MyoKardia, Inc. | Pyrazole compounds and preparation thereof |
-
2019
- 2019-02-01 CA CA3090204A patent/CA3090204A1/en active Pending
- 2019-02-01 BR BR112020015692-2A patent/BR112020015692A2/pt active Search and Examination
- 2019-02-01 EP EP19747117.0A patent/EP3746434A4/en active Pending
- 2019-02-01 SG SG11202007328UA patent/SG11202007328UA/en unknown
- 2019-02-01 JP JP2020541983A patent/JP7402804B2/ja active Active
- 2019-02-01 MY MYPI2020003963A patent/MY209060A/en unknown
- 2019-02-01 WO PCT/IN2019/050076 patent/WO2019150392A1/en not_active Ceased
- 2019-02-01 US US16/966,502 patent/US11873289B2/en active Active
- 2019-02-01 MA MA054677A patent/MA54677A/fr unknown
- 2019-02-01 CN CN201980011350.9A patent/CN111670184A/zh active Pending
- 2019-02-01 AU AU2019213854A patent/AU2019213854C1/en active Active
- 2019-02-01 MX MX2020008151A patent/MX2020008151A/es unknown
- 2019-02-01 IL IL276410A patent/IL276410B2/en unknown
- 2019-02-01 KR KR1020207022279A patent/KR102951622B1/ko active Active
-
2020
- 2020-07-31 MX MX2025003379A patent/MX2025003379A/es unknown
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007284386A (ja) | 2006-04-18 | 2007-11-01 | Kumiai Chem Ind Co Ltd | ３−ピラゾリルフェニルスルフィド誘導体及びそれを有効成分として含有する殺虫・殺ダニ・殺線虫剤 |
| WO2012166415A1 (en) | 2011-05-27 | 2012-12-06 | Amira Pharmaceuticals, Inc. | Heterocyclic autotaxin inhibitors and uses thereof |
| WO2016118774A1 (en) | 2015-01-22 | 2016-07-28 | MyoKardia, Inc. | 4-methylsulfonyl-substituted piperidine urea compounds for the treatment of dilated cardiomyopathy (dcm) |
| WO2018132372A1 (en) | 2017-01-10 | 2018-07-19 | Sanford Burnham Prebys Medical Discovery Institute | Small molecule activators of nicotinamide phosphoribosyltransferase (nampt) and uses thereof |
| WO2018191283A1 (en) | 2017-04-11 | 2018-10-18 | Oric Pharmaceuticals, Inc. | Glucocorticoid receptor modulators |
Non-Patent Citations (3)
| Title |
|---|
| REGISTRY(STN)[online]，検索日2023年1月16日:2010年 3月19日RN:1211751-27-7 |
| REGISTRY(STN)[online]，検索日2023年1月16日:2017年 7月27日RN:2104044-77-9, 2017年 7月27日RN:2104044-77-9, 2013年12月18日RN:1497942-42-3, 2013年12月12日RN:1493355-09-1, 2013年11月29日RN:1483601-89-3, 2013年11月26日RN:1481670-85-2, 2013年11月24日RN:1479559-89-1, 2013年11月 3日RN:1468599-50-9, 2013年10月30日RN:1465992-88-4, 2013年10月28日RN:1465207-27-5, 2012年 3月15日RN:1361004-09-2, 2011年11月10日RN:1343840-74-3, 2011年11月 8日RN:1342785-14-1, |
| REGISTRY(STN)[online]，検索日2023年5月8日:2016年 1月31日RN:1856047-69-2 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP3746434A1 (en) | 2020-12-09 |
| IL276410B2 (en) | 2024-09-01 |
| IL276410A (en) | 2020-09-30 |
| MX2020008151A (es) | 2020-09-18 |
| US11873289B2 (en) | 2024-01-16 |
| KR102951622B1 (ko) | 2026-04-13 |
| AU2019213854C1 (en) | 2023-12-14 |
| US20210053940A1 (en) | 2021-02-25 |
| SG11202007328UA (en) | 2020-08-28 |
| MX2025003379A (es) | 2025-05-02 |
| MA54677A (fr) | 2021-11-17 |
| MY209060A (en) | 2025-06-18 |
| KR20200118025A (ko) | 2020-10-14 |
| CA3090204A1 (en) | 2019-08-08 |
| EP3746434A4 (en) | 2021-11-17 |
| AU2019213854B2 (en) | 2023-06-15 |
| CN111670184A (zh) | 2020-09-15 |
| JP2021512127A (ja) | 2021-05-13 |
| AU2019213854A1 (en) | 2020-09-03 |
| BR112020015692A2 (pt) | 2020-12-08 |
| WO2019150392A1 (en) | 2019-08-08 |
| IL276410B1 (en) | 2024-05-01 |
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