JP7399850B2 - 芳香族ニトリル化合物の製造方法 - Google Patents

芳香族ニトリル化合物の製造方法 Download PDF

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JP7399850B2
JP7399850B2 JP2020515623A JP2020515623A JP7399850B2 JP 7399850 B2 JP7399850 B2 JP 7399850B2 JP 2020515623 A JP2020515623 A JP 2020515623A JP 2020515623 A JP2020515623 A JP 2020515623A JP 7399850 B2 JP7399850 B2 JP 7399850B2
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compound represented
formula
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carboxylic acid
reaction
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JPWO2019208807A5 (https=
JPWO2019208807A1 (ja
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正樹 長濱
秀貴 大宮
大樹 尾門
裕次 谷池
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API Corp
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/20—Preparation of carboxylic acid nitriles by dehydration of carboxylic acid amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C233/11—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
    • C07C255/33—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring with cyano groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by saturated carbon chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/34—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfuric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/06—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/16—Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation
    • C07C51/305—Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation with sulfur or sulfur-containing compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/58—Preparation of carboxylic acid halides
    • C07C51/60—Preparation of carboxylic acid halides by conversion of carboxylic acids or their anhydrides or esters, lactones, salts into halides with the same carboxylic acid part
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C07C57/38—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C07C57/38—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings polycyclic
    • C07C57/40—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings polycyclic containing condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/194—Radicals derived from thio- or thiono carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
JP2020515623A 2018-04-26 2019-04-26 芳香族ニトリル化合物の製造方法 Active JP7399850B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862663014P 2018-04-26 2018-04-26
US62/663,014 2018-04-26
US201862780445P 2018-12-17 2018-12-17
US62/780,445 2018-12-17
PCT/JP2019/018065 WO2019208807A1 (ja) 2018-04-26 2019-04-26 芳香族ニトリル化合物の製造方法

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JPWO2019208807A1 JPWO2019208807A1 (ja) 2021-04-30
JPWO2019208807A5 JPWO2019208807A5 (https=) 2022-05-09
JP7399850B2 true JP7399850B2 (ja) 2023-12-18

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US (2) US12054448B2 (https=)
EP (2) EP3786152B1 (https=)
JP (1) JP7399850B2 (https=)
KR (2) KR102796989B1 (https=)
CN (3) CN118439973A (https=)
CA (1) CA3098437C (https=)
ES (1) ES3015171T3 (https=)
PL (1) PL3786152T3 (https=)
WO (1) WO2019208807A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018159028A1 (ja) * 2017-03-01 2018-09-07 株式会社エーピーアイ コーポレーション Ｎ－ベンジル－２－ブロモ－３－メトキシプロピオン酸アミド及びその中間体の製造方法
WO2021085468A1 (ja) * 2019-10-29 2021-05-06 株式会社エーピーアイ コーポレーション 高純度２－ナフチルアセトニトリル及びその製造方法
CN115784929B (zh) * 2022-12-21 2023-10-13 浦拉司科技（上海）有限责任公司 一种巴豆腈的制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005529973A (ja) 2002-06-20 2005-10-06 アストラゼネカ・アクチエボラーグ ３−シアノ−１−ナフトエ酸およびその類似体の製造法
WO2014001939A1 (en) 2012-06-30 2014-01-03 Alembic Pharmaceuticals Limited Process for preparation of agomelatine and crystalline form i thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61268650A (ja) * 1985-05-21 1986-11-28 Otsuka Pharmaceut Factory Inc ナフトキノン誘導体
JP2001039904A (ja) 1999-07-29 2001-02-13 Sumikin Chemical Co Ltd ブロモアルキルナフタレンの製造方法
NZ592836A (en) 2005-07-27 2013-01-25 Dov Pharmaceutical Inc Novel 1-aryl-3-azabicyclo[3.1.0]hexanes: preparation and use to treat neuropsychiatric disorders
JP2010268650A (ja) * 2009-05-18 2010-11-25 Daikin Ind Ltd アキシャルギャップ型回転電機
KR20160101012A (ko) 2013-12-09 2016-08-24 뉴로반스, 인크. 신규 조성물
WO2021085468A1 (ja) 2019-10-29 2021-05-06 株式会社エーピーアイ コーポレーション 高純度２－ナフチルアセトニトリル及びその製造方法

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005529973A (ja) 2002-06-20 2005-10-06 アストラゼネカ・アクチエボラーグ ３−シアノ−１−ナフトエ酸およびその類似体の製造法
WO2014001939A1 (en) 2012-06-30 2014-01-03 Alembic Pharmaceuticals Limited Process for preparation of agomelatine and crystalline form i thereof

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
ALAM, M. M. et al.，Synthetic Communications，2003年
HULKENBERG, A. et al.，Tetrahedron Letters，1982年，Vol.23, No.14，pp.1505-1508
PRICE, C. C. et al.，J.Org.Chem.，1949年

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Publication number Publication date
WO2019208807A1 (ja) 2019-10-31
EP3786152A4 (en) 2021-06-16
EP3786152B1 (en) 2024-12-25
US12054448B2 (en) 2024-08-06
EP4520753A3 (en) 2025-05-28
JPWO2019208807A1 (ja) 2021-04-30
CN120441453A (zh) 2025-08-08
ES3015171T3 (en) 2025-04-29
KR20240121346A (ko) 2024-08-08
PL3786152T3 (pl) 2025-04-28
CA3098437C (en) 2025-04-01
EP3786152A1 (en) 2021-03-03
CA3098437A1 (en) 2019-10-31
KR20210005663A (ko) 2021-01-14
US20240351978A1 (en) 2024-10-24
CN118439973A (zh) 2024-08-06
EP4520753A2 (en) 2025-03-12
KR102796989B1 (ko) 2025-04-18
CN112041298A (zh) 2020-12-04
US20210078940A1 (en) 2021-03-18

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